#chembiol
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pwk2024.bsky.social
A most excellent molecule (and chemist) with which to conclude the week #SynChem #MedChem #ChemBiol #DrugDesign #chemsky 🧪
new.enaminestore.com/catalog/EN30...
October 18, 2024 at 2:29 PM
pwk2024.bsky.social
#ChemBiol #MS #AnalChem #ChemPostDoc #PostDocJobs #chemsky 🧪
January 7, 2025 at 10:28 AM
mads-chem.bsky.social
Had an amazing time at #abpp2025 over the last couple of days. Incredible lineup of speakers showcasing why #ABPP and #proteomics have transformational for #drugdiscovery and #chembiol
Already looking forward for #abpp2027 in @LeidenScience
April 1, 2025 at 3:10 PM
pwk2024.bsky.social
Opportunity in chemical biology & #proteomics at Pfizer (Groton CT USA) ref: 4924293 | closing: 06-Dec-2024 #ChemBiol #biochem #chemsky 🧪
pfizer.wd1.myworkdayjobs.com/PfizerCareer...
Senior Scientist, Chemical Biology and Proteomics
Would you like to discover the medicines of the future? At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Chemical Biology and Proteomics group, we play a vital role in this missio...
pfizer.wd1.myworkdayjobs.com
November 27, 2024 at 7:08 AM
dorigquiroga.bsky.social
Our new work on trans-Pt(II) complexes is out! We've uncovered some unique reactivity – check it out!.https://pubs.rsc.org/en/content/articlepdf/2025/QI/D5QI00674K. #chemistry #chembiol
pubs.rsc.org
June 18, 2025 at 9:40 PM
cp-cellchembiol.bsky.social
Online now! Online now! Chemoproteomic profiling of itaconate-derived protein modifications #chembiol
Chemoproteomic profiling of itaconate-derived protein modifications
Wang et al. herein review recent progress in the systematic identification of post-translational modifications and non-covalent interactions mediated by the immunomodulatory metabolite itaconate using chemoproteomic methods. These studies have provided rich resources to guide future functional studies to better understand the multiple roles of itaconate in host-pathogen interactions.
dlvr.it
September 25, 2026 at 3:30 PM
mads-chem.bsky.social
First up on day 2 of @euromedchem.bsky.social #EFMCISCB25 is Ben Davis from @ox.ac.uk talking about awesome #chemistry to edit #proteins eg. chemical #mutagenesis, such as Cys>Dha>Xxx transitions #chembiol #chemsky
January 30, 2025 at 8:14 AM
mads-chem.bsky.social
Great opportunity for #PhD #postdoc to showcase their #chemistry #chemicalprobe #proteomics #chembiol research at the next @chembiotalks.bsky.social
Looking forward to keynotes from @craigmcrews.bsky.social and @oconnorlab.bsky.social and exciting #earlycareer Flashtalks!! #chemsky
chembiotalks.bsky.social Virtual ChemBioTalks @chembiotalks.bsky.social · May 1
Do you want to present your #ChemBio research to a global audience at the 5th Virtual ChemBio Talks?

If you are a #PhD or #postdoc, here is your chance! Apply for a Flash Talk via our abstract challenge. Deadline is June 30th.

#ChemSky

chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
May 1, 2025 at 8:08 PM
pwk2024.bsky.social
#PostDoc opportunity in targeted protein degradation at Institute of Cancer Research (Sutton UK) closing: 05-Jan-2025 | duration: 3 years #TPD #ChemBiol #Medchem #ChemPostDoc #PostDocJobs #UKChemJobs #chemsky 🧪
jobs.icr.ac.uk/vacancies/10...
Postdoctoral Training Fellow - Chemistry, Targeted Protein Degradation in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Chemistry, Targeted Protein Degradation vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Future ...
jobs.icr.ac.uk
December 6, 2024 at 7:37 AM
cp-cellchembiol.bsky.social
Online now! Online now! A STING inhibitor suppresses ferroptosis through radical-trapping antioxidant activity #chembiol
A STING inhibitor suppresses ferroptosis through radical-trapping antioxidant activity
(Cell Chemical Biology 33, ▪▪–▪▪.e1–e6, December 17, 2026)
dlvr.it
September 21, 2026 at 3:30 PM
pwk2024.bsky.social
Opportunity for lab-based medicinal chemist/chemical biologist at The Francis Crick Institute (London UK) ref: R2461 | closing: 11-Nov-2025 #MedChem #ChemBiol #SynChem #ChemJobs #UKChemJobs #chemsky 🧪
crick.wd3.myworkdayjobs.com/External/job...
Senior Laboratory Research Scientist - Medicinal Chemist/Chemical Biologist
Salary for this Role: From £45,700 with benefits, subject to skills & experience Job Title: Senior Laboratory Research Scientist - Medicinal Chemist/Chemical Biologist Reports to: Christelle Soudy...
crick.wd3.myworkdayjobs.com
October 29, 2025 at 7:22 AM
cp-cellchembiol.bsky.social
Online now! Online now! G protein diffusion states reveal receptor binding dynamics at single-molecule scale #chembiol
G protein diffusion states reveal receptor binding dynamics at single-molecule scale
Mathiasen et al. provide a diffusion-based single-molecule approach for studying how G protein-coupled receptors engage G proteins in living cells. Native interactions are not resolved at 15 ms, but a nucleotide-decoupled Gαi1 4A mutant shows that agonist increases the rate of receptor engagement without altering complex lifetime, consistent with efficacy being reflected in engagement probability.
dlvr.it
September 22, 2026 at 3:30 PM
mads-chem.bsky.social
Can't wait for 4 days of #chembiol #medchem #chemicalprobes #drugdiscovery and #chemoproteomics
@RACInational
#MCCB2025 Great line of #science and catching up with old friends in #NT
bit.ly/3PNkUl6
January 25, 2025 at 3:25 PM
pwk2024.bsky.social
Jones (Chemical Science 2025) Advances in sulfonyl exchange chemical biology: expanding druggable target space. #ChemBiol #MedChem #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1039/D5SC...
Advances in sulfonyl exchange chemical biology: expanding druggable target space
Targeted covalent inhibitors possess advantages over reversible binding drugs, that include higher potency, enhanced selectivity and prolonged pharmacodynamic duration. The standard paradigm for coval...
doi.org
May 29, 2025 at 6:25 AM
mads-chem.bsky.social
Big thanks to talented #PhD candidates Jakob van der Wall and Georgia Andriopoulou for representing our lab @led3hub.bsky.social Early #DrugDiscovery symposium yesterday, sharing how #chemoproteomics and new #chemistry can tackle traditional challenging #cancer & #immune targets!
#chembiol
June 12, 2026 at 10:20 AM
pwk2024.bsky.social
Opportunity for lab-based medicinal chemist in chemical biology at Vertex (Oxford UK) ref: REQ-24560 #MedChem #ChemBiol #SynChem #UKChemJobs #ChemJobs #chemsky 🧪
vrtx.wd5.myworkdayjobs.com/en-US/vertex...
Medicinal Chemistry / Chemical Biology Research Scientist
Job Description General Summary: Vertex Pharmaceuticals has an exciting opportunity at the Oxford site for a Research Scientist to join the Chemical Biology team within Medicinal Chemistry. In this la...
vrtx.wd5.myworkdayjobs.com
February 18, 2025 at 9:48 AM
mads-chem.bsky.social
Up next at #EFMCISCB25 @kjohnsson.bsky.social sharing #fluorescent tools for cell imaging and @mvdstelt.bsky.social from @unileiden.bsky.social showcasing #chembiol and #proteomics to understand #lipid signaling in the diseased brain.
January 30, 2025 at 10:24 AM
cp-cellchembiol.bsky.social
Online now! Online now! Lysosome-targeting chimeras enable targeted protein degradation #chembiol
Lysosome-targeting chimeras enable targeted protein degradation
Bozhao Li et al. review lysosome-targeting chimeras (LYTACs) as a transformative strategy for degrading extracellular and membrane proteins. They outline receptor-guided design principles, endocytic routing mechanisms, and translational challenges, highlighting how LYTACs expand targeted protein degradation beyond the proteasome.
dlvr.it
February 18, 2026 at 4:30 PM
cp-cellchembiol.bsky.social
Online now! Online now! The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue #chembiol
The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue
Hinshaw et al. determine the molecular basis for TRIM21 recruitment to the nuclear pore protein NUP98, showing that an induced protein-protein interface drives the potency and selectivity of the molecular glue mechanism.
dlvr.it
May 27, 2026 at 3:30 PM
pwk2024.bsky.social
Kim, Grams & Hsu (Chem Rev 2025 #OpenAccess) Advancing Covalent Ligand and Drug Discovery beyond Cysteine | #MedChem #ChemBiol #DrugDiscovery #DrugDesign #cheminformatics #chemsky 🧪
doi.org/10.1021/acs....
Advancing Covalent Ligand and Drug Discovery beyond Cysteine
Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional dru...
doi.org
May 28, 2025 at 6:11 AM
cp-cellchembiol.bsky.social
Online now! Online now! Advances in degradomics technologies to assess proteolytic cleavage events #chembiol
Advances in degradomics technologies to assess proteolytic cleavage events
Ziegler et al. outline how modern proteomics and mass spectrometry enable precise identification of protease-generated cleavage sites. They highlight enrichment-based and enrichment-free degradomics workflows used to map N- and C-terminal peptides, define protease specificity, and uncover substrate networks that drive health and disease.
dlvr.it
February 2, 2026 at 4:30 PM
cp-cellchembiol.bsky.social
Online now! Online now! Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies #chembiol
Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
Marglous et al. generated a database of anti-glycan antibody sequences, expressed and characterized a library of 154 antibodies, and generated DNA-barcoded antibodies for single-cell transcriptome and glycome profiling. Glycans associated with cancer stem cells and metastasis were uncovered, demonstrating utility for basic and clinical research.
dlvr.it
December 15, 2025 at 4:30 PM
pwk2024.bsky.social
#PostDoc opportunity for structural/chemical biologist at Centre for Targeted Protein Degradation, University of Dundee (UK) ref: UOD1992 | duration: 3 years | closing: 06-Oct-2025 #ChemBiol #ChemPostDoc #PostDocJobs #chemsky 🧪
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - CeTPD - UOD1992
Closing date: Monday 6 October 2025, 23:59
www.dundee.ac.uk
September 10, 2025 at 7:07 AM
cp-cellchembiol.bsky.social
Online now! Online now! Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO #chembiol
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO
Lindsey et al. integrate structural studies with activity-based protein profiling to characterize a druggable pocket proximal to the RNA-binding interface of NONO that can be covalently targeted by low-reactivity chlorofluoroacetamide ligands to remodel the transcriptomes and suppress the growth of cancer cells.
dlvr.it
January 19, 2026 at 4:31 PM
cp-cellchembiol.bsky.social
Online now! Online now! Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion #chembiol
Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion
ApoE is a central player in the development of Alzheimer’s disease. Donovan et al. use phenotypic screening, chemoproteomics, and mechanistic studies to show transcription factor AhR antagonism modulates astrocytic ApoE secretion.
dlvr.it
January 5, 2026 at 4:30 PM