Lymphatic ERG Governs Junctional Plasticity and Fluid Clearance via an EDNRB Signaling Axis in Pulmonary Fibrosis https://www.biorxiv.org/content/10.64898/2026.09.17.752506v1
September 24, 2026 at 12:30 AM
Lymphatic ERG Governs Junctional Plasticity and Fluid Clearance via an EDNRB Signaling Axis in Pulmonary Fibrosis https://www.biorxiv.org/content/10.64898/2026.09.17.752506v1
Lymphatic ERG Governs Junctional Plasticity and Fluid Clearance via an EDNRB Signaling Axis in Pulmonary Fibrosis https://www.biorxiv.org/content/10.64898/2026.09.17.752506v1
September 24, 2026 at 12:30 AM
Lymphatic ERG Governs Junctional Plasticity and Fluid Clearance via an EDNRB Signaling Axis in Pulmonary Fibrosis https://www.biorxiv.org/content/10.64898/2026.09.17.752506v1
Nicotinamide opposes ET-1's adverse effect on uterine decidualization via EDNRB https://www.biorxiv.org/content/10.1101/2025.09.18.677237v1
September 19, 2025 at 11:31 PM
Nicotinamide opposes ET-1's adverse effect on uterine decidualization via EDNRB https://www.biorxiv.org/content/10.1101/2025.09.18.677237v1
The authors included RRIDs in their in Molecular Oncology paper! RRIDs improve reproducibility in scientific research. #RRID #reproducibility #OpenScience
EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas
Read the full paper: EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas
doi.org
April 29, 2026 at 7:00 AM
The authors included RRIDs in their in Molecular Oncology paper! RRIDs improve reproducibility in scientific research. #RRID #reproducibility #OpenScience
On the bright side, there are potentially some rather promising therapies to reverse graying... possibly.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
March 23, 2025 at 7:05 AM
On the bright side, there are potentially some rather promising therapies to reverse graying... possibly.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
RRIDs were included in this in Cancer Medicine paper. Thanks for making your methods matter! #OpenResearch #accelerateopenscience #OpenScience
Role of Ca2+‐Dependent Epithelial‐Mesenchymal Transition in Malignant Progression of Colorectal Cancer: Special Focus on REG Iα/EDNRB
Read the full paper: Role of Ca2+‐Dependent Epithelial‐Mesenchymal Transition in Malignant Progression of Colorectal Cancer: Special Focus on REG Iα/EDNRB
doi.org
April 16, 2026 at 7:11 AM
RRIDs were included in this in Cancer Medicine paper. Thanks for making your methods matter! #OpenResearch #accelerateopenscience #OpenScience
RRIDs were included in this None paper. Thanks for making your methods matter! #OpenScience #OpenScience #reproducibility
Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas
doi.org
September 17, 2025 at 7:00 AM
RRIDs were included in this None paper. Thanks for making your methods matter! #OpenScience #OpenScience #reproducibility
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #methodsmatter #STMpublishing #ReproducibleResearch
Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease
doi.org
October 24, 2025 at 7:01 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #methodsmatter #STMpublishing #ReproducibleResearch
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #STMpublishing #OpenScience #RRID
Joint disruption of Ret and Ednrb transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung disease
doi.org
November 29, 2025 at 8:01 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #STMpublishing #OpenScience #RRID
BD Biosciences's resource, RRID:AB_394656, was just reported to be used in "An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis". Thank you for making your methods matter! #RRID #accelerateopenscience
doi.org
April 9, 2025 at 7:00 AM
BD Biosciences's resource, RRID:AB_394656, was just reported to be used in "An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis". Thank you for making your methods matter! #RRID #accelerateopenscience
Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome https://www.biorxiv.org/content/10.1101/2023.10.27.564370v1
Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome https://www.biorxiv.org/content/10.1101/2023.10.27.564370v1
Mutations in the human genes encoding the endothelin ligand-receptor pair EDN3 and EDNRB cause Waard
www.biorxiv.org
October 28, 2023 at 6:31 AM
Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome https://www.biorxiv.org/content/10.1101/2023.10.27.564370v1
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
May 7, 2025 at 4:00 PM
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.03.04.641483v1
https://www.biorxiv.org/content/10.1101/2025.03.04.641483v1
March 11, 2025 at 4:48 PM
Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.03.04.641483v1
https://www.biorxiv.org/content/10.1101/2025.03.04.641483v1
#JournalClub
"Ian Folkert and and colleagues show that iron-rich tumor-associated macrophages shape anti-tumor immunity — pointing to a promising new target to boost immunotherapy responses." - Marc Guasch, PhD student
rupress.org/jem/article/...
"Ian Folkert and and colleagues show that iron-rich tumor-associated macrophages shape anti-tumor immunity — pointing to a promising new target to boost immunotherapy responses." - Marc Guasch, PhD student
rupress.org/jem/article/...
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis | Journal of Experimental Medicine | Rockefeller University Press
rupress.org
April 24, 2025 at 4:28 PM
#JournalClub
"Ian Folkert and and colleagues show that iron-rich tumor-associated macrophages shape anti-tumor immunity — pointing to a promising new target to boost immunotherapy responses." - Marc Guasch, PhD student
rupress.org/jem/article/...
"Ian Folkert and and colleagues show that iron-rich tumor-associated macrophages shape anti-tumor immunity — pointing to a promising new target to boost immunotherapy responses." - Marc Guasch, PhD student
rupress.org/jem/article/...
Joint disruption of Ret and Ednrb transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung disease
https://littlebunker.com/2025/10/29/research_papers-joint-disruption-of-ret-and-ed-ae7bf921/
https://littlebunker.com/2025/10/29/research_papers-joint-disruption-of-ret-and-ed-ae7bf921/
October 29, 2025 at 9:37 PM
Joint disruption of Ret and Ednrb transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung disease
https://littlebunker.com/2025/10/29/research_papers-joint-disruption-of-ret-and-ed-ae7bf921/
https://littlebunker.com/2025/10/29/research_papers-joint-disruption-of-ret-and-ed-ae7bf921/
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
May 7, 2025 at 2:47 PM
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas https://www.biorxiv.org/content/10.1101/2025.09.05.674570v1
September 11, 2025 at 11:48 AM
Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas https://www.biorxiv.org/content/10.1101/2025.09.05.674570v1
Finally, this has implications for gene annotation. There is ever more evidence for these isoforms and some have already become the main isoform.
If this happens, the N-terminal ext. may get tagged with spurious pathogenic mutations (as in PUS1, TMCO1 and EDNRB) that will be hard to correct.
If this happens, the N-terminal ext. may get tagged with spurious pathogenic mutations (as in PUS1, TMCO1 and EDNRB) that will be hard to correct.
December 15, 2025 at 3:09 PM
Finally, this has implications for gene annotation. There is ever more evidence for these isoforms and some have already become the main isoform.
If this happens, the N-terminal ext. may get tagged with spurious pathogenic mutations (as in PUS1, TMCO1 and EDNRB) that will be hard to correct.
If this happens, the N-terminal ext. may get tagged with spurious pathogenic mutations (as in PUS1, TMCO1 and EDNRB) that will be hard to correct.
To avoid the circular annotation of bogus ClinVar pathogenic variants, the annotation of these non-conserved upstream translations must be handled with care.
Here are two annotated signal-peptide displacing examples that are already annotated with imaginary pathogenic variations (TMCO1 and EDNRB).
Here are two annotated signal-peptide displacing examples that are already annotated with imaginary pathogenic variations (TMCO1 and EDNRB).
November 28, 2024 at 9:17 AM
To avoid the circular annotation of bogus ClinVar pathogenic variants, the annotation of these non-conserved upstream translations must be handled with care.
Here are two annotated signal-peptide displacing examples that are already annotated with imaginary pathogenic variations (TMCO1 and EDNRB).
Here are two annotated signal-peptide displacing examples that are already annotated with imaginary pathogenic variations (TMCO1 and EDNRB).
Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease https://www.biorxiv.org/content/10.1101/2025.03.04.641483v1
March 11, 2025 at 10:34 AM
Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease https://www.biorxiv.org/content/10.1101/2025.03.04.641483v1
Nicotinamide opposes ET-1's adverse effect on uterine decidualization via EDNRB https://www.biorxiv.org/content/10.1101/2025.09.18.677237v1
September 19, 2025 at 11:31 PM
Nicotinamide opposes ET-1's adverse effect on uterine decidualization via EDNRB https://www.biorxiv.org/content/10.1101/2025.09.18.677237v1
Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development https://www.biorxiv.org/content/10.1101/2024.02.13.580135v1
Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development https://www.biorxiv.org/content/10.1101/2024.02.13.580135v1
Two major ligand-receptor signaling axes - endothelin Edn3 and its receptor Ednrb, and glial-derived
www.biorxiv.org
February 14, 2024 at 4:36 PM
Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development https://www.biorxiv.org/content/10.1101/2024.02.13.580135v1
Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas https://www.biorxiv.org/content/10.1101/2025.09.05.674570v1
September 11, 2025 at 11:48 AM
Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas https://www.biorxiv.org/content/10.1101/2025.09.05.674570v1
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1
May 7, 2025 at 2:47 PM
Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations https://www.biorxiv.org/content/10.1101/2025.04.30.651587v1