April 15, 2026 at 8:58 PM
New TYP lab paper out today in @pnas.org from former PhD student Zach Augur and postdoc @garrettfogo.bsky.social all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: www.pnas.org/doi/10.1073/...
BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease–linked proteins via proteasome, autophagy, and retromer interactions | PNAS
Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone-assisted selective
autophagy, and in the brain, is most highly expressed in astrocy...
www.pnas.org
September 29, 2026 at 12:30 AM
New TYP lab paper out today in @pnas.org from former PhD student Zach Augur and postdoc @garrettfogo.bsky.social all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: www.pnas.org/doi/10.1073/...
A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Bidirectional Risk Modulator Along the DCM-HCM Spectrum
This cross-sectional study evaluates the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).
jamanetwork.com
December 26, 2024 at 5:27 PM
A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
In our new work, we identified 2 phosphatases, PP1 & PP5, to dephosphorylate the co-chaperone BAG3 regulating the process of chaperone-assisted selective autophagy to maintain cellular proteostasis: www.life-science-alliance.org/content/8/2/... Thanks everyone involved for this great collaboration!
Identification of phosphatases that dephosphorylate the co-chaperone BAG3
The co-chaperone BAG3 plays critical roles in maintaining cellular proteostasis. It associates with 14-3-3 proteins during the trafficking of aggregation-prone proteins and facilitates their degradati...
www.life-science-alliance.org
November 23, 2024 at 9:03 AM
In our new work, we identified 2 phosphatases, PP1 & PP5, to dephosphorylate the co-chaperone BAG3 regulating the process of chaperone-assisted selective autophagy to maintain cellular proteostasis: www.life-science-alliance.org/content/8/2/... Thanks everyone involved for this great collaboration!
Really interesting data about how BAG3 variants modify cardiomyopathy risk.
A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Bidirectional Risk Modulator Along the DCM-HCM Spectrum
This cross-sectional study evaluates the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).
jamanetwork.com
December 26, 2024 at 6:53 PM
Really interesting data about how BAG3 variants modify cardiomyopathy risk.
BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease–linked proteins via proteasome, autophagy, and retromer interactions #NeuroDegeneration 🧪🧠
https://www.pnas.org/doi/abs/10.1073/pnas.2528514123?af=R
https://www.pnas.org/doi/abs/10.1073/pnas.2528514123?af=R
October 8, 2026 at 10:04 AM
BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease–linked proteins via proteasome, autophagy, and retromer interactions #NeuroDegeneration 🧪🧠
https://www.pnas.org/doi/abs/10.1073/pnas.2528514123?af=R
https://www.pnas.org/doi/abs/10.1073/pnas.2528514123?af=R
☕Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with F-actin-bound actin-binding proteins.
👉https://rdcu.be/eRkQb
bit.ly/43LYEje
👉https://rdcu.be/eRkQb
bit.ly/43LYEje
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins - Nature Cell Biology
Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with...
bit.ly
November 23, 2025 at 7:04 AM
☕Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with F-actin-bound actin-binding proteins.
👉https://rdcu.be/eRkQb
bit.ly/43LYEje
👉https://rdcu.be/eRkQb
bit.ly/43LYEje
BAG3 mutations cause dilated cardiomyopathy but most research has focused on its function in heart muscle cells rather than other cardiac cell types.
Bryan Wang & team used engineered heart tissue to reveal BAG3 in cardiac fibroblasts has a role in fibrosis: https://www.jci.org/articles/view/181630
Bryan Wang & team used engineered heart tissue to reveal BAG3 in cardiac fibroblasts has a role in fibrosis: https://www.jci.org/articles/view/181630
January 15, 2025 at 2:20 PM
BAG3 mutations cause dilated cardiomyopathy but most research has focused on its function in heart muscle cells rather than other cardiac cell types.
Bryan Wang & team used engineered heart tissue to reveal BAG3 in cardiac fibroblasts has a role in fibrosis: https://www.jci.org/articles/view/181630
Bryan Wang & team used engineered heart tissue to reveal BAG3 in cardiac fibroblasts has a role in fibrosis: https://www.jci.org/articles/view/181630
Open Access! This thorough report examines the effects of truncating variants of TTN and BAG3 in a single family. Available at: www.sciencedirect.com/science/arti...
June 15, 2025 at 11:42 AM
Open Access! This thorough report examines the effects of truncating variants of TTN and BAG3 in a single family. Available at: www.sciencedirect.com/science/arti...
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins - Nature Cell Biology
Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with...
www.nature.com
October 31, 2025 at 3:06 PM
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 20, 2024 at 1:29 AM
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
link.springer.com
October 15, 2025 at 2:08 PM
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
December 1, 2023 at 10:05 PM
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
March 28, 2025 at 10:13 PM
Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"
Excited to share our new paper from the @typlab.bsky.social describing interesting new connections between BAG3 and the retromer complex, as well as proteostatic machinery as it relates to Alzheimer’s disease. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 29, 2026 at 11:43 AM
Excited to share our new paper from the @typlab.bsky.social describing interesting new connections between BAG3 and the retromer complex, as well as proteostatic machinery as it relates to Alzheimer’s disease. www.pnas.org/doi/10.1073/...
Single-nucleus RNA sequencing data (GSE184950) was used to identify potential cell type-specific common molecular drivers of #Parkinsons (HSPA1A, DNAJB1, BAG3, SYN1, CALB2, & NEFL); Celastrol, Withaferin-A, & Apomorphine suggested for PD
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 10:39 PM
Single-nucleus RNA sequencing data (GSE184950) was used to identify potential cell type-specific common molecular drivers of #Parkinsons (HSPA1A, DNAJB1, BAG3, SYN1, CALB2, & NEFL); Celastrol, Withaferin-A, & Apomorphine suggested for PD
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3 www.nature.com/articles/s41... #PancreaticCancer
Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3 - Cell Death & Differentiation
Cell Death & Differentiation - Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3
www.nature.com
January 31, 2026 at 6:57 PM
Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3 www.nature.com/articles/s41... #PancreaticCancer
The authors included RRIDs in their in Nature Cell Biology paper! We value the author's support of reproducibility. #methodsmatter #reproducibility #RRID
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins - Nature Cell Biology
Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with F-actin-bound actin-binding proteins.
doi.org
February 22, 2026 at 8:00 AM
The authors included RRIDs in their in Nature Cell Biology paper! We value the author's support of reproducibility. #methodsmatter #reproducibility #RRID
今日の風呂上がりアイスティーは皆んな大好きジャンナットのアールグレイ。以前もこれで水出しアイスティーを作った経緯があり信頼が深い。(あれが飲みたいな〜となるほどには美味しい)
程よいタンニン味とアールグレイの爽やかさがアイスティーにぴったり！昨日ちょっと濃い感じがしたので今日は水約600mlにtea bag3パックで作りました🫖私的にはこの濃さがちょうど良さそう。
#青空お茶部
程よいタンニン味とアールグレイの爽やかさがアイスティーにぴったり！昨日ちょっと濃い感じがしたので今日は水約600mlにtea bag3パックで作りました🫖私的にはこの濃さがちょうど良さそう。
#青空お茶部
June 18, 2025 at 12:15 PM
今日の風呂上がりアイスティーは皆んな大好きジャンナットのアールグレイ。以前もこれで水出しアイスティーを作った経緯があり信頼が深い。(あれが飲みたいな〜となるほどには美味しい)
程よいタンニン味とアールグレイの爽やかさがアイスティーにぴったり！昨日ちょっと濃い感じがしたので今日は水約600mlにtea bag3パックで作りました🫖私的にはこの濃さがちょうど良さそう。
#青空お茶部
程よいタンニン味とアールグレイの爽やかさがアイスティーにぴったり！昨日ちょっと濃い感じがしたので今日は水約600mlにtea bag3パックで作りました🫖私的にはこの濃さがちょうど良さそう。
#青空お茶部
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes https://www.biorxiv.org/content/10.64898/2025.12.17.694879v1
December 18, 2025 at 7:15 AM
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes https://www.biorxiv.org/content/10.64898/2025.12.17.694879v1
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2025.12.17.694879v1
https://www.biorxiv.org/content/10.64898/2025.12.17.694879v1
December 18, 2025 at 8:02 AM
BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2025.12.17.694879v1
https://www.biorxiv.org/content/10.64898/2025.12.17.694879v1
An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish https://www.biorxiv.org/content/10.1101/2024.10.24.620101v1
An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish https://www.biorxiv.org/content/10.1101/2024.10.24.620101v1
Dysregulated proteostasis in cardiomyocytes is an important pathological event in BAG3 cardiomyopath
www.biorxiv.org
October 28, 2024 at 5:32 AM
An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish https://www.biorxiv.org/content/10.1101/2024.10.24.620101v1
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6 - Nature Communications
Myopathy caused by BAG3 mutation disrupts muscle protein homeostasis and leads to severe muscle weakness. In mouse models, the authors demonstrate that impaired autophagy drives the pathology, while g...
www.nature.com
April 12, 2026 at 6:04 PM
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish https://www.biorxiv.org/content/10.1101/2024.10.24.620101v1
An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish https://www.biorxiv.org/content/10.1101/2024.10.24.620101v1
Dysregulated proteostasis in cardiomyocytes is an important pathological event in BAG3 cardiomyopath
www.biorxiv.org
October 28, 2024 at 5:32 AM
An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish https://www.biorxiv.org/content/10.1101/2024.10.24.620101v1