What is responsible for the halogen specificity & is there a Substrate binding Site in #VHPOs? Learn more about this amazing enzyme class in our latest paper @naturecomms.bsky.social Congratulations to the Team! www.nature.com/articles/s41...
Unraveling the molecular basis of substrate specificity and halogen activation in vanadium-dependent haloperoxidases - Nature Communications
Vanadium-dependent haloperoxidases (VHPOs) are versatile enzymes that catalyze oxidation of halides followed by halogenation of electron-rich substrates, but the factors dictating substrate and haloge...
www.nature.com
March 2, 2025 at 8:34 PM
What is responsible for the halogen specificity & is there a Substrate binding Site in #VHPOs? Learn more about this amazing enzyme class in our latest paper @naturecomms.bsky.social Congratulations to the Team! www.nature.com/articles/s41...
Inspired by natural cryptic halogenation, the Gulder group @biomicat developed a biocatalytic bromination-arylation cascade for efficient biaryl synthesis, combining bio- & chemocatalysis. #VHPOs #Biocatalysis #OpenAccess #ChemSky #OrgLett pubs.acs.org/doi/10.1021/...
Chemoenzymatic C,C-Bond Forming Cascades by Cryptic Vanadium Haloperoxidase Catalyzed Bromination
Inspired by natural cryptic halogenation in C,C-bond formation, this study developed a synthetic approach combining biocatalytic bromination with transition-metal-catalyzed cross-coupling. Using the cyanobacterial AmVHPO, a robust and sustainable bromination-arylation cascade was created. Genetic modifications allowed enzyme immobilization, enhancing the compatibility between biocatalysis and chemocatalysis. This mild, efficient method for synthesizing biaryl compounds provides a foundation for future biochemo cascade reactions harnessing halogenation as a traceless directing tool.
pubs.acs.org
January 3, 2025 at 3:41 PM
Inspired by natural cryptic halogenation, the Gulder group @biomicat developed a biocatalytic bromination-arylation cascade for efficient biaryl synthesis, combining bio- & chemocatalysis. #VHPOs #Biocatalysis #OpenAccess #ChemSky #OrgLett pubs.acs.org/doi/10.1021/...
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals https://www.biorxiv.org/content/10.1101/2024.07.31.606109v1
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals https://www.biorxiv.org/content/10.1101/2024.07.31.606109v1
Site-selective vanadium-dependent haloperoxidases (VHPOs) are a unique enzyme family that catalyze s
www.biorxiv.org
August 2, 2024 at 3:46 AM
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals https://www.biorxiv.org/content/10.1101/2024.07.31.606109v1
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals https://www.biorxiv.org/content/10.1101/2024.07.31.606109v1
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals https://www.biorxiv.org/content/10.1101/2024.07.31.606109v1
Site-selective vanadium-dependent haloperoxidases (VHPOs) are a unique enzyme family that catalyze s
www.biorxiv.org
August 2, 2024 at 3:46 AM
Vanadium-dependent haloperoxidases from diverse microbes halogenate exogenous alkyl quinolone quorum sensing signals https://www.biorxiv.org/content/10.1101/2024.07.31.606109v1
