imagine having beta cells in your body. that shit must be so embarassing
May 24, 2025 at 5:02 AM
imagine having beta cells in your body. that shit must be so embarassing
haters are jealous of me being so alpha that my immune system purged my body of all beta cells
September 6, 2025 at 5:32 AM
haters are jealous of me being so alpha that my immune system purged my body of all beta cells
the apoe4 gene, a major alzheimer's risk, damages brain blood vessels by turning pericytes (vessel-stabilizing cells) into scar-formers, leading to amyloid buildup. blocking a protein called tgf-beta protected these cells!
September 27, 2026 at 2:05 PM
the apoe4 gene, a major alzheimer's risk, damages brain blood vessels by turning pericytes (vessel-stabilizing cells) into scar-formers, leading to amyloid buildup. blocking a protein called tgf-beta protected these cells!
induction with antithymocyte globulin followed by maintenance with tacrolimus plus sirolimus. About two million Americans have type 1 diabetes, which is caused when the immune system destroys islet cells. A subset of islet cells, the beta cells, secrete insulin. Without insulin, glucose cannot enter
June 23, 2025 at 4:03 PM
induction with antithymocyte globulin followed by maintenance with tacrolimus plus sirolimus. About two million Americans have type 1 diabetes, which is caused when the immune system destroys islet cells. A subset of islet cells, the beta cells, secrete insulin. Without insulin, glucose cannot enter
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 4, 2025 at 11:38 PM
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
On the jump forward of CRISPR genome editing beta islet cells, preempting the need for immunosuppression, for a one-shot treatment of autoimmune (Type 1) diabetes
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
September 6, 2025 at 4:11 PM
On the jump forward of CRISPR genome editing beta islet cells, preempting the need for immunosuppression, for a one-shot treatment of autoimmune (Type 1) diabetes
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
Gonads and germ cells have an interdependent relationship in the cnidarian #Hydractinia. Germ cells secrete a TGF-beta ligand (called Gonadless) to induce and maintain the somatic gonad; gonads activate Tfap2 in pluripotent stem cells (i-cells) to commit them to germ fate
tinyurl.com/245rw699
tinyurl.com/245rw699
January 8, 2025 at 7:03 PM
Gonads and germ cells have an interdependent relationship in the cnidarian #Hydractinia. Germ cells secrete a TGF-beta ligand (called Gonadless) to induce and maintain the somatic gonad; gonads activate Tfap2 in pluripotent stem cells (i-cells) to commit them to germ fate
tinyurl.com/245rw699
tinyurl.com/245rw699
Scientists use a bacterium, Agrobacterium tumefaciens, which naturally infects & transfers its DNA to plant cells.
They add the beta-carotene gene to the bacterium, which transfers it to rice cells. The rice cells grow into mature plants that produce beta-carotene in 8-12 months.
10/
They add the beta-carotene gene to the bacterium, which transfers it to rice cells. The rice cells grow into mature plants that produce beta-carotene in 8-12 months.
10/
June 24, 2025 at 10:32 PM
Scientists use a bacterium, Agrobacterium tumefaciens, which naturally infects & transfers its DNA to plant cells.
They add the beta-carotene gene to the bacterium, which transfers it to rice cells. The rice cells grow into mature plants that produce beta-carotene in 8-12 months.
10/
They add the beta-carotene gene to the bacterium, which transfers it to rice cells. The rice cells grow into mature plants that produce beta-carotene in 8-12 months.
10/
Medical isn't my field but I like to read their studies of their breakthroughs. Mt. Sinai was able to convert pancreatic alpha cells which are abundant into insulin producing long term beta cells via a drug they made in chorus with ozempic. Previously beta cells would have to be implanted.
May 1, 2025 at 9:57 PM
Medical isn't my field but I like to read their studies of their breakthroughs. Mt. Sinai was able to convert pancreatic alpha cells which are abundant into insulin producing long term beta cells via a drug they made in chorus with ozempic. Previously beta cells would have to be implanted.
Happy to share these gorgeous images of a chicken neural tube with fiery green, orange, and blue microtubules and explanted #NeuralCrest cells with green actin and pink microtubules taken by Camilo Echeverria on this #FluorescenceFriday. #DevBio @ucdavis.bsky.social @ucdavisvetmed.bsky.social
September 19, 2025 at 5:39 PM
Happy to share these gorgeous images of a chicken neural tube with fiery green, orange, and blue microtubules and explanted #NeuralCrest cells with green actin and pink microtubules taken by Camilo Echeverria on this #FluorescenceFriday. #DevBio @ucdavis.bsky.social @ucdavisvetmed.bsky.social
Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing!
👇
www.cell.com/cell-reports...
👇
www.cell.com/cell-reports...
January 19, 2025 at 11:37 AM
Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing!
👇
www.cell.com/cell-reports...
👇
www.cell.com/cell-reports...
A new generation of radiotherapies promises a more targeted attack on cancer.
Learn more on #WorldCancerResearchDay: https://scim.ag/3IwH8YW
Learn more on #WorldCancerResearchDay: https://scim.ag/3IwH8YW
September 24, 2026 at 4:55 PM
A new generation of radiotherapies promises a more targeted attack on cancer.
Learn more on #WorldCancerResearchDay: https://scim.ag/3IwH8YW
Learn more on #WorldCancerResearchDay: https://scim.ag/3IwH8YW
Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells
Very cool organoid model used to model how macrophage-mediated pyroptosis may contribute to beta cell death during SARS-CoV-2 & coxsackie B virus infections
www.news-medical.net/news/2024091...
Very cool organoid model used to model how macrophage-mediated pyroptosis may contribute to beta cell death during SARS-CoV-2 & coxsackie B virus infections
www.news-medical.net/news/2024091...
Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells
Researchers from Weill Cornell Medicine have used a cutting-edge model system to uncover the mechanism by which SARS-CoV-2, the virus that causes COVID-19, induces new cases of diabetes, and worsens c...
www.news-medical.net
November 18, 2024 at 11:24 PM
Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells
Very cool organoid model used to model how macrophage-mediated pyroptosis may contribute to beta cell death during SARS-CoV-2 & coxsackie B virus infections
www.news-medical.net/news/2024091...
Very cool organoid model used to model how macrophage-mediated pyroptosis may contribute to beta cell death during SARS-CoV-2 & coxsackie B virus infections
www.news-medical.net/news/2024091...
My NIH postdoctoral research looks at mitochondria in beta-cells of the pancreas (the insulin-producing cells of the body) to research new treatments that could prevent or slow the progression of diabetes 🔬
To help people understand the importance of NIH, share what you’ve used their funding for (in easily understandable terms).
I’ll start: my NIH postdoc funding helped me develop and test AI tools that could identify skin cancer across diverse skin tones.
I’ll start: my NIH postdoc funding helped me develop and test AI tools that could identify skin cancer across diverse skin tones.
January 29, 2025 at 1:09 AM
My NIH postdoctoral research looks at mitochondria in beta-cells of the pancreas (the insulin-producing cells of the body) to research new treatments that could prevent or slow the progression of diabetes 🔬
Ah something I am an expert in.
The US pioneered this work. The protocol to differentiate stem cells into beta cells was done by Melton, and refined by Leibel’s group. Melton did this at Harvard. He left Harvard to work at Vertex. They have a trial currently testing the technique for T1DM.
The US pioneered this work. The protocol to differentiate stem cells into beta cells was done by Melton, and refined by Leibel’s group. Melton did this at Harvard. He left Harvard to work at Vertex. They have a trial currently testing the technique for T1DM.
July 20, 2026 at 2:19 PM
Ah something I am an expert in.
The US pioneered this work. The protocol to differentiate stem cells into beta cells was done by Melton, and refined by Leibel’s group. Melton did this at Harvard. He left Harvard to work at Vertex. They have a trial currently testing the technique for T1DM.
The US pioneered this work. The protocol to differentiate stem cells into beta cells was done by Melton, and refined by Leibel’s group. Melton did this at Harvard. He left Harvard to work at Vertex. They have a trial currently testing the technique for T1DM.
Common beta-blockers are fat soluble and slightly alkaline. This lets them pass through the membrane into cells. They then get charged and can't get back out. They go to the lysosome, but don't digest because of alkalinity. This causes an inflammation response that can be blocked by antihistamines.
January 24, 2024 at 6:21 PM
Common beta-blockers are fat soluble and slightly alkaline. This lets them pass through the membrane into cells. They then get charged and can't get back out. They go to the lysosome, but don't digest because of alkalinity. This causes an inflammation response that can be blocked by antihistamines.
In a major scientific breakthrough, Chinese researchers may have developed a potential cure for Type 2 diabetes — a chronic condition affecting hundreds of millions globally. The treatment works by regenerating insulin-producing beta cells in the pancreas, effectively reversing the disease rather
July 5, 2025 at 11:35 PM
In a major scientific breakthrough, Chinese researchers may have developed a potential cure for Type 2 diabetes — a chronic condition affecting hundreds of millions globally. The treatment works by regenerating insulin-producing beta cells in the pancreas, effectively reversing the disease rather
🌙 I'm cissexual (only into people with beta cells)
September 6, 2025 at 5:57 AM
🌙 I'm cissexual (only into people with beta cells)
Sun exposure causes DNA mutations in skin cells that can eventually lead to cancer, but a common skin virus might help the immune system fight back.
Common virus may help protect skin against Sun damage
Beta human papillomavirus helps the immune system target mutated skin cells, a “provocative” mouse and human study suggests
scim.ag
January 10, 2025 at 5:39 PM
Sun exposure causes DNA mutations in skin cells that can eventually lead to cancer, but a common skin virus might help the immune system fight back.
Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling
Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by
the same signals that trigger insulin secretion. This activation, in turn, inhibits
insulin release via RhoA-dependent...
www.cell.com
May 18, 2025 at 2:20 PM
Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
This is pretty promising. Here's the original science article www.nejm.org/doi/full/10....
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
May 22, 2026 at 10:34 PM
This is pretty promising. Here's the original science article www.nejm.org/doi/full/10....
New NSFW Roguelike!
B@@Bs!
B@@Bs is a classic ASCII roguelike where you take up TWO cells, turn sideways to fit, and charm the women of the dungeon instead of killing them.
18+ roguelike. Beta out now, link in reply.
#roguelike #gamedev #indiedev #indiegame
perkygoblin.itch.io/boobs-a-nsfw...
B@@Bs!
B@@Bs is a classic ASCII roguelike where you take up TWO cells, turn sideways to fit, and charm the women of the dungeon instead of killing them.
18+ roguelike. Beta out now, link in reply.
#roguelike #gamedev #indiedev #indiegame
perkygoblin.itch.io/boobs-a-nsfw...
September 27, 2026 at 2:14 AM
New NSFW Roguelike!
B@@Bs!
B@@Bs is a classic ASCII roguelike where you take up TWO cells, turn sideways to fit, and charm the women of the dungeon instead of killing them.
18+ roguelike. Beta out now, link in reply.
#roguelike #gamedev #indiedev #indiegame
perkygoblin.itch.io/boobs-a-nsfw...
B@@Bs!
B@@Bs is a classic ASCII roguelike where you take up TWO cells, turn sideways to fit, and charm the women of the dungeon instead of killing them.
18+ roguelike. Beta out now, link in reply.
#roguelike #gamedev #indiedev #indiegame
perkygoblin.itch.io/boobs-a-nsfw...
See the problem is your pancreas is too WOKE. It’s actually a problem with your beta cells in the islets of Langerhans, you need to make them ALPHA
May 26, 2025 at 4:41 AM
See the problem is your pancreas is too WOKE. It’s actually a problem with your beta cells in the islets of Langerhans, you need to make them ALPHA