The mosquitoes are resilient, love people and could be in your yard.

The mosquitoes are resilient, love people and could be in your yard.

Uberaba apresenta alto índice de infestação do mosquito Aedes aegypti Reprodução/TV Integração Uberaba está em situação de risco para infestação do Aedes aegypti, segundo dados do levantame...

In the past, Americans were infected with dengue after being bitten by mosquitoes while traveling. But now, most of the current transmission is from local mosquitoes.

Mosquito-borne alphaviruses represent an increasing global health threat, yet there are currently no antiviral interventions capable of targeting both the vertebrate host and mosquito vector. Here, we investigated the antiviral potential of the heparan sulfate proteoglycan-mimicking zwitterionic polymer ZP12 against alphavirus infection in Aedes aegypti mosquitoes. ZP12 exhibited potent antiviral and virucidal activity against Ross River virus (RRV) and Semliki Forest virus (SFV) in C6/36 mosquito cells. Antiviral activity was retained in ex vivo mosquito gut cultures, where both high (100 g/mL) and low (0.5 g/mL) concentrations significantly reduced RRV replication, with viral titres reduced by up to five orders of magnitude at peak infection. Delayed-treatment studies demonstrated that ZP12 retained antiviral activity after infection had been initiated, although efficacy declined as treatment was delayed. To evaluate prophylactic delivery, mosquitoes were exposed to ZP12 through sugar feeding prior to viral challenge. While this approach did not directly protect against subsequent gut infection, follow-up experiments demonstrated that ZP12 remained biologically active within the mosquito, suggesting that limited delivery to the midgut rather than loss of antiviral activity restricted efficacy. Collectively, these findings demonstrate that ZP12 is a potent antiviral and virucidal agent against alphaviruses in mosquito cells and tissues and supports its further development as a transmission-blocking strategy for arboviral control.

Com o maior índice de infestação do Aedes aegypti desde 2012, a dengue em Uberaba coloca 16 regiões em alerta máximo e mobiliza agentes para conter criadouros.

Com o maior índice de infestação do Aedes aegypti desde 2012, a dengue em Uberaba coloca 16 regiões em alerta máximo e mobiliza agentes para conter criadouros.

Mosquito-borne alphaviruses represent an increasing global health threat, yet there are currently no antiviral interventions capable of targeting both the vertebrate host and mosquito vector. Here, we investigated the antiviral potential of the heparan sulfate proteoglycan-mimicking zwitterionic polymer ZP12 against alphavirus infection in Aedes aegypti mosquitoes. ZP12 exhibited potent antiviral and virucidal activity against Ross River virus (RRV) and Semliki Forest virus (SFV) in C6/36 mosquito cells. Antiviral activity was retained in ex vivo mosquito gut cultures, where both high (100 g/mL) and low (0.5 g/mL) concentrations significantly reduced RRV replication, with viral titres reduced by up to five orders of magnitude at peak infection. Delayed-treatment studies demonstrated that ZP12 retained antiviral activity after infection had been initiated, although efficacy declined as treatment was delayed. To evaluate prophylactic delivery, mosquitoes were exposed to ZP12 through sugar feeding prior to viral challenge. While this approach did not directly protect against subsequent gut infection, follow-up experiments demonstrated that ZP12 remained biologically active within the mosquito, suggesting that limited delivery to the midgut rather than loss of antiviral activity restricted efficacy. Collectively, these findings demonstrate that ZP12 is a potent antiviral and virucidal agent against alphaviruses in mosquito cells and tissues and supports its further development as a transmission-blocking strategy for arboviral control.

Chikungunya ditularkan nyamuk Aedes dan ditandai demam mendadak disertai nyeri sendi hebat yang pada sebagian orang bertahan berbulan-bulan. Kenali gejala, cara membedakannya dari dengue, pengobatan, dan pencegahannya.