November 18, 2025 at 11:32 AM
📣 Massively proud of this ⬇️ great study, led by the brilliant @mesny.bsky.social surprisingly uncovering that many pathogen effectors stem from ancient antimicrobials 🤯 #EffectorWisdom #EvoMPMI
📣 NEW PREPRINT 📝
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
Plant-associated fungi co-opt ancient antimicrobials for host manipulation
Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, ...
www.biorxiv.org
August 15, 2025 at 7:58 AM
📣 Massively proud of this ⬇️ great study, led by the brilliant @mesny.bsky.social surprisingly uncovering that many pathogen effectors stem from ancient antimicrobials 🤯 #EffectorWisdom #EvoMPMI
Rewinding the tape: historical contingency and functional constraints have shaped the evolution of APikL virulence effectors in the blast fungus https://www.biorxiv.org/content/10.1101/2025.08.12.669671v1
August 12, 2025 at 9:41 PM
Kudos Madhu @JMadhuprakash, Mau @mpcontreras4 and the whole team for this beautiful structure and study! 😍 #EffectorWisdom #NLRbiology #PlantSci
Thrilled to share our latest preprint! This work started during my PhD and was finished together with @jmadhuprakash.bsky.social. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity!
www.biorxiv.org/content/10.1...
1/15
www.biorxiv.org/content/10.1...
1/15
July 9, 2025 at 4:37 PM
Kudos Madhu @JMadhuprakash, Mau @mpcontreras4 and the whole team for this beautiful structure and study! 😍 #EffectorWisdom #NLRbiology #PlantSci
We’re excited to share our latest work on plant pathogen effector protein evolution @biorxivpreprint.bsky.social. With @kamounlab.bsky.social and Abbas Maqbool.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rewinding the tape: historical contingency and functional constraints have shaped the evolution of APikL virulence effectors in the blast fungus
Protein evolution is influenced by historical contingencies and functional constraints, but their combined impact on rapidly diversifying pathogen virulence effectors remains poorly understood. Here, ...
www.biorxiv.org
August 13, 2025 at 3:08 PM
An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity https://www.biorxiv.org/content/10.1101/2025.07.06.663370v1
July 8, 2025 at 6:32 PM
Our model: Once activated, dissociated NRC protomers assemble in a stepwise manner to form a full hexameric resistosome. AVRcap1b blocks this process, capturing NRC assembly intermediates and relocating them via the TOL-ESCRT pathway.
Effector biology rocks! #EffectorWisdom
8/10
Effector biology rocks! #EffectorWisdom
8/10
July 16, 2025 at 12:27 PM
Our model: Once activated, dissociated NRC protomers assemble in a stepwise manner to form a full hexameric resistosome. AVRcap1b blocks this process, capturing NRC assembly intermediates and relocating them via the TOL-ESCRT pathway.
Effector biology rocks! #EffectorWisdom
8/10
Effector biology rocks! #EffectorWisdom
8/10
Wonderful news to see our basic research on the effector targets sHMA make it into GE field trials. Kudos Team #BLASTOFF #openriceblast #effectorwisdom @ThorstenLangner @ryoheiterauchi @vittoriabr www.nature.com/articles/d43...
Green shoots of hope for Italy’s first gene-edited crop field trial
Temporary relaxing of regulations brings request for outdoor trial of fungus-resistant rice variety. Temporary relaxing of regulations brings request for outdoor trial of fungus-resistant rice variety...
www.nature.com
February 1, 2024 at 8:44 AM
Wonderful news to see our basic research on the effector targets sHMA make it into GE field trials. Kudos Team #BLASTOFF #openriceblast #effectorwisdom @ThorstenLangner @ryoheiterauchi @vittoriabr www.nature.com/articles/d43...
Quizás, Quizás, Quizás #EffectorWisdom youtu.be/CmLNM6WHUHc?...
Gaby Moreno - "Quizás, Quizás, Quizás" | LIVE at The Kennedy Center
Gaby Moreno performs "Quizás, Quizás, Quizás" LIVE at the Kennedy Center.Watch the full concert: https://www.youtube.com/watch?v=qkBexC-n0DsSubscribe to The ...
youtu.be
March 12, 2024 at 3:25 AM
Quizás, Quizás, Quizás #EffectorWisdom youtu.be/CmLNM6WHUHc?...
🎶 Oh, it’s cryo-time again, you're gonna freeze me
I can see that vitreous glint in your eyes
I can tell by the way you purified me, darling — ooh
That it won’t be long before it’s cryo-time ❄️🧊🧬
#NLRbiology #EffectorWisdom
youtu.be/QqC_X3ZXyXY?...
I can see that vitreous glint in your eyes
I can tell by the way you purified me, darling — ooh
That it won’t be long before it’s cryo-time ❄️🧊🧬
#NLRbiology #EffectorWisdom
youtu.be/QqC_X3ZXyXY?...
Ray Charles - Crying Time (Official Lyric Video)
YouTube video by Ray Charles
youtu.be
August 7, 2025 at 3:54 PM
🎶 Oh, it’s cryo-time again, you're gonna freeze me
I can see that vitreous glint in your eyes
I can tell by the way you purified me, darling — ooh
That it won’t be long before it’s cryo-time ❄️🧊🧬
#NLRbiology #EffectorWisdom
youtu.be/QqC_X3ZXyXY?...
I can see that vitreous glint in your eyes
I can tell by the way you purified me, darling — ooh
That it won’t be long before it’s cryo-time ❄️🧊🧬
#NLRbiology #EffectorWisdom
youtu.be/QqC_X3ZXyXY?...
What do effectors do?
1. Inhibit...
2. Activate/co-opt...
3. Connect/short-circuit...
..Effector-Targeted Pathway(s).
#EffectorWisdom #plantpath #plantsci
1. Inhibit...
2. Activate/co-opt...
3. Connect/short-circuit...
..Effector-Targeted Pathway(s).
#EffectorWisdom #plantpath #plantsci
September 26, 2023 at 3:15 PM
What do effectors do?
1. Inhibit...
2. Activate/co-opt...
3. Connect/short-circuit...
..Effector-Targeted Pathway(s).
#EffectorWisdom #plantpath #plantsci
1. Inhibit...
2. Activate/co-opt...
3. Connect/short-circuit...
..Effector-Targeted Pathway(s).
#EffectorWisdom #plantpath #plantsci