Repetitive negative thinking as a transdiagnostic cognitive process
Review by Michelle L. Moulds & Peter M. McEvoy
go.nature.com/4jgZ5Id
Review by Michelle L. Moulds & Peter M. McEvoy
go.nature.com/4jgZ5Id
January 14, 2025 at 3:27 PM
Repetitive negative thinking as a transdiagnostic cognitive process
Review by Michelle L. Moulds & Peter M. McEvoy
go.nature.com/4jgZ5Id
Review by Michelle L. Moulds & Peter M. McEvoy
go.nature.com/4jgZ5Id
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉
www.nature.com/articles/s41...
🧵1👇
www.nature.com/articles/s41...
🧵1👇
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data
Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
www.nature.com
June 4, 2025 at 6:30 PM
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉
www.nature.com/articles/s41...
🧵1👇
www.nature.com/articles/s41...
🧵1👇
Now online in @biologicalpsych.bsky.social CNNI - our paper showing that reliance on habitual responding in transdiagnostic compulsivity may be underpinned by uncertainty about learned environmental structure
📃 www.sciencedirect.com/science/arti...
📃 www.sciencedirect.com/science/arti...
January 21, 2026 at 3:45 PM
Now online in @biologicalpsych.bsky.social CNNI - our paper showing that reliance on habitual responding in transdiagnostic compulsivity may be underpinned by uncertainty about learned environmental structure
📃 www.sciencedirect.com/science/arti...
📃 www.sciencedirect.com/science/arti...
Defining transdiagnostic constructs to advance clinical research
Comment by Hilde M. Geurts & Iris L. Rapoport
go.nature.com/3VIOxHH
Comment by Hilde M. Geurts & Iris L. Rapoport
go.nature.com/3VIOxHH
December 17, 2024 at 2:17 PM
Defining transdiagnostic constructs to advance clinical research
Comment by Hilde M. Geurts & Iris L. Rapoport
go.nature.com/3VIOxHH
Comment by Hilde M. Geurts & Iris L. Rapoport
go.nature.com/3VIOxHH
Very excited to announce that this work is now published in Scientific Data! doi.org/10.1038/s415...
August 20, 2026 at 5:42 PM
Very excited to announce that this work is now published in Scientific Data! doi.org/10.1038/s415...
Identifying behavioral markers of transdiagnostic psychopathology with smartphone sensors
osf.io/preprints/ps...
osf.io/preprints/ps...
OSF
osf.io
December 19, 2024 at 8:56 PM
Identifying behavioral markers of transdiagnostic psychopathology with smartphone sensors
osf.io/preprints/ps...
osf.io/preprints/ps...
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 3:59 PM
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
So glad this review paper on the possible use of Default Mode Network functional connectivity as a transdiagnostic biomarker was published in Biological Psychiatry: CNNI.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Default mode network functional connectivity as a transdiagnostic biomarker of cognitive function
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition…
www.sciencedirect.com
January 12, 2025 at 11:03 PM
So glad this review paper on the possible use of Default Mode Network functional connectivity as a transdiagnostic biomarker was published in Biological Psychiatry: CNNI.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Transdiagnostic fMRI Dataset With 300+ Deeply Phenotyped Subjects Across Resting and Task States | medRxiv www.medrxiv.org/content/10.1...
July 21, 2025 at 4:37 AM
A Transdiagnostic fMRI Dataset With 300+ Deeply Phenotyped Subjects Across Resting and Task States | medRxiv www.medrxiv.org/content/10.1...
Compassion as a transdiagnostic target to reduce mental health symptoms and promote well-being
Review by James N. Kirby (@jameskirby.bsky.social)
Web: go.nature.com/43lyXqc
PDF: rdcu.be/echYo
#psychology #clinicalpsych #psychscisky
Review by James N. Kirby (@jameskirby.bsky.social)
Web: go.nature.com/43lyXqc
PDF: rdcu.be/echYo
#psychology #clinicalpsych #psychscisky
March 5, 2025 at 1:51 PM
Compassion as a transdiagnostic target to reduce mental health symptoms and promote well-being
Review by James N. Kirby (@jameskirby.bsky.social)
Web: go.nature.com/43lyXqc
PDF: rdcu.be/echYo
#psychology #clinicalpsych #psychscisky
Review by James N. Kirby (@jameskirby.bsky.social)
Web: go.nature.com/43lyXqc
PDF: rdcu.be/echYo
#psychology #clinicalpsych #psychscisky
New from @haleyrwang.bsky.social: Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis - Biological Psychiatry www.biologicalpsychiatryjournal.com/article/S000...
Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis
Early psychosis (EP) is characterized by neurobiological changes, including alterations
in resting-state functional connectivity (RSFC). We now understand that symptoms and
neural changes may overlap ...
www.biologicalpsychiatryjournal.com
November 3, 2025 at 7:29 PM
New from @haleyrwang.bsky.social: Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis - Biological Psychiatry www.biologicalpsychiatryjournal.com/article/S000...
REM sleep and nightmares as transdiagnostic features of psychiatric disorders:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Systematic review: REM sleep, dysphoric dreams and nightmares as transdiagnostic features of psychiatric disorders with emotion dysregulation - Clinical implications
Fragmented rapid eye movement (REM) sleep disrupts the overnight resolution of emotional distress, a process crucial for emotion regulation. Emotion d…
www.sciencedirect.com
February 16, 2025 at 8:18 AM
REM sleep and nightmares as transdiagnostic features of psychiatric disorders:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
It sounds like this would simplify the search for underlying causes & treatments, but it's actually the exact opposite.
Even if two people had the same set of genetic variants, they might be given entirely different diagnoses based on individual variation.
Even if two people had the same set of genetic variants, they might be given entirely different diagnoses based on individual variation.
Transdiagnostic dimensions of psychopathology explain individuals’ unique deviations from normative neurodevelopment in brain structure - Translational Psychiatry
Translational Psychiatry - Transdiagnostic dimensions of psychopathology explain individuals’ unique deviations from normative neurodevelopment in brain structure
www.nature.com
December 14, 2025 at 2:39 PM
It sounds like this would simplify the search for underlying causes & treatments, but it's actually the exact opposite.
Even if two people had the same set of genetic variants, they might be given entirely different diagnoses based on individual variation.
Even if two people had the same set of genetic variants, they might be given entirely different diagnoses based on individual variation.
1/7
Excited to share our new @elife.bsky.social Reviewed Preprint! 🧠
How do higher-order cognitive processes like abstraction & metacognition map onto transdiagnostic mental health dimensions?
We combined computational modeling of a RL task with symptom profiling
🔗 doi.org/10.7554/eLif...
Excited to share our new @elife.bsky.social Reviewed Preprint! 🧠
How do higher-order cognitive processes like abstraction & metacognition map onto transdiagnostic mental health dimensions?
We combined computational modeling of a RL task with symptom profiling
🔗 doi.org/10.7554/eLif...
Mapping abstraction and metacognition onto distinct transdiagnostic symptom profiles
doi.org
September 3, 2026 at 7:09 AM
1/7
Excited to share our new @elife.bsky.social Reviewed Preprint! 🧠
How do higher-order cognitive processes like abstraction & metacognition map onto transdiagnostic mental health dimensions?
We combined computational modeling of a RL task with symptom profiling
🔗 doi.org/10.7554/eLif...
Excited to share our new @elife.bsky.social Reviewed Preprint! 🧠
How do higher-order cognitive processes like abstraction & metacognition map onto transdiagnostic mental health dimensions?
We combined computational modeling of a RL task with symptom profiling
🔗 doi.org/10.7554/eLif...
Online Transdiagnostic Emotion Regulation Treatment for Adolescents With Mental Health ProblemsA Randomized Clinical Trial jamanetwork.com/journals/jam...
Online Emotion Regulation Treatment for Adolescents With Mental Health Problems
This randomized clinical trial examines the feasibility, acceptability, and efficacy of a brief online transdiagnostic emotion regulation treatment for adolescents with mental health problems.
jamanetwork.com
June 15, 2025 at 1:51 AM
Online Transdiagnostic Emotion Regulation Treatment for Adolescents With Mental Health ProblemsA Randomized Clinical Trial jamanetwork.com/journals/jam...
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry | Scientific Data www.nature.com/articles/s41...
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data
Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
www.nature.com
June 3, 2025 at 11:10 AM
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry | Scientific Data www.nature.com/articles/s41...
Transdiagnostic thinking could accelerate autism science | The Transmitter: Neuroscience News and Perspectives www.thetransmitter.org/spectrum/to-...
Transdiagnostic thinking could accelerate autism science
Our tendency to focus on one condition at a time likely silos expertise and services—and obscures critical connections across diagnostic categories.
www.thetransmitter.org
February 6, 2025 at 10:21 PM
Transdiagnostic thinking could accelerate autism science | The Transmitter: Neuroscience News and Perspectives www.thetransmitter.org/spectrum/to-...
New preprint from the lab! Led by @martingell.bsky.social .
There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊
"Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"
There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊
"Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵
Link: www.biorxiv.org/content/10.6...
1/10
Link: www.biorxiv.org/content/10.6...
1/10
March 11, 2026 at 5:09 PM
New preprint from the lab! Led by @martingell.bsky.social .
There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊
"Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"
There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊
"Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵
Link: www.biorxiv.org/content/10.6...
1/10
Link: www.biorxiv.org/content/10.6...
1/10
March 11, 2026 at 4:55 PM
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵
Link: www.biorxiv.org/content/10.6...
1/10
Link: www.biorxiv.org/content/10.6...
1/10
Exercise as a transdiagnostic intervention for improving mental health
Our new umbrella review of 99 RCTs (n=5656) across 11 disorders. Exercise = effective transdiagnostic intervention (SMD= -0.67)
HT Marco Solmi, @brendonstubbs.bsky.social et al
www.sciencedirect.com/science/arti...
Our new umbrella review of 99 RCTs (n=5656) across 11 disorders. Exercise = effective transdiagnostic intervention (SMD= -0.67)
HT Marco Solmi, @brendonstubbs.bsky.social et al
www.sciencedirect.com/science/arti...
Exercise as a transdiagnostic intervention for improving mental health: an umbrella review
Exercise is beneficial for mental health in general, but no review has systematically assessed its potential transdiagnostic nature, i.e. whether it i…
www.sciencedirect.com
February 20, 2025 at 11:32 PM
Exercise as a transdiagnostic intervention for improving mental health
Our new umbrella review of 99 RCTs (n=5656) across 11 disorders. Exercise = effective transdiagnostic intervention (SMD= -0.67)
HT Marco Solmi, @brendonstubbs.bsky.social et al
www.sciencedirect.com/science/arti...
Our new umbrella review of 99 RCTs (n=5656) across 11 disorders. Exercise = effective transdiagnostic intervention (SMD= -0.67)
HT Marco Solmi, @brendonstubbs.bsky.social et al
www.sciencedirect.com/science/arti...
🧠 Neurodevelopmental conditions like #Autism, #ADHD & more share overlapping traits. A transdiagnostic framework could unlock new treatments & better support for children.
@adamguastella.bsky.social
Read more ➡️ bit.ly/Transdiagnos...
@adamguastella.bsky.social
Read more ➡️ bit.ly/Transdiagnos...
February 13, 2025 at 5:25 AM
🧠 Neurodevelopmental conditions like #Autism, #ADHD & more share overlapping traits. A transdiagnostic framework could unlock new treatments & better support for children.
@adamguastella.bsky.social
Read more ➡️ bit.ly/Transdiagnos...
@adamguastella.bsky.social
Read more ➡️ bit.ly/Transdiagnos...
Smartphone sensors used to monitor behavioral markers in adults found associations with transdiagnostic psychopathology domains like internalizing, detachment, disinhibition, and the general impairment factor. ja.ma/44EN9e6
July 4, 2025 at 1:52 AM
Smartphone sensors used to monitor behavioral markers in adults found associations with transdiagnostic psychopathology domains like internalizing, detachment, disinhibition, and the general impairment factor. ja.ma/44EN9e6
August 14, 2025 at 11:59 AM
We are delighted to be working with the ReSET Project team in 2025, to help them disseminate the findings of their amazing school-based, transdiagnostic, preventative intervention for adolescent mental health. resetproject.co.uk
The ReSET Project – Building resilience through socio-emotional training – Building resilience through socio-emotional training
resetproject.co.uk
January 8, 2025 at 9:38 AM
We are delighted to be working with the ReSET Project team in 2025, to help them disseminate the findings of their amazing school-based, transdiagnostic, preventative intervention for adolescent mental health. resetproject.co.uk