"Like Monarez, O’Neill is not a physician" is a fascinating sentence. It seems like it might be relevant that Susan Monarez has a PhD (dissertation: "Macrophage regulation by trypanosome GIP-SVSG during trypanosoma brucei rhodesiense infection ") while Jim O'Neill is a venture capitalist with an MA.
Breaking news: The White House selected Jim O’Neill, a top deputy to RFK Jr., to serve as acting head of the CDC after a clash over vaccine policy ended in the departure of several agency leaders.
White House taps top RFK Jr. deputy as acting CDC director
The decision comes a day after Trump fired Susan Monarez, the Senate-confirmed CDC director, prompting a series of resignations of other top officials there.
wapo.st
August 28, 2025 at 10:29 PM
"Like Monarez, O’Neill is not a physician" is a fascinating sentence. It seems like it might be relevant that Susan Monarez has a PhD (dissertation: "Macrophage regulation by trypanosome GIP-SVSG during trypanosoma brucei rhodesiense infection ") while Jim O'Neill is a venture capitalist with an MA.
Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
June 12, 2025 at 8:49 AM
Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms | Science www.science.org/doi/10.1126/...
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms
The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this ...
www.science.org
March 13, 2025 at 7:57 PM
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms | Science www.science.org/doi/10.1126/...
Solving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force!
Preprint here:
www.biorxiv.org/content/10.1...
Preprint here:
www.biorxiv.org/content/10.1...
February 11, 2025 at 8:54 AM
Solving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force!
Preprint here:
www.biorxiv.org/content/10.1...
Preprint here:
www.biorxiv.org/content/10.1...
Nature research paper: Structural basis of the RNA-editing cascade in trypanosome mitochondria
go.nature.com/3T9HlWV
go.nature.com/3T9HlWV
Structural basis of the RNA-editing cascade in trypanosome mitochondria - Nature
Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.
go.nature.com
July 23, 2026 at 12:13 PM
Nature research paper: Structural basis of the RNA-editing cascade in trypanosome mitochondria
go.nature.com/3T9HlWV
go.nature.com/3T9HlWV
Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training
November 26, 2024 at 9:12 PM
Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training
Happy New Year from the Trypanosome Cell Biology Unit! @pasteur.fr @inserm.fr
January 8, 2026 at 8:42 PM
Happy New Year from the Trypanosome Cell Biology Unit! @pasteur.fr @inserm.fr
Don't respect the hard work. Respect the expertise.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
August 30, 2025 at 9:23 PM
Don't respect the hard work. Respect the expertise.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
How do African trypanosomes regulate the complement system? Check out our new study from @BiochemCook, in which he identified a new trypanosome receptor which binds to the core C3bBb convertase of the complement system and blocks its activity. Real all about it! doi.org/10.64898/202...
August 20, 2026 at 7:55 PM
How do African trypanosomes regulate the complement system? Check out our new study from @BiochemCook, in which he identified a new trypanosome receptor which binds to the core C3bBb convertase of the complement system and blocks its activity. Real all about it! doi.org/10.64898/202...
Brilliant work with unprecedented level of resolution of the trypanosome axoneme!
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms | Science www.science.org/doi/10.1126/...
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms
The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this ...
www.science.org
March 13, 2025 at 9:00 PM
Brilliant work with unprecedented level of resolution of the trypanosome axoneme!
In situ cryo-ET reveals restricted docking of intraflagellar transport at the base of the trypanosome flagellum www.biorxiv.org/content/10.64898/2025.12.23.690766v1 #cryoem
December 26, 2025 at 12:21 PM
In situ cryo-ET reveals restricted docking of intraflagellar transport at the base of the trypanosome flagellum www.biorxiv.org/content/10.64898/2025.12.23.690766v1 #cryoem
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
February 4, 2025 at 1:43 PM
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
Fun Fact:
If a kissing bug bites you it could be carrying a parasite called a trypanosome. It won’t bother you for a while but whenever it feels like it, it will start to eat little holes in your heart. And then you’ll probably die from heart failure.
Ok goodbye.
If a kissing bug bites you it could be carrying a parasite called a trypanosome. It won’t bother you for a while but whenever it feels like it, it will start to eat little holes in your heart. And then you’ll probably die from heart failure.
Ok goodbye.
I actually followed cause of the animal facts then yo ass just stopped smh
April 12, 2026 at 4:36 PM
Fun Fact:
If a kissing bug bites you it could be carrying a parasite called a trypanosome. It won’t bother you for a while but whenever it feels like it, it will start to eat little holes in your heart. And then you’ll probably die from heart failure.
Ok goodbye.
If a kissing bug bites you it could be carrying a parasite called a trypanosome. It won’t bother you for a while but whenever it feels like it, it will start to eat little holes in your heart. And then you’ll probably die from heart failure.
Ok goodbye.
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
February 4, 2025 at 9:22 AM
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
Drs @singh-parul.bsky.social @trypsleon.bsky.social Maureen Cabahug @fariatrypslab.bsky.social & @jessmbryant.bsky.social review #Plasmodium & #Trypanosoma #genome organization.
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
August 14, 2025 at 6:42 PM
Drs @singh-parul.bsky.social @trypsleon.bsky.social Maureen Cabahug @fariatrypslab.bsky.social & @jessmbryant.bsky.social review #Plasmodium & #Trypanosoma #genome organization.
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
#Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment
www.cell.com/trends/paras...
Huge Congratulations to Dr @chloebarnes.bsky.social who sailed through her PhD viva today @blslancasteruni.bsky.social
With thanks to examiners Michael Lewis and Paul McKean.
Chloe is now a ⭐️ PDRA with @juanquintana.bsky.social @lydiabeckeriii.bsky.social
With thanks to examiners Michael Lewis and Paul McKean.
Chloe is now a ⭐️ PDRA with @juanquintana.bsky.social @lydiabeckeriii.bsky.social
July 9, 2025 at 4:53 PM
Huge Congratulations to Dr @chloebarnes.bsky.social who sailed through her PhD viva today @blslancasteruni.bsky.social
With thanks to examiners Michael Lewis and Paul McKean.
Chloe is now a ⭐️ PDRA with @juanquintana.bsky.social @lydiabeckeriii.bsky.social
With thanks to examiners Michael Lewis and Paul McKean.
Chloe is now a ⭐️ PDRA with @juanquintana.bsky.social @lydiabeckeriii.bsky.social
#ResultatScientifique🔎| Le glycérol des tissus prépare les trypanosomes à infecter la mouche tsé-tsé, même lorsqu’ils sont rares dans le sang 🦠
▶️ buff.ly/WvmF539
✍️ Frédéric Bringaud
🤝 @univbordeaux.bsky.social @cnrsaquitaine.bsky.social @inserm.fr
▶️ buff.ly/WvmF539
✍️ Frédéric Bringaud
🤝 @univbordeaux.bsky.social @cnrsaquitaine.bsky.social @inserm.fr
Le glycérol cutané prépare le trypanosome à sa transmission à la mouche
Comment les tr
buff.ly
September 28, 2026 at 4:00 PM
#ResultatScientifique🔎| Le glycérol des tissus prépare les trypanosomes à infecter la mouche tsé-tsé, même lorsqu’ils sont rares dans le sang 🦠
▶️ buff.ly/WvmF539
✍️ Frédéric Bringaud
🤝 @univbordeaux.bsky.social @cnrsaquitaine.bsky.social @inserm.fr
▶️ buff.ly/WvmF539
✍️ Frédéric Bringaud
🤝 @univbordeaux.bsky.social @cnrsaquitaine.bsky.social @inserm.fr
Great collaboration with @bastinlab.bsky.social to image node cilia and assess in parallel ccdc40 function in mouse and trypanosome cilia.
There is more than cilia beating in the establishment of left-right symmetry! Proud to have contributed to this beautiful study by Amaia Ochandorena Saa @meilhacsigolene.bsky.social where Thierry Blisnick imaged mouse node by SEM
doi/10.1126/sciadv.adx6486
@pasteur.fr @institutimagine.bsky.social
doi/10.1126/sciadv.adx6486
@pasteur.fr @institutimagine.bsky.social
August 8, 2026 at 7:22 AM
Great collaboration with @bastinlab.bsky.social to image node cilia and assess in parallel ccdc40 function in mouse and trypanosome cilia.
Une nouvelle cible thérapeutique contre la maladie du sommeil ? 🧬
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Découverte d’une protéine d’intérêt chez le trypanosome vecteur de la maladie du sommeil
Trypanosoma brucei est un parasite responsable de graves maladies chez l’Homme et le bétail en Afrique.
www.insb.cnrs.fr
April 22, 2025 at 2:02 PM
Une nouvelle cible thérapeutique contre la maladie du sommeil ? 🧬
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
The Kowalinski group's latest study on trypanosome parasites reveals significant differences between the trypanosomal and human nuclear cap-binding complex.
This key player in cellular RNA metabolism could be a potential target for novel anti-parasitic drugs.
www.embl.org/news/science...
This key player in cellular RNA metabolism could be a potential target for novel anti-parasitic drugs.
www.embl.org/news/science...
January 21, 2025 at 8:21 AM
The Kowalinski group's latest study on trypanosome parasites reveals significant differences between the trypanosomal and human nuclear cap-binding complex.
This key player in cellular RNA metabolism could be a potential target for novel anti-parasitic drugs.
www.embl.org/news/science...
This key player in cellular RNA metabolism could be a potential target for novel anti-parasitic drugs.
www.embl.org/news/science...
Avian trypanosomes in Thai bulbuls: an integrative study combining morphology and molecular analyses.
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
September 23, 2026 at 1:00 PM
Avian trypanosomes in Thai bulbuls: an integrative study combining morphology and molecular analyses.
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
Molecular screening revealed substantially more infections than microscopy and uncovered mixed infections involving multiple trypanosome strains and/or species.🧪
🔗 doi.org/10.1051/para...
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
February 4, 2025 at 7:14 PM
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
The Matthews Lab | Biology
The Matthews Lab
biology.ed.ac.uk
October 17, 2025 at 12:06 PM
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions pubmed.ncbi.nlm.nih.gov/42469243/
July 18, 2026 at 9:21 AM
Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions pubmed.ncbi.nlm.nih.gov/42469243/
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
October 10, 2025 at 4:14 PM
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6