#cephalicfurrow
Paper celebrations. Or rather papers celebration. 🎉 Inclusive. #Hydra #CephalicFurrow @mpi-cbg.de #LoPaTs
August 9, 2025 at 1:17 PM
Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)
September 4, 2025 at 5:18 PM
Final thanks to reviewers @amartinezarias.bsky.social @thibautbrunet.bsky.social & Cassandra Extavour and the editor @endofthepier.bsky.social. Quest for the mysteries of #cephalicfurrow and #Evolution_of_Morphogenesis continues (9/9)

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September 4, 2025 at 5:18 PM
In Steffen's lab, @girishkalephd.bsky.social and Verena went out of their way to heroically sample much expanded range of fly phylogeny. #cephalicfurrow and lack there of split neatly along the divide of cyclorrhapha/non-cyclorrhapha. (4/9)
September 4, 2025 at 5:18 PM
#cephalicfurrow forms and retracts to prevent tissue collision. Blocking it optogenetically not only causes buckling during #gastrulation, it also causes specific defects several hours after normal timeframe of retraction. More mysteries yet to be solved! (3/9)
September 4, 2025 at 5:18 PM
With storytelling spirit, #cephalicfurrow is a bit of a personal obsession for nearly 20 yrs. Got me Helen Hay Whitney for my time with Eric Wieschaus and yet failed me completely, until Steffen came to the rescue figuring out its motor (tinyurl.com/3axmm2mm) with help of @hfspo.bsky.social (7/9)
September 4, 2025 at 5:18 PM
🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists.
In @nature.com
doi.org/10.1038/s415...
Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature
Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.
doi.org
September 18, 2025 at 9:49 AM