AbstractAims. Central insulin has been shown to regulate eating behavior and cognitive processes in a sex-specific manner. Besides memory, the hippocampus

AbstractContext. Statin treatment lowers low-density lipoprotein (LDL) cholesterol thereby reducing cardiovascular risk. Meta-analyses of clinical trials r

AbstractIntroduction. Patients with Cushing’s syndrome (CS) suffer from metabolic and cardio-vascular comorbidities caused by hypercortisolism. The human g

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AbstractContext. Hip fractures incur high morbidity and mortality. Data on secular trends in mortality from hip fractures and risk predictive models are sc

AbstractContext. Trabecular bone score (TBS), a gray-level texture index derived from lumbar spine (LS) dual-energy x-ray absorptiometry (DXA) scans, is de

AbstractContext. Experimental evidence indicates that resistin, an adipokine, negatively impacts muscle metabolism by hindering myogenesis.Objective. To ex

Abstract. Type 1 diabetes (T1D) results from the autoimmune destruction of the insulin-producing β cells. Genetic factors account for approximately 50% of

Abstract. Diabetes is associated with increased atherosclerotic cardiovascular disease (ASCVD) risk, a leading cause of morbidity and mortality. Disordered

AbstractContext. Women with preexisting diabetes mellitus (PDM) are at increased risk of pregnancy-related complications.Objective. To summarize the availa

Abstract. Pathologic hypogonadism occurs when serum testosterone is significantly and persistently reduced by irreversible organic (structural, genetic) di

AbstractContext/Objective. Diabetes mellitus (DM), a possible adverse effect of childhood cancer treatment, is strongly associated with cardiovascular dise

Denham, J. & Spencer, S. J. Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations. Am. J. Physiol. Endocrinol. Metab. 319, E320–E329 (2020). Zaborowski, M. P., Balaj, L., Breakefield, X. O. & Lai, C. P. Extracellular vesicles: composition, biological relevance, and methods of study. Bioscience 65, 783–797 (2015). Nair, V. D. et al. Sedentary and trained older men have distinct circulating exosomal microRNA profiles at baseline and in response to acute exercise. Front. Physiol. 11, 605 (2020). Vanderboom, P. M. et al. A size-exclusion-based approach for purifying extracellular vesicles from human plasma. Cell Rep. Methods 1, 100055 (2021). Bei, Y. et al. Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury. Basic Res. Cardiol. 112, 38 (2017). Safdar, A., Saleem, A. & Tarnopolsky, M. A. The potential of endurance exercise-derived exosomes to treat metabolic diseases. Nat. Rev. Endocrinol. 12, 504–517 (2016). Pegtel, D. M. et al. Functional delivery of viral miRNAs via exosomes. Proc. Natl Acad. Sci. USA 107, 6328–6333 (2010). Herranz, H. & Cohen, S. M. MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev. 24, 1339–1344 (2010). Arner, P. & Kulyté, A. MicroRNA regulatory networks in human adipose tissue...

AbstractContext. Menopause is thought to have beneficial effects in women with prolactinoma, potentially offering a higher chance for successful dopamine a

AbstractContext. Intermuscular adipose tissue (IMAT) at different anatomical locations may exert distinct effects on cardiometabolic risk.Objective. The pr