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Proteolysis targeting chimera (PROTAC) technology has revolutionized targeted protein degradation via the ubiquitin–proteasome system. Despite their e…

A meditation on what we lose when we excessively measure our lives.

#BìnhNóngLạnhGas #Owani #Akura #GasTrựcTiếp #VòiSen #Shopee #MãGiảmGiá #Deal0đ #Lazada Bình nóng lạnh gas Owani / Akura dùng gas trực tiếp tặng vòi sen là một sản phẩm chất lượng cao, đáng tin cậy và tiện lợi cho mọi gia đình. Với thiết kế hiện đại, tiết kiệm không gian và dễ dàng lắp đặt, bình nóng lạnh gas này sẽ là sự lựa chọn hoàn hảo cho không gian nhà bếp của bạn.

Here’s Sean Voisen writing about how programming is a feeling: > For those of us who enjoy programming, there is a deep satisfaction that comes from solving problems through well-written code, a kind of ineffable joy found in the elegant expression of a system through our favorite syntax. It is akin to the same satisfaction a craftsperson might find at the end of the day after toiling away on well-made piece of furniture, the culmination of small dopamine hits that come from sweating the details on something and getting them just right. Maybe nobody will notice those details, but it doesn’t matter. We care, we notice, we get joy from the aesthetics of the craft. This got me thinking about the idea of satisfaction in craft. Where does it come from? In part, I think, it comes from arriving at a deeper, and more intimate _understanding of_ and _relationship to_ what you’re working with. For example, I think of a sushi chef. I’m not a sushi chef, but I’ve tried my hand at making rolls and I’ve seen _Jiro Dreams of Sushi_ , so I have a speck of familiarity with the spectrum from beginner to expert. When you first start out, you’re focused on the outcome. “Can I do this? Let see if I can pull it off.” Then comes the excitement of, “Hey I made my own roll!” That’s as far as many of us go. But if you keep going, you end up in a spot where you’re more worried about what goes into the roll than the outcome of roll itself. Where was the fish sourced from? How was it sourced? Was it ever frozen? A million and one questions about _what goes into_ the process, which inevitably shape _what comes out of it_. And I think an obsession with the details of what goes in drives your satisfaction of what comes out. In today’s moment, I wonder if AI tools help or hinder fostering a sense of wonder in what it means to craft something? When you craft something, you’re driven further into the essence of the materials you work. But AI can easily reverse this, where you care less about what goes in and only what comes out. One question I’m asking myself is: do I care _more_ or _less_ about what I’ve made when I’m done using AI to help make it?

Books I’ve read, grouped by year.

YouTube video by Inside Personal Growth

New blog post in marginalia, reflections inspired by Alan Jacobs’ “The Pleasures of Reading in an Age of Distraction.” (Yes I did use that extra hour yesterday to finish this up.) #books #reading htt...