Yogev, D. et al. Current state of the art and future directions for implantable sensors in medical technology: clinical needs and engineering challenges. APL Bioeng. 7, 031506 (2023). Fuada, S., Särestöniemi, M. & Katz, M. Analyzing emerging trends in wireless implantable medical devices (IMDs): a bibliometric study. Int. J. Online Biomed. Eng. 20, 115–143 (2024). The Global Market for Medical Devices, 10th edn (Kalorama Information, 2019). Suryaprabha, T. et al. Smart wearable and implantable biosensors for continuous health monitoring: materials, biocompatibility, and AI integration. npj Flex. Electron. 10, 46 (2026). Li, C. et al. Design of biodegradable, implantable devices towards clinical translation. Nat. Rev. Mater. 5, 61–81 (2020). Long, Y., Li, J., Yang, F., Wang, J. & Wang, X. Wearable and implantable electroceuticals for therapeutic electrostimulations. Adv. Sci. 8, 2004023 (2021). Maisel, W. H. Safety issues involving medical devices: implications of recent implantable cardioverter-defibrillator malfunctions. JAMA 294, 955–958 (2005). Andresen, N. S. et al. Cochlear implant revisions over three decades of experience. Otol. Neurotol. 44, 555–562 (2023). Weber, M. et al. Revision surgery in total joint replacement is cost-intensive. BioMed Res. Int. 2018, 8987104 (2018). Papasteriadis, E. & Margos, N. P. The world’s longest lasting VVI pacemaker device for over...

Chen, C., Ding, S. & Wang, J. Digital health for aging populations. Nat. Med. 29, 1623–1630 (2023). Paci, M. M. et al. Smart closed-loop drug delivery systems. Nat. Rev. Bioeng. 3, 816–834 (2025). Choi, Y. S. et al. A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy. Science 376, 1006–1012 (2022). Jiang, Y. et al. Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing. Nat. Biotechnol. 41, 652–662 (2022). Zhang, Q. et al. A prototype closed-loop brain-machine interface for the study and treatment of pain. Nat. Biomed. Eng. 7, 533–545 (2023). Wei, Y. et al. Integrated individually addressable microneedle arrays for robust glucose monitoring and on-demand insulin releasing. Microsyst. Nanoeng. 11, 211 (2025). Zou, Y. et al. A closed-loop bioelectronic patch for intelligent blood pressure management. Sci. Adv. 11, eadx6438 (2025). Gu, G. et al. A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback. Nat. Biomed. Eng. 7, 589–598 (2023). Chen, S. et al. Transforming healthcare: intelligent wearable sensors empowered by smart materials and artificial intelligence. Adv. Mater. 37, 2500412 (2025). Wang, G. et al. Optimized glycemic control of type 2 diabetes with reinforcement learning: a proof-of-concept trial. Nat...

Shu, T., Herrera-Arcos, G., Taylor, C. R. & Herr, H. M. Mechanoneural interfaces for bionic integration. Nat. Rev. Bioeng. 2, 374–391 (2024). Moon, H. et al. Adhesive nonfibrotic bioelectronic interfaces on diverse peripheral nerves for long-term functional neuromodulation. Sci. Adv. 11, eadz3668 (2025). This paper highlights a robust adhesive strategy for establishing long-term nonfibrotic bioelectronic interfaces on peripheral nerves, providing an advance towards stable chronic neuromodulation. Payne, S. C. et al. Correlation of electrical impedance and evoked potentials with properties of the electrode interface using in situ block-face imaging of the rat pelvic nerve. Neuromodulation 28, 1274–1285 (2025). This paper highlights a multimodal framework combining in situ histological imaging with electrophysiological measurements to uncover the complex biophysical dynamics of chronic peripheral nerve interfaces. Carnicer-Lombarte, A. et al. Ultraconformable cuff implants for long-term bidirectional interfacing of peripheral nerves at sub-nerve resolutions. Nat. Commun. 15, 7523 (2024). This paper highlights the development of ultraconformable peripheral nerve cuff implants that achieve long-term, stable, fascicle-level bidirectional interfacing with minimal foreign-body reaction, representing an advance towards chronic high-resolution bioelectronic nerve modulation. Yang, M. et al. Highly-stable, injectable, conductive hydrogel for chronic neuromodulation. Nat. Commun. 15, 7993 (2024). Akouissi, O., Lacour, S. P., Micera, S. &...

Graded running imposes distinct biomechanical and physiological demands compared with level running, which influences performance outcomes and injury risk. Uphill running requires great propulsion and...

Luo, Y. et al. Technology roadmap for flexible sensors. ACS Nano 17, 5211–5295 (2023). Someya, T., Bao, Z. & Malliaras, G. G. The rise of plastic bioelectronics. Nature 540, 379–385 (2016). Yin, J., Wang, S., Tat, T. & Chen, J. Motion artefact management for soft bioelectronics. Nat. Rev. Bioeng. 2, 541–558 (2024). Wang, S. et al. Skin electronics from scalable fabrication of an intrinsically stretchable transistor array. Nature 555, 83–88 (2018). Zhong, D. et al. High-speed and large-scale intrinsically stretchable integrated circuits. Nature 627, 313–320 (2024). Cea, C. et al. Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics. Nat. Mater. 22, 1227–1235 (2023). Kim, J. et al. Monolithically integrated high-density vertical organic electrochemical transistor arrays and complementary circuits. Nat. Electron. 7, 234–243 (2024). Gong, S. et al. Hierarchically resistive skins as specific and multimetric on-throat wearable biosensors. Nat. Nanotechnol. 18, 889–897 (2023). Liu, Z. et al. A three-dimensionally architected electronic skin mimicking human mechanosensation. Science 384, 987–994 (2024). Gu, Y. et al. Three-dimensional transistor arrays for intra- and inter-cellular recording. Nat. Nanotechnol. 17, 292–300 (2022). Lee, G.-H. et al. Conductance stable and mechanically durable bi-layer EGaIn composite-coated stretchable fiber for 1D bioelectronics. Nat. Commun. 14, 4173 (2023). Deng,...

Group, I. P. C. Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Infect. Dis. 24, 868–895 (2024). Allen, T. et al. Global hotspots and correlates of emerging zoonotic diseases. Nat. Commun. 8, 1124 (2017). Prasad, C. P., Tripathi, S. C., Kumar, M. & Mohapatra, P. Passage number of cancer cell lines: importance, intricacies, and way-forward. Biotechnol. Bioeng. 120, 2049–2055 (2023). Mukherjee, P., Roy, S., Ghosh, D. & Nandi, S. K. Role of animal models in biomedical research: a review. Lab. Anim. Res. 38, 18 (2022). Schmeisser, S. et al. New approach methodologies in human regulatory toxicology—not if, but how and when! Env. Int. 178, 108082 (2023). Beilmann, M. et al. Application of new approach methodologies for nonclinical safety assessment of drug candidates. Nat. Rev. Drug. Discov. 24, 705–725 (2025). Artegiani, B. & Hendriks, D. Organoids from pluripotent stem cells and human tissues: when two cultures meet each other. Dev. Cell 60, 493–511 (2025). Schutgens, F. & Clevers, H. Human organoids: tools for understanding biology and treating diseases. Annu. Rev. Pathol. 15, 211–234 (2020). Wang, D., Villenave, R., Stokar-Regenscheit, N. & Clevers, H. Human organoids as 3D in vitro...

Wang, L. V. & Hu, S. Photoacoustic tomography: in vivo imaging from organelles to organs. Science 335, 1458–1462 (2012). Razansky, D. et al. Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo. Nat. Photonics 3, 412–417 (2009). Ntziachristos, V. & Razansky, D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chem. Rev. 110, 2783–2794 (2010). Park, J. et al. Clinical translation of photoacoustic imaging. Nat. Rev. Bioeng 3, 193–212 (2025). Deán-Ben, X. L. et al. Advanced optoacoustic methods for multiscale imaging of in vivo dynamics. Chem. Soc. Rev. 46, 2158–2198 (2017). Wang, L. V. & Yao, J. A practical guide to photoacoustic tomography in the life sciences. Nat. Methods 13, 627–638 (2016). Chen, Z. et al. Multimodal optoacoustic imaging: methods and contrast materials. Chem. Soc. Rev. 53, 6068–6099 (2024). Merčep, E. et al. Transmission–reflection optoacoustic ultrasound (TROPUS) computed tomography of small animals. Light Sci. Appl. 8, 18 (2019). Chen, Z. et al. Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging. Light Sci. Appl. 11, 332 (2022). Chen, Z. et al. Hybrid system for in vivo epifluorescence and 4D optoacoustic imaging. Opt. Lett. 42, 4577–4580 (2017). Deán-Ben, X. L. et al. Deep optoacoustic localization microangiography of ischemic stroke...

Fuller, R. et al. Pollution and health: a progress update. Lancet Planet. Health 6, e535–e547 (2022). Inda, M. E. & Lu, T. K. Microbes as biosensors. Annu. Rev. Microbiol. 74, 337–359 (2020). Maresca, D. et al. Biomolecular ultrasound and sonogenetics. Annu. Rev. Chem. Biomol. Eng 9, 229–252 (2018). Li, S., Zuo, X., Carpenter, M. D., Verduzco, R. & Ajo-Franklin, C. M. Microbial bioelectronic sensors for environmental monitoring. Nat. Rev. Bioeng 3, 30–49 (2025). Atkinson, J. T. et al. Real-time bioelectronic sensing of environmental contaminants. Nature 611, 548–553 (2022). Karbelkar, A. A., Reynolds, E. E., Ahlmark, R. & Furst, A. L. A microbial electrochemical technology to detect and degrade organophosphate pesticides. ACS Cent. Sci. 7, 1718–1727 (2021). Webster, D. P. et al. An arsenic-specific biosensor with genetically engineered Shewanella oneidensis in a bioelectrochemical system. Biosens. Bioelectron. 62, 320–324 (2014). Li, S., De Groote Tavares, C., Tolar, J. G. & Ajo-Franklin, C. M. Selective bioelectronic sensing of pharmacologically relevant quinones using extracellular electron transfer in Lactiplantibacillus plantarum. Biosens. Bioelectron. 243, 115762 (2024). Gao, Y., Ryu, J., Liu, L. & Choi, S. A simple, inexpensive, and rapid method to assess antibiotic effectiveness against exoelectrogenic bacteria. Biosens. Bioelectron. 168, 112518 (2020). Cho, J. H.,...

Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance 1990–2021: A systematic analysis with forecasts to 2050. Lancet 404, 1199–1226 (2024). Díaz-Ponce, A., Galdámez-Martínez, A. & Dutour-Sikiric, M. Recent advances in the green synthesis of bimetallic nanoparticles and their applications. Nanoscale Adv. 9, 2425–2441 (2024). Hao, Z., Wang, X. & Li, J. Chitosan-based nanocomposites for biomedical applications: A review of recent advances. Front. Bioeng. Biotechnol. 11, 1337543 (2024). Vasiliev, G. A., Kondratiev, M. S. & Belonogov, E. K. Synergistic antibacterial effect of silver and copper nanoparticles stabilized by biopolymers. Sci. Rep. 13, 9202 (2023). Saeed, H., Rahman, M. M. & Siddiqui, M. N. Green synthesis of Ag/Cu bimetallic nanoparticles using plant extracts and their antimicrobial properties. Polymers 16, 2662 (2024). Rashid, T. A., Islam, M. R. & Ahmed, S. Sustainable synthesis of metal-based nanocomposites for environmental remediation: A comprehensive review. RSC Adv. 15, 1850–1875 (2025). Kopperundevi, K., Balasubramanian, V. & Jayaram, S. Chitosan-capped bimetallic nanoparticles: Synthesis, characterization, and multi-functional applications. ChemistrySelect 9, e202303489 (2024). El-Naggar, N. E., Hussein, H. & El-Sawah, A. M. Green synthesis of bimetallic nanoparticles using citrus waste for enhanced antimicrobial activity. Sci. Rep. 14, 11336 (2024). Liew, S. S., Ho, W. Y., Yeap, S. K. &...