Finally, a paper to cite when reviewers come back asking for the TUDCA experiment
#ER_literature
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
www.molbiolcell.org/doi/10.1091/...
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
www.molbiolcell.org/doi/10.1091/...
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae | Molecular Biology of the Cell
Cells counter accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) through activation of the Unfolded Protein Response (UPR). Small molecules termed chemical chaperones can p...
www.molbiolcell.org
December 15, 2024 at 7:42 PM
Finally, a paper to cite when reviewers come back asking for the TUDCA experiment
Between this and the TUDCA, maybe bearmaxxing was always the way to go.
September 29, 2026 at 4:13 AM
Between this and the TUDCA, maybe bearmaxxing was always the way to go.
Tag 17: gestern unfreiwilliger Belastungstest in Form von Putzen für unvermeidbaren Besuch. Gesamt > 5000 Schritte, abends dann Fatigue und Muskelschmerzen. Heute kein PEM, aber merkliche Eintrübung des Wohlbefindens, v.a. Erschöpfung. Vitalwerte allerdings sehr gut.
#tudca #cureme
#tudca #cureme
September 8, 2023 at 12:27 PM
Tag 17: gestern unfreiwilliger Belastungstest in Form von Putzen für unvermeidbaren Besuch. Gesamt > 5000 Schritte, abends dann Fatigue und Muskelschmerzen. Heute kein PEM, aber merkliche Eintrübung des Wohlbefindens, v.a. Erschöpfung. Vitalwerte allerdings sehr gut.
#tudca #cureme
#tudca #cureme
haben sich normalisiert.
Vll. ist es was für dich. Das T in TUDCA steht übrigens für ein Taurin Molekül.
/2
Vll. ist es was für dich. Das T in TUDCA steht übrigens für ein Taurin Molekül.
/2
October 18, 2023 at 6:59 PM
haben sich normalisiert.
Vll. ist es was für dich. Das T in TUDCA steht übrigens für ein Taurin Molekül.
/2
Vll. ist es was für dich. Das T in TUDCA steht übrigens für ein Taurin Molekül.
/2
For example this study of mitochondrial disruption in ME/CFS produced two potential treatments to trial: TUDCA and salubrinal. Very cool stuff, I want to see so much more work to understand what disease mechanisms we need to target, and then run trials accordingly.
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome
Chronic fatigue is a debilitating symptom that affects many individuals, but its mechanism remains poorly understood. This study shows that endoplamic reticulum (ER) stress–induced WASF3 protein localizes to mitochondria and disrupts respiratory ...
pmc.ncbi.nlm.nih.gov
February 19, 2026 at 8:34 PM
For example this study of mitochondrial disruption in ME/CFS produced two potential treatments to trial: TUDCA and salubrinal. Very cool stuff, I want to see so much more work to understand what disease mechanisms we need to target, and then run trials accordingly.
New research by Erik Snapp @hhmijanelia.bsky.social & Patrick Lajoie @westernu.bsky.social challenges the classification of the bile acid TUDCA as a chemical chaperone & proposes a strategy to evaluate other putative chemical chaperones to determine their modes of action. https://hhmi.news/4jemZUL
January 14, 2025 at 5:30 PM
New research by Erik Snapp @hhmijanelia.bsky.social & Patrick Lajoie @westernu.bsky.social challenges the classification of the bile acid TUDCA as a chemical chaperone & proposes a strategy to evaluate other putative chemical chaperones to determine their modes of action. https://hhmi.news/4jemZUL
I swear by TUDCA. Took 5-6 weeks to notice a difference but it was a significant one as greatly reduced my muscle fatigue and weakness.
August 6, 2025 at 12:00 PM
I swear by TUDCA. Took 5-6 weeks to notice a difference but it was a significant one as greatly reduced my muscle fatigue and weakness.
#ER_literature
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
www.molbiolcell.org/doi/10.1091/...
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
www.molbiolcell.org/doi/10.1091/...
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae | Molecular Biology of the Cell
Cells counter accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) through activation of the Unfolded Protein Response (UPR). Small molecules termed chemical chaperones can p...
www.molbiolcell.org
December 12, 2024 at 6:15 PM
#ER_literature
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
www.molbiolcell.org/doi/10.1091/...
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
www.molbiolcell.org/doi/10.1091/...
Tag 3 mit der Leberpflege und ich habe mich von meinem Ausflug an den See und dem Schwimmen erholt.
K.A. ob das der Gang der Dinge war oder das NEM. Aber ich wollte berichten und kann hiermit einen positiven Auftakt vermelden.
#mecfs #cureME #Tudca
K.A. ob das der Gang der Dinge war oder das NEM. Aber ich wollte berichten und kann hiermit einen positiven Auftakt vermelden.
#mecfs #cureME #Tudca
August 24, 2023 at 5:03 PM
Tag 3 mit der Leberpflege und ich habe mich von meinem Ausflug an den See und dem Schwimmen erholt.
K.A. ob das der Gang der Dinge war oder das NEM. Aber ich wollte berichten und kann hiermit einen positiven Auftakt vermelden.
#mecfs #cureME #Tudca
K.A. ob das der Gang der Dinge war oder das NEM. Aber ich wollte berichten und kann hiermit einen positiven Auftakt vermelden.
#mecfs #cureME #Tudca
MBoC
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae, by Patrick Lajoie, Western University, et al.
doi.org/10.1091/mbc.... #ASCB #CellBiology
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae, by Patrick Lajoie, Western University, et al.
doi.org/10.1091/mbc.... #ASCB #CellBiology
March 20, 2025 at 12:22 PM
MBoC
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae, by Patrick Lajoie, Western University, et al.
doi.org/10.1091/mbc.... #ASCB #CellBiology
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae, by Patrick Lajoie, Western University, et al.
doi.org/10.1091/mbc.... #ASCB #CellBiology
I wasn't taking TUDCA for my liver + my liver results were always in normal range anyway. I started taking it because of Hwang's study showing ER stress in MECFS patients. TUDCA has been shown to reduce ER stress in mitochondria so I just threw it into my stack. I've been on 500mg a day for 1.5yrs.
August 6, 2025 at 3:02 PM
I wasn't taking TUDCA for my liver + my liver results were always in normal range anyway. I started taking it because of Hwang's study showing ER stress in MECFS patients. TUDCA has been shown to reduce ER stress in mitochondria so I just threw it into my stack. I've been on 500mg a day for 1.5yrs.
TUDCA also allowed me to tolerate dairy and gluten again and eliminated my eye floaters that I've had since the onset of my MECFS.
August 6, 2025 at 3:03 PM
TUDCA also allowed me to tolerate dairy and gluten again and eliminated my eye floaters that I've had since the onset of my MECFS.
Can a bile acid protect the brain? TUDCA shows promise for Alzheimer’s, Parkinson’s, and MS.
Read more: ndnr.com/neurology/tudca-ne...
Read more: ndnr.com/neurology/tudca-ne...
July 21, 2025 at 1:51 AM
Can a bile acid protect the brain? TUDCA shows promise for Alzheimer’s, Parkinson’s, and MS.
Read more: ndnr.com/neurology/tudca-ne...
Read more: ndnr.com/neurology/tudca-ne...
It is a lot but I went from barely walking and mostly bedbound and planning medical suicide to being disabled-ly functional. Most important bits revolved around kickstarting mitochondrial turnover: PQQ, TUDCA, ALA, L-carnitine, Bs especially TTFD, glutathione ... these may not help everyone.
May 13, 2026 at 3:56 PM
It is a lot but I went from barely walking and mostly bedbound and planning medical suicide to being disabled-ly functional. Most important bits revolved around kickstarting mitochondrial turnover: PQQ, TUDCA, ALA, L-carnitine, Bs especially TTFD, glutathione ... these may not help everyone.
this one is compounded ursodiol
you can get TUDCA as a supplement (it's just ursodiol with taurine conjugated to it, which is what happens in the gut anyway)
I'd been avoiding that because I didn't want to feed b. wadsworthia in my gut but at this point, fuck it, I'm going to try it and see
you can get TUDCA as a supplement (it's just ursodiol with taurine conjugated to it, which is what happens in the gut anyway)
I'd been avoiding that because I didn't want to feed b. wadsworthia in my gut but at this point, fuck it, I'm going to try it and see
December 24, 2025 at 6:37 PM
this one is compounded ursodiol
you can get TUDCA as a supplement (it's just ursodiol with taurine conjugated to it, which is what happens in the gut anyway)
I'd been avoiding that because I didn't want to feed b. wadsworthia in my gut but at this point, fuck it, I'm going to try it and see
you can get TUDCA as a supplement (it's just ursodiol with taurine conjugated to it, which is what happens in the gut anyway)
I'd been avoiding that because I didn't want to feed b. wadsworthia in my gut but at this point, fuck it, I'm going to try it and see
New study on the gut-lung axis 🫁
Authors show that gut Eggerthella lenta can produce taurine ursodeoxycholic acid (TUDCA) which impairs neutrophil function by reducing AMPK phosphorylation & exacerbating bacterial lung infections, esp. in bronchiectasis patients
🔗 www.science.org/doi/10.1126/...
Authors show that gut Eggerthella lenta can produce taurine ursodeoxycholic acid (TUDCA) which impairs neutrophil function by reducing AMPK phosphorylation & exacerbating bacterial lung infections, esp. in bronchiectasis patients
🔗 www.science.org/doi/10.1126/...
A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection
TUDCA from gut E. lenta hinders AMPK activation and neutrophil phagocytosis, worsening bacterial lung infection in patients with bronchiectasis.
www.science.org
February 28, 2025 at 1:44 AM
New study on the gut-lung axis 🫁
Authors show that gut Eggerthella lenta can produce taurine ursodeoxycholic acid (TUDCA) which impairs neutrophil function by reducing AMPK phosphorylation & exacerbating bacterial lung infections, esp. in bronchiectasis patients
🔗 www.science.org/doi/10.1126/...
Authors show that gut Eggerthella lenta can produce taurine ursodeoxycholic acid (TUDCA) which impairs neutrophil function by reducing AMPK phosphorylation & exacerbating bacterial lung infections, esp. in bronchiectasis patients
🔗 www.science.org/doi/10.1126/...
Ich habe keine schlechten Leberwerte, aber nehme als Therapieversuch für MECFS TUDCA ein. Das wird zugleich als Leberpflege beworben. Mir geht es seither besser, Kausalzusammenhänge lasse ich mal außen vor.
Mein Mann hat kein MECFS, aber schlechte Leberwerte. Er hat es genommen und seine Werte 1/
Mein Mann hat kein MECFS, aber schlechte Leberwerte. Er hat es genommen und seine Werte 1/
October 18, 2023 at 6:56 PM
Ich habe keine schlechten Leberwerte, aber nehme als Therapieversuch für MECFS TUDCA ein. Das wird zugleich als Leberpflege beworben. Mir geht es seither besser, Kausalzusammenhänge lasse ich mal außen vor.
Mein Mann hat kein MECFS, aber schlechte Leberwerte. Er hat es genommen und seine Werte 1/
Mein Mann hat kein MECFS, aber schlechte Leberwerte. Er hat es genommen und seine Werte 1/
June 26, 2026 at 9:16 AM
Nothing deleterious about UDCA though , TUDCA just has a lot of bonuses
April 28, 2026 at 1:32 PM
Nothing deleterious about UDCA though , TUDCA just has a lot of bonuses
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May 17, 2025 at 1:59 PM
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But it would be a lot better as a digestive aid per se than either TUDCA or UDCA would; combining it with TUDCA would be a lovely combo
U could try ox bile with meals and TUDCA whenever u please , it will resorb and recirculate if u keep it topped up
U could try ox bile with meals and TUDCA whenever u please , it will resorb and recirculate if u keep it topped up
April 28, 2026 at 1:50 PM
But it would be a lot better as a digestive aid per se than either TUDCA or UDCA would; combining it with TUDCA would be a lovely combo
U could try ox bile with meals and TUDCA whenever u please , it will resorb and recirculate if u keep it topped up
U could try ox bile with meals and TUDCA whenever u please , it will resorb and recirculate if u keep it topped up