A reminder: for genotypes to produce phenotypes, they have to go through development
January 8, 2025 at 5:09 PM
A reminder: for genotypes to produce phenotypes, they have to go through development
So there's this idea again to just let H5N1 rip through the US chicken population to find and breed resistant genotypes.
There are no resistant genotypes. Modern farmed chicken are all direct descendants of very few optimized breeding lines and because of that are genetically extremely homogenous.
There are no resistant genotypes. Modern farmed chicken are all direct descendants of very few optimized breeding lines and because of that are genetically extremely homogenous.
July 8, 2025 at 6:43 AM
So there's this idea again to just let H5N1 rip through the US chicken population to find and breed resistant genotypes.
There are no resistant genotypes. Modern farmed chicken are all direct descendants of very few optimized breeding lines and because of that are genetically extremely homogenous.
There are no resistant genotypes. Modern farmed chicken are all direct descendants of very few optimized breeding lines and because of that are genetically extremely homogenous.
A new report describes two new genotypes of H5N6 recently isolated in China, with one carrying the internal genes from LPAI H9N2 demonstrating worrisome signs of mammalian adaptation.
January 8, 2025 at 4:55 PM
A new report describes two new genotypes of H5N6 recently isolated in China, with one carrying the internal genes from LPAI H9N2 demonstrating worrisome signs of mammalian adaptation.
The tech bro fascination with eugenics is so on brand. The idea that you could make accurate, actionable predictions from individual genotypes (with all their complex, non-linear interactions) from averaged, linearly modeled population-level genomic statistics is just another big data fantasy
December 12, 2024 at 4:13 PM
The tech bro fascination with eugenics is so on brand. The idea that you could make accurate, actionable predictions from individual genotypes (with all their complex, non-linear interactions) from averaged, linearly modeled population-level genomic statistics is just another big data fantasy
So, not COVID related BUT, this is REALLY exciting news. Phase I/II data shows Moderna’s Norovirus vaccine candidate mRNA-1403, has shown early signs of efficacy AND elicited robust serum HBGA-blocking antibody responses against ALL THREE NoV genotypes. Let’s talk about that! 🧪🧵⬇️
January 16, 2025 at 5:00 PM
So, not COVID related BUT, this is REALLY exciting news. Phase I/II data shows Moderna’s Norovirus vaccine candidate mRNA-1403, has shown early signs of efficacy AND elicited robust serum HBGA-blocking antibody responses against ALL THREE NoV genotypes. Let’s talk about that! 🧪🧵⬇️
“Let’s just let chestnut blight rip through the chestnut population so we can find and breed resistant genotypes.”
[50 years later]
“Well, shit.”
[50 years later]
“Well, shit.”
So there's this idea again to just let H5N1 rip through the US chicken population to find and breed resistant genotypes.
There are no resistant genotypes. Modern farmed chicken are all direct descendants of very few optimized breeding lines and because of that are genetically extremely homogenous.
There are no resistant genotypes. Modern farmed chicken are all direct descendants of very few optimized breeding lines and because of that are genetically extremely homogenous.
July 8, 2025 at 1:27 PM
“Let’s just let chestnut blight rip through the chestnut population so we can find and breed resistant genotypes.”
[50 years later]
“Well, shit.”
[50 years later]
“Well, shit.”
I see we’re doing deextinction discourse again, I’ll bite!
Genotypes (DNA variation) alone do not make a phenotype (how bodies look, function, behave).
Even if we reproduced an extinct genome, that animal doesn’t necessarily have the developmental context and learned culture of the extinct species
Genotypes (DNA variation) alone do not make a phenotype (how bodies look, function, behave).
Even if we reproduced an extinct genome, that animal doesn’t necessarily have the developmental context and learned culture of the extinct species
It's not a dire wolf. It's a gray wolf clone with 20 dire-wolf gene edits, and with some dire wolf traits. And here's my story! Gift link: www.nytimes.com/2025/04/07/s...
April 8, 2025 at 12:43 AM
I see we’re doing deextinction discourse again, I’ll bite!
Genotypes (DNA variation) alone do not make a phenotype (how bodies look, function, behave).
Even if we reproduced an extinct genome, that animal doesn’t necessarily have the developmental context and learned culture of the extinct species
Genotypes (DNA variation) alone do not make a phenotype (how bodies look, function, behave).
Even if we reproduced an extinct genome, that animal doesn’t necessarily have the developmental context and learned culture of the extinct species
BREAKING: A new swine flu strain, H1avN2#, has rapidly spread across pig farms in France, causing more severe illness.
This highly mutated strain is evading existing immunity and has led to the emergence of five new genotypes.
This highly mutated strain is evading existing immunity and has led to the emergence of five new genotypes.
February 1, 2025 at 3:47 PM
BREAKING: A new swine flu strain, H1avN2#, has rapidly spread across pig farms in France, causing more severe illness.
This highly mutated strain is evading existing immunity and has led to the emergence of five new genotypes.
This highly mutated strain is evading existing immunity and has led to the emergence of five new genotypes.
![Comic. [Person with shoulder-length hair and another person pointing at branching diagram on a poster.] PERSON 1 with shoulder-length hair: Our admixture analysis showed that these genotypes arose in the ancestral population almost entirely through sexual intercourse. Upon realizing this, we of course promptly deleted all our data. VOICE FROM OFF-PANEL: What? Why?? PERSON 1: We’re not *weirdos!* Jeez, give these people some privacy!](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreifmvcqrs6hxqgfoqhpcpf3jgxtstiuuklbbuy6z3omh4q4olnecia)
June 1, 2026 at 7:05 PM
Enterocytozoon bieneusi is widespread in sika deer in China: a survey of 466 faecal samples from four provinces found a 44.4% prevalence and 11 genotypes, including two novel genotypes.
BEB6 was the predominant genotype.🧪
🔗 doi.org/10.1051/para...
BEB6 was the predominant genotype.🧪
🔗 doi.org/10.1051/para...
September 23, 2026 at 10:02 AM
Enterocytozoon bieneusi is widespread in sika deer in China: a survey of 466 faecal samples from four provinces found a 44.4% prevalence and 11 genotypes, including two novel genotypes.
BEB6 was the predominant genotype.🧪
🔗 doi.org/10.1051/para...
BEB6 was the predominant genotype.🧪
🔗 doi.org/10.1051/para...
Phenomics reminder; 1,000,000 traits on 100 genotypes is still only 100 genotypes.
November 21, 2023 at 11:56 PM
Phenomics reminder; 1,000,000 traits on 100 genotypes is still only 100 genotypes.
The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.
September 28, 2025 at 12:25 AM
The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.
That's strange, just upthread you were saying that trans girls who hadn't gone through male puberty would be eligible to play girls' sports, but now you're checking their genotypes
October 24, 2024 at 7:21 PM
That's strange, just upthread you were saying that trans girls who hadn't gone through male puberty would be eligible to play girls' sports, but now you're checking their genotypes
This is the same bullshit as “sex is in every cell of the body”.
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
But my whole point is that this demonstrates how absolutely ridiculous of a scientific and biological proposition this understanding of sex is.
Somehow no amount of her womanhood and female experience counts anymore because of a DNA test? Bullshit!
Somehow no amount of her womanhood and female experience counts anymore because of a DNA test? Bullshit!
June 4, 2025 at 6:34 AM
This is the same bullshit as “sex is in every cell of the body”.
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
Genotypes are not a more accurate representation of phenotypes than phenotypes themselves
This paper is making the rounds again!
Exciting update is we just got some funding to study caterpillar performance on local and nonlocal ecotypes! (Plant genotypes adapted to other ecoregions).
Stay tuned for more caterpillar pictures this summer! 🐛
Exciting update is we just got some funding to study caterpillar performance on local and nonlocal ecotypes! (Plant genotypes adapted to other ecoregions).
Stay tuned for more caterpillar pictures this summer! 🐛
April 9, 2026 at 12:39 PM
This paper is making the rounds again!
Exciting update is we just got some funding to study caterpillar performance on local and nonlocal ecotypes! (Plant genotypes adapted to other ecoregions).
Stay tuned for more caterpillar pictures this summer! 🐛
Exciting update is we just got some funding to study caterpillar performance on local and nonlocal ecotypes! (Plant genotypes adapted to other ecoregions).
Stay tuned for more caterpillar pictures this summer! 🐛
Midst of the labs Genetics publish-athon from @ccaseys.bsky.social. Infecting a population on host genotypes spread across 8 dicots we could show that a generalist pathogen has both generalist and specialist genes url:https://academic.oup.com/genetics/article/doi/10.1093/genetics/iyaf079/8158657
June 9, 2025 at 7:07 PM
Midst of the labs Genetics publish-athon from @ccaseys.bsky.social. Infecting a population on host genotypes spread across 8 dicots we could show that a generalist pathogen has both generalist and specialist genes url:https://academic.oup.com/genetics/article/doi/10.1093/genetics/iyaf079/8158657
“Prior exposure to GI.3, GII.2, and GII.17 infections enhanced susceptibility to subsequent infections with several other norovirus genotypes.”
January 17, 2025 at 11:59 AM
“Prior exposure to GI.3, GII.2, and GII.17 infections enhanced susceptibility to subsequent infections with several other norovirus genotypes.”
June 6, 2025 at 6:33 PM
amenable to composition updates to address changes in genotype prevalence, may represent a promising strategy. mRNA-1403 is a trivalent mRNA-based candidate containing three mRNAs that encode for the major capsid protein 1 (VP1) of three globally prevalent NoV genotypes-GII.4,
January 16, 2025 at 5:08 PM
amenable to composition updates to address changes in genotype prevalence, may represent a promising strategy. mRNA-1403 is a trivalent mRNA-based candidate containing three mRNAs that encode for the major capsid protein 1 (VP1) of three globally prevalent NoV genotypes-GII.4,
Amazing piece of work demonstrating emergence, replacement and spatial movement of HPAI genotypes in N. America.
👉 www.science.org/doi/10.1126/...
👉 www.science.org/doi/10.1126/...
July 14, 2025 at 3:30 AM
Amazing piece of work demonstrating emergence, replacement and spatial movement of HPAI genotypes in N. America.
👉 www.science.org/doi/10.1126/...
👉 www.science.org/doi/10.1126/...
New proposal for Apple: in the next iteration of OSX please add a feature so the contacts software automatically recognizes a vcf with genotypes and displays the data.
October 24, 2025 at 3:36 AM
New proposal for Apple: in the next iteration of OSX please add a feature so the contacts software automatically recognizes a vcf with genotypes and displays the data.
Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi
January 17, 2025 at 10:39 AM
Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi
Although they are the same subtype, the flu A H1N1 and H3N2 are actually a lot of different viruses. Within each subtype are many different genotypes. Flu is an RNA virus that acquires mutations as it spreads through host populations. Flu viruses are very diverse.
February 19, 2025 at 11:30 AM
Although they are the same subtype, the flu A H1N1 and H3N2 are actually a lot of different viruses. Within each subtype are many different genotypes. Flu is an RNA virus that acquires mutations as it spreads through host populations. Flu viruses are very diverse.
injection-related. Furthermore, mRNA-1403 elicited robust serum HBGA-blocking antibody responses against all three NoV genotypes and across all dose levels. In addition, similar findings for reactogenicity, safety, and immunogenicity were observed for both younger and older
January 16, 2025 at 5:11 PM
injection-related. Furthermore, mRNA-1403 elicited robust serum HBGA-blocking antibody responses against all three NoV genotypes and across all dose levels. In addition, similar findings for reactogenicity, safety, and immunogenicity were observed for both younger and older