Stress-inducible WASF3 regulates brain metabolism and cognitive function — Syed et al
"we investigated the role of WASF3 in brain metabolism and function using WASF3 transgenic and knockout mouse models."
#MECFS
"we investigated the role of WASF3 in brain metabolism and function using WASF3 transgenic and knockout mouse models."
#MECFS
Article Link
www.pnas.org
November 2, 2026 at 7:00 AM
Stress-inducible WASF3 regulates brain metabolism and cognitive function — Syed et al
"we investigated the role of WASF3 in brain metabolism and function using WASF3 transgenic and knockout mouse models."
#MECFS
"we investigated the role of WASF3 in brain metabolism and function using WASF3 transgenic and knockout mouse models."
#MECFS
Fresh of publication in PNAS
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Abu M. Syed, Jin Ma, Ping-yuan Wang, +8 , and Paul M. Hwang
#ME/CFS #WASF3 🧠 💪🏻💪🏻 🫘
www.pnas.org/doi/10.1073/...
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Abu M. Syed, Jin Ma, Ping-yuan Wang, +8 , and Paul M. Hwang
#ME/CFS #WASF3 🧠 💪🏻💪🏻 🫘
www.pnas.org/doi/10.1073/...
Stress-inducible WASF3 regulates brain metabolism and cognitive function | PNAS
Wiskott–Aldrich syndrome protein family member 3 (WASF3) disrupts mitochondrial respiration
and is induced in association with endoplasmic reticulu...
www.pnas.org
October 28, 2026 at 3:54 PM
Fresh of publication in PNAS
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Abu M. Syed, Jin Ma, Ping-yuan Wang, +8 , and Paul M. Hwang
#ME/CFS #WASF3 🧠 💪🏻💪🏻 🫘
www.pnas.org/doi/10.1073/...
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Abu M. Syed, Jin Ma, Ping-yuan Wang, +8 , and Paul M. Hwang
#ME/CFS #WASF3 🧠 💪🏻💪🏻 🫘
www.pnas.org/doi/10.1073/...
Thanks to the Dr. Ruth Report for alerting us to another paper on WASF3. Further evidence of the potential importance of this molecule as a cause of fatigue and brain fog in people with ME/CFS and LC.
November 3, 2026 at 4:44 AM
Thanks to the Dr. Ruth Report for alerting us to another paper on WASF3. Further evidence of the potential importance of this molecule as a cause of fatigue and brain fog in people with ME/CFS and LC.
New Paul Hwang paper! 👀
“This study shows that stress-inducible Wiskott–Aldrich syndrome protein family member 3 (WASF3), previously linked to mitochondrial dysfunction in skeletal muscle of patients with ME/CFS, also suppresses oxidative metabolism in the brain.”
#MECFS
“This study shows that stress-inducible Wiskott–Aldrich syndrome protein family member 3 (WASF3), previously linked to mitochondrial dysfunction in skeletal muscle of patients with ME/CFS, also suppresses oxidative metabolism in the brain.”
#MECFS
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Wiskott–Aldrich syndrome protein family member disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in ME/CFS
www.pnas.org/doi/10.1073/...
Wiskott–Aldrich syndrome protein family member disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in ME/CFS
www.pnas.org/doi/10.1073/...
October 28, 2026 at 10:44 PM
New Paul Hwang paper! 👀
“This study shows that stress-inducible Wiskott–Aldrich syndrome protein family member 3 (WASF3), previously linked to mitochondrial dysfunction in skeletal muscle of patients with ME/CFS, also suppresses oxidative metabolism in the brain.”
#MECFS
“This study shows that stress-inducible Wiskott–Aldrich syndrome protein family member 3 (WASF3), previously linked to mitochondrial dysfunction in skeletal muscle of patients with ME/CFS, also suppresses oxidative metabolism in the brain.”
#MECFS
Also gives further support to my Substack piece discussing a treatment to reduce WASF3
lnkd.in/ggutQCa3
lnkd.in/gGGzgnYh
lnkd.in/ggutQCa3
lnkd.in/gGGzgnYh
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
November 3, 2026 at 4:44 AM
Also gives further support to my Substack piece discussing a treatment to reduce WASF3
lnkd.in/ggutQCa3
lnkd.in/gGGzgnYh
lnkd.in/ggutQCa3
lnkd.in/gGGzgnYh
NIH researchers found that elevated WASF3 disrupts mitochondrial energy production in mouse brains.
Removing WASF3 improved metabolism and protected cognition under stress, revealing a potential mechanism for brain fog in ME/CFS and Long COVID.
www.pnas.org/doi/10.1073/...
Removing WASF3 improved metabolism and protected cognition under stress, revealing a potential mechanism for brain fog in ME/CFS and Long COVID.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 28, 2026 at 2:08 PM
NIH researchers found that elevated WASF3 disrupts mitochondrial energy production in mouse brains.
Removing WASF3 improved metabolism and protected cognition under stress, revealing a potential mechanism for brain fog in ME/CFS and Long COVID.
www.pnas.org/doi/10.1073/...
Removing WASF3 improved metabolism and protected cognition under stress, revealing a potential mechanism for brain fog in ME/CFS and Long COVID.
www.pnas.org/doi/10.1073/...
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Wiskott–Aldrich syndrome protein family member disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in ME/CFS
www.pnas.org/doi/10.1073/...
Wiskott–Aldrich syndrome protein family member disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in ME/CFS
www.pnas.org/doi/10.1073/...
October 28, 2026 at 2:51 PM
Stress-inducible WASF3 regulates brain metabolism and cognitive function
Wiskott–Aldrich syndrome protein family member disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in ME/CFS
www.pnas.org/doi/10.1073/...
Wiskott–Aldrich syndrome protein family member disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in ME/CFS
www.pnas.org/doi/10.1073/...
"...und legen nahe, dass eine gezielte Beeinflussung der ER-Stress-WASF3-Signalübertragung kognitive Symptome bei ME/CFS und verwandten postviralen Erschöpfungssyndromen allgemein lindern könnte."
October 29, 2026 at 7:47 AM
"...und legen nahe, dass eine gezielte Beeinflussung der ER-Stress-WASF3-Signalübertragung kognitive Symptome bei ME/CFS und verwandten postviralen Erschöpfungssyndromen allgemein lindern könnte."
"...Studie zeigt, dass das stressinduzierbare Protein WASF3 (Wiskott-Aldrich-Syndrom-Protein-Familienmitglied 3) – das bereits mit mitochondrialen Funktionsstörungen in der Skelettmuskulatur von ME/CFS-Patienten in Verbindung gebracht wurde – auch den oxidativen Stoffwechsel im Gehirn unterdrückt."
October 29, 2026 at 7:44 AM
"...Studie zeigt, dass das stressinduzierbare Protein WASF3 (Wiskott-Aldrich-Syndrom-Protein-Familienmitglied 3) – das bereits mit mitochondrialen Funktionsstörungen in der Skelettmuskulatur von ME/CFS-Patienten in Verbindung gebracht wurde – auch den oxidativen Stoffwechsel im Gehirn unterdrückt."
good to confirm existing science but pretty sure I've been reading about WASF3 for SEVEN YEARS now
they need to start working on dedicated drugs for it
because it's obvious now repurposing existing drugs isn't going to do it
new drugs will take a decade to get to market
do not have decade left
they need to start working on dedicated drugs for it
because it's obvious now repurposing existing drugs isn't going to do it
new drugs will take a decade to get to market
do not have decade left
October 28, 2026 at 2:12 PM
good to confirm existing science but pretty sure I've been reading about WASF3 for SEVEN YEARS now
they need to start working on dedicated drugs for it
because it's obvious now repurposing existing drugs isn't going to do it
new drugs will take a decade to get to market
do not have decade left
they need to start working on dedicated drugs for it
because it's obvious now repurposing existing drugs isn't going to do it
new drugs will take a decade to get to market
do not have decade left
Mitochondrial disrupter WASF3: A Critically Important Process in #ME/CFS? Paul Hwang’s Surprising Saga and hopefully further research into it and possible treatments
@cortjohnson.bsky.social
www.healthrising.org/blog/2026/09...
@cortjohnson.bsky.social
www.healthrising.org/blog/2026/09...
WASF3: A Critically Important Process in ME/CFS? Paul Hwang's Surprising Saga - Health Rising
A mitochondrial disrupter called WASF3 could be dysregulating many systems in ME/CFS.
www.healthrising.org
September 19, 2026 at 1:05 AM
Mitochondrial disrupter WASF3: A Critically Important Process in #ME/CFS? Paul Hwang’s Surprising Saga and hopefully further research into it and possible treatments
@cortjohnson.bsky.social
www.healthrising.org/blog/2026/09...
@cortjohnson.bsky.social
www.healthrising.org/blog/2026/09...
WASF3 and ER Stress ME/CFS/Long COVID Model @cortjohnson.bsky.social article : Dr. Paul Hwang links ER-stress–induced WASF3 to mitochondrial disruption in ME/CFS & proposes a mechanism that could extend to Long COVID & other post-viral diseases. www.healthrising.org/blog/2026/09...
WASF3: A Critically Important Process in ME/CFS? Paul Hwang's Surprising Saga - Health Rising
A mitochondrial disrupter called WASF3 could be dysregulating many systems in ME/CFS.
www.healthrising.org
September 16, 2026 at 3:54 AM
WASF3 and ER Stress ME/CFS/Long COVID Model @cortjohnson.bsky.social article : Dr. Paul Hwang links ER-stress–induced WASF3 to mitochondrial disruption in ME/CFS & proposes a mechanism that could extend to Long COVID & other post-viral diseases. www.healthrising.org/blog/2026/09...
So the infection triggers the endoplasmic reticulum spiral and dysregulates WASF3?
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
Increased ROS levels in #LongCOVID patients may loop back and damage the ER, creating a vicious circle:
#medsky
No #energy
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
Increased ROS levels in #LongCOVID patients may loop back and damage the ER, creating a vicious circle:
#medsky
No #energy
September 15, 2026 at 3:32 PM
So the infection triggers the endoplasmic reticulum spiral and dysregulates WASF3?
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
Increased ROS levels in #LongCOVID patients may loop back and damage the ER, creating a vicious circle:
#medsky
No #energy
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
Increased ROS levels in #LongCOVID patients may loop back and damage the ER, creating a vicious circle:
#medsky
No #energy
I know! I was pretty siked about the WASF3 discovery, but it’s just been yet another dropped ball.
September 15, 2026 at 2:21 AM
I know! I was pretty siked about the WASF3 discovery, but it’s just been yet another dropped ball.
Increased ROS levels in #LongCOVID patients may loop back and damage the endoplasmic reticulum, creating a vicious circle:
High ER stress, caused by an infection, dysregulates WASF3.
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
#medsky
No #energy
High ER stress, caused by an infection, dysregulates WASF3.
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
#medsky
No #energy
September 13, 2026 at 10:16 PM
Increased ROS levels in #LongCOVID patients may loop back and damage the endoplasmic reticulum, creating a vicious circle:
High ER stress, caused by an infection, dysregulates WASF3.
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
#medsky
No #energy
High ER stress, caused by an infection, dysregulates WASF3.
WASF3 damages the electron transport chain, reducing ATP production and increasing ROS.
#medsky
No #energy
Health Rising: 'WASF3: A Critically Important Process in ME/CFS? Paul Hwang’s Surprising Saga'
'Hwang brought in samples from ME/CFS patients..he & colleagues found significantly increased WASF3 levels and dramatically reduced cytochrome oxidase & MTO1 levels'
www.healthrising.org/blog/2026/09...
'Hwang brought in samples from ME/CFS patients..he & colleagues found significantly increased WASF3 levels and dramatically reduced cytochrome oxidase & MTO1 levels'
www.healthrising.org/blog/2026/09...
WASF3: A Critically Important Process in ME/CFS? Paul Hwang's Surprising Saga - Health Rising
A mitochondrial disrupter called WASF3 could be dysregulating many systems in ME/CFS.
www.healthrising.org
September 13, 2026 at 5:45 PM
Health Rising: 'WASF3: A Critically Important Process in ME/CFS? Paul Hwang’s Surprising Saga'
'Hwang brought in samples from ME/CFS patients..he & colleagues found significantly increased WASF3 levels and dramatically reduced cytochrome oxidase & MTO1 levels'
www.healthrising.org/blog/2026/09...
'Hwang brought in samples from ME/CFS patients..he & colleagues found significantly increased WASF3 levels and dramatically reduced cytochrome oxidase & MTO1 levels'
www.healthrising.org/blog/2026/09...
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome
Ping-yuan Wang, Jin Ma, Young-Chae Kim, and Paul M. Hwang (2023)
#ME/CFS #pwME #WASF3 #Mitochondria
Ping-yuan Wang, Jin Ma, Young-Chae Kim, and Paul M. Hwang (2023)
#ME/CFS #pwME #WASF3 #Mitochondria
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome | PNAS
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by various
disabling symptoms including exercise intolerance and is di...
www.pnas.org
September 7, 2026 at 4:43 PM
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome
Ping-yuan Wang, Jin Ma, Young-Chae Kim, and Paul M. Hwang (2023)
#ME/CFS #pwME #WASF3 #Mitochondria
Ping-yuan Wang, Jin Ma, Young-Chae Kim, and Paul M. Hwang (2023)
#ME/CFS #pwME #WASF3 #Mitochondria
salubrinal and WASF3 is fascinating
there is much weaker natural alternative perhaps in TUDCA
Tauroursodeoxycholic-acid is a naturally occurring hydrophilic bile acid that has been used for centuries in Chinese medicine
www.nih.gov/news-events/...
there is much weaker natural alternative perhaps in TUDCA
Tauroursodeoxycholic-acid is a naturally occurring hydrophilic bile acid that has been used for centuries in Chinese medicine
www.nih.gov/news-events/...
Protein may be linked to exercise intolerance in ME/CFS
A study suggested that high levels of a protein may reduce energy production in the muscle cells of people with ME/CFS.
www.nih.gov
July 23, 2025 at 6:21 PM
salubrinal and WASF3 is fascinating
there is much weaker natural alternative perhaps in TUDCA
Tauroursodeoxycholic-acid is a naturally occurring hydrophilic bile acid that has been used for centuries in Chinese medicine
www.nih.gov/news-events/...
there is much weaker natural alternative perhaps in TUDCA
Tauroursodeoxycholic-acid is a naturally occurring hydrophilic bile acid that has been used for centuries in Chinese medicine
www.nih.gov/news-events/...
So NIH continues down this path of devoting resources to studying T cell exhaustion, WASF3 in subset of intramural cohort but also effort preference framed by behavioral science. I am not sure what to make of this. Also how has the funding status changed since this presentation was made?
March 31, 2025 at 2:33 AM
So NIH continues down this path of devoting resources to studying T cell exhaustion, WASF3 in subset of intramural cohort but also effort preference framed by behavioral science. I am not sure what to make of this. Also how has the funding status changed since this presentation was made?
"She wrote to a scientist about her fatigue. It inspired a breakthrough."
This is the background story to the recent study which reported excessive levels of the WASF3 protein in ME/CFS.
www.washingtonpost.com/health/2023/...
This is the background story to the recent study which reported excessive levels of the WASF3 protein in ME/CFS.
www.washingtonpost.com/health/2023/...
www.washingtonpost.com
September 17, 2023 at 12:19 PM
"She wrote to a scientist about her fatigue. It inspired a breakthrough."
This is the background story to the recent study which reported excessive levels of the WASF3 protein in ME/CFS.
www.washingtonpost.com/health/2023/...
This is the background story to the recent study which reported excessive levels of the WASF3 protein in ME/CFS.
www.washingtonpost.com/health/2023/...