#TotalSynthesis
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christmann.bsky.social
Lorenz Wiese completed the #TotalSynthesis of the #Meroterpenoid #naturalproduct Cleistocaltone A, a #RSV #Inhibitor. Congrats, Lorenz! Now available on
ChemRxiv: chemrxiv.org/engage/chemr...
November 13, 2024 at 2:56 PM
totalsynthesis.bsky.social
#TotalSynthesis is here @bsky.app
November 12, 2024 at 6:41 PM
beilstein-institut.bsky.social
Meet Dr. Martí Recort-Fornals at the Island2 Chem Conference from September 2 to 4, 2026 at the University of La Laguna, Tenerife. 
🔗 https://island2chemconference.com/
#Island2ChemConference #Island2Chem #catalysis #TotalSynthesis #PhysicalChemistry #OrganicChemistry
August 31, 2026 at 8:03 AM
synlettjournal.bsky.social
Unlocking complex spirocyclic oroidin #alkaloids like palau’amine🔬 Carl Lovely & co-workers report a novel Diels–Alder sequence with tandem #TBAF desilylation, oxidation & rearrangement to create a versatile intermediate for #TotalSynthesis.
#cycloaddition

👉 buff.ly/mi6k9Sl
August 15, 2025 at 7:02 AM
synthesis1969.bsky.social
Go check out how Debendra K. Mohapatra and team achieved the first asymmetric total synthesis and structural confirmation of lobophopyranone A and B from commercially available starting materials! 🔬💡
#TotalSynthesis

Learn more 👉 https://buff.ly/4ghzWKM
February 7, 2025 at 8:00 AM
asbmb.bsky.social
"We try to help access these molecules not only in an efficient way but also in a creative way in order to expand chemical knowledge about how we put molecules together."
—Stanna Dorn, a #postdoc in @reiswoman.bsky.social's lab
ow.ly/MIqh50VHRHk
#TotalSynthesis #OrganicChemistry #ASBMBMOSAIC
Finding a symphony among complex molecules
MOSAIC scholar Stanna Dorn uses total synthesis to recreate rare bacterial natural products with potential therapeutic applications.
ow.ly
April 25, 2025 at 5:17 PM
synthesis1969.bsky.social
🧪 Explore this paper by Emmanuel Roulland & co-workers on the synthesis of the complex polyketidic macrolactam of incednine! This work advances #TotalSynthesis strategies such as a Pd-catalyzed cross-coupling and Horner–Wadsworth–Emmons olefination

👉 buff.ly/N3niEoF
March 31, 2025 at 7:00 AM
tbpoulsen.bsky.social
Congrats to all of the authors, in particular to Florian Kromm and Søren Borcher Møller who lead this work together. 👏 We are grateful for the @erc.europa.eu opa.eu for funding.
#totalsynthesis
May 29, 2025 at 11:44 AM
synlettjournal.bsky.social
Rajendra Rohokale & co-workers report the enantioselective synthesis of 2-azido-norfuranomycin from a D-glucose-derived chiral synthon⚗️ Key steps include oxidative cleavage, azido-olefin formation & ring-closing metathesis to build the dihydrofuran core🔬
#TotalSynthesis

👉 buff.ly/w3Et1yY
April 3, 2026 at 7:01 AM
synthesis1969.bsky.social
Go check out how Alakesh Bisai and co-workers achieved an efficient asymmetric approach to ergot alkaloids via highly regioselective Heck cyclization!🔬💡
#TotalSynthesis

Learn more 👉 www.thieme-connect.com/products/ejo...
January 20, 2025 at 4:39 PM
russellcoxchem.bsky.social
One Step Rational #TotalSynthesis of Daptomycins

Lipidation Engineering in Daptomycin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Lipidation Engineering in Daptomycin Biosynthesis
Lipopeptides are an important family of natural products, some of which are clinically used as antibiotics to treat multidrug-resistant pathogens. Although the lipid moieties play a crucial role in ba...
pubs.acs.org
November 19, 2024 at 3:47 PM
synthesis1969.bsky.social
Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis

👉 buff.ly/XvYGfsW
September 8, 2025 at 7:01 AM
synlettjournal.bsky.social
🧪An overlooked gem in synthesis? Qian & Gui highlight the untapped potential of #sitolactone —a cheap, commercially available chiral building block with major promise for natural product synthesis🌿 Despite its value, it has featured in only a handful of #TotalSynthesis

👉 buff.ly/ppWNWYK
July 3, 2026 at 7:02 AM
synthesis1969.bsky.social
✨Bürgenstock Special Section 2023✨

First enantioselective #TotalSynthesis of lucidumone in 13 steps🍄! Aurélien de la Torre @auredelatorre.bsky.social & co-workers use a retro-[4+2]/#DielsAlder cascade to access this COX-2 selective #meroterpenoid

👉 buff.ly/O6SQ8Os
August 26, 2025 at 7:01 AM
chemistryunb.bsky.social
It’s March break, but chemistry keeps coming to UNB! Huck Grover from @memorialu.bsky.social walking us through a Diazo cascade during their Atlantic Seminar series. #chemsky #totalsynthesis
Huck Grover in front of summary slide with title “Summary of Diazo Cascade”
March 3, 2025 at 5:15 PM
livesinchem.bsky.social
🎁HBT Paul Knochel (LMU Munich), who turns 70 today—unbelievable knowing his charming boyish appeal. Developing new synthetic methods, in particular based on organometallic compounds, and applying them in the #TotalSynthesis of natural products has become a hallmark of the Knochel group.
Paul Knochel · ©Société Chimique de France
November 15, 2025 at 6:12 AM
russellcoxchem.bsky.social
One Step #TotalSynthesis of Colchicine

pubs.acs.org/doi/10.1021/...
Total Biosynthesis of the Tubulin-Binding Alkaloid Colchicine
Colchicine (1) is a bioactive plant alkaloid from Colchicum and Gloriosa species that is used as a pharmaceutical treatment for inflammatory diseases, including gouty arthritis and familial Mediterran...
pubs.acs.org
January 26, 2025 at 1:02 PM
russellcoxchem.bsky.social
One Step #TotalSynthesis of Homomorphins

pubs.acs.org/doi/10.1021/...
Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System
Fungal secondary metabolite (SM) biosynthetic gene clusters (BGCs) containing dimethylallyltryptophan synthases (DMATSs) produce structurally diverse prenylated indole alkaloids with wide-ranging acti...
pubs.acs.org
November 22, 2024 at 9:21 AM
synthesis1969.bsky.social
Michalak & Vanderwal report a clever, Cl-guided stereocontrolled formal synthesis of Steviol — using a removable chlorine center and epoxide-initiated bicyclization for precise stereochemistry🔄⚗️
#terpenoids #TotalSynthesis

👉 buff.ly/Q2ize6T
January 16, 2026 at 8:01 AM
russellcoxchem.bsky.social
One step #TotalSynthesis of PF1163A by the Matsuda group.

doi.org/10.1021/acs....
Involvement of a Noncanonical Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid in the Biosynthesis of Sterol-C4-methyl Oxidase Inhibitor PF1163A
PF1163A (1) is a fungal metabolite that inhibits sterol-C4-methyl oxidase. In this study, we identified the biosynthetic gene cluster of 1 and elucidated its biosynthetic pathway through heterologous ...
doi.org
January 3, 2025 at 9:47 AM
synthesis1969.bsky.social
Have a look into this concise asymmetric #TotalSynthesis of Deepoxyalchornoic acid and (12R,13R)-Isoleukotoxin Diol by Rodney A. Fernandes and co-workers.

Learn more 👉 thieme-connect.com/products/ejo...
January 24, 2025 at 3:39 PM
synthesis1969.bsky.social
Dive into the chemistry of #cotylenin & #fusicoccin ✨ Discover how they modulate 14-3-3 protein–client interactions and check out the divergent syntheses of brassicicene & talarmalnoid B using Studer’s Mukaiyama hydration by Shenvi @shenvi.bsky.social & co-workers
#TotalSynthesis

👉 buff.ly/eVPZoqE
March 27, 2026 at 8:01 AM
russellcoxchem.bsky.social
One Step #TotalSynthesis of 3'-N-debenzoyl-2'-deoxy-paclitaxel

www.biorxiv.org/content/10.1...
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...
www.biorxiv.org
November 10, 2024 at 3:56 PM
beilstein-institut.bsky.social
There’s still time to submit to the thematic issue “Concept-driven strategies in target-oriented synthesis” edited by David Yu-Kai Chen, Chao Li & Yefeng Tang: 🔗 https://tinyurl.com/2rhvpube

Submission deadline 📅 July 31, 2025

#TotalSynthesis #BJOC 💎🔓
@tsinghuauniversity.bsky.social
July 9, 2025 at 1:01 PM
beilstein-institut.bsky.social
In this review, Zhiqiang Ma and co-researchers focus on the applications of enantioselective #desymmetrization of prochiral 1,3-diols in the synthesis of natural products and biologically active molecules. 
➡️ https://tinyurl.com/wjrztj83
#AsymmetricSynthesis #NaturalProduct #TotalSynthesis
#BJOC 💎🔓
January 16, 2026 at 9:01 AM