#TrialEmulation
LightNews LightNews
journal-cer.bsky.social
📢New article alert

New Research article in JCER on "Considerations for emulations of randomized controlled trials using real-world data: learnings from an emulation of MONALEESA-2".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #RWD #RWE #TrialEmulation #BreastCancer
becarispublishing.com
October 31, 2025 at 12:29 PM
paperposterbot.bsky.social
arXiv📈🤖
TrialEmulation: An R Package to Emulate Target Trials for Causal Analysis of Observational Time-to-event Data
By
arXiv:2402.12083v1 Announce Type: new Abstract: Randomised controlled trials (RCTs) are regarded as the gold standard for estimating causal treatment effects on health outcomes. However, RCTs are not always feasible, because of time, budget or ethical constraints. Observational data such as those from electronic health records (EHRs) offer an alternative way to estimate the causal effects of treatments. Recently, the `target trial emulation' framework was proposed by Hernan and Robins (2016) to provide a formal structure for estimating causal treatment effects from observational data. To promote more widespread implementation of target trial emulation in practice, we develop the R package TrialEmulation to emulate a sequence of target trials using observational time-to-event data, where individuals who start to receive treatment and those who have not been on the treatment at the baseline of the emulated trials are compared in terms of their risks of an outcome event. Specifically, TrialEmulation provides (1) data preparation for emulating a sequence of target trials, (2) calculation of the inverse probability of treatment and censoring weights to handle treatment switching and dependent censoring, (3) fitting of marginal structural models for the time-to-event outcome given baseline covariates, (4) estimation and inference of marginal intention to treat and per-protocol effects of the treatment in terms of marginal risk differences between treated and untreated for a user-specified target trial population. In particular, TrialEmulation can accommodate large data sets (e.g., from EHRs) within memory constraints of R by processing data in chunks and applying case-control sampling. We demonstrate the functionality of TrialEmulation using a simulated data set that mimics typical observational time-to-event data in practice.
March 9, 2026 at 7:19 PM
cranberriesfeed.bsky.social
CRAN updates: GPTreeO learningtower mcauchyd msPCA rgoogleads TrialEmulation #rstats
August 25, 2026 at 11:02 AM
cranupdates.bsky.social
Updates on CRAN: mcauchyd (1.3.6), mggd (1.3.7), MLE (1.9), msPCA (0.5.1), nmfkc (0.9.6), nodbi (0.15.0), nominatimlite (0.7.0), pammtools (0.8.1), resmush (1.0.3), rfacebookstat (2.16.1), rgoogleads (0.15.0), TrialEmulation (0.0.5), walking (0.8.2)
August 25, 2026 at 1:50 PM
paperposterbot.bsky.social
TrialEmulation: An R Package to Emulate Target Trials for Causal Analysis of Observational Time-to-event Data https://arxiv.org/abs/2402.12083 arXiv:2402.12083v1 Announce Type: new Abstract: Randomised controlled trials (RCTs) are regarded as the gold standard for estimating causal treatment eff 📈🤖
February 20, 2024 at 5:09 PM
cranberriesfeed.bsky.social
CRAN updates: babynamesIL colorRamp2 gecko interflex panelView quasar RFIF rvMF scip telescope this.path TrialEmulation #rstats
April 10, 2026 at 9:02 AM
cranberriesfeed.bsky.social
CRAN updates: admiraldev counterfactuals gunsales openalexR retroharmonize SHARK4R TestGenerator tglkmeans TrialEmulation #rstats
January 14, 2026 at 9:02 AM
cranberriesfeed.bsky.social
CRAN updates: aramappings bage CoxPlus gdalraster splineplot TrialEmulation #rstats
November 19, 2025 at 9:02 AM
cranberriesfeed.bsky.social
CRAN updates: ggeffects mxcc rice TrialEmulation #rstats
June 13, 2025 at 11:18 AM
cranberriesfeed.bsky.social
CRAN updates: esquisse fastplyr geometa shinyWidgets TrialEmulation #rstats
February 21, 2025 at 1:02 PM
cranberriesfeed.bsky.social
CRAN updates: TrialEmulation #rstats
November 29, 2024 at 6:02 PM
cranberriesfeed.bsky.social
CRAN updates: psvmSDR TrialEmulation #rstats
September 9, 2024 at 1:02 PM
cranberriesfeed.bsky.social
CRAN updates: familiar multinma qlcal TrialEmulation #rstats
January 24, 2024 at 2:02 PM
cranupdates.bsky.social
Updates on CRAN: rsconnect (1.8.0), rvMF (0.1.2), samr (3.0.1), scip (1.10.0-3), SeleMix (1.0.4), telescope (0.2-2), this.path (2.8.0), timeROC (0.4.1), TrialEmulation (0.0.4.11), TSSS (1.3.4-7), wordPuzzleR (0.1.2)
April 10, 2026 at 10:08 AM
cranupdates.bsky.social
Updates on CRAN: morse (3.3.5), openalexR (3.0.1), OPI (3.0.6), prabclus (2.3-5), protti (1.0.0), retroharmonize (0.2.7), RMark (3.0.6), s20x (3.2.2), sarp.snowprofile (1.4.1), SHARK4R (1.0.3), tglkmeans (0.5.8), TrialEmulation (0.0.4.9), xlr (1.1.0)
January 14, 2026 at 9:31 AM
cranupdates.bsky.social
Updates on CRAN: autograph (0.5.0), DrugUtilisation (1.0.5), EgoCor (1.3.4), fitODBOD (1.5.5), migraph (1.5.6), OmopSketch (1.0.0), refugees (2025.06.0), sdbuildR (1.0.8), SIMPLE.REGRESSION (0.2.8), TrialEmulation (0.0.4.8)
November 19, 2025 at 1:33 PM
cranupdates.bsky.social
Updates on CRAN: mxcc (0.0.3), ProxReg (1.1.1), rice (1.2.0), rnmamod (0.5.0), rvinecopulib (0.7.3.1.0), secr (5.2.4), sjstats (0.19.1), survivoR (2.3.6), TrialEmulation (0.0.4.5)
June 13, 2025 at 1:38 PM
cranupdates.bsky.social
Updates on CRAN: moonboot (1.0.1), MultiTraits (0.3.0), phylotypr (0.1.1), r2rtf (1.1.2), ReDaMoR (0.8.2), shinyWidgets (0.9.0), spfilteR (2.1.0), TrialEmulation (0.0.4.2)
February 21, 2025 at 5:19 PM
cranupdates.bsky.social
Updates on CRAN: eks (1.0.6), RcppAPT (0.0.10), tramME (1.0.7), TrialEmulation (0.0.4.0)
November 29, 2024 at 9:18 PM
cranupdates.bsky.social
Updates on CRAN: aggTrees (2.1.0), BREADR (1.0.2), geepack (1.3.11.1), jtdm (0.1-3), LorenzRegression (2.0.0), MiscMetabar (0.9.3), OBIC (3.0.3), psvmSDR (1.0.2), TrialEmulation (0.0.3.9), wINEQ (1.2.1)
September 9, 2024 at 1:24 PM
cranupdates.bsky.social
Updates on CRAN: MazamaLocationUtils (0.4.3), mccca (1.1.0.1), MHD (0.1.2), multinma (0.6.0), nortsTest (1.1.1), qlcal (0.0.10), qlifetable (0.0.2-4), RApiDatetime (0.0.9), rubias (0.3.4), scGOclust (0.2.1), TDA (1.9.1), tidyr (1.3.1), TrialEmulation (0.0.3.8), voluModel (0.2.1), weird (1.0.2)
January 24, 2024 at 5:17 PM
arxiv-stat-me.bsky.social
Li Su, Roonak Rezvani, Shaun R. Seaman, Colin Starr, Isaac Gravestock
TrialEmulation: An R Package to Emulate Target Trials for Causal Analysis of Observational Time-to-event Data
https://arxiv.org/abs/2402.12083
February 20, 2024 at 6:01 AM
dexmd.bsky.social
Prof James Wason talks about trial emulation within the NIHR-funded @ai-multiply.bsky.social project, with collaborators Prof Adam Todd and Dr Ellen Moss.
#trialemulation
@nihr.bsky.social
@ai-multiply.bsky.social
February 2, 2026 at 4:35 PM