Identifying chemical compounds that target trans-regulatory networks (TRNs) underlying molecular programs of cells for directed cellular conversion (i.e. differentiation, reprogramming, transdifferent...

Une cultivatrice. Parmi les 8.870 femmes de mon arbre, il y en a 8 qui portent un nom commençant par Z, dont : ZYNER Marie Catherine, cultivatriceElle s’est mariée avec Nicolas Joseph GILLET v…

Une cultivatrice. Parmi les 8.870 femmes de mon arbre, il y en a 8 qui portent un nom commençant par Z, dont : ZYNER Marie Catherine, cultivatriceElle s’est mariée avec Nicolas Joseph GILLET v…

Sen, D. & Gilbert, W. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature 334, 364–366 (1988). This seminal study reported that DNA sequences containing clusters of guanine residues can self-assemble into four-stranded structures designated G4-DNA by Hoogsteen hydrogen bonding, and the G4 mediates pairing of homologous chromosomes during meiosis. Varshney, D., Spiegel, J., Zyner, K., Tannahill, D. & Balasubramanian, S. The regulation and functions of DNA and RNA G-quadruplexes. Nat. Rev. Mol. Cell. Biol. 21, 459–474 (2020). This review article highlights the role of G4s as molecular switches that control gene expression, DNA replication, and RNA processing. Huppert, J. L. & Balasubramanian, S. Prevalence of quadruplexes in the human genome. Nucleic Acids Res. 33, 2908–2916 (2005). Chambers, V. S. et al. High-throughput sequencing of DNA G-quadruplex structures in the human genome. Nat. Biotechnol. 33, 877–881 (2015). Biffi, G., Tannahill, D., McCafferty, J. & Balasubramanian, S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat. Chem. 5, 182–186 (2013). An engineered structure-specific antibody against G-quadruplex DNA is described that can be used to visualize DNA G4 in human cells in a quantitative manner, paving the way for many applications in G-quadruplex biology...