FastGA -> ALNview; step into the centromeric matrix! github.com/thegenemyers Probably the best dot plot software on the planet...
November 11, 2025 at 7:20 PM
FastGA -> ALNview; step into the centromeric matrix! github.com/thegenemyers Probably the best dot plot software on the planet...
Nature research paper: Centromeric footprints preserve telomere integrity in ALT cancers
go.nature.com/4x7Fdyn
go.nature.com/4x7Fdyn
Centromeric footprints preserve telomere integrity in ALT cancers - Nature
Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.
go.nature.com
June 9, 2026 at 10:15 AM
Nature research paper: Centromeric footprints preserve telomere integrity in ALT cancers
go.nature.com/4x7Fdyn
go.nature.com/4x7Fdyn
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 3:14 PM
Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 3, 2025 at 11:26 AM
#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...
Structure and sequence fill evolutionary gaps for essential centromeric proteins.
Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick.
Article by Kelsey Woodruff.
www.fredhutch.org/content/www/...
Paper: www.science.org/doi/10.1126/...
Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick.
Article by Kelsey Woodruff.
www.fredhutch.org/content/www/...
Paper: www.science.org/doi/10.1126/...
Structure and sequence fill evolutionary gaps for essential centromeric proteins
Researchers in the Basic Sciences Division track evolutionary origins for an essential protein
www.fredhutch.org
September 4, 2026 at 3:27 AM
Structure and sequence fill evolutionary gaps for essential centromeric proteins.
Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick.
Article by Kelsey Woodruff.
www.fredhutch.org/content/www/...
Paper: www.science.org/doi/10.1126/...
Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick.
Article by Kelsey Woodruff.
www.fredhutch.org/content/www/...
Paper: www.science.org/doi/10.1126/...
I am happy to present our work @liverworks.bsky.social @robinburns.bsky.social @alisondawnscott.bsky.social on centromeric repeat turnovers, of which we counted three in the Arabidopsis genus:
The Nature of Centromeric Repeat Turnovers in the genus Arabidopsis
Centromeres are critical for accurate segregation of chromosomes and are often composed of megabases of tandemly arranged satellite repeats. Yet, despite their conserved function, the DNA sequence of ...
www.biorxiv.org
September 16, 2026 at 3:25 PM
I am happy to present our work @liverworks.bsky.social @robinburns.bsky.social @alisondawnscott.bsky.social on centromeric repeat turnovers, of which we counted three in the Arabidopsis genus:
Our latest work using TIRFM to uncover mechanisms that stabilize the centromeric nucleosome:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Stable centromere association of the yeast histone variant Cse4 requires its essential N-terminal domain | The EMBO Journal
imageimageCentromeres contain a histone H3 variant that is essential for kinetochore assembly.
This work reports that the extended N-terminus of the budding yeast centromeric histone,
Cse4, stabilizes...
www.embopress.org
January 14, 2025 at 11:26 PM
Our latest work using TIRFM to uncover mechanisms that stabilize the centromeric nucleosome:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1 www.biorxiv.org/content/10.1...
www.biorxiv.org
September 29, 2025 at 11:14 AM
CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1 www.biorxiv.org/content/10.1...
Excited to share our latest update on @cp-cell.bsky.social!
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 3:47 PM
Excited to share our latest update on @cp-cell.bsky.social!
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
February 5, 2025 at 5:33 PM
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1
February 9, 2025 at 2:04 AM
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1
Representing Swiss Research in beautiful Perth 🇨🇭🇦🇺
Shared our journey exploring centromeric transposable elements at #AusEvol2024! 🌿
Our research unveils the interplay between specialized centromeric TEs and how their "escape" across chromosomes reshapes the functional genome.
Paper coming soon 🤓
Shared our journey exploring centromeric transposable elements at #AusEvol2024! 🌿
Our research unveils the interplay between specialized centromeric TEs and how their "escape" across chromosomes reshapes the functional genome.
Paper coming soon 🤓
December 20, 2024 at 9:57 PM
Representing Swiss Research in beautiful Perth 🇨🇭🇦🇺
Shared our journey exploring centromeric transposable elements at #AusEvol2024! 🌿
Our research unveils the interplay between specialized centromeric TEs and how their "escape" across chromosomes reshapes the functional genome.
Paper coming soon 🤓
Shared our journey exploring centromeric transposable elements at #AusEvol2024! 🌿
Our research unveils the interplay between specialized centromeric TEs and how their "escape" across chromosomes reshapes the functional genome.
Paper coming soon 🤓
I am very pleased to share that I have been awarded a #MSCA #postdoc fellowship to study structural aspects of inner kinetochore nucleation on centromeric DNA with @andrea-musacchio.bsky.social 🧬🔬
The 2024 Marie Skłodowska-Curie Actions Postdoctoral Fellowship call results are in.
With a budget of €417 million, we are funding nearly 1,700 researchers from 🇪🇺 and beyond.
They will strengthen EU research in key areas such as social inclusion, AI, and cancer research ↓
europa.eu/!BmWRkh
With a budget of €417 million, we are funding nearly 1,700 researchers from 🇪🇺 and beyond.
They will strengthen EU research in key areas such as social inclusion, AI, and cancer research ↓
europa.eu/!BmWRkh
February 14, 2025 at 10:55 AM
I am very pleased to share that I have been awarded a #MSCA #postdoc fellowship to study structural aspects of inner kinetochore nucleation on centromeric DNA with @andrea-musacchio.bsky.social 🧬🔬
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Dissecting DNMT3B functions in Immunodeficiency-centromeric instability facial anomalies syndrome at University of Edinburgh on Fi...
PhD Project - Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Dissecting DNMT3B functions in Immunodeficiency-centromeric instability facial anomalies syndrome at University of E...
www.findaphd.com
April 23, 2025 at 9:49 AM
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
The Nature of Centromeric Repeat Turnovers in the genus Arabidopsis https://www.biorxiv.org/content/10.64898/2026.09.10.749358v1
September 16, 2026 at 2:32 PM
The Nature of Centromeric Repeat Turnovers in the genus Arabidopsis https://www.biorxiv.org/content/10.64898/2026.09.10.749358v1
Very excited to share this new preprint from the lab (shorturl.at/l7lNq)! @hendersi.bsky.social si.bsky.social @camplantsci.bsky.social
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis
H3K4me3 is a fundamental and highly conserved chromatin mark across eukaryotes, playing a central role in many genome-related processes, including transcription, maintenance of cell identity, DNA dama...
shorturl.at
February 12, 2025 at 8:42 AM
Very excited to share this new preprint from the lab (shorturl.at/l7lNq)! @hendersi.bsky.social si.bsky.social @camplantsci.bsky.social
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis - Nature
An Arabidopsis long terminal repeat retrotransposon integrates de novo into regions occupied by centromere-specific histone variant, showing the impact of centromeric chromatin on transposable element...
www.nature.com
January 2, 2025 at 5:24 PM
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Centromeric chromatin clearings demarcate the site of kinetochore formation
@cellcellpress.bsky.social @yiweichang.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @yiweichang.bsky.social
www.cell.com/cell/fulltex...
January 23, 2025 at 6:57 PM
Centromeric chromatin clearings demarcate the site of kinetochore formation
@cellcellpress.bsky.social @yiweichang.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @yiweichang.bsky.social
www.cell.com/cell/fulltex...
These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar
Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology - The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review...
rdcu.be
August 3, 2026 at 6:54 PM
These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar
Ok this is too complicated for me to summarize but very very cool from Roddy O’Sullivan and Yael Nechemia-Arbely from the Hillman Cancer Center at Pitt. ALT cancers can get centromeric insertions at telomeres that are inportant for telomere integrity in ALT!! www.nature.com/articles/s41...
Centromeric footprints preserve telomere integrity in ALT cancers - Nature
Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.
www.nature.com
June 3, 2026 at 7:04 PM
Ok this is too complicated for me to summarize but very very cool from Roddy O’Sullivan and Yael Nechemia-Arbely from the Hillman Cancer Center at Pitt. ALT cancers can get centromeric insertions at telomeres that are inportant for telomere integrity in ALT!! www.nature.com/articles/s41...
Jeremy Hollis’ detective story on centromeric histone chaperones (HJURP/Cal1) is now published after peer review with a few extra goodies.
@jeremyahollis.bsky.social
@nlehrbach.bsky.social
@cbmoens.bsky.social
@irinakitop.bsky.social
@basicsci.fredhutch.org
www.science.org/doi/10.1126/...
@jeremyahollis.bsky.social
@nlehrbach.bsky.social
@cbmoens.bsky.social
@irinakitop.bsky.social
@basicsci.fredhutch.org
www.science.org/doi/10.1126/...
July 1, 2026 at 6:30 PM
Jeremy Hollis’ detective story on centromeric histone chaperones (HJURP/Cal1) is now published after peer review with a few extra goodies.
@jeremyahollis.bsky.social
@nlehrbach.bsky.social
@cbmoens.bsky.social
@irinakitop.bsky.social
@basicsci.fredhutch.org
www.science.org/doi/10.1126/...
@jeremyahollis.bsky.social
@nlehrbach.bsky.social
@cbmoens.bsky.social
@irinakitop.bsky.social
@basicsci.fredhutch.org
www.science.org/doi/10.1126/...
Out now in @newphyt.bsky.social with @joannarifkin.bsky.social, @jotlovell.bsky.social, @spicybotrytis.bsky.social & more! Our high-quality pennycress pangenome is a striking example of genome architecture shaping different kinds of genomic variation, including some surprising centromeric movement
Structure and sequence evolution in the pennycress (Thlaspi arvense) pangenome
Eukaryotic genomes harbor many forms of variation, including nucleotide diversity and structural polymorphisms, which experience natural selection and contribute to genome evolution and biodiversity...
doi.org
April 3, 2026 at 3:23 PM
Out now in @newphyt.bsky.social with @joannarifkin.bsky.social, @jotlovell.bsky.social, @spicybotrytis.bsky.social & more! Our high-quality pennycress pangenome is a striking example of genome architecture shaping different kinds of genomic variation, including some surprising centromeric movement
new out in @nature.com www.nature.com/articles/s41...
Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature
Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...
www.nature.com
March 6, 2025 at 8:26 AM
new out in @nature.com www.nature.com/articles/s41...
Chromosomes are often classified as either monocentric (single centromere per chr) or holocentric (centromeric activity spread across each chr).
In reality, there is a continuum in centromere organisation - and cyperids are a fascinating system to explore this in as James shows in this preprint! 🌱
In reality, there is a continuum in centromere organisation - and cyperids are a fascinating system to explore this in as James shows in this preprint! 🌱
Why do the chromosomes of cyperids (sedges & rushes) split and fuse so regularly on evolutionary timescales?
Is it because they have so many centromeres?
Our new preprint, the first major paper of my PhD, addresses this question. 🧵⬇️ 1/12
www.biorxiv.org/content/10.6...
Is it because they have so many centromeres?
Our new preprint, the first major paper of my PhD, addresses this question. 🧵⬇️ 1/12
www.biorxiv.org/content/10.6...
March 3, 2026 at 5:12 PM
Chromosomes are often classified as either monocentric (single centromere per chr) or holocentric (centromeric activity spread across each chr).
In reality, there is a continuum in centromere organisation - and cyperids are a fascinating system to explore this in as James shows in this preprint! 🌱
In reality, there is a continuum in centromere organisation - and cyperids are a fascinating system to explore this in as James shows in this preprint! 🌱
Centromeric origin of Arabidopsis interstitial telomeric repeat domains https://www.biorxiv.org/content/10.64898/2026.05.10.723265v1
May 12, 2026 at 1:32 PM
Centromeric origin of Arabidopsis interstitial telomeric repeat domains https://www.biorxiv.org/content/10.64898/2026.05.10.723265v1