Nature research paper: Synthesis of enantioenriched atropisomers by biocatalytic deracemization
go.nature.com/3JTpxuD
go.nature.com/3JTpxuD
Synthesis of enantioenriched atropisomers by biocatalytic deracemization - Nature
A new method for deracemization of atropisomers is described which leverages a P450 enzyme-mediated process involving bond rotation for enantioenrichment.
go.nature.com
November 14, 2025 at 6:19 PM
Nature research paper: Synthesis of enantioenriched atropisomers by biocatalytic deracemization
go.nature.com/3JTpxuD
go.nature.com/3JTpxuD
Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social
cen.acs.org/synthesis/bi...
cen.acs.org/synthesis/bi...
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs
cen.acs.org
November 12, 2025 at 4:48 PM
Atropisomers are popular as chiral ligands and have been showing up in drugs and drug candidates. Making just one atropisomer isn’t trivial, though. That could change, thanks to @alisonnarayan.bsky.social and @narayanlab.bsky.social. My latest for @cenmag.bsky.social
cen.acs.org/synthesis/bi...
cen.acs.org/synthesis/bi...
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs
cen.acs.org
November 28, 2025 at 2:37 PM
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs
cen.acs.org
November 15, 2025 at 11:09 AM
An enzyme gives atropisomers a specific twist
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
Biocatalytic approach could be used to make chiral ligands and drugs. cen.acs.org/synthesis/bi... #chemsky 🧪
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 30, 2025 at 1:16 AM
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 30, 2025 at 1:17 AM
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
February 6, 2026 at 8:25 PM
new paper out in @helvchimacta.bsky.social
😊 Great work by #SophieAMaguire 👏
on how to control #atropisomerism in #porphyrins onlinelibrary.wiley.com/doi/10.1002/... collaboration @tcddublin.bsky.social @ias-tum.bsky.social
supported by @researchireland.ie @tum.de
😊 Great work by #SophieAMaguire 👏
on how to control #atropisomerism in #porphyrins onlinelibrary.wiley.com/doi/10.1002/... collaboration @tcddublin.bsky.social @ias-tum.bsky.social
supported by @researchireland.ie @tum.de
Controlling Rotational Motion of Nonplanar Porphyrin Atropisomers by Metal Coordination
The unpredictable rotational barriers of nonplanar porphyrin atropisomers can be combated using metal coordination to form porphyrin superstructures, selectively capturing a single atropisomer from a...
onlinelibrary.wiley.com
December 8, 2025 at 4:49 PM
new paper out in @helvchimacta.bsky.social
😊 Great work by #SophieAMaguire 👏
on how to control #atropisomerism in #porphyrins onlinelibrary.wiley.com/doi/10.1002/... collaboration @tcddublin.bsky.social @ias-tum.bsky.social
supported by @researchireland.ie @tum.de
😊 Great work by #SophieAMaguire 👏
on how to control #atropisomerism in #porphyrins onlinelibrary.wiley.com/doi/10.1002/... collaboration @tcddublin.bsky.social @ias-tum.bsky.social
supported by @researchireland.ie @tum.de
Philippe Lesot
Successful and fruitful collaboration between Aix-Marseille university (ISM2/FCM) and Paris-Saclay university (ICMMO - UMR 8182) published @chemicalscience.rsc.org
See the link below :
@cnrs-paris-saclay.bsky.social @univparissaclay.bsky.social
pubs.rsc.org/en/content/a...
Successful and fruitful collaboration between Aix-Marseille university (ISM2/FCM) and Paris-Saclay university (ICMMO - UMR 8182) published @chemicalscience.rsc.org
See the link below :
@cnrs-paris-saclay.bsky.social @univparissaclay.bsky.social
pubs.rsc.org/en/content/a...
[1H]/[2H] discriminated bianthryl atropisotopomers: enantiospecific syntheses from BINOL and direct multi-spectroscopic analyses of their isotopic chirality
The synthesis of two [1H]/[2H] discriminated bianthryl atropisotopomers (i.e., isotopically chiral atropisomers, vide infra) with ≥97% enantiomeric excess (ee) from the atropisomers of commercial (aS)...
pubs.rsc.org
February 13, 2026 at 10:39 AM
Philippe Lesot
Successful and fruitful collaboration between Aix-Marseille university (ISM2/FCM) and Paris-Saclay university (ICMMO - UMR 8182) published @chemicalscience.rsc.org
See the link below :
@cnrs-paris-saclay.bsky.social @univparissaclay.bsky.social
pubs.rsc.org/en/content/a...
Successful and fruitful collaboration between Aix-Marseille university (ISM2/FCM) and Paris-Saclay university (ICMMO - UMR 8182) published @chemicalscience.rsc.org
See the link below :
@cnrs-paris-saclay.bsky.social @univparissaclay.bsky.social
pubs.rsc.org/en/content/a...
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 30, 2025 at 12:46 AM
Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
In @acsnano we show the synthesis and lifting experiments of frustrated atropisomers using low temperature force spectroscopy and MD simulations.
Fundings: @nanolino-unibas.bsky.social
@snsf-ch.bsky.social, @sniunibas.bsky.social, @unibas.ch, @erc.europa.eu
pubs.acs.org/doi/10.1021/...
Fundings: @nanolino-unibas.bsky.social
@snsf-ch.bsky.social, @sniunibas.bsky.social, @unibas.ch, @erc.europa.eu
pubs.acs.org/doi/10.1021/...
On-Surface Synthesis and Cryogenic Exfoliation of Sterically Frustrated Atropisomers
On-surface synthesis provides exceptional control over nanostructure and material composition, enabling the creation of molecular compounds that are difficult or impossible to obtain with other synthe...
pubs.acs.org
April 7, 2025 at 7:17 AM
In @acsnano we show the synthesis and lifting experiments of frustrated atropisomers using low temperature force spectroscopy and MD simulations.
Fundings: @nanolino-unibas.bsky.social
@snsf-ch.bsky.social, @sniunibas.bsky.social, @unibas.ch, @erc.europa.eu
pubs.acs.org/doi/10.1021/...
Fundings: @nanolino-unibas.bsky.social
@snsf-ch.bsky.social, @sniunibas.bsky.social, @unibas.ch, @erc.europa.eu
pubs.acs.org/doi/10.1021/...
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 13, 2025 at 3:24 PM
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 13, 2025 at 3:23 PM
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 13, 2025 at 5:28 AM
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
Researchers from the @narayanlab.bsky.social have unlocked a novel mechanism for transforming molecules. Their findings, described in a new @nature.com study, open new ways to develop important molecules with fewer wasteful byproducts.
nature.com/articles/s41...
nature.com/articles/s41...
Synthesis of enantioenriched atropisomers by biocatalytic deracemization - Nature
A new method for deracemization of atropisomers is described which leverages a P450 enzyme-mediated process involving bond rotation for enantioenrichment.
nature.com
November 12, 2025 at 8:39 PM
Researchers from the @narayanlab.bsky.social have unlocked a novel mechanism for transforming molecules. Their findings, described in a new @nature.com study, open new ways to develop important molecules with fewer wasteful byproducts.
nature.com/articles/s41...
nature.com/articles/s41...
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
October 13, 2025 at 5:27 AM
Design and construction of difunctionalized C−N atropisomers via lipase-catalyzed desymmetrization and kinetic resolution of N-naphthol-carbazoles
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
#research #organicchemistry #atropisomer
Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates (Šimek et al.) – @natcomms.nature.com: doi.org/10.1038/s414...
@iocbprague.bsky.social @sciencecharles.bsky.social
Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates (Šimek et al.) – @natcomms.nature.com: doi.org/10.1038/s414...
@iocbprague.bsky.social @sciencecharles.bsky.social
May 30, 2025 at 1:37 PM
#research #organicchemistry #atropisomer
Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates (Šimek et al.) – @natcomms.nature.com: doi.org/10.1038/s414...
@iocbprague.bsky.social @sciencecharles.bsky.social
Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates (Šimek et al.) – @natcomms.nature.com: doi.org/10.1038/s414...
@iocbprague.bsky.social @sciencecharles.bsky.social
and at the same time Sophie, Liam, Freya and Karolina were busy at the @rsc.org #OrganicChemistryIreland meeting in Belfast 😀. #porphyrins #atropisomers #bicyclopentane #flowchemistry ⚗️ ... @researchireland.ie
May 9, 2025 at 3:02 PM
and at the same time Sophie, Liam, Freya and Karolina were busy at the @rsc.org #OrganicChemistryIreland meeting in Belfast 😀. #porphyrins #atropisomers #bicyclopentane #flowchemistry ⚗️ ... @researchireland.ie
With our latest #WEASEL release, it is time to introduce another workflow: the fully automated calculation of rotational barriers for arbitrary molecules, enabling the reliable identification and classification of #atropisomers.
www.faccts.de/weasel/
#FACCTs #Workflows #QuantumChem #CompChem #CADD
www.faccts.de/weasel/
#FACCTs #Workflows #QuantumChem #CompChem #CADD
February 19, 2026 at 10:25 AM
With our latest #WEASEL release, it is time to introduce another workflow: the fully automated calculation of rotational barriers for arbitrary molecules, enabling the reliable identification and classification of #atropisomers.
www.faccts.de/weasel/
#FACCTs #Workflows #QuantumChem #CompChem #CADD
www.faccts.de/weasel/
#FACCTs #Workflows #QuantumChem #CompChem #CADD
🧪 A team of organic chemists led by Paulo Paioti at @iocbprague.bsky.social developed a platform to produce drug-like #atropisomers with C–N restricted bonds. 1/7🧵
#chemistry #chemie #iocb #iocbprague #atropisomer #research #czechscience
#chemistry #chemie #iocb #iocbprague #atropisomer #research #czechscience
July 10, 2025 at 12:27 PM
🧪 A team of organic chemists led by Paulo Paioti at @iocbprague.bsky.social developed a platform to produce drug-like #atropisomers with C–N restricted bonds. 1/7🧵
#chemistry #chemie #iocb #iocbprague #atropisomer #research #czechscience
#chemistry #chemie #iocb #iocbprague #atropisomer #research #czechscience
While rest of us had group meeting in the rain🌧️ @tbsi-tcd.bsky.social @tcddublin.bsky.social in Dublin: Karolina, Sophie, and Liam are off into the sun 🌞in Salerno at the #SupraChemDays25 meeting showing off cool chemistry ⚗️on #porphyrins, #organocatalysis, #atropisomers, #bicyclopentane 😀
June 12, 2025 at 6:56 PM
While rest of us had group meeting in the rain🌧️ @tbsi-tcd.bsky.social @tcddublin.bsky.social in Dublin: Karolina, Sophie, and Liam are off into the sun 🌞in Salerno at the #SupraChemDays25 meeting showing off cool chemistry ⚗️on #porphyrins, #organocatalysis, #atropisomers, #bicyclopentane 😀
Not all molecules that look the same are the same. Using HRIM on MOBIE, scientists at AbbVie separated structurally similar small molecules and atropisomers, revealing differences beyond conventional methods.
Find AbbVie & more: view-su2.highspot.com/viewer/cafe9...
#MOBIE #HRIM #Pharma
Find AbbVie & more: view-su2.highspot.com/viewer/cafe9...
#MOBIE #HRIM #Pharma
Home | Highspot
view-su2.highspot.com
June 23, 2026 at 2:50 PM
Not all molecules that look the same are the same. Using HRIM on MOBIE, scientists at AbbVie separated structurally similar small molecules and atropisomers, revealing differences beyond conventional methods.
Find AbbVie & more: view-su2.highspot.com/viewer/cafe9...
#MOBIE #HRIM #Pharma
Find AbbVie & more: view-su2.highspot.com/viewer/cafe9...
#MOBIE #HRIM #Pharma
Site-Selective C–H Functionalization Used to Prepare Atropisomers:
Organic photoredox catalysis provides a general approach to the coupling of biaryls with a range of nucleophiles
www.chemistryviews.org/site-selecti...
Organic photoredox catalysis provides a general approach to the coupling of biaryls with a range of nucleophiles
www.chemistryviews.org/site-selecti...
February 18, 2025 at 1:09 AM
Site-Selective C–H Functionalization Used to Prepare Atropisomers:
Organic photoredox catalysis provides a general approach to the coupling of biaryls with a range of nucleophiles
www.chemistryviews.org/site-selecti...
Organic photoredox catalysis provides a general approach to the coupling of biaryls with a range of nucleophiles
www.chemistryviews.org/site-selecti...
Access to enantioenriched atropisomers through biocatalytic deracemization
Authors: Casey Roos, S. Luke Schulert, Lara Zetzsche, Spencer McMinn, Angela Cheong, Eunjae Shim, Eugene Kwan, Alison Narayan
DOI: 10.26434/chemrxiv-2025-6s0hk
Authors: Casey Roos, S. Luke Schulert, Lara Zetzsche, Spencer McMinn, Angela Cheong, Eunjae Shim, Eugene Kwan, Alison Narayan
DOI: 10.26434/chemrxiv-2025-6s0hk
February 11, 2025 at 10:40 AM
Access to enantioenriched atropisomers through biocatalytic deracemization
Authors: Casey Roos, S. Luke Schulert, Lara Zetzsche, Spencer McMinn, Angela Cheong, Eunjae Shim, Eugene Kwan, Alison Narayan
DOI: 10.26434/chemrxiv-2025-6s0hk
Authors: Casey Roos, S. Luke Schulert, Lara Zetzsche, Spencer McMinn, Angela Cheong, Eunjae Shim, Eugene Kwan, Alison Narayan
DOI: 10.26434/chemrxiv-2025-6s0hk
The final version of this manuscript is up at acs catalysis.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
March 6, 2026 at 8:12 PM
The final version of this manuscript is up at acs catalysis.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...