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GALE is a tumor-intrinsic checkpoint of Vγ9Vδ2 T cell-mediated killing

#gdTcells @natcancer.nature.com
GALE is a tumor-intrinsic checkpoint of Vγ9Vδ2 T cell-mediated killing - Nature Cancer
Shan et al. identified UDP-galactose 4-epimerase as an immune checkpoint of Vγ9Vδ2 T cell-mediated cancer cell killing by enhancing interaction of CD155 and CEACAM1 with their receptors TIGIT and TIM3...
www.nature.com
October 31, 2026 at 11:16 AM
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Defective Vδ2+ T cell metabolic and functional responses in obesity are reversed with bariatric surgery

#gdTcells @insight.jci.org
JCI Insight - Defective Vδ2+ T cell metabolic and functional responses in obesity are reversed with bariatric surgery
insight.jci.org
October 21, 2026 at 10:17 AM
forum-gd.bsky.social
Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

#gdTcells
Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity
Absence of branched N-glycans on γδ T cells acts as a peripheral signal that amplifies a type 3/IL-17A response in autoimmunity.
www.science.org
October 17, 2026 at 5:17 PM
science.org
How does the body balance immune response and tissue damage during a parasite infection?

A new #ScienceImmunology study in helminth-infected mice shows dermal gdTcells that migrate to the lung activate immune pathways that protect tissues. https://scim.ag/4hrcdvD
Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection
Lung anthelmintic responses during hookworm infection are regulated by skin-derived γδ T cells.
scim.ag
October 12, 2026 at 9:00 PM
forum-gd.bsky.social
Stress-Sensing Over TCR Recognition: γδ T-cell therapy for CMV infection after transplantation

#gdTcells @kidneyint.bsky.social
Stress-Sensing Over TCR Recognition: γδ T-cell therapy for CMV infection after transplantation
Cytomegalovirus (CMV) remains a prevalent infectious complication following kidney transplantation. Although antiviral treatments have substantially improved outcomes, CMV continues to cause morbidity...
www.kidney-international.org
October 11, 2026 at 7:41 AM
forum-gd.bsky.social
Single-cell transcriptomic reference map of human peripheral blood γδ T cells from 1 year to 90 years reveals major changes before adulthood

#gdTcells @cp-cellreports.bsky.social
Single-cell transcriptomic reference map of human peripheral blood γδ T cells from 1 year to 90 years reveals major changes before adulthood
γδ T cells have an unconventional biology as they develop as functional cells in the thymus, to thereafter adapt to postnatal cues and persist into ad…
www.sciencedirect.com
October 7, 2026 at 12:32 PM
science.org
How does the body balance immune response and tissue damage during a #parasite infection?

A new Science #Immunology study in helminth-infected mice shows dermal #gdTcells that migrate to the lung activate immune pathways that protect tissues. https://scim.ag/4hrcdvD
Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection
Lung anthelmintic responses during hookworm infection are regulated by skin-derived γδ T cells.
scim.ag
October 6, 2026 at 3:00 PM
forum-gd.bsky.social
Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection

#gdTcells
Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection
Lung anthelmintic responses during hookworm infection are regulated by skin-derived γδ T cells.
www.science.org
October 3, 2026 at 11:38 AM
forum-gd.bsky.social
γδ T cell receptor dependencies define a unique immunosurveillance modality

#gdTcells @nature.com
γδ T cell receptor dependencies define a unique immunosurveillance modality - Nature
Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence that underpins their conserved roles in ...
www.nature.com
October 2, 2026 at 6:15 AM
forum-gd.bsky.social
γδ T cells modulate anti-tumor immunity in small cell lung cancer

#gdTcells @cp-cancercell.bsky.social
γδ T cells modulate anti-tumor immunity in small cell lung cancer
Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigene…
www.sciencedirect.com
September 20, 2026 at 6:26 PM
forum-gd.bsky.social
γδ T cells BiTE back at small cell lung cancer

#gdTcells @cp-cancercell.bsky.social
www.sciencedirect.com
September 20, 2026 at 6:29 PM
forum-gd.bsky.social
Identification of broadly tumour-reactive γδ TCRs from multiple myeloma

#gdTcells @nature.com
Identification of broadly tumour-reactive γδ TCRs from multiple myeloma - Nature
A machine-learning algorithm, PreGame, is developed to identify tumour-reactive γδ T cells from single-cell CITE sequencing data, and expansion of this cell population can be used as a biomarker of th...
www.nature.com
September 17, 2026 at 10:44 AM
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Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer

#gdTcells @sigtrans-sttt.bsky.social
Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer
www.nature.com
September 16, 2026 at 12:01 PM
neilemccarthy.bsky.social
Surely this is the PERFECT year for the #gammadeltaTcell badge given that Prof Adrian Hayday is keynote speaker?! 👀 @forum-gd.bsky.social #gdTcells
September 10, 2026 at 7:39 PM
forum-gd.bsky.social
Butyrophilin 3A1 engages the CDR2δ loop of the Vγ9Vδ2+ T cell receptor

#gdTcells
Butyrophilin 3A1 engages the CDR2δ loop of the Vγ9Vδ2+ T cell receptor
Fulford et al. show an interaction between butyrophilin (BTN) 3A1 and the δ chain of the Vγ9Vδ2+ T cell receptor. These data suggest that BTN3A1, along with BTN2A1, is sufficient to mediate Vγ9Vδ2+ T ...
www.cell.com
September 9, 2026 at 10:20 AM
forum-gd.bsky.social
Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

#gdTcells @jem.org
Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity
Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduce
rupress.org
September 5, 2026 at 11:12 AM
forum-gd.bsky.social
IL-17A-producing γδ T cells control pulmonary Mycobacterium abscessus infection in mice

#gdTcells @natmicrobiol.nature.com
IL-17A-producing γδ T cells control pulmonary Mycobacterium abscessus infection in mice - Nature Microbiology
Researchers identify interleukin-17A+ γδ T cells as key immune defenders against non-tuberculous mycobacteria infections, demonstrating their ability to protect hosts when IFNγ immunity is impaired.
www.nature.com
September 4, 2026 at 10:44 AM
forum-gd.bsky.social
γδ T cells and cancer

#gdTcells
JCI - γδ T cells and cancer
www.jci.org
September 2, 2026 at 10:27 AM
forum-gd.bsky.social
Enrichment of CD4−CD8− cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease

#gdTcells @cp-iscience.bsky.social
Enrichment of CD4−CD8− cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease
Immunology; Omics
www.cell.com
August 29, 2026 at 4:56 PM
forum-gd.bsky.social
γδ T cells in colorectal and liver cancer

#gdTcells @natrevgastrohep.nature.com
γδ T cells in colorectal and liver cancer - Nature Reviews Gastroenterology & Hepatology
γδ T cells are an important component of local immune surveillance. This Review discusses their role in colorectal cancer and hepatocellular carcinoma development and provides a detailed overview of t...
www.nature.com
August 26, 2026 at 10:24 AM
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Immune cell subsets that predict cytomegalovirus reactivation magnitude after haematopoietic stem cell transplantation

#gdTcells @bloodjournal.bsky.social
Immune cell subsets that predict cytomegalovirus reactivation magnitude after haematopoietic stem cell transplantation
Key Points. Higher proportions of CD4+ T, Vδ2T and MAIT cells expressing CD69 can identify HSCT recipients at risk of HCMV reactivation.EM CD8+T, TIM-3+CD8
ashpublications.org
August 19, 2026 at 10:22 AM
forum-gd.bsky.social
GPCR-Gα13 signaling regulates survival of intestinal intraepithelial CD8+ lymphocytes through migration to cytokine-rich niches

#gdTcells @cp-immunity.bsky.social
GPCR-Gα13 signaling regulates survival of intestinal intraepithelial CD8+ lymphocytes through migration to cytokine-rich niches
The intestinal barrier harbors numerous intraepithelial lymphocytes (IELs) that promote tissue integrity and whose dysfunction contributes to disease. Earley et al. studied the G-protein coupled recep...
www.cell.com
August 18, 2026 at 11:01 AM
forum-gd.bsky.social
Baseline circulating and tumor γδ T cells and early circulating CD8⁺PD1⁺ expansion predict response to Atezolizumab-bevacizumab in HCC

#gdTcells
Baseline circulating and tumor γδ T cells and early circulating CD8⁺PD1⁺ expansion predict response to Atezolizumab-bevacizumab in HCC
Abstract. Background: We aimed to identify circulating and tumor immune features predictive of oncological outcomes under Atezolizumab-Bevacizumab (AtezoBev) therapy for hepatocellular carcinoma (HCC)...
aacrjournals.org
August 18, 2026 at 10:24 AM
forum-gd.bsky.social
Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota

#gdTcells
Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota
The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophag...
www.science.org
August 15, 2026 at 7:01 PM
forum-gd.bsky.social
Starting now, August #GDTcelclubwebinar by Drs. Georgia Nasi and Michael St. Paul. Join us!

First, Georgia, talking about Harnessing skin GDTcells for Immunotherapy in cSCC.

nyulangone.zoom.us/j/9589051706...

Meeting ID: 958 9051 7066
Password: 369081
August 13, 2026 at 4:05 PM