Abstract. Plasmids are major drivers of bacterial horizontal gene transfer, including transfer of antimicrobial resistance. Plasmid dissemination extends b

A study led by researchers from the Germans Trias i Pujol Research Institute (IGTP) and the Blood and Tissue Bank (BST) has developed and validated a manufacturing platform for extracellular vesicles that meets pharmaceutical quality requirements, marking a key step toward their clinical application.

Nature Biomedical Engineering, Published online: 02 November 2026; doi:10.1038/s41551-026-01842-0Author Correction: Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues

A team from the Research Institute of the McGill University Health Center (The Institute) have discovered a new type of extracellular vesicle released by migrating cancer cells, revealing a previously...

Analyzing 515 clinical proteomes reveals that the plasma extracellular vesicle core is driven by a charge-based corona and physical co-isolation and identifies 8 distinct functional modules, reshaping...

Oncogenesis - Macrophage-mediated extracellular matrix remodeling awakens dormant breast cancer cells

BUFFALO, NY — October 29, 2026 — A new #research paper was #published in Volume 18 of Aging on October 8, 2026, titled “Small extracellular vesicles as mediators of paracrine senescence in cellular mo

A new technique to diagnose chronic inflammation developed at Nagoya University can read information from the surface and within individual extracellular vesicles in blood and urine.

Published in Proceedings of the National Academy of Sciences of the United States of America

Tsering et al. describe a class of extracellular vesicles called motile vesicles (MoVes) that is produced by migrating cancer cells, contains genomic DNA and includes organelles that can be transferre...

A new technique to diagnose chronic inflammation developed at Nagoya University can read information from the surface and within individual extracellular vesicles in blood and urine. This technique co...

Understanding how neural circuits generate behavior requires knowledge of both neural activity patterns and the cell types they originate from. While the scale of neuronal recordings has dramatically increased since the advent of dense multicontact probes, accurate identification of cell types remains elusive. Traditional approaches have used spike width to attempt a classification, with narrow spikes assumed to be inhibitory interneurons. However, fast pyramidal tract neurons (PTNs; known to be excitatory) with thin spikes and interneurons with wide spikes challenge these assumptions. Here we accomplish three related objectives. First, we produce a ground truth dataset of extracellular spike shapes from electrophysiologically identified pyramidal neurons from primary (M1) and supplementary motor areas (SMA) and optogenetically identified interneurons in M1 in female macaque monkeys. Next, we show that spike width correlates with antidromic latency not only in M1 but also in the SMA, suggesting that it is a physiologically meaningful measure across the motor cortex. Finally, we introduce our unsupervised ensemble clustering method, “ACORN,” and characterize its performance on our neocortical macaque dataset, the C4 cerebellar database, and a juxtacellularly recorded mouse dataset, demonstrating strong out-of-the-box performance across species, brain areas, and recording techniques. ACORN can cluster neuronal waveforms without training or tuning and provides data-derived confidence values for its predictions. Our ground truth data can be used as a reference to help identify or verify clusters in novel datasets. Together, our method and database provide a streamlined foundation for electrophysiological cell classification without necessitating changes to recording paradigms.

Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.