📝 Online now - the Review "E3 ubiquitin ligases in signaling, disease, and therapeutics" from Shaun Olsen et al.

#ubiquitin #E3UbiquitinLigase #UbiquitinProteasomeSystem #TargetedProteinDegradation

Read it here 👉 authors.elsevier.com/sd/article/S...

This review explores how the #UbiquitinProteasomeSystem regulates BCR-ABL signaling, #leukemia stem-cell survival, and drug response in #ChronicMyeloidLeukemia, highlighting UPS targets to overcome #TKI resistance & improve outcomes. @zzu_china

#OpenAccess: doi.org/10.1016/j.ge...

This review outlines the mechanism of #TyrosineKinaseInhibitors drug resistance in #CML treatment, describes the basic composition of #UbiquitinProteasomeSystem (UPS), & highlights the research progress of UPS-related molecules on CML TKI resistance. #medsky

#OpenAccess: www.sciencedirect.co...