#Flozin vindication!
Hi Swapnil, as you may know 2 large RCTs, DAPA-PKD & STOP-PKD have secured academic funding to evaluate the use of SGLT2i in ADPKD. They are set to launch in 2026.
Upon completion, both trials will combine their datasets in a pooled analysis, called FLOZIN-PKD. Hope you like the name 😉
Upon completion, both trials will combine their datasets in a pooled analysis, called FLOZIN-PKD. Hope you like the name 😉
January 18, 2025 at 3:10 PM
#Flozin vindication!
November 17, 2024 at 1:05 PM
And as I shared with you earlier but now I will publicly GLP1 + flozin even in established DKD can really delay progression!!
September 30, 2026 at 10:51 PM
And as I shared with you earlier but now I will publicly GLP1 + flozin even in established DKD can really delay progression!!
The first simultaneous publication from #ISNWCN
journals.lww.com/jasn/fulltex... in @asnpublications.bsky.social JASN
Atrasentan reduced proteinuria in IgAN even if on RASi + Flozin
journals.lww.com/jasn/fulltex... in @asnpublications.bsky.social JASN
Atrasentan reduced proteinuria in IgAN even if on RASi + Flozin
March 29, 2026 at 5:22 AM
The first simultaneous publication from #ISNWCN
journals.lww.com/jasn/fulltex... in @asnpublications.bsky.social JASN
Atrasentan reduced proteinuria in IgAN even if on RASi + Flozin
journals.lww.com/jasn/fulltex... in @asnpublications.bsky.social JASN
Atrasentan reduced proteinuria in IgAN even if on RASi + Flozin
100% David
We talk about 4 pillars for treatment of diabetic kidney disease
If we get G-force on time (+/- a flozin) that’s the only pillar you need!
We talk about 4 pillars for treatment of diabetic kidney disease
If we get G-force on time (+/- a flozin) that’s the only pillar you need!
September 30, 2026 at 10:46 PM
100% David
We talk about 4 pillars for treatment of diabetic kidney disease
If we get G-force on time (+/- a flozin) that’s the only pillar you need!
We talk about 4 pillars for treatment of diabetic kidney disease
If we get G-force on time (+/- a flozin) that’s the only pillar you need!
June 5, 2025 at 9:54 AM
Cool acronym of the day for a very cool Flozin trial
‘APPLE TREE’ for empa versus dapa
#NephSky
cc @christosargyrop.bsky.social
‘APPLE TREE’ for empa versus dapa
#NephSky
cc @christosargyrop.bsky.social
There is an ongoing danish study called APPLE TREE randomizing patients who are being perscribed SGLT2i to either empa, dapa or cana. Maybe we’ll ger the answer here: lundbeckfonden.com/en/the-apple...
The APPLE TREE study
Daniel Christensen, Department of Cardiology, Herlev and Gentofte Hospital, has been awarded an Early-career clinician scientist research grant worth DKK 916.199.
lundbeckfonden.com
October 23, 2025 at 10:55 AM
Cool acronym of the day for a very cool Flozin trial
‘APPLE TREE’ for empa versus dapa
#NephSky
cc @christosargyrop.bsky.social
‘APPLE TREE’ for empa versus dapa
#NephSky
cc @christosargyrop.bsky.social
Slidedeck from an internal presentation on diabetic kidney disease 👇
Nephrologist's take on the effect and impact of SGLT-2 inhibitors, GLP-1 RAs and ns-MRA on #Kidney Disease in people with #diabetes #flozin #sglt2i #MRA #GLP1RA
#MedEd #MedSky #NephSky
www.slideshare.net/slideshow/ne...
Nephrologist's take on the effect and impact of SGLT-2 inhibitors, GLP-1 RAs and ns-MRA on #Kidney Disease in people with #diabetes #flozin #sglt2i #MRA #GLP1RA
#MedEd #MedSky #NephSky
www.slideshare.net/slideshow/ne...
November 11, 2024 at 2:07 PM
#ThrowbackThursday
Mechanism of Flozin action
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice from the highly cited archive
Mechanism of Flozin action
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice from the highly cited archive
September 4, 2025 at 11:52 AM
#ThrowbackThursday
Mechanism of Flozin action
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice from the highly cited archive
Mechanism of Flozin action
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice from the highly cited archive
This "living" guideline document will unlive many people with diabetes if applied.
Why are guideline ppl addicted to sulfunylureas/nsulin/metformin ?
Those are useful to lower A1c from stratospheric levels, but if we are thinking hard outcomes improvement, the answer is #flozin & #glp1
#fail
Why are guideline ppl addicted to sulfunylureas/nsulin/metformin ?
Those are useful to lower A1c from stratospheric levels, but if we are thinking hard outcomes improvement, the answer is #flozin & #glp1
#fail
August 15, 2025 at 12:46 PM
funnily the data/confidence in metformin use in CKD is coming just as flozin/GLP1s make it less relevant
November 23, 2024 at 12:39 PM
funnily the data/confidence in metformin use in CKD is coming just as flozin/GLP1s make it less relevant
Today’s trials at #KidneyWk
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
November 7, 2025 at 10:39 AM
Today’s trials at #KidneyWk
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
I use metformin in kidney transplant recipients as a first line agent in post-transplant diabetes when eGFR >30 😬
Then a flozin. Then a GLP-1 RA
All good 👍
#NephJC
Then a flozin. Then a GLP-1 RA
All good 👍
#NephJC
April 16, 2025 at 1:24 AM
I use metformin in kidney transplant recipients as a first line agent in post-transplant diabetes when eGFR >30 😬
Then a flozin. Then a GLP-1 RA
All good 👍
#NephJC
Then a flozin. Then a GLP-1 RA
All good 👍
#NephJC
What do you think of mandating:
‘RASi + Flozin’ as background standard of care
Then drug versus an active comparator on top of SoC? (eg prednisone or budesonide)
#NephSky
‘RASi + Flozin’ as background standard of care
Then drug versus an active comparator on top of SoC? (eg prednisone or budesonide)
#NephSky
October 4, 2025 at 3:52 PM
What do you think of mandating:
‘RASi + Flozin’ as background standard of care
Then drug versus an active comparator on top of SoC? (eg prednisone or budesonide)
#NephSky
‘RASi + Flozin’ as background standard of care
Then drug versus an active comparator on top of SoC? (eg prednisone or budesonide)
#NephSky
yup - after #KidneyWk 2020
Alicia McDonough and @juancarlosqvelez.bsky.social were calling them -gliflozins and -flozins so we went to the next step!
Alicia McDonough and @juancarlosqvelez.bsky.social were calling them -gliflozins and -flozins so we went to the next step!
February 16, 2026 at 8:53 PM
yup - after #KidneyWk 2020
Alicia McDonough and @juancarlosqvelez.bsky.social were calling them -gliflozins and -flozins so we went to the next step!
Alicia McDonough and @juancarlosqvelez.bsky.social were calling them -gliflozins and -flozins so we went to the next step!
Cana is the flozin pioneer who died of dysentery.
November 18, 2024 at 12:58 AM
Cana is the flozin pioneer who died of dysentery.
Team potassium and coming off the bench players flozin, high dose diuretic, bicarb and k binder
January 17, 2025 at 6:43 AM
Team potassium and coming off the bench players flozin, high dose diuretic, bicarb and k binder
Jonathan Pollack, IgA nepropathy (pronounced EYE-gan) patient from St. Louis, currently enjoying being on a flozin plus all sorts of other medications to try and avoid being on a flozin and dialysis later on. No COI. JAFO today.
#NephJC
#NephJC
February 11, 2026 at 2:08 AM
Jonathan Pollack, IgA nepropathy (pronounced EYE-gan) patient from St. Louis, currently enjoying being on a flozin plus all sorts of other medications to try and avoid being on a flozin and dialysis later on. No COI. JAFO today.
#NephJC
#NephJC
But yes, I #agreewithScott - would add RASi + Flozin right away
January 15, 2025 at 11:33 AM
But yes, I #agreewithScott - would add RASi + Flozin right away
Hi Swapnil, as you may know 2 large RCTs, DAPA-PKD & STOP-PKD have secured academic funding to evaluate the use of SGLT2i in ADPKD. They are set to launch in 2026.
Upon completion, both trials will combine their datasets in a pooled analysis, called FLOZIN-PKD. Hope you like the name 😉
Upon completion, both trials will combine their datasets in a pooled analysis, called FLOZIN-PKD. Hope you like the name 😉
January 18, 2025 at 1:51 PM
Hi Swapnil, as you may know 2 large RCTs, DAPA-PKD & STOP-PKD have secured academic funding to evaluate the use of SGLT2i in ADPKD. They are set to launch in 2026.
Upon completion, both trials will combine their datasets in a pooled analysis, called FLOZIN-PKD. Hope you like the name 😉
Upon completion, both trials will combine their datasets in a pooled analysis, called FLOZIN-PKD. Hope you like the name 😉
The nice thing about knowing #rstats, is that one can often answer some clinical questions using public data. E.g. do I expect a benefit when combining #flozin and #Glp1RA in patients living with diabetes and kidney disease?
Let's use 👇from www.sciencedirect.com/science/arti... to answer the Q 1/
Let's use 👇from www.sciencedirect.com/science/arti... to answer the Q 1/
November 11, 2024 at 11:49 PM
The nice thing about knowing #rstats, is that one can often answer some clinical questions using public data. E.g. do I expect a benefit when combining #flozin and #Glp1RA in patients living with diabetes and kidney disease?
Let's use 👇from www.sciencedirect.com/science/arti... to answer the Q 1/
Let's use 👇from www.sciencedirect.com/science/arti... to answer the Q 1/
Luckily they did the responsible thing and followed up with a larger case control study using ICES, now live at @jamacurrent.bsky.social Network Open
jamanetwork.com/journals/jam...
Statin + Flozin = same or lower rates of rhabdomyolysis! 😅
2/2
jamanetwork.com/journals/jam...
Statin + Flozin = same or lower rates of rhabdomyolysis! 😅
2/2
November 17, 2024 at 2:40 PM
Luckily they did the responsible thing and followed up with a larger case control study using ICES, now live at @jamacurrent.bsky.social Network Open
jamanetwork.com/journals/jam...
Statin + Flozin = same or lower rates of rhabdomyolysis! 😅
2/2
jamanetwork.com/journals/jam...
Statin + Flozin = same or lower rates of rhabdomyolysis! 😅
2/2