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Read the full paper: Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development

A groundbreaking new study unveils critical insights into the molecular pathways driving renal inflammation and fibrosis, conditions that pose significant challenges in chronic kidney disease (CKD)

Nature Communications, Published online: 10 April 2026; doi:10.1038/s41467-026-71553-2Here the authors report that WNT10B, a ligand of the Wnt family, mediates renal inflammation and fibrosis. Mechanistic work in male mice with induced chronic kidney disease shows that the WNT10B/FOXO6 axis controls tubular senescence fate transition and pro-inflammatory microenviroment formation through metabolic reprogramming.

Nature Communications, Published online: 10 April 2026; doi:10.1038/s41467-026-71553-2Here the authors report that WNT10B, a ligand of the Wnt family, mediates renal inflammation and fibrosis. Mechanistic work in male mice with induced chronic kidney disease shows that the WNT10B/FOXO6 axis controls tubular senescence fate transition and pro-inflammatory microenviroment formation through metabolic reprogramming.

Nature Reviews Nephrology, Published online: 01 May 2026; doi:10.1038/s41581-026-01083-zWNT10B–FOXO6 in senescence fate transition and fibrosis

Nature Reviews Nephrology, Published online: 01 May 2026; doi:10.1038/s41581-026-01083-zWNT10B–FOXO6 in senescence fate transition and fibrosis

Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone homeostasis in eugonadic youn...

ALPL + PDGFD + (AP + ) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains. Targeting specific EGR1 domains to activate PeSCs in situ presents a promising strategy for enhancing craniofacial bone regeneration. Abstract Oral and craniofacial bone regeneration remains challenging due to unique anatomical and functional demands. Rodent models have limited translational value because of significant structural differences from humans. The study reveals high similarity in calvarial periosteal cell composition between miniature pigs and humans at single-cell resolution. ALPL + PDGFD + (AP + ) cells are identified as distinct calvarial periosteal stem cells (PeSCs) that possess self-renewal and differentiation potential in both swine and human calvarial periosteum. Postnatally, AP + PeSCs exhibit reduced activity compared to their embryonic counterparts, with EGR1 recognized as a crucial factor for their activation. Upon activation, these cells effectively facilitate the repair of craniofacial bone injuries. EGR1 regulates PeSCs development by modulating BMP signaling through its Znf2 domain and activating these cells via the CTNNB1/WNT10B pathway through its Znf2/3 domains in response to injury. The validation of the findings using human cranial periosteal samples from various developmental stages (embryonic and adult) further supports the results obtained from large animal experiments, providing a solid scientific foundation for the clinical application of AP + cranial periosteal stem cells. Additionally, targeting specific EGR1 domains for in situ activation of PeSCs offers a promising strategy for enhancing bone regeneration.