Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.
April 5, 2026 at 2:30 AM
Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.
1G EGFR drugs? Pfizer, Genentech, etc. Osimertinib, the 3G EGFR inhibitor? AstraZeneca. pmc.ncbi.nlm.nih.gov/articles/PMC...
April 5, 2026 at 3:11 AM
1G EGFR drugs? Pfizer, Genentech, etc. Osimertinib, the 3G EGFR inhibitor? AstraZeneca. pmc.ncbi.nlm.nih.gov/articles/PMC...
NEW #Oncology:
EGFR expression mediates resistance to T-DXd (EGFR overexpression ⬇️ HER2 homodimerization & HER2/ADC internalization)
Combining with EGFR mAbs restored HER2/ADC trafficking & ⬆️ activity in nonclinical models
#DrugDevelopment #OncoSky
www.cell.com/cell-reports...
EGFR expression mediates resistance to T-DXd (EGFR overexpression ⬇️ HER2 homodimerization & HER2/ADC internalization)
Combining with EGFR mAbs restored HER2/ADC trafficking & ⬆️ activity in nonclinical models
#DrugDevelopment #OncoSky
www.cell.com/cell-reports...
EGFR-directed antibodies promote HER2 ADC internalization and efficacy
Gupta et al. demonstrate that high EGFR expression mediates resistance to HER2 antibody
drug conjugates (ADCs) including trastuzumab deruxtecan (T-DXd) by limiting HER2/ADC
internalization. The additi...
www.cell.com
November 12, 2024 at 12:33 PM
NEW #Oncology:
EGFR expression mediates resistance to T-DXd (EGFR overexpression ⬇️ HER2 homodimerization & HER2/ADC internalization)
Combining with EGFR mAbs restored HER2/ADC trafficking & ⬆️ activity in nonclinical models
#DrugDevelopment #OncoSky
www.cell.com/cell-reports...
EGFR expression mediates resistance to T-DXd (EGFR overexpression ⬇️ HER2 homodimerization & HER2/ADC internalization)
Combining with EGFR mAbs restored HER2/ADC trafficking & ⬆️ activity in nonclinical models
#DrugDevelopment #OncoSky
www.cell.com/cell-reports...
Looking in the freezer and calculating my eGFR.
estimated
Gyoza
Functional
Reserve
estimated
Gyoza
Functional
Reserve
my problem with gyoza is that they normally come in an order of about 6, but what I really need is 100 of them
November 24, 2025 at 6:29 PM
Looking in the freezer and calculating my eGFR.
estimated
Gyoza
Functional
Reserve
estimated
Gyoza
Functional
Reserve
Excited to share our new paper, now published in Nature Cell Biology! 🎉
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
www.nature.com
July 7, 2026 at 1:09 PM
Excited to share our new paper, now published in Nature Cell Biology! 🎉
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
tinyurl.com
September 13, 2025 at 6:05 PM
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
Amivantamab is a targeted bispecific antibody and works by targeting cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumors grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack
August 24, 2026 at 5:26 PM
Amivantamab is a targeted bispecific antibody and works by targeting cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumors grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack
Proposed age-adjusted eGFR thresholds for CKD 👇
#Nephpearls #NephSky
eGFR 75 for ages <40 years
eGFR 60 for 40-65 years
eGFR 45 for >65 years
👉 link.springer.com/book/10.1007...
👉 pubmed.ncbi.nlm.nih.gov/31506289/
#Nephpearls #NephSky
eGFR 75 for ages <40 years
eGFR 60 for 40-65 years
eGFR 45 for >65 years
👉 link.springer.com/book/10.1007...
👉 pubmed.ncbi.nlm.nih.gov/31506289/
January 10, 2025 at 3:26 PM
Proposed age-adjusted eGFR thresholds for CKD 👇
#Nephpearls #NephSky
eGFR 75 for ages <40 years
eGFR 60 for 40-65 years
eGFR 45 for >65 years
👉 link.springer.com/book/10.1007...
👉 pubmed.ncbi.nlm.nih.gov/31506289/
#Nephpearls #NephSky
eGFR 75 for ages <40 years
eGFR 60 for 40-65 years
eGFR 45 for >65 years
👉 link.springer.com/book/10.1007...
👉 pubmed.ncbi.nlm.nih.gov/31506289/
New Toettchlab paper alert!
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
July 24, 2026 at 2:47 PM
New Toettchlab paper alert!
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration.
www.cell.com/cell-systems...
But if the Cys eGFR and the eGFR diff provides prognostic information and you have that right there, since you need a cystatin C to get the combined eGFR why not harvest that information. Prognosis is sometimes more important than accurate eGFR #NephJC
July 23, 2025 at 1:52 AM
But if the Cys eGFR and the eGFR diff provides prognostic information and you have that right there, since you need a cystatin C to get the combined eGFR why not harvest that information. Prognosis is sometimes more important than accurate eGFR #NephJC
exclusion criteria included indigo children, starseeds, empaths, arcturians, and eGFR < 30 mL/min
April 26, 2025 at 12:36 PM
exclusion criteria included indigo children, starseeds, empaths, arcturians, and eGFR < 30 mL/min
Creatinin bei 22 und eGFR bei 1,8 schon beeindruckend, kennt man ja normalerweise andersrum
October 11, 2025 at 4:26 PM
Creatinin bei 22 und eGFR bei 1,8 schon beeindruckend, kennt man ja normalerweise andersrum
FDA-approved EGFR inhibitors in lung cancer!
#LungCancer #EGFR #Oncology
@oncoalert.bsky.social
@oncbrothers.bsky.social @stephenvliu.bsky.social @theaacr.bsky.social
#LungCancer #EGFR #Oncology
@oncoalert.bsky.social
@oncbrothers.bsky.social @stephenvliu.bsky.social @theaacr.bsky.social
December 7, 2024 at 11:17 AM
FDA-approved EGFR inhibitors in lung cancer!
#LungCancer #EGFR #Oncology
@oncoalert.bsky.social
@oncbrothers.bsky.social @stephenvliu.bsky.social @theaacr.bsky.social
#LungCancer #EGFR #Oncology
@oncoalert.bsky.social
@oncbrothers.bsky.social @stephenvliu.bsky.social @theaacr.bsky.social
An inherited genetic mutation may increase lung cancer risk among people who have never smoked, according to a new Science study.
Learn more in this week’s issue: https://scim.ag/3Td6qQV
Learn more in this week’s issue: https://scim.ag/3Td6qQV
September 17, 2026 at 6:05 PM
An inherited genetic mutation may increase lung cancer risk among people who have never smoked, according to a new Science study.
Learn more in this week’s issue: https://scim.ag/3Td6qQV
Learn more in this week’s issue: https://scim.ag/3Td6qQV
Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
https://go.nature.com/4k6SCQD
https://go.nature.com/4k6SCQD
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures - Nature
We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 deletion.
go.nature.com
February 20, 2025 at 2:49 PM
Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
https://go.nature.com/4k6SCQD
https://go.nature.com/4k6SCQD
EGFR Positive Lung Cancer UK - One story can change medical practice
@egfrpositiveuk.bsky.social
oncodaily.com/blog/egfr-po...
#Cancer #CancerResearch #LungCancer #EGFR #LCSM #Medicine #Health #Oncology #OncoDaily
@egfrpositiveuk.bsky.social
oncodaily.com/blog/egfr-po...
#Cancer #CancerResearch #LungCancer #EGFR #LCSM #Medicine #Health #Oncology #OncoDaily
One story can change medical practice - EGFR Positive Lung Cancer UK - OncoDaily
One story can change medical practice - EGFR Positive Lung Cancer UK / cancer, EGFR Positive Lung Cancer UK, Lung cancer, OncoDaily, Oncology
oncodaily.com
March 22, 2025 at 7:59 PM
EGFR Positive Lung Cancer UK - One story can change medical practice
@egfrpositiveuk.bsky.social
oncodaily.com/blog/egfr-po...
#Cancer #CancerResearch #LungCancer #EGFR #LCSM #Medicine #Health #Oncology #OncoDaily
@egfrpositiveuk.bsky.social
oncodaily.com/blog/egfr-po...
#Cancer #CancerResearch #LungCancer #EGFR #LCSM #Medicine #Health #Oncology #OncoDaily
Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏
jitc.bmj.com/content/13/7...
jitc.bmj.com/content/13/7...
Allogeneic cetuximab-armed gamma delta T cells using antibody-cell conjugation technology for the treatment of EGFR-expressing solid tumors
Background Targeting epidermal growth factor receptor (EGFR) has become a strategic approach in cancer therapy, using various modalities including chimeric antigen receptor (CAR)-αβT cell therapies. D...
jitc.bmj.com
September 12, 2025 at 5:18 AM
Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏
jitc.bmj.com/content/13/7...
jitc.bmj.com/content/13/7...
Tirzepatide decreased CVD death or worsening heart failure in HFpEF+obesity in SUMMIT; baseline eGFR 56, 58% CKD3, 33% albuminuria) Tirzepatide (vs placebo) lowered SBP -5mmHg, blood vol, CRP 37%, ACR 25%, ntproBNP 11%. Increased eGFR 2.9 at 52wks w/slight initial dip
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 19, 2025 at 3:14 PM
Tirzepatide decreased CVD death or worsening heart failure in HFpEF+obesity in SUMMIT; baseline eGFR 56, 58% CKD3, 33% albuminuria) Tirzepatide (vs placebo) lowered SBP -5mmHg, blood vol, CRP 37%, ACR 25%, ntproBNP 11%. Increased eGFR 2.9 at 52wks w/slight initial dip
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An inherited genetic mutation may increase lung cancer risk among people who have never smoked, with carriers of the rare EGFR T790M variant facing roughly 25 times the risk of lung cancer overall and 62 times the risk among never-smokers, according to a new study in Science. https://scim.ag/4yDSuP2
Germline EGFR T790M mutation and lung cancer risk
Most lung cancers are tobacco related, with genetic factors influencing smoking behavior identified through genome-wide association studies. However, inherited risk in familial and non-smoking-related...
scim.ag
September 22, 2026 at 7:57 PM
An inherited genetic mutation may increase lung cancer risk among people who have never smoked, with carriers of the rare EGFR T790M variant facing roughly 25 times the risk of lung cancer overall and 62 times the risk among never-smokers, according to a new study in Science. https://scim.ag/4yDSuP2
You say "happy birthday," I say "Another year older, another loss of 0.9 ml/min of eGFR"
September 19, 2025 at 3:41 PM
You say "happy birthday," I say "Another year older, another loss of 0.9 ml/min of eGFR"
There is a particular style of understatement that exists only in scientific writing.
February 15, 2025 at 4:59 AM
There is a particular style of understatement that exists only in scientific writing.
Not all EGFR mutations are the same - Eric K. Singhi
@lungoncdoc.bsky.social
oncodaily.com/blog/246541
#Cancer #Medicine #Health #LungCancer #EGFR #Mutation #Oncology #OncoDaily
@lungoncdoc.bsky.social
oncodaily.com/blog/246541
#Cancer #Medicine #Health #LungCancer #EGFR #Mutation #Oncology #OncoDaily
Eric K. Singhi: Not all EGFR mutations are the same - OncoDaily
Eric K. Singhi: Not all EGFR mutations are the same / cancer, EGFR Mutations, Eric K. Singhi, OncoDaily, Oncology, Xiuning Le
oncodaily.com
February 22, 2025 at 1:14 PM
Not all EGFR mutations are the same - Eric K. Singhi
@lungoncdoc.bsky.social
oncodaily.com/blog/246541
#Cancer #Medicine #Health #LungCancer #EGFR #Mutation #Oncology #OncoDaily
@lungoncdoc.bsky.social
oncodaily.com/blog/246541
#Cancer #Medicine #Health #LungCancer #EGFR #Mutation #Oncology #OncoDaily
don't interrupt me, i'm doing important work!!*
*reverse engineering how some researchers used the wrong formula AND the wrong constants to calculate eGFR in a clinical trial
pubpeer.com/publications...
*reverse engineering how some researchers used the wrong formula AND the wrong constants to calculate eGFR in a clinical trial
pubpeer.com/publications...
November 3, 2025 at 4:53 PM
don't interrupt me, i'm doing important work!!*
*reverse engineering how some researchers used the wrong formula AND the wrong constants to calculate eGFR in a clinical trial
pubpeer.com/publications...
*reverse engineering how some researchers used the wrong formula AND the wrong constants to calculate eGFR in a clinical trial
pubpeer.com/publications...
Real-World Study of EGFR-TKI Rechallenge With Another TKI After 1st line Osimertinib Discontinuation
“EGFR-TKI rechallenge with another TKI is well tolerated in patients with EGFR-mutated NSCLC.”
onlinelibrary.wiley.com/doi/10.1111/...
“EGFR-TKI rechallenge with another TKI is well tolerated in patients with EGFR-mutated NSCLC.”
onlinelibrary.wiley.com/doi/10.1111/...
Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis of the Reiwa Study
This subset analysis of a multicenter prospective observational study (Reiwa) shows that EGFR-TKI rechallenge with another TKI is well tolerated in patients with EGFR-mutated NSCLC, especially those ....
onlinelibrary.wiley.com
December 9, 2024 at 1:04 AM
Real-World Study of EGFR-TKI Rechallenge With Another TKI After 1st line Osimertinib Discontinuation
“EGFR-TKI rechallenge with another TKI is well tolerated in patients with EGFR-mutated NSCLC.”
onlinelibrary.wiley.com/doi/10.1111/...
“EGFR-TKI rechallenge with another TKI is well tolerated in patients with EGFR-mutated NSCLC.”
onlinelibrary.wiley.com/doi/10.1111/...
