#capivasertib
Great news for AKT inhibitors! Capivasertib in combo with abiraterone and ADT improves progression free survival in PTEN deficient prostate cancer! Anticipating approval for this combo, coming off the approval of capi in ER+be breast cancer. Good work AZ!

www.onclive.com/view/capivas...
Capivasertib Plus Abiraterone/ADT Improves rPFS in PTEN-Deficient mHSPC
Capivasertib plus abiraterone and ADT improved rPFS in PTEN-deficient metastatic hormone-sensitive prostate cancer.
www.onclive.com
November 26, 2024 at 5:45 PM
New pill can slow progression of incurable breast cancer. 🧪 www.bbc.co.uk/news/article...
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.co.uk
April 11, 2025 at 4:56 AM
New pill that can slow progression of incurable breast cancer available in the clinic.

Capivasertib combined with hormone therapy doubled the time the cancer took to grow, delaying the need for chemotherapy, & shrank tumours in 23% of patients.

🧪💊

www.bbc.co.uk/news/article...
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.co.uk
April 11, 2025 at 8:06 AM
#BBCNews - New pill can slow progression of incurable breast cancer
www.bbc.com/news/article...
#capivasertib
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.com
April 11, 2025 at 5:39 AM
Major breakthrough in BREAST CANCER treatment: The NHS has approved Capivasertib, a new drug that helps slow the spread of an incurable type of breast cancer. This marks a significant step forward in offering patients more time and hope. clinicaltrials.gov/study/NCT043...
April 15, 2025 at 8:00 AM
Capivasertib given to breast cancer patients in Wales for first time
Capivasertib given to breast cancer patients in Wales for first time
Gwen Buchan, 62, says capivasertib will allow her to see her son's wedding and offers her "hope".
www.bbc.com
June 1, 2025 at 9:22 PM
Game-changing New Breast Cancer Drug available on NHS
Capivasertib doubles progression-free survival for advanced ER+ HER2- breast cancer with an AKT1, PIK3CA and PTEN

youtu.be/0xJYqbBB33Y?...
Breast Cancer Breakthrough: Capivasertib's Amazing Results
YouTube video by Dr Liz O'Riordan
youtu.be
April 11, 2025 at 6:15 AM
CAPItello-281 phase 3 in PTEN-deficient Metastatic Hormone-Sensitive Prostate Cancer - Rana McKay

https://oncodaily.com/blog/rana-mckay194507

ucsdmedschool.bsky.social theaacr.bsky.social

##Abiraterone ##Cancer ##CAPItello281 ##Capivasertib ##Medicine ##Health ##MedOnc ##mHSPC ##OncoDaily ##Oncology ##PTEN
Rana McKay: CAPItello-281 phase 3 in PTEN-deficient Metastatic Hormone-Sensitive Prostate Cancer - OncoDaily
Rana McKay: CAPItello-281 phase 3 in PTEN-deficient Metastatic Hormone-Sensitive Prostate Cancer / abiraterone, cancer, CAPItello-281, Capivasertib, fight
oncodaily.com
December 3, 2024 at 5:00 AM
Phase 3 trial, published in 2023 in New England Journal of Medicine 🧪💊 :

Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer
www.nejm.org/doi/full/10....
Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer | NEJM
AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with horm...
www.nejm.org
April 11, 2025 at 8:06 AM
Thoughts on this: clinicaltrials.gov/study/NCT048... (with 2 additional protocols now for tazemetostat or capivasertib)

vs hormone therapy & radiation?

54 yrs. Gleason 9. Grade 5. Stage 3.

#MedSky #urology #oncology #prostate #cancer
ClinicalTrials.gov
clinicaltrials.gov
February 22, 2026 at 5:16 PM
for ~1 in 4 guys with metastatic prostate cancer, treatment wasn't tailored to their pten genetic flaw. but now, fda approved a drug combo that finally targets that specific mutation. that's a really important step from a phase 3 trial.
FDA Approves Capivasertib Plus Abiraterone and Prednisone for PTEN-Deficient Prostate Cancer
The U.S. Food and Drug Administration (FDA) has approved capivasertib (Truqap) in combination with abiraterone and prednisone for adults with metastatic hormone-sensitive prostate cancer that has a PT
www.fda.gov
June 15, 2026 at 8:02 AM
A new type of drug for one of the most common kinds of advanced breast cancer is now available on the NHS in England.

Some 3,000 women a year could benefit from capivasertib after a clinical trial showed it can slow progression of the disease, and shrink tumours in a quarter of people.
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.co.uk
April 11, 2025 at 6:12 AM
NEWS: NICE has recommended capivasertib for advanced #BreastCancer.

The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.

Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...
April 11, 2025 at 6:37 AM
Great news!

The SMC has recommended both elascestrant, and capivasertib with fulvestrant for use on the NHS in Scotland for eligible metastatic breast cancer patients: breastcancernow.org/about-us/med...
We respond to SMC decision recommending elacestrant & capivasertib with fulvestrant
Melanie Sturtevant, associate director of policy, evidence and influencing at Breast Cancer Now, said:
breastcancernow.org
September 8, 2026 at 8:39 AM
Menarini Group Unveils Promising Data From Elacestrant and Capivasertib Study at ASCO 2026#Italy#Elacestrant#Florence#Menarini_Group#Capivasertib
Menarini Group Unveils Promising Data From Elacestrant and Capivasertib Study at ASCO 2026
Menarini Group has announced promising early results from the ELEVATE study evaluating elacestrant with capivasertib for ER+, HER2- metastatic breast cancer, showcased at ASCO 2026.
third-news.com
May 28, 2026 at 4:51 PM
New pill can slow progression of incurable breast cancer
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.com
April 10, 2025 at 11:06 PM
Menarini Group Unveils Promising ELEVATE Study Data on Elacestrant and Capivasertib in Breast Cancer Treatment#Italy#Menarini#Elacestrant#Florence#Capivasertib
Menarini Group Unveils Promising ELEVATE Study Data on Elacestrant and Capivasertib in Breast Cancer Treatment
Menarini Group presents exciting preliminary data on the efficacy and safety of Elacestrant combined with Capivasertib for ER+/HER2- metastatic breast cancer at ASCO 2026.
third-news.com
May 29, 2026 at 9:17 PM
www.bbc.co.uk/news/article.... Excellent news for breast cancer patients, based on great work from ICR scientists including our own Nick Turner.
New pill can slow progression of incurable breast cancer
Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.
www.bbc.co.uk
April 11, 2025 at 5:35 AM
Menarini Group Reveals Promising ELEVATE Study Results on Elacestrant and Capivasertib for ER+, HER2- Breast Cancer#Italy#Menarini#Elacestrant#Florence#Capivasertib
Menarini Group Reveals Promising ELEVATE Study Results on Elacestrant and Capivasertib for ER+, HER2- Breast Cancer
Menarini Group provides new insights into the ELEVATE study, showcasing the potential of elacestrant and capivasertib for treating ER+, HER2- metastatic breast cancer. Key findings will be showcased at ASCO 2026.
third-news.com
May 29, 2026 at 3:48 PM
How would you treat this woman? And survey says…
Pretty interesting since Capivasertib was approved barely over a year ago
#SABCS24
December 11, 2024 at 10:24 PM
🚨 FDA Approves capivasertib Plus Abiraterone as First Targeted Therapy for PTEN-Deficient Metastatic Hormone-Sensitive Prostate Cancer

Source AstraZeneca

www.astrazeneca.com/media-centre...
June 12, 2026 at 7:44 PM
Industry Announcement: CAPItello281 Phase III Source AstraZeneca

Capivasertib combined with/ADT improved rPFS in PTEN-deficient met hormone-sensitive #ProstateCancer Vs abiraterone & ADT w/placebo
OS data immature, early indications suggest potential OS benefit

www.astrazeneca.com/media-centre...
Truqap combination in PTEN-deficient metastatic hormone-sensitive prostate cancer demonstrated statistically significant and clinically meaningful improvement in radiographic progression-free survival...
www.astrazeneca.com
November 25, 2024 at 3:43 PM
FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting www.medpagetoday.com/hematologyon...
FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting
Capivasertib plus abiraterone combination lands indication for PTEN-deficient tumors
www.medpagetoday.com
June 13, 2026 at 4:43 AM
7/18 #TumorBoardTuesday
👩🏻‍🏫Mini Tweetorial 4🏫

💊Several FDA👍PIK3CA-inhibitors: Capivasertib or Alpelisib or Inalvosalib
🤔 When and how do you PIK one of the PIK3CA of the 3 available?
✌️Alpelisib & Capivasertib are approved in 2nd line mER+ BC combined with fulvestrant
🔎 NGS results, Baseline A1C
October 22, 2025 at 12:38 AM