Endolysin LysSte134_1 Reduces Staphylococcus Bacterial Load in Infected Wounds In Vivo
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t.co
September 26, 2026 at 11:05 AM
Endolysin LysSte134_1 Reduces Staphylococcus Bacterial Load in Infected Wounds In Vivo
#Antibiotics administered together with the enzyme endolysin from bacteriophages protect against infection by resistant bacteria in all bodily organs in mice – including the brain, which antibiotics alone have difficulty reaching. Study published in Molecular Medicine 🧪 news.ki.se/researchers-...
Researchers restore antibiotic effect in the event of resistance
Bacterial resistance negates the effect of antibiotics in the treatment of infection. Using mouse models, researchers now show that if antibiotics are administered with an enzyme called endolysin, the...
news.ki.se
May 7, 2025 at 3:36 PM
#Antibiotics administered together with the enzyme endolysin from bacteriophages protect against infection by resistant bacteria in all bodily organs in mice – including the brain, which antibiotics alone have difficulty reaching. Study published in Molecular Medicine 🧪 news.ki.se/researchers-...
Removing an S-layer enables endolysin-derived probes to detect Paenibacillus thiaminolyticus in mixed bacterial populations https://www.biorxiv.org/content/10.64898/2026.09.23.753664v1
September 24, 2026 at 10:16 PM
Removing an S-layer enables endolysin-derived probes to detect Paenibacillus thiaminolyticus in mixed bacterial populations https://www.biorxiv.org/content/10.64898/2026.09.23.753664v1
New paper from the CEB- @uminho.bsky.social & APC
𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞 𝐝𝐞𝐥𝐢𝐯𝐞𝐫𝐲 𝐨𝐟 𝐚𝐧 𝐚𝐧𝐭𝐢-𝐋𝐢𝐬𝐭𝐞𝐫𝐢𝐚 𝐞𝐧𝐝𝐨𝐥𝐲𝐬𝐢𝐧 𝐯𝐢𝐚 𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐞𝐝 𝐩𝐫𝐨𝐛𝐢𝐨𝐭𝐢𝐜 𝑺𝒂𝒄𝒄𝒉𝒂𝒓𝒐𝒎𝒚𝒄𝒆𝒔 𝒃𝒐𝒖𝒍𝒂𝒓𝒅𝒊𝒊
Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social
𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞 𝐝𝐞𝐥𝐢𝐯𝐞𝐫𝐲 𝐨𝐟 𝐚𝐧 𝐚𝐧𝐭𝐢-𝐋𝐢𝐬𝐭𝐞𝐫𝐢𝐚 𝐞𝐧𝐝𝐨𝐥𝐲𝐬𝐢𝐧 𝐯𝐢𝐚 𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐞𝐝 𝐩𝐫𝐨𝐛𝐢𝐨𝐭𝐢𝐜 𝑺𝒂𝒄𝒄𝒉𝒂𝒓𝒐𝒎𝒚𝒄𝒆𝒔 𝒃𝒐𝒖𝒍𝒂𝒓𝒅𝒊𝒊
Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social
March 3, 2026 at 8:13 AM
New paper from the CEB- @uminho.bsky.social & APC
𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞 𝐝𝐞𝐥𝐢𝐯𝐞𝐫𝐲 𝐨𝐟 𝐚𝐧 𝐚𝐧𝐭𝐢-𝐋𝐢𝐬𝐭𝐞𝐫𝐢𝐚 𝐞𝐧𝐝𝐨𝐥𝐲𝐬𝐢𝐧 𝐯𝐢𝐚 𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐞𝐝 𝐩𝐫𝐨𝐛𝐢𝐨𝐭𝐢𝐜 𝑺𝒂𝒄𝒄𝒉𝒂𝒓𝒐𝒎𝒚𝒄𝒆𝒔 𝒃𝒐𝒖𝒍𝒂𝒓𝒅𝒊𝒊
Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social
𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞 𝐝𝐞𝐥𝐢𝐯𝐞𝐫𝐲 𝐨𝐟 𝐚𝐧 𝐚𝐧𝐭𝐢-𝐋𝐢𝐬𝐭𝐞𝐫𝐢𝐚 𝐞𝐧𝐝𝐨𝐥𝐲𝐬𝐢𝐧 𝐯𝐢𝐚 𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐞𝐝 𝐩𝐫𝐨𝐛𝐢𝐨𝐭𝐢𝐜 𝑺𝒂𝒄𝒄𝒉𝒂𝒓𝒐𝒎𝒚𝒄𝒆𝒔 𝒃𝒐𝒖𝒍𝒂𝒓𝒅𝒊𝒊
Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social
Removing an S-layer enables endolysin-derived probes to detect Paenibacillus thiaminolyticus in mixed bacterial populations https://www.biorxiv.org/content/10.64898/2026.09.23.753664v1
September 24, 2026 at 10:16 PM
Removing an S-layer enables endolysin-derived probes to detect Paenibacillus thiaminolyticus in mixed bacterial populations https://www.biorxiv.org/content/10.64898/2026.09.23.753664v1
improved #bovine #mastitis treatment using designer #endolysin in #streptococcus uberis #mouse model
#Researchpaper with E. Meyer in @SpringerMicBio :
bit.ly/LysinMastitis
#antibiotic #bacteria #infectious #disease #sustainable #agriculture
#phage #protein #engineering
#Researchpaper with E. Meyer in @SpringerMicBio :
bit.ly/LysinMastitis
#antibiotic #bacteria #infectious #disease #sustainable #agriculture
#phage #protein #engineering
February 1, 2024 at 12:26 PM
improved #bovine #mastitis treatment using designer #endolysin in #streptococcus uberis #mouse model
#Researchpaper with E. Meyer in @SpringerMicBio :
bit.ly/LysinMastitis
#antibiotic #bacteria #infectious #disease #sustainable #agriculture
#phage #protein #engineering
#Researchpaper with E. Meyer in @SpringerMicBio :
bit.ly/LysinMastitis
#antibiotic #bacteria #infectious #disease #sustainable #agriculture
#phage #protein #engineering
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
May 13, 2025 at 7:38 AM
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
Identification and characterization of the antigonococcal prophage-encoded endolysin Phi1gp518 https://www.biorxiv.org/content/10.64898/2026.07.09.737475v1
July 13, 2026 at 5:19 PM
Identification and characterization of the antigonococcal prophage-encoded endolysin Phi1gp518 https://www.biorxiv.org/content/10.64898/2026.07.09.737475v1
A novel enterococcus phage endolysin Lys22 with a wide host range against mixed biofilm of Enterococcus faecalis, Staphylococcus aureus and Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2025.03.11.642608v1
March 21, 2025 at 7:16 PM
A novel enterococcus phage endolysin Lys22 with a wide host range against mixed biofilm of Enterococcus faecalis, Staphylococcus aureus and Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2025.03.11.642608v1
Endolysin of Aeromonas bacteriophage 3: a novel Ca(2+)-activated peptidoglycan hydrolase giving insight into the regulation of phage lysis in Gram-negative bacteria.
DOI: 10.1016/j.ijbiomac.2025.146934
https://pubmed.ncbi.nlm.nih.gov/40825433/
DOI: 10.1016/j.ijbiomac.2025.146934
https://pubmed.ncbi.nlm.nih.gov/40825433/
Endolysin of Aeromonas bacteriophage 3: a novel Ca2+-activated peptidoglycan hydrolase giving insight into the regulation of phage lysis in Gram-negative bacteria - PubMed
A search for bacteriophage proteins with an EF-like calcium-binding loop, first discovered in the phage T5 endolysin (EndoT5), revealed a group of 71 peptidases of the M15_C subfamily. All the sequences found belonged to the phages infecting Gram-negative bacteria (Escherichia, Salmonella, Klebsiell …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 7:30 PM
Endolysin of Aeromonas bacteriophage 3: a novel Ca(2+)-activated peptidoglycan hydrolase giving insight into the regulation of phage lysis in Gram-negative bacteria.
DOI: 10.1016/j.ijbiomac.2025.146934
https://pubmed.ncbi.nlm.nih.gov/40825433/
DOI: 10.1016/j.ijbiomac.2025.146934
https://pubmed.ncbi.nlm.nih.gov/40825433/
Rebecca is now trying to clone the endolysin to determine these experimentally!
November 20, 2024 at 10:38 AM
Rebecca is now trying to clone the endolysin to determine these experimentally!
To escape their hosts, bacteriophages use endolysins to break down bacterial cell walls and spread to new targets.
For World Phage Day, our new #FEMSmicroBlog explores how the endolysin from a staphylococcal phage is optimized to kill its bacterial host. #FascinatingMicrobes
For World Phage Day, our new #FEMSmicroBlog explores how the endolysin from a staphylococcal phage is optimized to kill its bacterial host. #FascinatingMicrobes
#FEMSmicroBlog: Double trouble: How a Mini-Me endolysin isoform supercharges bacterial lysis
For World Phage Day, this #FEMSmicroBlog explores the endolysin from a staphylococcal phage, optimized to kill its bacterial host.
buff.ly
October 23, 2025 at 7:02 AM
To escape their hosts, bacteriophages use endolysins to break down bacterial cell walls and spread to new targets.
For World Phage Day, our new #FEMSmicroBlog explores how the endolysin from a staphylococcal phage is optimized to kill its bacterial host. #FascinatingMicrobes
For World Phage Day, our new #FEMSmicroBlog explores how the endolysin from a staphylococcal phage is optimized to kill its bacterial host. #FascinatingMicrobes
Phage N4 uses a SAR endolysin-holin system for host cell lysis https://www.biorxiv.org/content/10.1101/2025.11.12.688109v1
November 13, 2025 at 1:16 AM
Phage N4 uses a SAR endolysin-holin system for host cell lysis https://www.biorxiv.org/content/10.1101/2025.11.12.688109v1
New in JB: Chandramowli, Devreese et al. explore how Abx can drive vesicle formation in S. maltophilia via the maltocin endolysin (mal), resulting in single layer OMVs that include cytoplasmic proteins.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol @microsky.bsky.social
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol @microsky.bsky.social
August 17, 2026 at 2:22 PM
New in JB: Chandramowli, Devreese et al. explore how Abx can drive vesicle formation in S. maltophilia via the maltocin endolysin (mal), resulting in single layer OMVs that include cytoplasmic proteins.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol @microsky.bsky.social
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriol @microsky.bsky.social
The excitement continues! Check out my latest preprint examining how phages have adapted to lyse different bacterial envelopes. I found a lysis gene (lysZ) that is conserved in phages that infect corynebacteria mycobacteria, and other actinos.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
Most bacteriophages lyse their host cell to release progeny virions. Double-stranded DNA phages typically promote host lysis using a holin-endolysin system. Holins form pores in the cytoplasmic membra...
www.biorxiv.org
June 25, 2025 at 3:49 PM
The excitement continues! Check out my latest preprint examining how phages have adapted to lyse different bacterial envelopes. I found a lysis gene (lysZ) that is conserved in phages that infect corynebacteria mycobacteria, and other actinos.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🎉 New publication from the #MIBIREM project by our partner #Ghent University in the Journal of Bacteriology on bacterial stress responses & vesicle formation.
Congrats to LM-UGent team!
📖 zenodo.org/records/2146...
#Microbiology #SoilHealth #Bioremediation #Science @scienceinnovation.ec.europa.eu
Congrats to LM-UGent team!
📖 zenodo.org/records/2146...
#Microbiology #SoilHealth #Bioremediation #Science @scienceinnovation.ec.europa.eu
July 21, 2026 at 9:41 AM
🎉 New publication from the #MIBIREM project by our partner #Ghent University in the Journal of Bacteriology on bacterial stress responses & vesicle formation.
Congrats to LM-UGent team!
📖 zenodo.org/records/2146...
#Microbiology #SoilHealth #Bioremediation #Science @scienceinnovation.ec.europa.eu
Congrats to LM-UGent team!
📖 zenodo.org/records/2146...
#Microbiology #SoilHealth #Bioremediation #Science @scienceinnovation.ec.europa.eu
Why do #phages make short #endolysin isoforms? 🧬🦠 Dunne team in @ethz.ch, using Staph φ2638A, reveals both full-length and short variants form heterodimers to boost lysis & phage release—explaining conserved internalTSSs in phage genomes!
buff.ly/1I0H9ya
buff.ly/1I0H9ya
July 18, 2025 at 12:02 PM
Why do #phages make short #endolysin isoforms? 🧬🦠 Dunne team in @ethz.ch, using Staph φ2638A, reveals both full-length and short variants form heterodimers to boost lysis & phage release—explaining conserved internalTSSs in phage genomes!
buff.ly/1I0H9ya
buff.ly/1I0H9ya
DNA damage-associated vesicle production in Stenotrophomonas maltophilia is mediated by a cryptic tailocin endolysin https://www.biorxiv.org/content/10.1101/2025.03.20.644284v1
March 21, 2025 at 3:16 AM
DNA damage-associated vesicle production in Stenotrophomonas maltophilia is mediated by a cryptic tailocin endolysin https://www.biorxiv.org/content/10.1101/2025.03.20.644284v1
Happy to announce that the second paper from the doctoral work of Akash Shambharkar describing two Proteus phage endolysins, is now available on the website of the journal Applied Microbiology and Biotechnology
doi.org/10.1007/s002...
#phage #endolysin #lysin
doi.org/10.1007/s002...
#phage #endolysin #lysin
doi.org
June 16, 2026 at 4:26 PM
Happy to announce that the second paper from the doctoral work of Akash Shambharkar describing two Proteus phage endolysins, is now available on the website of the journal Applied Microbiology and Biotechnology
doi.org/10.1007/s002...
#phage #endolysin #lysin
doi.org/10.1007/s002...
#phage #endolysin #lysin
🎯 𝗖𝗮𝗻 𝘄𝗲 𝗽𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻-𝗲𝗱𝗶𝘁 𝘁𝗵𝗲 𝗴𝘂𝘁 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 ? The gut microbiome plays a central role in digestion, immunity, and health. A new #NCCR Microbiomes study explores whether a #phage derived endolysin can selectively remove one of these bacteria without disturbing others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phage endolysin enables targeted manipulation of the small intestinal microbiota and uncovers niche overlap between oral and butyrate-producing taxa - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Phage endolysin enables targeted manipulation of the small intestinal microbiota and uncovers niche overlap between oral and butyrate-producing taxa
www.nature.com
July 16, 2026 at 8:37 AM
🎯 𝗖𝗮𝗻 𝘄𝗲 𝗽𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻-𝗲𝗱𝗶𝘁 𝘁𝗵𝗲 𝗴𝘂𝘁 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 ? The gut microbiome plays a central role in digestion, immunity, and health. A new #NCCR Microbiomes study explores whether a #phage derived endolysin can selectively remove one of these bacteria without disturbing others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New preprint from the lab led by Alex Dobrila!
We show that butyrate-dependent toxin release in C. difficile is mediated by a broadly-conserved endolysin (EndD), which is under the control of the sporulation sigma factor SigK. Excited to share this story! 👇
www.biorxiv.org/content/10.6...
We show that butyrate-dependent toxin release in C. difficile is mediated by a broadly-conserved endolysin (EndD), which is under the control of the sporulation sigma factor SigK. Excited to share this story! 👇
www.biorxiv.org/content/10.6...
EndD mediates butyrate-dependent toxin release in Clostridioides difficile
Clostridioides difficile is an urgent threat to human health. Current treatments for C. difficile infections (CDIs) are antibiotics and microbiome restoration therapy (MRT) for recurrent cases. Howeve...
www.biorxiv.org
June 24, 2026 at 2:28 PM
New preprint from the lab led by Alex Dobrila!
We show that butyrate-dependent toxin release in C. difficile is mediated by a broadly-conserved endolysin (EndD), which is under the control of the sporulation sigma factor SigK. Excited to share this story! 👇
www.biorxiv.org/content/10.6...
We show that butyrate-dependent toxin release in C. difficile is mediated by a broadly-conserved endolysin (EndD), which is under the control of the sporulation sigma factor SigK. Excited to share this story! 👇
www.biorxiv.org/content/10.6...
Phage Endolysin Enables Targeted Manipulation of the Small Intestinal Microbiota and Uncovers Niche Overlap Between Oral and Butyrate-Producing Taxa https://www.biorxiv.org/content/10.64898/2026.01.06.697609v1
January 6, 2026 at 7:16 PM
Phage Endolysin Enables Targeted Manipulation of the Small Intestinal Microbiota and Uncovers Niche Overlap Between Oral and Butyrate-Producing Taxa https://www.biorxiv.org/content/10.64898/2026.01.06.697609v1