General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

Aviation News – A Cessna F172P, registered PH-WMA, crashed in a field near Gerderath, close to Erkelenz, Germany, killing all three people on board. The aircraft was destroyed in the accident, while the circumstances surrounding the crash remain unknown. The aircraft had departed Hilversum Airfield (EHHV) in the Netherlands at 10:24 hours. It was operating a flight that later ended in the field at Gerderath, although further details about the flight path and the events leading up to the accident have not yet been established.

Endogenous human herpesvirus 6 (eHHV-6), in which the entire viral genome is integrated into human chromosomes, is present in approximately 1% of the population and has been associated with various clinical conditions, including neurological disorders. However, its biological significance remains unclear due to the lack of appropriate experimental models.MethodsWe established a patient-derived induced pluripotent stem cell (iPSC)–based tissue culture model using lymphoblastoid cell lines from individuals with eHHV-6B. iPSCs retaining the integrated viral genome were generated and subsequently differentiated into neural stem cells (NSCs). Viral gene expression was evaluated by RT-qPCR under basal conditions and following chemical stimulation.ResultsThe integrated HHV-6B genome was transcriptionally silent in iPSCs but exhibited spontaneous low-level expression of the immediate-early gene U90 and the late gene U100 in NSCs. Chemical stimulation further enhanced U90 expression, whereas induction of U100 did not reach statistical significance. These findings indicate preferential activation of early viral transcriptional programs in neural lineage cells.ConclusionsNeural lineage cells provide a permissive environment for expression of eHHV-6B transcripts. This patient-derived iPSC-based model provides a platform for investigating the biological significance of neural lineage-specific eHHV-6 transcripts and may facilitate interpretation of HHV-6 DNA detection in patients with eHHV-6 by enabling studies of cell type-dependent viral transcription.

Published in Nature genetics

The detection of anellovirus or eHHV-6B genomes in the blood virome seems to correlate with the risk or severity of rheumatic diseases and COVID-19.

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic ...

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic ...

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

General weather, closest aviation weather, Maps, hotels and aeronautical information for Hilversum airport (Netherlands)

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic ...

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic ...