Having spent years building a network on twitter, I'm reluctant to start over, but I hear good things...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
Mapping glycoprotein structure reveals Flaviviridae evolutionary history - Nature
Combined phylogenetic analyses and glycoprotein structure prediction across the Flaviviridae reveals divergent membrane fusion systems and provides insights into the complex evolutionary history withi...
www.nature.com
November 7, 2024 at 9:47 PM
Having spent years building a network on twitter, I'm reluctant to start over, but I hear good things...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
Konvergenz ihrer Wirkmechanismen. Proteine verschiedener, hochinfektiöser Virusfamilien mit zoonotischem Potenzial (z. B. Coronaviridae, Flaviviridae, Orthomyxoviridae) aktivieren gemeinsame Wirtszellprozesse: Die Aktivierung der glialen Toll-like-Rezeptor(TLR)4/TLR2-Signalwege,
June 7, 2026 at 8:32 PM
Konvergenz ihrer Wirkmechanismen. Proteine verschiedener, hochinfektiöser Virusfamilien mit zoonotischem Potenzial (z. B. Coronaviridae, Flaviviridae, Orthomyxoviridae) aktivieren gemeinsame Wirtszellprozesse: Die Aktivierung der glialen Toll-like-Rezeptor(TLR)4/TLR2-Signalwege,
@eddieholmes.bsky.social gave a tour de force on virus discovery and evolution!
Showcasing our work on Flaviviridae glyco evolution with @jonathonmifsud.bsky.social & @grovearmada.bsky.social
www.nature.com/articles/s41...
+work on segmented CoVs I can't wait to get my hands on! 👀
#CSHApandemic
Showcasing our work on Flaviviridae glyco evolution with @jonathonmifsud.bsky.social & @grovearmada.bsky.social
www.nature.com/articles/s41...
+work on segmented CoVs I can't wait to get my hands on! 👀
#CSHApandemic
Mapping glycoprotein structure reveals Flaviviridae evolutionary history - Nature
Combined phylogenetic analyses and glycoprotein structure prediction across the Flaviviridae reveals divergent membrane fusion systems and provides insights into the complex evolutionary history withi...
www.nature.com
December 7, 2024 at 11:58 AM
@eddieholmes.bsky.social gave a tour de force on virus discovery and evolution!
Showcasing our work on Flaviviridae glyco evolution with @jonathonmifsud.bsky.social & @grovearmada.bsky.social
www.nature.com/articles/s41...
+work on segmented CoVs I can't wait to get my hands on! 👀
#CSHApandemic
Showcasing our work on Flaviviridae glyco evolution with @jonathonmifsud.bsky.social & @grovearmada.bsky.social
www.nature.com/articles/s41...
+work on segmented CoVs I can't wait to get my hands on! 👀
#CSHApandemic
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
www.nature.com
November 6, 2025 at 12:52 PM
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social
October 31, 2025 at 12:44 PM
Monumental effort led by Peter Simmonds and Jens Kuhn to reorganize the Family Flaviviridae based on analysis of RNA-directed RNA polymerase (RdRP) hallmark gene sequences is finally out. Enjoy reading. #ICTV @utmbhealth.bsky.social @astmh.bsky.social @sbvirologia.bsky.social
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
Author summary Flaviviridae viruses—including JEV, CSFV, and HCV—deploy intricate molecular strategies to subvert host innate immune surveillance and establish chronic infections, representing signifi...
journals.plos.org
December 5, 2025 at 2:15 PM
Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
*flertando*
O HCV pertence a família dos flavivirus (Flaviviridae), junto com a dengue e a febre amarela. Recentemente, os vírus que pertencem ao gênero "Flavivirus" e que estavam na família Flaviviridae foram renomeados para orthoflavivirus, para evitar confusão taxonômica entre gênero e família.
O HCV pertence a família dos flavivirus (Flaviviridae), junto com a dengue e a febre amarela. Recentemente, os vírus que pertencem ao gênero "Flavivirus" e que estavam na família Flaviviridae foram renomeados para orthoflavivirus, para evitar confusão taxonômica entre gênero e família.
*flertando*
a transformada de Fourier serve pra decompor uma onda em componentes de frequência, basta convolver a resposta ao impulso com a função alvo, com base na assinatura de frequência você pode comprimir a onda original fazendo uma quantização, ou computar uma assinatura sonora pra reconhecim
a transformada de Fourier serve pra decompor uma onda em componentes de frequência, basta convolver a resposta ao impulso com a função alvo, com base na assinatura de frequência você pode comprimir a onda original fazendo uma quantização, ou computar uma assinatura sonora pra reconhecim
May 25, 2026 at 8:37 PM
*flertando*
O HCV pertence a família dos flavivirus (Flaviviridae), junto com a dengue e a febre amarela. Recentemente, os vírus que pertencem ao gênero "Flavivirus" e que estavam na família Flaviviridae foram renomeados para orthoflavivirus, para evitar confusão taxonômica entre gênero e família.
O HCV pertence a família dos flavivirus (Flaviviridae), junto com a dengue e a febre amarela. Recentemente, os vírus que pertencem ao gênero "Flavivirus" e que estavam na família Flaviviridae foram renomeados para orthoflavivirus, para evitar confusão taxonômica entre gênero e família.
Retired microbiology teacher here w/a quick story. Teaching micro one day - students working hard on the flaviviridae. Serious stuff. Student randomly calls out “Flavor Flav!” and cracks us all up. Your name became our catchphrase for the semester. Great memory that I’ve wanted to share with you!
August 6, 2026 at 4:04 PM
Retired microbiology teacher here w/a quick story. Teaching micro one day - students working hard on the flaviviridae. Serious stuff. Student randomly calls out “Flavor Flav!” and cracks us all up. Your name became our catchphrase for the semester. Great memory that I’ve wanted to share with you!
Out now!
Taxonomic expansion and reorganization of Flaviviridae
@vasilakislab.bsky.social @grovearmada.bsky.social & co
#microsky
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae
@vasilakislab.bsky.social @grovearmada.bsky.social & co
#microsky
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
www.nature.com
November 7, 2025 at 11:15 AM
Out now!
Taxonomic expansion and reorganization of Flaviviridae
@vasilakislab.bsky.social @grovearmada.bsky.social & co
#microsky
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae
@vasilakislab.bsky.social @grovearmada.bsky.social & co
#microsky
www.nature.com/articles/s41...
Hepatitis A, Hepatitis B and Non-A, Non-B Hepatitis (NANBH). They knew that NANBH looked like and acted like Hep A and Hep B but wasn't. So they named it NANBH. When they learned of the pathogen that causes NANBH (a flaviviridae imaginatively named "Hepatitis C Virus"), they
11/
11/
August 27, 2026 at 9:07 AM
Hepatitis A, Hepatitis B and Non-A, Non-B Hepatitis (NANBH). They knew that NANBH looked like and acted like Hep A and Hep B but wasn't. So they named it NANBH. When they learned of the pathogen that causes NANBH (a flaviviridae imaginatively named "Hepatitis C Virus"), they
11/
11/
And fantastic to see Joe Grove and co (inc the ubiquitous Eddie 😂) in nature too today. Amazing use of alphafold combined with viral phylogenetics to understand the structural evolution of flavivirus glycoproteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping glycoprotein structure reveals Flaviviridae evolutionary history - Nature
Combined phylogenetic analyses and glycoprotein structure prediction across the Flaviviridae reveals divergent membrane fusion systems and provides insights into the complex evolutionary history withi...
www.nature.com
September 4, 2024 at 8:07 PM
And fantastic to see Joe Grove and co (inc the ubiquitous Eddie 😂) in nature too today. Amazing use of alphafold combined with viral phylogenetics to understand the structural evolution of flavivirus glycoproteins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Anatomy, Ecology and Virology of these Amazing 🦠 - Spyros You Rocked Those GPs - @spyroslytras.bsky.social 😉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping glycoprotein structure reveals Flaviviridae evolutionary history - Nature
Combined phylogenetic analyses and glycoprotein structure prediction across the Flaviviridae reveals divergent membrane fusion systems and provides insights into the complex evolutionary history withi...
www.nature.com
May 17, 2025 at 12:01 PM
Anatomy, Ecology and Virology of these Amazing 🦠 - Spyros You Rocked Those GPs - @spyroslytras.bsky.social 😉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New paper alert🚨 We've mapped glycoproteins across Flaviviridae using phylogenetics & machine-learning-enabled protein structure prediction, uncovering complex evolutionary history shaping this family's virology & ecology. 🧵 ⬇️
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
February 7, 2024 at 10:51 AM
New paper alert🚨 We've mapped glycoproteins across Flaviviridae using phylogenetics & machine-learning-enabled protein structure prediction, uncovering complex evolutionary history shaping this family's virology & ecology. 🧵 ⬇️
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Das #WestNilVirus wird durch Mückenstiche #Moskitos übertragen u breitet sich in #NewOrleans u anderswo aus. Vor allem Vögel & Pferde sind betroffen, aber auch zunehmend Menschen.
Jeder 100. entwickelt neuroinvasive Symptome
#Klimakrise führt zur Verbreitung
www.rki.de/DE/Themen/In...
Jeder 100. entwickelt neuroinvasive Symptome
#Klimakrise führt zur Verbreitung
www.rki.de/DE/Themen/In...
June 16, 2025 at 6:30 AM
Das #WestNilVirus wird durch Mückenstiche #Moskitos übertragen u breitet sich in #NewOrleans u anderswo aus. Vor allem Vögel & Pferde sind betroffen, aber auch zunehmend Menschen.
Jeder 100. entwickelt neuroinvasive Symptome
#Klimakrise führt zur Verbreitung
www.rki.de/DE/Themen/In...
Jeder 100. entwickelt neuroinvasive Symptome
#Klimakrise führt zur Verbreitung
www.rki.de/DE/Themen/In...
AI is transforming virus research - opening up new ways to study evolution & protein structure.
Foundation-funded @grovearmada.bsky.social will share insights at an upcoming event in Italy.
See his recent paper on Flaviviridae viruses - RNA viruses that pose serious health risks: shorturl.at/W16gM
Foundation-funded @grovearmada.bsky.social will share insights at an upcoming event in Italy.
See his recent paper on Flaviviridae viruses - RNA viruses that pose serious health risks: shorturl.at/W16gM
August 19, 2025 at 1:34 PM
AI is transforming virus research - opening up new ways to study evolution & protein structure.
Foundation-funded @grovearmada.bsky.social will share insights at an upcoming event in Italy.
See his recent paper on Flaviviridae viruses - RNA viruses that pose serious health risks: shorturl.at/W16gM
Foundation-funded @grovearmada.bsky.social will share insights at an upcoming event in Italy.
See his recent paper on Flaviviridae viruses - RNA viruses that pose serious health risks: shorturl.at/W16gM
A #taxonomic revision of the human/animal RNA viruses #Flaviviridae identifies 4 divergent RdRP clades and restructures 12 genera across 3 families within Amarillovirales. #VirusEvolution
📄 https://doi.org/10.1038/s41564-025-02134-0
👤 EVBC: P. Simmonds, A. Butković, J. Mifsud, M. Beer, J.H. Kuhn
📄 https://doi.org/10.1038/s41564-025-02134-0
👤 EVBC: P. Simmonds, A. Butković, J. Mifsud, M. Beer, J.H. Kuhn
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flaviviridae.
doi.org
December 1, 2025 at 7:21 AM
A #taxonomic revision of the human/animal RNA viruses #Flaviviridae identifies 4 divergent RdRP clades and restructures 12 genera across 3 families within Amarillovirales. #VirusEvolution
📄 https://doi.org/10.1038/s41564-025-02134-0
👤 EVBC: P. Simmonds, A. Butković, J. Mifsud, M. Beer, J.H. Kuhn
📄 https://doi.org/10.1038/s41564-025-02134-0
👤 EVBC: P. Simmonds, A. Butković, J. Mifsud, M. Beer, J.H. Kuhn
Wonderful to host @jonathonmifsud.bsky.social at UQ today for the SCMB Seminar Series. An excellent journey using protein structural information to study viral evolution across deep time, including new insights into the evolutionary history of Flaviviridae (RIP) and viral membrane fusion mechanisms.
March 6, 2026 at 4:42 AM
Wonderful to host @jonathonmifsud.bsky.social at UQ today for the SCMB Seminar Series. An excellent journey using protein structural information to study viral evolution across deep time, including new insights into the evolutionary history of Flaviviridae (RIP) and viral membrane fusion mechanisms.
Ya veo que no, que es solo para países donde esa encefalitis es endémica.
cne.isciii.es/servicios/en...
cne.isciii.es/servicios/en...
CNE - Encefalitis transmitida por garrapatas
La encefalitis transmitida por garrapatas es una enfermedad aguda del sistema nervioso central, causada por un arbovirus del género Flavivirus de la familia Flaviviridae. Se han descrito 3 subtipos de...
cne.isciii.es
May 17, 2026 at 7:03 AM
Ya veo que no, que es solo para países donde esa encefalitis es endémica.
cne.isciii.es/servicios/en...
cne.isciii.es/servicios/en...
#Medsky🧪 #IDsky #Neurosky #pedsky #immunosky #publichealth #Parkinsonsdisease ( neurodegenerative disorder with both genetic & environmental factors contributing to pathogenesis. Viral infections are potential environmental triggers that influence PD pathology . #HumanPegivirus
Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication
Human pegivirus (HPgV-1), previously known as GB virus C (GBV-C) or hepatitis G virus (HGV), is a single-stranded positive RNA virus belonging to the genus Pegivirus of the Flaviviridae family. It ...
www.tandfonline.com
July 9, 2025 at 8:31 PM
#Medsky🧪 #IDsky #Neurosky #pedsky #immunosky #publichealth #Parkinsonsdisease ( neurodegenerative disorder with both genetic & environmental factors contributing to pathogenesis. Viral infections are potential environmental triggers that influence PD pathology . #HumanPegivirus
Excellent Flaviviridae meeting (Flaviviruses and hepatitis C virus) October 13th-16th, 2025 Singapore - don't miss out on hearing our Keynote Dan Barouche speak so close to home! Details to follow!
January 29, 2025 at 10:48 PM
Excellent Flaviviridae meeting (Flaviviruses and hepatitis C virus) October 13th-16th, 2025 Singapore - don't miss out on hearing our Keynote Dan Barouche speak so close to home! Details to follow!
The meteoric increase of known viruses ofter requires reexamination of taxonomic relationships. ICTV's efforts for the reclassification of the family Flaviviridae was just dropped. pubmed.ncbi.nlm.nih.gov/39868175/. @createneo.bsky.social @amersocvirology.bsky.social @mauriciolnogueira.bsky.social
Integrated analysis of protein sequence and structure redefines viral diversity and the taxonomy of the Flaviviridae - PubMed
The <i>Flaviviridae</i> are a family of non-segmented positive-sense enveloped RNA viruses containing significant pathogens including hepatitis C virus and yellow fever virus. Recent large-scale metag...
pubmed.ncbi.nlm.nih.gov
January 29, 2025 at 11:54 PM
The meteoric increase of known viruses ofter requires reexamination of taxonomic relationships. ICTV's efforts for the reclassification of the family Flaviviridae was just dropped. pubmed.ncbi.nlm.nih.gov/39868175/. @createneo.bsky.social @amersocvirology.bsky.social @mauriciolnogueira.bsky.social
www.bbc.co.uk/news/article... a nice step forward but annoyingly inconsistent as some “pathogens” are species (eg Lassa) and others are whole orders of viruses (Flaviviridae). I think there’s better way to focus people. Interesting are those not on it though.
Priority pathogens: UK draws up new disease-threat watch list
Some are viruses with global pandemic potential - like Covid - others infectious illnesses with no treatments.
www.bbc.co.uk
March 25, 2025 at 7:34 AM
www.bbc.co.uk/news/article... a nice step forward but annoyingly inconsistent as some “pathogens” are species (eg Lassa) and others are whole orders of viruses (Flaviviridae). I think there’s better way to focus people. Interesting are those not on it though.