Harshi Peiris, Ph.D.
A gut bacterium is showing up — or rather disappearing — across all three phases of COVID-19.
🦠Severely ill patients have less of it.
🦠Recovered patients get it back.
🦠Long COVID patients don't.
Its name is Faecalibacterium prausnitzii. And what it does explains a lot. 👇
A gut bacterium is showing up — or rather disappearing — across all three phases of COVID-19.
🦠Severely ill patients have less of it.
🦠Recovered patients get it back.
🦠Long COVID patients don't.
Its name is Faecalibacterium prausnitzii. And what it does explains a lot. 👇
June 26, 2026 at 11:51 PM
Harshi Peiris, Ph.D.
A gut bacterium is showing up — or rather disappearing — across all three phases of COVID-19.
🦠Severely ill patients have less of it.
🦠Recovered patients get it back.
🦠Long COVID patients don't.
Its name is Faecalibacterium prausnitzii. And what it does explains a lot. 👇
A gut bacterium is showing up — or rather disappearing — across all three phases of COVID-19.
🦠Severely ill patients have less of it.
🦠Recovered patients get it back.
🦠Long COVID patients don't.
Its name is Faecalibacterium prausnitzii. And what it does explains a lot. 👇
this could be us 🥺 but we're online and eukaryotic 😔
August 4, 2025 at 1:40 PM
this could be us 🥺 but we're online and eukaryotic 😔
First post on a lovely story from the lab that shows that Faecalibacterium prausnitzii can package its own genome in bite-size segments in phage-like capsids
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 26, 2024 at 5:14 PM
First post on a lovely story from the lab that shows that Faecalibacterium prausnitzii can package its own genome in bite-size segments in phage-like capsids
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Out Now! Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice #MicroSky
Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice
Nature Microbiology, Published online: 17 April 2026; doi:10.1038/s41564-026-02326-2Phosphoribosyl pyrophosphate synthetase from Faecalibacterium prausnitzii inhibits PD-L1 trafficking to boost anti-tumour immunity and potentiate anti-PD-1 immune checkpoint inhibitor therapy during colorectal cancer.
go.nature.com
April 17, 2026 at 7:13 PM
Out Now! Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice #MicroSky
2) It looks like the post was made with AI hallucinations. The microbe strain they mention "Faecalibacterium prausnitzii" was reduced in ME/CFS patients in a 2023 study by the Lipkin group at Columbia university.
But there wasn't a treatment trial of these bacteria.
But there wasn't a treatment trial of these bacteria.
March 13, 2026 at 8:30 AM
2) It looks like the post was made with AI hallucinations. The microbe strain they mention "Faecalibacterium prausnitzii" was reduced in ME/CFS patients in a 2023 study by the Lipkin group at Columbia university.
But there wasn't a treatment trial of these bacteria.
But there wasn't a treatment trial of these bacteria.
🧵 2/6
Intermittent fasting ↑ beneficial SCFA-producers like Faecalibacterium & Roseburia.
🌐 #IntermittentFasting #Microbiome #SCFA @ewingt-phd.bsky.social @oleksandrkashuba.bsky.social @alokjha09.bsky.social @spatzlhirn.bsky.social @mikaiaalto.bsky.social @haoyin.bsky.social
Intermittent fasting ↑ beneficial SCFA-producers like Faecalibacterium & Roseburia.
🌐 #IntermittentFasting #Microbiome #SCFA @ewingt-phd.bsky.social @oleksandrkashuba.bsky.social @alokjha09.bsky.social @spatzlhirn.bsky.social @mikaiaalto.bsky.social @haoyin.bsky.social
August 11, 2025 at 2:02 PM
🧵 2/6
Intermittent fasting ↑ beneficial SCFA-producers like Faecalibacterium & Roseburia.
🌐 #IntermittentFasting #Microbiome #SCFA @ewingt-phd.bsky.social @oleksandrkashuba.bsky.social @alokjha09.bsky.social @spatzlhirn.bsky.social @mikaiaalto.bsky.social @haoyin.bsky.social
Intermittent fasting ↑ beneficial SCFA-producers like Faecalibacterium & Roseburia.
🌐 #IntermittentFasting #Microbiome #SCFA @ewingt-phd.bsky.social @oleksandrkashuba.bsky.social @alokjha09.bsky.social @spatzlhirn.bsky.social @mikaiaalto.bsky.social @haoyin.bsky.social
#phage #phagesky
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques
www.tandfonline.com/doi/full/10....
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques
www.tandfonline.com/doi/full/10....
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques
The associations of the gut microbiome and virome with human health and disease are increasingly numerous and clear. The mechanistic roles of bacteriophages (phages) in the microbiome, however, are...
www.tandfonline.com
August 10, 2025 at 4:32 PM
#phage #phagesky
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques
www.tandfonline.com/doi/full/10....
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques
www.tandfonline.com/doi/full/10....
Fasting led to increases in beneficial gut bacteria including Akkermansia muciniphila, Bifidobacterium, and Faecalibacterium prausnitzii—all of which have been linked to decreased inflammation and better gut barrier function.
August 11, 2025 at 2:06 PM
Fasting led to increases in beneficial gut bacteria including Akkermansia muciniphila, Bifidobacterium, and Faecalibacterium prausnitzii—all of which have been linked to decreased inflammation and better gut barrier function.
New research finds that oral treatment with Faecalibacterium prausnitzii, which is depleted in the #Parkinsons patient microbiome, improves motor deficits in α-synuclein overexpressing (Thy1-ASO) mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 6, 2026 at 8:37 PM
New research finds that oral treatment with Faecalibacterium prausnitzii, which is depleted in the #Parkinsons patient microbiome, improves motor deficits in α-synuclein overexpressing (Thy1-ASO) mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Awesome new paper from my @isbsci.bsky.social colleague, Sid Venkatesh: "A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase"
A new gut-brain connection, where certain F. prau strains help stimulate appetite by modulating the endocannabinoid pool.
www.science.org/doi/10.1126/...
A new gut-brain connection, where certain F. prau strains help stimulate appetite by modulating the endocannabinoid pool.
www.science.org/doi/10.1126/...
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase
Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially...
www.science.org
October 24, 2024 at 10:23 PM
Awesome new paper from my @isbsci.bsky.social colleague, Sid Venkatesh: "A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase"
A new gut-brain connection, where certain F. prau strains help stimulate appetite by modulating the endocannabinoid pool.
www.science.org/doi/10.1126/...
A new gut-brain connection, where certain F. prau strains help stimulate appetite by modulating the endocannabinoid pool.
www.science.org/doi/10.1126/...
Eat your veggies, beans, and whole grains!
Among the many key insights from this global-scale study is how a fiber-rich diet promotes Faecalibacterium spp., which break down the fiber to short-chain fatty acids protective vs. disease-associated 𝘌. 𝘤𝘰𝘭𝘪 and 𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢
www.nature.com/articles/s41...
Among the many key insights from this global-scale study is how a fiber-rich diet promotes Faecalibacterium spp., which break down the fiber to short-chain fatty acids protective vs. disease-associated 𝘌. 𝘤𝘰𝘭𝘪 and 𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢
www.nature.com/articles/s41...
Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations - Nature Microbiology
Assessing more than 12,000 metagenomic samples from across the world using computational approaches, the authors determined interactions between species that co-colonize or co-exclude Enterobacteriace...
www.nature.com
January 11, 2025 at 1:13 PM
Eat your veggies, beans, and whole grains!
Among the many key insights from this global-scale study is how a fiber-rich diet promotes Faecalibacterium spp., which break down the fiber to short-chain fatty acids protective vs. disease-associated 𝘌. 𝘤𝘰𝘭𝘪 and 𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢
www.nature.com/articles/s41...
Among the many key insights from this global-scale study is how a fiber-rich diet promotes Faecalibacterium spp., which break down the fiber to short-chain fatty acids protective vs. disease-associated 𝘌. 𝘤𝘰𝘭𝘪 and 𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢
www.nature.com/articles/s41...
Gut Microbiota & Dementia
New research shows that changes in gut bacteria may play a big role in mild cognitive impairment and dementia. Higher levels of these bacteria were linked with potentailly heathier brains: Faecalibacterium, Ruminococcaceae, and Lachnospiraceae.
New research shows that changes in gut bacteria may play a big role in mild cognitive impairment and dementia. Higher levels of these bacteria were linked with potentailly heathier brains: Faecalibacterium, Ruminococcaceae, and Lachnospiraceae.
December 1, 2025 at 10:30 PM
Gut Microbiota & Dementia
New research shows that changes in gut bacteria may play a big role in mild cognitive impairment and dementia. Higher levels of these bacteria were linked with potentailly heathier brains: Faecalibacterium, Ruminococcaceae, and Lachnospiraceae.
New research shows that changes in gut bacteria may play a big role in mild cognitive impairment and dementia. Higher levels of these bacteria were linked with potentailly heathier brains: Faecalibacterium, Ruminococcaceae, and Lachnospiraceae.
🍊 El consumo regular de cítricos, como naranjas, puede reducir el riesgo de depresión al aumentar la bacteria Faecalibacterium prausnitzii, que ayuda a producir neurotransmisores como serotonina y dopamina.
Paper: doi.org/10.1186/s401...
Paper: doi.org/10.1186/s401...
February 26, 2025 at 8:17 PM
🍊 El consumo regular de cítricos, como naranjas, puede reducir el riesgo de depresión al aumentar la bacteria Faecalibacterium prausnitzii, que ayuda a producir neurotransmisores como serotonina y dopamina.
Paper: doi.org/10.1186/s401...
Paper: doi.org/10.1186/s401...
Faecalibacterium prausnitzii strain A2-165 has already been reclassified as Faecalibacterium duncaniae. Our article reached over 45 citations.
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Genome-based, phenotypic and chemotaxonomic classification of Faecalibacterium strains: proposal of three novel species Faecalibacterium duncaniae sp. nov., Faecalibacterium hattorii sp. nov. and Faec...
Faecalibacterium prausnitzii
is one of the most important butyrate-producing bacteria in the human gut. Previous studies have suggested the presence of several phylogenetic groups, with differences at...
www.microbiologyresearch.org
February 14, 2025 at 1:37 PM
Faecalibacterium prausnitzii strain A2-165 has already been reclassified as Faecalibacterium duncaniae. Our article reached over 45 citations.
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Try it!
My two favourites for this so far are:
Akkermansia muciniphila
And
Faecalibacterium prausnitzii
My two favourites for this so far are:
Akkermansia muciniphila
And
Faecalibacterium prausnitzii
January 3, 2025 at 11:31 AM
Try it!
My two favourites for this so far are:
Akkermansia muciniphila
And
Faecalibacterium prausnitzii
My two favourites for this so far are:
Akkermansia muciniphila
And
Faecalibacterium prausnitzii
Host genetic regulation of human gut microbial structural variation
www.nature.com/articles/s41...
Very nice study on the GalNAc utilization gene cluster in Faecalibacterium prausnitzii, associated with ABO genotype.
www.nature.com/articles/s41...
Very nice study on the GalNAc utilization gene cluster in Faecalibacterium prausnitzii, associated with ABO genotype.
Host genetic regulation of human gut microbial structural variation - Nature
A meta-analysis of associations between human genetic variation and gut microbial structural variations shows that ABO genotype differentially affects the presence of Faecalibacterium prausnitzii...
www.nature.com
January 3, 2024 at 11:17 PM
Host genetic regulation of human gut microbial structural variation
www.nature.com/articles/s41...
Very nice study on the GalNAc utilization gene cluster in Faecalibacterium prausnitzii, associated with ABO genotype.
www.nature.com/articles/s41...
Very nice study on the GalNAc utilization gene cluster in Faecalibacterium prausnitzii, associated with ABO genotype.
Chinesische Forscher haben im letzten Jahr drei Bakterienstämme im Darm entdeckt, die am häufigsten mit Depressionen verbunden waren:
Parabakteroides, Alistipes und Faecalibacterium
#depression #depressiv #darm
Parabakteroides, Alistipes und Faecalibacterium
#depression #depressiv #darm
July 16, 2026 at 1:15 PM
Chinesische Forscher haben im letzten Jahr drei Bakterienstämme im Darm entdeckt, die am häufigsten mit Depressionen verbunden waren:
Parabakteroides, Alistipes und Faecalibacterium
#depression #depressiv #darm
Parabakteroides, Alistipes und Faecalibacterium
#depression #depressiv #darm
More exciting news about Faecalibacterium to come soon....
February 24, 2025 at 9:08 PM
More exciting news about Faecalibacterium to come soon....
Une nouvelle étude apporte de nouveaux éléments sur le mode d’action de la bactérie Faecalibacterium prausnitzii, ayant un rôle protecteur dans les maladies inflammatoires chroniques de l’intestin (MICI), comme la maladie de Crohn.
Lire le communiqué : presse.inserm.fr/maladies-inf...
Lire le communiqué : presse.inserm.fr/maladies-inf...
Maladies inflammatoires et chroniques de l’intestin : le rôle anti-inflammatoire d’une bactérie du microbiote intestinal ouvre la voie vers de nouvelles pistes thérapeutiques - Salle de presse de l'In...
Une étude impliquant des chercheurs de Sorbonne Université, de l’Inserm, d’INRAE et de l’AP-HP, en collaboration avec la société de biotechnologie Exeliom Biosciences, apporte de nouveaux éléments sur...
presse.inserm.fr
March 3, 2026 at 10:15 AM
Une nouvelle étude apporte de nouveaux éléments sur le mode d’action de la bactérie Faecalibacterium prausnitzii, ayant un rôle protecteur dans les maladies inflammatoires chroniques de l’intestin (MICI), comme la maladie de Crohn.
Lire le communiqué : presse.inserm.fr/maladies-inf...
Lire le communiqué : presse.inserm.fr/maladies-inf...
When the microbiome meets the endocannabinoid system - cool paper from Sid Venkatesh & colleagues in Science
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase www.science.org/doi/10.1126/...
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase www.science.org/doi/10.1126/...
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase
Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially...
www.science.org
October 24, 2024 at 9:38 PM
When the microbiome meets the endocannabinoid system - cool paper from Sid Venkatesh & colleagues in Science
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase www.science.org/doi/10.1126/...
A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase www.science.org/doi/10.1126/...
GLP1 receptor agonists attenuate systemic inflammation through microbiota mediated enrichment of Faecalibacterium prausnitzii and Roseburia spp https://www.biorxiv.org/content/10.1101/2025.09.07.674712v1
September 12, 2025 at 10:17 AM
GLP1 receptor agonists attenuate systemic inflammation through microbiota mediated enrichment of Faecalibacterium prausnitzii and Roseburia spp https://www.biorxiv.org/content/10.1101/2025.09.07.674712v1
#Probiotics
Administration of a live gut bacterium (*) to Crohn's disease patients appears to be safe and modulates immune gene expression in the ileum, supporting its potential use as a biotherapeutic
(* Faecalibacterium prausnitzii)
Administration of a live gut bacterium (*) to Crohn's disease patients appears to be safe and modulates immune gene expression in the ileum, supporting its potential use as a biotherapeutic
(* Faecalibacterium prausnitzii)
Faecalibacterium prausnitzii EXL01 for the Maintenance of Steroid-induced Clinical Response or Remission in Patients with Crohn’s Disease: a first in human trial - Nature Communications
In this clinical trial the authors show that EXL01, a live bacterial therapy based on F. prausnitzii, can be safely administered to Crohn’s disease patients, showing immune gene modulation in the ileum and supporting its potential as a biotherapeutic.
dlvr.it
July 16, 2026 at 2:00 PM
#Probiotics
Administration of a live gut bacterium (*) to Crohn's disease patients appears to be safe and modulates immune gene expression in the ileum, supporting its potential use as a biotherapeutic
(* Faecalibacterium prausnitzii)
Administration of a live gut bacterium (*) to Crohn's disease patients appears to be safe and modulates immune gene expression in the ileum, supporting its potential use as a biotherapeutic
(* Faecalibacterium prausnitzii)
a gut microbe called Faecalibacterium prausnitzii thrives when we eat citrus fruits. It appears to influence the production of crucial brain chemicals like serotonin&dopamine that regulate our mood. Researchers found lower levels of this bacterium in people w depression MNT
March 9, 2025 at 9:15 PM
a gut microbe called Faecalibacterium prausnitzii thrives when we eat citrus fruits. It appears to influence the production of crucial brain chemicals like serotonin&dopamine that regulate our mood. Researchers found lower levels of this bacterium in people w depression MNT
【2025年2月 ハーバード大学】
オレンジを1日1個ぶん摂取していた人、
うつ病にならずにすむ率がかなり高め
うつ病リスクを20%軽減しうる
特定の腸内細菌 Faecalibacterium prausnitzii（F. prausnitzii）の好物が柑橘類の成分で、それでセロトニンやドーパミンの分泌に良い影響が出るらしい
medicalxpress.com/news/2025-02...
オレンジを1日1個ぶん摂取していた人、
うつ病にならずにすむ率がかなり高め
うつ病リスクを20%軽減しうる
特定の腸内細菌 Faecalibacterium prausnitzii（F. prausnitzii）の好物が柑橘類の成分で、それでセロトニンやドーパミンの分泌に良い影響が出るらしい
medicalxpress.com/news/2025-02...
Forget apples—researcher outlines how an orange a day may reduce depression risk by 20%
]Eating an orange a day may lower a person's depression risk by 20%, according to a study published in Microbiome. That might be because citrus stimulates the growth of Faecalibacterium prausnitzii (F...
medicalxpress.com
February 25, 2025 at 12:10 PM
【2025年2月 ハーバード大学】
オレンジを1日1個ぶん摂取していた人、
うつ病にならずにすむ率がかなり高め
うつ病リスクを20%軽減しうる
特定の腸内細菌 Faecalibacterium prausnitzii（F. prausnitzii）の好物が柑橘類の成分で、それでセロトニンやドーパミンの分泌に良い影響が出るらしい
medicalxpress.com/news/2025-02...
オレンジを1日1個ぶん摂取していた人、
うつ病にならずにすむ率がかなり高め
うつ病リスクを20%軽減しうる
特定の腸内細菌 Faecalibacterium prausnitzii（F. prausnitzii）の好物が柑橘類の成分で、それでセロトニンやドーパミンの分泌に良い影響が出るらしい
medicalxpress.com/news/2025-02...