The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
June 5, 2026 at 4:02 PM
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Excited to share DupyliCate - our new tool for discovery and characterization of gene duplications:
"DupyliCate - mining, classifying, and characterizing gene duplications"
doi.org/10.1101/2025...
#Bioinformatics #Python #Genomics #Evolution
@puckerlab.bsky.social
"DupyliCate - mining, classifying, and characterizing gene duplications"
doi.org/10.1101/2025...
#Bioinformatics #Python #Genomics #Evolution
@puckerlab.bsky.social
DupyliCate - mining, classifying, and characterizing gene duplications
Paralogs, copies of a gene, form an important basis for novelty during evolution. Analysis of such gene duplications is important to understand the emergence of novel traits during evolution. DupyliCa...
doi.org
October 14, 2025 at 5:26 AM
Excited to share DupyliCate - our new tool for discovery and characterization of gene duplications:
"DupyliCate - mining, classifying, and characterizing gene duplications"
doi.org/10.1101/2025...
#Bioinformatics #Python #Genomics #Evolution
@puckerlab.bsky.social
"DupyliCate - mining, classifying, and characterizing gene duplications"
doi.org/10.1101/2025...
#Bioinformatics #Python #Genomics #Evolution
@puckerlab.bsky.social
Uh, I think @elisabethbik.bsky.social has some explaining to do
November 8, 2024 at 11:24 PM
Uh, I think @elisabethbik.bsky.social has some explaining to do
All detectable ancient whole-genome duplications involve hybridization https://www.biorxiv.org/content/10.64898/2026.08.25.747000v1
August 28, 2026 at 5:30 PM
All detectable ancient whole-genome duplications involve hybridization https://www.biorxiv.org/content/10.64898/2026.08.25.747000v1
I’m adding some screenshots. I apologize for duplications because I don’t have my glasses on me
January 30, 2026 at 7:06 PM
I’m adding some screenshots. I apologize for duplications because I don’t have my glasses on me
Did you know that gene duplications play a crucial role in the evolution of plants and their ability to adapt to extreme environments? 🌿🌍
Here we explore gene and genome duplications in the salt and heavy metal tolerant species Cakile maritima: bsapubs.onlinelibrary.wiley.com/doi/full/10....
(🧵1/5)
Here we explore gene and genome duplications in the salt and heavy metal tolerant species Cakile maritima: bsapubs.onlinelibrary.wiley.com/doi/full/10....
(🧵1/5)
April 15, 2024 at 10:25 PM
Did you know that gene duplications play a crucial role in the evolution of plants and their ability to adapt to extreme environments? 🌿🌍
Here we explore gene and genome duplications in the salt and heavy metal tolerant species Cakile maritima: bsapubs.onlinelibrary.wiley.com/doi/full/10....
(🧵1/5)
Here we explore gene and genome duplications in the salt and heavy metal tolerant species Cakile maritima: bsapubs.onlinelibrary.wiley.com/doi/full/10....
(🧵1/5)
There are actually two inappropriate duplications!
June 19, 2025 at 4:31 AM
There are actually two inappropriate duplications!
Zeeba TV always making awesome videos to illustrate the duplications in our #ImageForensics concerns we post on PubPeer.
Areas of figures "more similar than expected"!
youtu.be/_9wGPBjWQwE
youtu.be/_9wGPBjWQwE
November 23, 2024 at 11:44 PM
Zeeba TV always making awesome videos to illustrate the duplications in our #ImageForensics concerns we post on PubPeer.
I went for a nice swim (60 laps, just under 40 min), finished my peer review, did an interview with a journalist, and checked some papers for image duplications. Now I am ready for the weekend!
October 3, 2025 at 11:38 PM
I went for a nice swim (60 laps, just under 40 min), finished my peer review, did an interview with a journalist, and checked some papers for image duplications. Now I am ready for the weekend!
For metabolic innovations, it seems local tandem duplications more important that whole genome duplication #PlantScience
August 20, 2026 at 11:01 PM
For metabolic innovations, it seems local tandem duplications more important that whole genome duplication #PlantScience
Timeline cleanse challenge: Can you spot the duplications here?
#ImageForensics
#ImageForensics
September 25, 2025 at 10:31 PM
Timeline cleanse challenge: Can you spot the duplications here?
#ImageForensics
#ImageForensics
Typeset version of new paper out in @genomebiolevol.bsky.social.
Link: academic.oup.com/gbe/article/...
We identified segmental duplications in genomes from 117 vertebrate species (thanks to @vertebrategenomes.bsky.social ). We describe the properties and evolution of segmental duplications.
Link: academic.oup.com/gbe/article/...
We identified segmental duplications in genomes from 117 vertebrate species (thanks to @vertebrategenomes.bsky.social ). We describe the properties and evolution of segmental duplications.
Genomes From 117 Vertebrate Species Reveal Rapidly Evolving Segmental-Duplication Landscapes
Abstract. Segmental duplications are major drivers of evolutionary innovation; yet, their dynamics across vertebrates remain poorly understood. Here, we id
academic.oup.com
July 30, 2026 at 3:08 PM
Typeset version of new paper out in @genomebiolevol.bsky.social.
Link: academic.oup.com/gbe/article/...
We identified segmental duplications in genomes from 117 vertebrate species (thanks to @vertebrategenomes.bsky.social ). We describe the properties and evolution of segmental duplications.
Link: academic.oup.com/gbe/article/...
We identified segmental duplications in genomes from 117 vertebrate species (thanks to @vertebrategenomes.bsky.social ). We describe the properties and evolution of segmental duplications.
Calling all OrthoFinder users!
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
www.biorxiv.org
January 29, 2026 at 12:07 PM
Calling all OrthoFinder users!
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.
GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...
(1/10)
The typeset version of our article, "Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation", is now online. This thread will provide an overview of how gene duplications have shaped modern variation in the amylase locus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation
Previous studies suggested that the copy number of the human salivary amylase gene, AMY1, correlates with starch-rich diets. However, evolutionary analyses are hampered by the absence of accurate, seq...
www.science.org
November 22, 2024 at 2:07 PM
The typeset version of our article, "Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation", is now online. This thread will provide an overview of how gene duplications have shaped modern variation in the amylase locus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Status report, "Getting Ready To Make Gravy, But This Happens First" dep't: Okay, time for a little rationalization of the sice racks... because nobody needs four jars of parsley. 😏
June 14, 2026 at 10:09 AM
Status report, "Getting Ready To Make Gravy, But This Happens First" dep't: Okay, time for a little rationalization of the sice racks... because nobody needs four jars of parsley. 😏
🧬 New paper! DupyliCate provides an automated solution for the identification and characterization of gene duplications.
📄 doi.org/10.1038/s415...
#Bioinformatics #Genomics @shakunthalan.bsky.social @bpucker.bsky.social
📄 doi.org/10.1038/s415...
#Bioinformatics #Genomics @shakunthalan.bsky.social @bpucker.bsky.social
DupyliCate: mining, classifying, and characterizing gene duplications - Scientific Reports
Scientific Reports - DupyliCate: mining, classifying, and characterizing gene duplications
doi.org
June 6, 2026 at 1:39 PM
🧬 New paper! DupyliCate provides an automated solution for the identification and characterization of gene duplications.
📄 doi.org/10.1038/s415...
#Bioinformatics #Genomics @shakunthalan.bsky.social @bpucker.bsky.social
📄 doi.org/10.1038/s415...
#Bioinformatics #Genomics @shakunthalan.bsky.social @bpucker.bsky.social
Our latest, led by the inimitable Chris Kay "Dated gene duplications elucidate the evolutionary assembly of eukaryotes" in which we used gene duplications to test hypotheses of eukaryogenesis. TLDR? They're all wrong. With @tweethinking.bsky.social @anya1.bsky.social @ssolo.bsky.social Davide Pisani
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...
www.nature.com
December 3, 2025 at 5:05 PM
Our latest, led by the inimitable Chris Kay "Dated gene duplications elucidate the evolutionary assembly of eukaryotes" in which we used gene duplications to test hypotheses of eukaryogenesis. TLDR? They're all wrong. With @tweethinking.bsky.social @anya1.bsky.social @ssolo.bsky.social Davide Pisani
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 15, 2025 at 8:32 PM
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sturgeons have undergone multiple whole-genome duplications, making some species octoploid (8x their original genome)! A. stellatus is a “low-ploidy” sturgeon, but its DNA still carries echoes of ancient duplications. #2025MMM doi.org/10.1038/s415...
March 14, 2025 at 1:40 AM
Sturgeons have undergone multiple whole-genome duplications, making some species octoploid (8x their original genome)! A. stellatus is a “low-ploidy” sturgeon, but its DNA still carries echoes of ancient duplications. #2025MMM doi.org/10.1038/s415...
Our paper on the evolution (duplicated) gene expression divergence in spatially resolved plant transcriptomes is now out @theplantcell.bsky.social
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
Gene expression divergence following gene and genome duplications in spatially resolved plant transcriptomes
After gene and genome duplications, expression divergence across cell types is not random, and it can be explained by a combination of gene age, gene funct
academic.oup.com
October 16, 2025 at 11:20 AM
Our paper on the evolution (duplicated) gene expression divergence in spatially resolved plant transcriptomes is now out @theplantcell.bsky.social
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
w/ @yvdp.bsky.social
#PlantSci #Evolution
academic.oup.com/plcell/advan...
Again, is it criminal if another scientist (like me) points out duplications in a 20-year old paper?
Are you accusing me of committing a crime if I do that?
Just trying to understand your reasoning.
Are you accusing me of committing a crime if I do that?
Just trying to understand your reasoning.
September 24, 2025 at 12:38 AM
Again, is it criminal if another scientist (like me) points out duplications in a 20-year old paper?
Are you accusing me of committing a crime if I do that?
Just trying to understand your reasoning.
Are you accusing me of committing a crime if I do that?
Just trying to understand your reasoning.
This is the best explanation for how genome duplications end up sticking around that I’ve ever seen.
Often that bug becomes a feature!
Often that bug becomes a feature!
March 18, 2025 at 2:29 PM
This is the best explanation for how genome duplications end up sticking around that I’ve ever seen.
Often that bug becomes a feature!
Often that bug becomes a feature!
How many duplications does it take to get a paper retracted?
@wiley.com's Liver International thinks that 10 duplications are still not enough, and issued a correction, just deleting the offending figure 6.
Unbelievable.
pubpeer.com/publications...
@wiley.com's Liver International thinks that 10 duplications are still not enough, and issued a correction, just deleting the offending figure 6.
Unbelievable.
pubpeer.com/publications...
May 7, 2025 at 8:28 PM
How many duplications does it take to get a paper retracted?
@wiley.com's Liver International thinks that 10 duplications are still not enough, and issued a correction, just deleting the offending figure 6.
Unbelievable.
pubpeer.com/publications...
@wiley.com's Liver International thinks that 10 duplications are still not enough, and issued a correction, just deleting the offending figure 6.
Unbelievable.
pubpeer.com/publications...
Whole genome duplications over 450 million years ago enabled the emergence of different kinds of brain cells 🧠
These cellular innovations are shared across vertebrates - from primitive fish to mammals - and form the basis of the sophisticated brains seen today 👇
These cellular innovations are shared across vertebrates - from primitive fish to mammals - and form the basis of the sophisticated brains seen today 👇
Ancient genome duplications laid the foundations of complex brains
bit.ly
June 11, 2026 at 9:31 AM
Whole genome duplications over 450 million years ago enabled the emergence of different kinds of brain cells 🧠
These cellular innovations are shared across vertebrates - from primitive fish to mammals - and form the basis of the sophisticated brains seen today 👇
These cellular innovations are shared across vertebrates - from primitive fish to mammals - and form the basis of the sophisticated brains seen today 👇