I'm glad to share my very first thesis paper published in Applied and Environmental Microbiology ! 🦠🪱🧪
#microsky#symbiosky#wormfeed
journals.asm.org/doi/10.1128/...
#microsky#symbiosky#wormfeed
journals.asm.org/doi/10.1128/...
Pleiotropic role of PAX cyclolipopeptides in the Xenorhabdus bacterium mutualistically associated with entomopathogenic nematodes | Applied and Environmental Microbiology
Xenorhabdus bacteria are models of particular interest for their mutualistic relationship with
Steinernema nematodes and their ability to produce a wide range of natural NRP-type bioactive
metabolites...
journals.asm.org
September 11, 2025 at 12:40 PM
I'm glad to share my very first thesis paper published in Applied and Environmental Microbiology ! 🦠🪱🧪
#microsky#symbiosky#wormfeed
journals.asm.org/doi/10.1128/...
#microsky#symbiosky#wormfeed
journals.asm.org/doi/10.1128/...
Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity
genes whose protein products neutralize toxins secreted by competitors. These arrays,
often linked to Xer pass...
www.cell.com
December 15, 2025 at 5:02 PM
Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Finally a Doctor! 🦠👩🏼🎓
I am honored to announce that I defended my doctoral thesis in microbiology/biochemistry with jury honors! 🎉
I am very pleased to have been able to identify key metabolites for Xenorhabdus/nematode symbiosis and I look forward to keep studying symbiosis in my postdoc research
I am honored to announce that I defended my doctoral thesis in microbiology/biochemistry with jury honors! 🎉
I am very pleased to have been able to identify key metabolites for Xenorhabdus/nematode symbiosis and I look forward to keep studying symbiosis in my postdoc research
November 14, 2025 at 11:19 AM
Finally a Doctor! 🦠👩🏼🎓
I am honored to announce that I defended my doctoral thesis in microbiology/biochemistry with jury honors! 🎉
I am very pleased to have been able to identify key metabolites for Xenorhabdus/nematode symbiosis and I look forward to keep studying symbiosis in my postdoc research
I am honored to announce that I defended my doctoral thesis in microbiology/biochemistry with jury honors! 🎉
I am very pleased to have been able to identify key metabolites for Xenorhabdus/nematode symbiosis and I look forward to keep studying symbiosis in my postdoc research
Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. Production of the NRPS BpsA from Streptomyces lavendulae and the RXP producer Xenorhabdus KJ12.1
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
September 20, 2023 at 3:46 PM
Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. Production of the NRPS BpsA from Streptomyces lavendulae and the RXP producer Xenorhabdus KJ12.1
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
12/12 Bakterie rodu Xenorhabdus jsou ale studovány ještě z jiného důvodu. Díky svým vlastnostem jsou jedním z kandidátů pro léčbu tzv. zlatého stafylokoka, bakterie nebezpečně rezistentní vůči antibiotikům.
January 5, 2026 at 11:34 AM
12/12 Bakterie rodu Xenorhabdus jsou ale studovány ještě z jiného důvodu. Díky svým vlastnostem jsou jedním z kandidátů pro léčbu tzv. zlatého stafylokoka, bakterie nebezpečně rezistentní vůči antibiotikům.
We propose immuno-centric view of secreted polymorphic toxin diversification and involvement of novel XPC systems in this process! Fantastic work of @jmartinkus.bsky.social with lab of @cascaleslab.bsky.social !
www.cell.com/current-biol...
www.cell.com/current-biol...
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity
genes whose protein products neutralize toxins secreted by competitors. These arrays,
often linked to Xer pass...
www.cell.com
December 15, 2025 at 5:45 PM
We propose immuno-centric view of secreted polymorphic toxin diversification and involvement of novel XPC systems in this process! Fantastic work of @jmartinkus.bsky.social with lab of @cascaleslab.bsky.social !
www.cell.com/current-biol...
www.cell.com/current-biol...
2/12 Vědci z univerzity Emory v americké Atlantě zkoumali mechanismy skoku červa, konkrétně škrkavky Steinernema carpocapsae (foto z wiki), na svoji oběť. Tahle škrkavka je docela rafinovaná potvora, která se symbioticky sžila s bakteriemi rodu Xenorhabdus.
January 5, 2026 at 11:34 AM
2/12 Vědci z univerzity Emory v americké Atlantě zkoumali mechanismy skoku červa, konkrétně škrkavky Steinernema carpocapsae (foto z wiki), na svoji oběť. Tahle škrkavka je docela rafinovaná potvora, která se symbioticky sžila s bakteriemi rodu Xenorhabdus.
🧑🤝🧑CRISPR/Cpf1 × pSEVA: a powerhouse combo in #SynBio! German researchers applied this strategy in Photorhabdus & Xenorhabdus, boosting production of high-value compounds like safracin B, a precursor to the anti-cancer drug ET-743. Read here👉 doi.org/10.1186/s129...
Genetic toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling - Microbial Cell Factories
Background Bacteria of the genus Photorhabdus and Xenorhabdus are motile, Gram-negative bacteria that live in symbiosis with entomopathogenic nematodes. Due to their complex life cycle, they produce…
doi.org
September 24, 2025 at 12:04 PM
🧑🤝🧑CRISPR/Cpf1 × pSEVA: a powerhouse combo in #SynBio! German researchers applied this strategy in Photorhabdus & Xenorhabdus, boosting production of high-value compounds like safracin B, a precursor to the anti-cancer drug ET-743. Read here👉 doi.org/10.1186/s129...
XopA: a novel type III secretion system effector in Xenorhabdus that modulates host cell responses through apoptosis, autophagy, and immune evasion | Microbiology Spectrum journals.asm.org/doi/10.1128/...
XopA: a novel type III secretion system effector in Xenorhabdus that modulates host cell responses through apoptosis, autophagy, and immune evasion | Microbiology Spectrum
This study reports the groundbreaking discovery of XopA as the first type III secretion
system effectors (T3SE) identified in Xenorhabdus bacteria. By demonstrating its unique ability to concurrently ...
journals.asm.org
April 25, 2026 at 2:51 PM
XopA: a novel type III secretion system effector in Xenorhabdus that modulates host cell responses through apoptosis, autophagy, and immune evasion | Microbiology Spectrum journals.asm.org/doi/10.1128/...
Jennifer Heppert is helping to develop a new Xenorhabdus-Steinernema system that should have easier CRISPR manipulation abilities. Specifically, she compared S. carpocapsae to the new S. hermaphroditum model and found conservation but also divergence in colonization dynamics. #BeneficialMicrobes
July 22, 2024 at 9:51 PM
Jennifer Heppert is helping to develop a new Xenorhabdus-Steinernema system that should have easier CRISPR manipulation abilities. Specifically, she compared S. carpocapsae to the new S. hermaphroditum model and found conservation but also divergence in colonization dynamics. #BeneficialMicrobes
Emmanuel Allwell: #Xenorhabdus nematophila tailocins display common heterospecific killing but vary in conspecific killing; susceptibility profiles of strains to lysates were associated with O-antigen biosynthesis genes #phages2025 🦠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Intraspecific bacterial competition mediated by rapidly diversifying tailocin and prophage loci
Signatures of selection in microbial genomes are often linked to biotic interactions, notably resistance to host immunity or bacteriophage attack. Here, we highlight the importance of competitive inte...
www.biorxiv.org
August 8, 2025 at 9:53 PM
Emmanuel Allwell: #Xenorhabdus nematophila tailocins display common heterospecific killing but vary in conspecific killing; susceptibility profiles of strains to lysates were associated with O-antigen biosynthesis genes #phages2025 🦠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🧬 Genetic tools for bacteria like Photorhabdus and Xenorhabdus were scarce—until now. @HelgeBode_Lab's team developed #SEVA-based expression vectors and genome editing tools, enabling production of valuable compounds, like anti-cancer drug precursors ⬇️
Genetic toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling - Microbial Cell Factories
Background Bacteria of the genus Photorhabdus and Xenorhabdus are motile, Gram-negative bacteria that live in symbiosis with entomopathogenic nematodes. Due to their complex life cycle, they produce…
buff.ly
January 7, 2025 at 10:30 AM
🧬 Genetic tools for bacteria like Photorhabdus and Xenorhabdus were scarce—until now. @HelgeBode_Lab's team developed #SEVA-based expression vectors and genome editing tools, enabling production of valuable compounds, like anti-cancer drug precursors ⬇️
Comparative genomics reveals extensive genomic conservation and limited microdiversification among Xenorhabdus bovienii isolates recovered from a single Steinernema feltiae isolation event. https://www.biorxiv.org/content/10.64898/2026.06.04.727993v1
June 9, 2026 at 5:36 AM
Comparative genomics reveals extensive genomic conservation and limited microdiversification among Xenorhabdus bovienii isolates recovered from a single Steinernema feltiae isolation event. https://www.biorxiv.org/content/10.64898/2026.06.04.727993v1
Comparative genomics reveals extensive genomic conservation and limited microdiversification among Xenorhabdus bovienii isolates recovered from a single Steinernema feltiae isolation event. https://www.biorxiv.org/content/10.64898/2026.06.04.727993v1
June 9, 2026 at 5:36 AM
Comparative genomics reveals extensive genomic conservation and limited microdiversification among Xenorhabdus bovienii isolates recovered from a single Steinernema feltiae isolation event. https://www.biorxiv.org/content/10.64898/2026.06.04.727993v1
Ne ratez pas notre prochain #WEBINAIRE du GT Peptides Antimicrobiens !
📅 Mardi 5 mai – 13h
📝 Titre : Rôles des peptides antimicrobiens PAX chez Xenorhabdus, des bactéries symbiotiques de nématodes entomopathogènes
📅 Mardi 5 mai – 13h
📝 Titre : Rôles des peptides antimicrobiens PAX chez Xenorhabdus, des bactéries symbiotiques de nématodes entomopathogènes
May 4, 2026 at 7:41 PM
Ne ratez pas notre prochain #WEBINAIRE du GT Peptides Antimicrobiens !
📅 Mardi 5 mai – 13h
📝 Titre : Rôles des peptides antimicrobiens PAX chez Xenorhabdus, des bactéries symbiotiques de nématodes entomopathogènes
📅 Mardi 5 mai – 13h
📝 Titre : Rôles des peptides antimicrobiens PAX chez Xenorhabdus, des bactéries symbiotiques de nématodes entomopathogènes
Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages.
DOI: 10.1186/s12864-024-10858-2
https://pubmed.ncbi.nlm.nih.gov/39548374/
DOI: 10.1186/s12864-024-10858-2
https://pubmed.ncbi.nlm.nih.gov/39548374/
Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages - PubMed
Our findings suggest that phage-related genes drive the genomic diversity in closely related Xenorhabdus symbionts, and that these may underlie some of the traits most associated with the lifestyle and survival of entomopathogenic nematodes and their bacteria: virulence and competition. This study e …
pubmed.ncbi.nlm.nih.gov
November 19, 2024 at 3:36 PM
Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages.
DOI: 10.1186/s12864-024-10858-2
https://pubmed.ncbi.nlm.nih.gov/39548374/
DOI: 10.1186/s12864-024-10858-2
https://pubmed.ncbi.nlm.nih.gov/39548374/
11/12 Mimochodem, bakterie rodu Xenorhabdus nebyly pozorovány mimo škrkavku. Škrkavka bez X. se v hostiteli nemůže usadit. X. bez škrkavky ano. V současnosti se vedou výzkumy na možnost použití těchto bakterií pro eliminaci některých hostitelů - hmyzích škůdců řepy, jabloní, kukuřice či brambor.
a close up of a red bug with aliabdi written in the corner
ALT: a close up of a red bug with aliabdi written in the corner
media.tenor.com
January 5, 2026 at 11:34 AM
11/12 Mimochodem, bakterie rodu Xenorhabdus nebyly pozorovány mimo škrkavku. Škrkavka bez X. se v hostiteli nemůže usadit. X. bez škrkavky ano. V současnosti se vedou výzkumy na možnost použití těchto bakterií pro eliminaci některých hostitelů - hmyzích škůdců řepy, jabloní, kukuřice či brambor.
RRID:SCR_017838 was used by the authors of the Frontiers in Microbiology paper "Quorum sensing regulators and non-ribosomal peptide synthetases govern antibacterial secretions in Xenorhabdus szentirmaii". RRIDs like this improve reproducibility in scientific research. #reproducibility
doi.org
April 8, 2025 at 7:01 AM
RRID:SCR_017838 was used by the authors of the Frontiers in Microbiology paper "Quorum sensing regulators and non-ribosomal peptide synthetases govern antibacterial secretions in Xenorhabdus szentirmaii". RRIDs like this improve reproducibility in scientific research. #reproducibility
After a long journey, we are happy to share our preprint about the biosynthesis of a new peptide deformylase inhibitor in collaboration with the Groll and Mazel labs: www.biorxiv.org/content/10.1...
Please also see two related publications in bioRxiv www.biorxiv.org/content/10.1....
Please also see two related publications in bioRxiv www.biorxiv.org/content/10.1....
Identification and biosynthesis of xildivaline, a novel and widespread peptide deformylase inhibitor from Gammaproteobacteria
Xenorhabdus strains, Gram-negative bacteria pathogenic to insects and symbionts to nematodes of the genus Steinernema are prolific producers of various natural products. Here we describe the xisABCDE ...
www.biorxiv.org
June 8, 2025 at 12:17 PM
After a long journey, we are happy to share our preprint about the biosynthesis of a new peptide deformylase inhibitor in collaboration with the Groll and Mazel labs: www.biorxiv.org/content/10.1...
Please also see two related publications in bioRxiv www.biorxiv.org/content/10.1....
Please also see two related publications in bioRxiv www.biorxiv.org/content/10.1....
Studying of the regulatory roles of response regulators #GlrR and ArcA in xenocoumacins biosynthesis in #Xenorhabdus nematophila CB6
doi.org/10.1016/j.ji...
✏️Prof. Guangyue Li team at #IPP, #CAAS
#plantpathology #plantprotection
doi.org/10.1016/j.ji...
✏️Prof. Guangyue Li team at #IPP, #CAAS
#plantpathology #plantprotection
December 16, 2025 at 7:39 AM
Studying of the regulatory roles of response regulators #GlrR and ArcA in xenocoumacins biosynthesis in #Xenorhabdus nematophila CB6
doi.org/10.1016/j.ji...
✏️Prof. Guangyue Li team at #IPP, #CAAS
#plantpathology #plantprotection
doi.org/10.1016/j.ji...
✏️Prof. Guangyue Li team at #IPP, #CAAS
#plantpathology #plantprotection
The nematode symbiotic bacterium Xenorhabdus griffiniae can sense and respond to the presence of its host Steinernema hermaphroditum https://www.biorxiv.org/content/10.1101/2025.06.16.660008v1
June 17, 2025 at 3:18 AM
The nematode symbiotic bacterium Xenorhabdus griffiniae can sense and respond to the presence of its host Steinernema hermaphroditum https://www.biorxiv.org/content/10.1101/2025.06.16.660008v1
Pleiotropic role of PAX cyclolipopeptides in the Xenorhabdus bacterium mutualistically associated with entomopathogenic nematodes https://www.biorxiv.org/content/10.1101/2025.04.11.648461v1
April 14, 2025 at 11:16 AM
Pleiotropic role of PAX cyclolipopeptides in the Xenorhabdus bacterium mutualistically associated with entomopathogenic nematodes https://www.biorxiv.org/content/10.1101/2025.04.11.648461v1
Quorum Sensing Regulators and Non-ribosomal Peptide Synthetases Govern Antibacterial Secretions in Xenorhabdus szentirmaii https://www.biorxiv.org/content/10.1101/2025.02.03.636359v1
February 5, 2025 at 4:16 AM
Quorum Sensing Regulators and Non-ribosomal Peptide Synthetases Govern Antibacterial Secretions in Xenorhabdus szentirmaii https://www.biorxiv.org/content/10.1101/2025.02.03.636359v1
Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages. https://www.biorxiv.org/content/10.1101/2024.03.08.584182v1
Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages. https://www.biorxiv.org/content/10.1101/2024.03.08.584182v1
Nematodes of the genus Steinernema and their Xenorhabdus bacterial symbionts are lethal entomopathog
www.biorxiv.org
March 10, 2024 at 4:18 AM
Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages. https://www.biorxiv.org/content/10.1101/2024.03.08.584182v1