Learn about fair tests of treatment through history (including modern history), in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday 11
In the week of World Sight Day (www.iapb.world/world_sight_...), this month’s #TrialsTuesday is a randomised trial showing the benefits of providing free glasses to tea pickers in India with poor vision.
The trial was called PROSPER. 1/8
In the week of World Sight Day (www.iapb.world/world_sight_...), this month’s #TrialsTuesday is a randomised trial showing the benefits of providing free glasses to tea pickers in India with poor vision.
The trial was called PROSPER. 1/8
World Sight Day
On World Sight Day, we cast a spotlight on the importance of eye care and encourage everyone to #LoveYourEyes. Join us on Thursday, 8 October 2026, and be part of focusing the worlds’ attention on eye...
www.iapb.world
October 6, 2026 at 12:52 PM
Learn about fair tests of treatment through history (including modern history), in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday 11
In the week of World Sight Day (www.iapb.world/world_sight_...), this month’s #TrialsTuesday is a randomised trial showing the benefits of providing free glasses to tea pickers in India with poor vision.
The trial was called PROSPER. 1/8
In the week of World Sight Day (www.iapb.world/world_sight_...), this month’s #TrialsTuesday is a randomised trial showing the benefits of providing free glasses to tea pickers in India with poor vision.
The trial was called PROSPER. 1/8
World Sight Day
On World Sight Day, we cast a spotlight on the importance of eye care and encourage everyone to #LoveYourEyes. Join us on Thursday, 8 October 2026, and be part of focusing the worlds’ attention on eye...
www.iapb.world
October 6, 2026 at 12:05 PM
#TrialsTuesday 11
In the week of World Sight Day (www.iapb.world/world_sight_...), this month’s #TrialsTuesday is a randomised trial showing the benefits of providing free glasses to tea pickers in India with poor vision.
The trial was called PROSPER. 1/8
In the week of World Sight Day (www.iapb.world/world_sight_...), this month’s #TrialsTuesday is a randomised trial showing the benefits of providing free glasses to tea pickers in India with poor vision.
The trial was called PROSPER. 1/8
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday #10
What temperature is best for a premature baby? This month’s Trials Tuesday answered this question 70 years ago and it continues to be cited by Cochrane Reviews when discussing the benefits of reducing heat loss in preterm babies. 1/8
www.cochranelibrary.com/cdsr/doi/10....
What temperature is best for a premature baby? This month’s Trials Tuesday answered this question 70 years ago and it continues to be cited by Cochrane Reviews when discussing the benefits of reducing heat loss in preterm babies. 1/8
www.cochranelibrary.com/cdsr/doi/10....
www.cochranelibrary.com
July 28, 2026 at 3:26 PM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
If you’d like to learn more about the importance of ISIS-2, watch the start of Richard Peto’s talk at Evidence Live 2015 www.youtube.com/watch?v=xYIP... or read his James Lind Library article from the following year 8/8
www.jameslindlibrary.org/articles/ref...
#EBHC @cebmoxford.bsky.social #MedHist
www.jameslindlibrary.org/articles/ref...
#EBHC @cebmoxford.bsky.social #MedHist
Richard Peto - Large-scale randomised evidence: how will it inform clinical practice?
YouTube video by CEBM Oxford
www.youtube.com
June 9, 2026 at 1:34 PM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
The NIHR judging panel said that STAMPEDE was “A study with clear evidence of global impact. It has impacted economic growth, saved lives and influenced policy, while also supporting the design of other studies." 8/8
www.nihr.ac.uk/about-us/our...
#ProstateCancer
@nihr.bsky.social
www.nihr.ac.uk/about-us/our...
#ProstateCancer
@nihr.bsky.social
www.nihr.ac.uk
May 12, 2026 at 1:05 PM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
It’s not known if van Helmont’s challenge was a rhetorical device, or whether the trial actually took place. However, Iain Donaldson, who wrote an article for me about it in 2016, suggests it was the former 8/8
www.jameslindlibrary.org/articles/joa...
www.jameslindlibrary.org/articles/joa...
van Helmont’s proposal for a randomised comparison of treating fevers with or without bloodletting and purging. - The James Lind Library
A challenge to Galenic medical theory and practice Galenic medicine still held sway in the seventeenth century, sanctioned by authority, hallowed by centuries of practice and universally taught in the...
www.jameslindlibrary.org
April 7, 2026 at 9:58 AM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday #6
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8
March 10, 2026 at 11:38 AM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday #5
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine
February 10, 2026 at 4:19 PM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday #4 The last TrialsTuesday was the MRC trial of streptomycin for TB that used random numbers to fill envelopes which, when opened, revealed a patient’s assigned treatment. But, what about using a more familiar method for using chance to choose between options: flipping a coin? 1/8
February 3, 2026 at 12:45 PM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
TrialsTuesday #3
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com
January 20, 2026 at 10:41 AM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday #2 Last week, I reminded you of my trial of oranges and lemons for scurvy. This week, it’s something from a mould that grows on apples, which was tested as a treatment for the common cold nearly 200 years later in the UK Medical Research Council (MRC) 1944 trial of patulin. 1/8
January 13, 2026 at 3:11 PM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
Learn about fair tests of treatment through history, in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#HistoryOfMedicine #EBM #EBHC #RCT
#TrialsTuesday #1 On this first Tuesday of 2026, I’m relaunching Trials Tuesday to illustrate the development of fair tests of treatment through history, featuring important clinical trials. I begin with my study of scurvy on board the Salisbury. 1/8 www.jameslindlibrary.org/articles/who...
January 6, 2026 at 10:58 AM
Learn about fair tests of treatment through history, in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT
#HistoryOfMedicine #EBM #EBHC #RCT
Here's a great example of how Trials Change Lives #ProstateCancer. It's #InternationalClinicalTrialsDay and you can watch for weekly #TrialsTuesday posts by following
@jameslindlibrary.bsky.social
@jameslindlibrary.bsky.social
#TrialsTuesday #8 1/8 On #InternationalClinicalTrialsDay 2025, we feature STAMPEDE, a trial that started in 2005 and announced its first practice changing results 10 years ago today, to the American Society of Oncology ascopubs.org/doi/10.1200/... @ascocancer.bsky.social @mrcctu.bsky.social
Docetaxel and/or zoledronic acid for hormone-naïve prostate cancer: First overall survival results from STAMPEDE (NCT00268476).
5001 Background: STAMPEDE is a randomised controlled trial using a novel multi-arm multi-stage design.
It recruits men (pts) with high-risk locally advanced or metastatic prostate cancer
(PCa) start...
ascopubs.org
May 20, 2025 at 3:22 PM
Here's a great example of how Trials Change Lives #ProstateCancer. It's #InternationalClinicalTrialsDay and you can watch for weekly #TrialsTuesday posts by following
@jameslindlibrary.bsky.social
@jameslindlibrary.bsky.social
My latest blog highlights an important trial from the mid 1950s showing the benefits of reducing heat loss in preterm babies, and illustrating how a hand-drawn graph 👇was used to plot the accumulating evidence and decide to stop the trial
www.jameslindlibrary.org/blogs/landma...
#TrialsTuesday
www.jameslindlibrary.org/blogs/landma...
#TrialsTuesday
July 30, 2026 at 8:19 AM
My latest blog highlights an important trial from the mid 1950s showing the benefits of reducing heat loss in preterm babies, and illustrating how a hand-drawn graph 👇was used to plot the accumulating evidence and decide to stop the trial
www.jameslindlibrary.org/blogs/landma...
#TrialsTuesday
www.jameslindlibrary.org/blogs/landma...
#TrialsTuesday
#TrialsTuesday #10
What temperature is best for a premature baby? This month’s Trials Tuesday answered this question 70 years ago and it continues to be cited by Cochrane Reviews when discussing the benefits of reducing heat loss in preterm babies. 1/8
www.cochranelibrary.com/cdsr/doi/10....
What temperature is best for a premature baby? This month’s Trials Tuesday answered this question 70 years ago and it continues to be cited by Cochrane Reviews when discussing the benefits of reducing heat loss in preterm babies. 1/8
www.cochranelibrary.com/cdsr/doi/10....
www.cochranelibrary.com
July 28, 2026 at 3:20 PM
#TrialsTuesday #10
What temperature is best for a premature baby? This month’s Trials Tuesday answered this question 70 years ago and it continues to be cited by Cochrane Reviews when discussing the benefits of reducing heat loss in preterm babies. 1/8
www.cochranelibrary.com/cdsr/doi/10....
What temperature is best for a premature baby? This month’s Trials Tuesday answered this question 70 years ago and it continues to be cited by Cochrane Reviews when discussing the benefits of reducing heat loss in preterm babies. 1/8
www.cochranelibrary.com/cdsr/doi/10....
#TrialsTuesday #9
Trials Tuesday has highlighted some clinical trials that were small but which nevertheless had an important impact. In contrast, this month’s trial is one that was described as “massive” by Keith Veronese in Making Medicine. It was called ISIS-2. 1/8
Trials Tuesday has highlighted some clinical trials that were small but which nevertheless had an important impact. In contrast, this month’s trial is one that was described as “massive” by Keith Veronese in Making Medicine. It was called ISIS-2. 1/8
June 9, 2026 at 1:31 PM
#TrialsTuesday #9
Trials Tuesday has highlighted some clinical trials that were small but which nevertheless had an important impact. In contrast, this month’s trial is one that was described as “massive” by Keith Veronese in Making Medicine. It was called ISIS-2. 1/8
Trials Tuesday has highlighted some clinical trials that were small but which nevertheless had an important impact. In contrast, this month’s trial is one that was described as “massive” by Keith Veronese in Making Medicine. It was called ISIS-2. 1/8
#TrialsTuesday #8 This month’s #TrialsTuesday features STAMPEDE. This trial for men with prostate cancer published its first practice changing results 10 years ago after a presentation to the American Society of Oncology in May 2015 1/8
ascopubs.org/doi/10.1200/...
@innovative-ctu.bsky.social #ASCO
ascopubs.org/doi/10.1200/...
@innovative-ctu.bsky.social #ASCO
ASCO Publications
ascopubs.org
May 12, 2026 at 1:03 PM
#TrialsTuesday #8 This month’s #TrialsTuesday features STAMPEDE. This trial for men with prostate cancer published its first practice changing results 10 years ago after a presentation to the American Society of Oncology in May 2015 1/8
ascopubs.org/doi/10.1200/...
@innovative-ctu.bsky.social #ASCO
ascopubs.org/doi/10.1200/...
@innovative-ctu.bsky.social #ASCO
#TrialsTuesday #7 This month, I’ll take you more than 100 years further back in time than my trial of scurvy. I’ll share with you a proposal for a study that highlighted the need for do a fair test to find out if a common treatment might do more harm than good 1/8
#FairTest #TestingTreatments
#FairTest #TestingTreatments
April 7, 2026 at 9:54 AM
#TrialsTuesday #7 This month, I’ll take you more than 100 years further back in time than my trial of scurvy. I’ll share with you a proposal for a study that highlighted the need for do a fair test to find out if a common treatment might do more harm than good 1/8
#FairTest #TestingTreatments
#FairTest #TestingTreatments
#TrialsTuesday #6
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8
March 10, 2026 at 11:35 AM
#TrialsTuesday #6
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8
#TrialsTuesday #5
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine
February 10, 2026 at 11:03 AM
#TrialsTuesday #5
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine
#TrialsTuesday #4 The last TrialsTuesday was the MRC trial of streptomycin for TB that used random numbers to fill envelopes which, when opened, revealed a patient’s assigned treatment. But, what about using a more familiar method for using chance to choose between options: flipping a coin? 1/8
February 3, 2026 at 12:40 PM
#TrialsTuesday #4 The last TrialsTuesday was the MRC trial of streptomycin for TB that used random numbers to fill envelopes which, when opened, revealed a patient’s assigned treatment. But, what about using a more familiar method for using chance to choose between options: flipping a coin? 1/8
TrialsTuesday #3
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com
January 20, 2026 at 10:38 AM
TrialsTuesday #3
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com
#TrialsTuesday #2 Last week, I reminded you of my trial of oranges and lemons for scurvy. This week, it’s something from a mould that grows on apples, which was tested as a treatment for the common cold nearly 200 years later in the UK Medical Research Council (MRC) 1944 trial of patulin. 1/8
January 13, 2026 at 10:19 AM
#TrialsTuesday #2 Last week, I reminded you of my trial of oranges and lemons for scurvy. This week, it’s something from a mould that grows on apples, which was tested as a treatment for the common cold nearly 200 years later in the UK Medical Research Council (MRC) 1944 trial of patulin. 1/8
#TrialsTuesday #1 On this first Tuesday of 2026, I’m relaunching Trials Tuesday to illustrate the development of fair tests of treatment through history, featuring important clinical trials. I begin with my study of scurvy on board the Salisbury. 1/8 www.jameslindlibrary.org/articles/who...
January 6, 2026 at 10:54 AM
#TrialsTuesday #1 On this first Tuesday of 2026, I’m relaunching Trials Tuesday to illustrate the development of fair tests of treatment through history, featuring important clinical trials. I begin with my study of scurvy on board the Salisbury. 1/8 www.jameslindlibrary.org/articles/who...
5/8 They were randomised to aspirin, streptokinase, both or neither in what’s called a factorial trial, which will feature more in a future #TrialsTuesday. This meant that half the patients got aspirin and half did not.
May 27, 2025 at 3:33 PM
5/8 They were randomised to aspirin, streptokinase, both or neither in what’s called a factorial trial, which will feature more in a future #TrialsTuesday. This meant that half the patients got aspirin and half did not.