#EUMIND2026 quoi de neuf ? les copathologies sont essentielles pour le diagnostic et la prise en soins de la maladie d’Alzheimer
September 22, 2026 at 12:00 PM
#EUMIND2026 quoi de neuf ? les copathologies sont essentielles pour le diagnostic et la prise en soins de la maladie d’Alzheimer
No real ‘biological-clinical alignment’ in #Alzheimers. Only 37.7% of BioFINDER-2 cohort matched pathological and clinical stages. How hard is it to say, 'biological' staging poorly predicts clinical disease, rather than blaming 'copathologies' for the discrepancy?
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
May 19, 2025 at 8:53 PM
No real ‘biological-clinical alignment’ in #Alzheimers. Only 37.7% of BioFINDER-2 cohort matched pathological and clinical stages. How hard is it to say, 'biological' staging poorly predicts clinical disease, rather than blaming 'copathologies' for the discrepancy?
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
📢 Read this recent feature in Inside Precision Medicine about how we’re teaming up with @alleninstitute.org to power new discoveries in #Parkinsons, #Alzheimers, & beyond.
Learn more: bit.ly/3H8PYLu
Learn more: bit.ly/3H8PYLu
Needed ASAP: The Partnership Rewiring Neurodegeneration Research
Aligning Science Across Parkinson’s (ASAP) and The Allen Institute will examine neurodegenerative disease copathologies to develop precision medicines.
https://bit.ly/3H8PYLu"
July 31, 2025 at 5:08 PM
📢 Read this recent feature in Inside Precision Medicine about how we’re teaming up with @alleninstitute.org to power new discoveries in #Parkinsons, #Alzheimers, & beyond.
Learn more: bit.ly/3H8PYLu
Learn more: bit.ly/3H8PYLu
See our new paper on the impact of Lewy and Alzheimer co-pathology on cognitive and clinical changes #DLBAwareness #Alzheimers #EndDementia #CoPathologies bit.ly/3DU8WDT
Cognitive decline profiles associated with lewy pathology in the context of Alzheimer’s disease neuropathologic change - Alzheimer's Research & Therapy
Background Alzheimer’s disease neuropathologic change (ADNC) and Lewy pathology (LP) often coexist in cognitively impaired individuals. These pathologies’ relative distribution and severity may modify...
bit.ly
January 13, 2025 at 9:05 PM
See our new paper on the impact of Lewy and Alzheimer co-pathology on cognitive and clinical changes #DLBAwareness #Alzheimers #EndDementia #CoPathologies bit.ly/3DU8WDT
Check out a new article detailing how the @asapresearch.parkinsonsroadmap.org and @alleninstitute.org collaboration is driving #neurodegeneration research forward!
Read about CAS founder and CEO Ekemini Riley and COO Sonya Dumanis and their instrumental work in the ASAP initiative! bit.ly/3H8PYLu
Read about CAS founder and CEO Ekemini Riley and COO Sonya Dumanis and their instrumental work in the ASAP initiative! bit.ly/3H8PYLu
Needed ASAP: The Partnership Rewiring Neurodegeneration Research
Aligning Science Across Parkinson’s (ASAP) and the Allen Institute will examine neurodegenerative disease copathologies to develop precision medicines.
bit.ly
August 5, 2025 at 5:18 PM
Check out a new article detailing how the @asapresearch.parkinsonsroadmap.org and @alleninstitute.org collaboration is driving #neurodegeneration research forward!
Read about CAS founder and CEO Ekemini Riley and COO Sonya Dumanis and their instrumental work in the ASAP initiative! bit.ly/3H8PYLu
Read about CAS founder and CEO Ekemini Riley and COO Sonya Dumanis and their instrumental work in the ASAP initiative! bit.ly/3H8PYLu
www.podbean.com/pw/pbblog-nr...
Great podcast about the #LANDMARK project @imperialbrains.bsky.social featuring Michael Johnson and David Dexter discussing multiple important aspects of this major #Parkinson's study including #brainbank research, the #drugpipeline , #copathologies and much more...
Great podcast about the #LANDMARK project @imperialbrains.bsky.social featuring Michael Johnson and David Dexter discussing multiple important aspects of this major #Parkinson's study including #brainbank research, the #drugpipeline , #copathologies and much more...
The North of Scotland Parkinson’s Research Podcast Series | The North of Scotland Parkinson’s Research Interest Group
The North of Scotland Parkinson’s Research Interest Group (NoSPRIG) is part of a nationwide network of research groups supporting Parkinson’s UK by increasing awareness and involvement in research at ...
www.podbean.com
December 7, 2025 at 4:14 PM
www.podbean.com/pw/pbblog-nr...
Great podcast about the #LANDMARK project @imperialbrains.bsky.social featuring Michael Johnson and David Dexter discussing multiple important aspects of this major #Parkinson's study including #brainbank research, the #drugpipeline , #copathologies and much more...
Great podcast about the #LANDMARK project @imperialbrains.bsky.social featuring Michael Johnson and David Dexter discussing multiple important aspects of this major #Parkinson's study including #brainbank research, the #drugpipeline , #copathologies and much more...
P-tau abnormalities appear in the spinal cord of CTE cases, not just the brain. This may open pathways toward in vivo biomarkers (finally!). #CTE #brain
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy
This case-control study evaluates spinal cord pathologies associated with exposure to repetitive head impacts or chronic traumatic encephalopathy neuropathologic change in the brain among autopsied in...
jamanetwork.com
January 28, 2026 at 4:08 AM
P-tau abnormalities appear in the spinal cord of CTE cases, not just the brain. This may open pathways toward in vivo biomarkers (finally!). #CTE #brain
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
ATTs in Patients With Non-AD Copathologies jamanetwork.com/journals/jam...
ATTs in Patients With Non-AD Copathologies
This Viewpoint examines how clinicians should approach amyloid-targeting therapies in patients with Alzheimer disease and suspected copathologies, emphasizing individualized decision-making, current e...
jamanetwork.com
September 1, 2026 at 1:46 PM
ATTs in Patients With Non-AD Copathologies jamanetwork.com/journals/jam...
Among older adults, more than 80% of the individuals had mixed pathologies, with 280 distinct combinations of copathologies; hierarchical clustering and functional mixed-effects models identified 5 distinct neuropathologic profiles. ja.ma/49qlZKt
January 16, 2026 at 7:30 PM
Among older adults, more than 80% of the individuals had mixed pathologies, with 280 distinct combinations of copathologies; hierarchical clustering and functional mixed-effects models identified 5 distinct neuropathologic profiles. ja.ma/49qlZKt
Isn't it both according to their analysis? Biological staging poorly predicts clinical disease, in part due to copathologies?
May 19, 2025 at 11:44 PM
Isn't it both according to their analysis? Biological staging poorly predicts clinical disease, in part due to copathologies?
Feed: "Inside Precision Medicine"
By: Jonathan D. Grinstein, PhD on Tuesday, July 29, 2025
By: Jonathan D. Grinstein, PhD on Tuesday, July 29, 2025
Needed ASAP: The Partnership Rewiring Neurodegeneration Research
Aligning Science Across Parkinson’s (ASAP) and The Allen Institute will examine neurodegenerative disease copathologies to develop precision medicines.
www.insideprecisionmedicine.com
July 29, 2025 at 8:13 PM
Feed: "Inside Precision Medicine"
By: Jonathan D. Grinstein, PhD on Tuesday, July 29, 2025
By: Jonathan D. Grinstein, PhD on Tuesday, July 29, 2025
L’AP-HP promeut la coordination entre psychiatrie et neurologie, deux spécialités longtemps cloisonnées, afin d’améliorer la prise en charge des patients présentant des copathologies, malgré les batailles de conception qui traversent la profession.
Journée de la santé mentale : l’AP-HP mise sur le couple psychiatrie-neurologie
Journée de la santé mentale : l’AP-HP mise sur le couple psychiatrie-neurologie - L’Assistance Publique-Hôpitaux de Paris promeut la coordination entre psychiatrie et neurologie, deux spécialités longtemps cloisonnées, afin d’améliorer la prise en charge des patients présentant des copathologies, malgré les batailles de conception qui traversent la profession.
l.whatsupdoc-lemag.fr
October 10, 2025 at 3:02 PM
L’AP-HP promeut la coordination entre psychiatrie et neurologie, deux spécialités longtemps cloisonnées, afin d’améliorer la prise en charge des patients présentant des copathologies, malgré les batailles de conception qui traversent la profession.
Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer's disease copathologies
->Nature | #Health #Disease | More info from EcoSearch
->Nature | #Health #Disease | More info from EcoSearch
Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer's disease copathologies
We characterized the in vivo regional gray matter patterns of neurite and dendritic abnormalities in the continuum of prodromal and probable DLB and evaluated their associations with co-existing AD PET biomarkers and cerebrovascular burden. First, the DLB spectrum group showed...
www.nature.com
May 12, 2025 at 6:24 AM
Correction: Brain Microstructure in Lewy Body Dementia
In a recent compelling development within the realm of neurodegenerative disease research, an international team of scientists has addressed critical cortical microstructural abnormalities linked to dementia with Lewy bodies (DLB) and how…
In a recent compelling development within the realm of neurodegenerative disease research, an international team of scientists has addressed critical cortical microstructural abnormalities linked to dementia with Lewy bodies (DLB) and how…
Correction: Brain Microstructure in Lewy Body Dementia
In a recent compelling development within the realm of neurodegenerative disease research, an international team of scientists has addressed critical cortical microstructural abnormalities linked to dementia with Lewy bodies (DLB) and how these anomalies intersect with Alzheimer's disease copathologies. This correction and refinement of earlier work elucidate profound insights into the overlapping pathological mechanisms that underlie these devastating disorders, offering promising avenues for diagnostic precision and therapeutic innovation.
scienmag.com
July 24, 2025 at 1:55 AM
Correction: Brain Microstructure in Lewy Body Dementia
In a recent compelling development within the realm of neurodegenerative disease research, an international team of scientists has addressed critical cortical microstructural abnormalities linked to dementia with Lewy bodies (DLB) and how…
In a recent compelling development within the realm of neurodegenerative disease research, an international team of scientists has addressed critical cortical microstructural abnormalities linked to dementia with Lewy bodies (DLB) and how…
Misfolded alpha synuclein co-occurrence with Alzheimer's disease proteinopathy https://www.medrxiv.org/content/10.1101/2024.10.11.24315349v1
Misfolded alpha synuclein co-occurrence with Alzheimer's disease proteinopathy https://www.medrxiv.org/content/10.1101/2024.10.11.24315349v1
INTRODUCTION: Multi-etiology dementia necessitates in-vivo markers of copathologies including misfol
www.medrxiv.org
October 13, 2024 at 5:26 PM
Misfolded alpha synuclein co-occurrence with Alzheimer's disease proteinopathy https://www.medrxiv.org/content/10.1101/2024.10.11.24315349v1
Large cohort study finds plasma pTau217 (but not GFAP or NfL) levels accurately reflect the presence of #Alzheimer neuropathological change in the brain even in individuals with a primary neuropathologic diagnosis of a non-AD dementia
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias | Neurology
Background and ObjectivesAlzheimer disease (AD) and its related disorders (ADRDs) are characterized by a high
frequency of copathologies. We aimed to determine the specificity of plasma pTau217,
glial...
www.neurology.org
January 30, 2026 at 5:19 PM
Large cohort study finds plasma pTau217 (but not GFAP or NfL) levels accurately reflect the presence of #Alzheimer neuropathological change in the brain even in individuals with a primary neuropathologic diagnosis of a non-AD dementia
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
"It is now well established that copathologies are the rule rather than the exception. Many patients exhibit a combination of protein aggregates, including tau, α-synuclein, TDP-43, & amyloid-β, often alongside cerebrovascular disease"
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Copathology in Atypical Parkinsonism
This Viewpoint reports on the potential of multimodal approaches that include validation, standardization, and ethical considerations in diagnosing neurodegenerative diseases, many of which have overl...
jamanetwork.com
June 29, 2025 at 5:07 PM
"It is now well established that copathologies are the rule rather than the exception. Many patients exhibit a combination of protein aggregates, including tau, α-synuclein, TDP-43, & amyloid-β, often alongside cerebrovascular disease"
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Read the full article in JNM here: jnm.snmjournals.org/content/earl...
Copathologies of Limbic-Predominant Age-Related TDP-43 Encephalopathy and Alzheimer Disease: [18F]FDG PET Statistical Mapping and Quantitative MRI Volumetry
Limbic-predominant age-related transactive response DNA-binding protein 43 kDa encephalopathy (LATE) is emerging as a prevalent neurodegenerative disorder in aging populations, mimicking the clinical ...
jnm.snmjournals.org
February 24, 2026 at 2:24 PM
Read the full article in JNM here: jnm.snmjournals.org/content/earl...
tinyurl.com/pc888p8b
Indeed, to date, virtually all reported cases of #CTE-NC report prior exposure to mild #traumaticbraininjury (#TBI) and/or repetitive head impacts (RHI)
Indeed, to date, virtually all reported cases of #CTE-NC report prior exposure to mild #traumaticbraininjury (#TBI) and/or repetitive head impacts (RHI)
Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy
This case-control study evaluates spinal cord pathologies associated with exposure to repetitive head impacts or chronic traumatic encephalopathy neuropathologic change in the brain among autopsied in...
tinyurl.com
March 13, 2026 at 8:47 PM
tinyurl.com/pc888p8b
Indeed, to date, virtually all reported cases of #CTE-NC report prior exposure to mild #traumaticbraininjury (#TBI) and/or repetitive head impacts (RHI)
Indeed, to date, virtually all reported cases of #CTE-NC report prior exposure to mild #traumaticbraininjury (#TBI) and/or repetitive head impacts (RHI)
Amyloid-linked versus age-driven copathologies in Alzheimer’s dementia: differential associations with APOE ε4 #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-9044264/latest
https://www.researchsquare.com/article/rs-9044264/latest
March 16, 2026 at 5:01 PM
Amyloid-linked versus age-driven copathologies in Alzheimer’s dementia: differential associations with APOE ε4 #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-9044264/latest
https://www.researchsquare.com/article/rs-9044264/latest
Older adults whose cognitive symptoms were more severe than their biological #Alzheimers stage often had additional pathologies, a cross-sectional study showed. Alexa Pichet Binette, Ruben Smith, Gemma Salvadó, et al. @lunduniversity.bsky.social @jama.com Neuro jamanetwork.com/journals/jam...
Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease
This study compares individuals who have discrepant biological and clinical stages with those who have congruent stages in terms of copathologies, comorbidities, and demographics.
jamanetwork.com
May 23, 2025 at 1:28 PM
Older adults whose cognitive symptoms were more severe than their biological #Alzheimers stage often had additional pathologies, a cross-sectional study showed. Alexa Pichet Binette, Ruben Smith, Gemma Salvadó, et al. @lunduniversity.bsky.social @jama.com Neuro jamanetwork.com/journals/jam...