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What does Trump's handwriting tell us about the man? Mike Fuoco interviewed Michelle for a front-page feature in the Pittsburgh Post-Gazette on Presidential signatures.  What's in a president's signat...

Background: Mild cognitive impairment (MCI) is a precursor of dementia. Therefore, MCI identification and monitoring are crucial to delaying dementia onset. Given the limits of existing clinical tests, objective support tools are needed. Objective: This work investigates quantitative handwriting analysis, tailored to enable domestic monitoring, as a noninvasive approach for MCI screening and assessment. Methods: A sensorized ink pen, used on paper and equipped with sensors, memory, and a communication unit, was used for data acquisition. The tasks included writing a grocery list and free text to mimic daily life handwriting, and a clinical dictation test (parole-non-parole [PnP] test), featuring regular, irregular, and made-up words, aimed at assessing MCI dysgraphia. From the recorded data, 106 indicators describing the performance in terms of time, fluency, exerted force, and pen inclination were computed. A total of 57 patients with MCI were recruited, of whom 45 performed a test-retest protocol. The indicators were examined to assess their test-retest reliability. The indicators from the test repetition were used to assess their relationship with the scores of clinical tests via correlation analysis. For the PnP test, differences in the indicators among the 3 types of words were statistically investigated. These analyses were conducted separately for the cursive (2/3 of the sample) and block letters (1/3 of the sample) allographs, with the level of significance set at 5%. Data from healthy older adults were available for the grocery list (34 participants) and free text (45 participants) tasks. These were exploited to build machine learning classification models for the distinction between patients with MCI and healthy controls. Results: When dealing with reliability, 93% and 44% of the indicators were characterized by a significant reliability of at least moderate intensity for cursive and block letters respectively. As for the correlation analysis, patients with preserved cognitive status and daily life functionality were associated with significantly better temporal performances, both in free writing and PnP. The analysis of PnP highlighted the presence of surface dysgraphia in the recruited sample, as irregular words showed significantly worse temporal indicators with respect to regular and made-up ones. The classification models’ built-in free writing data achieved accuracies ranging from 0.80 to 0.93 and F1-scores from 0.81 to 0.92 according to the input dataset. Conclusions: The presented results suggest the suitability of ecological handwriting analysis for the all-around monitoring of MCI, from early screening to disease progression evaluation.

Sarah stared at her laptop screen, fingers hovering over the keyboard. Her to-do list app showed 47 uncompleted tasks, color-coded by priority and sorted by

A new University at Buffalo-led study outlines how artificial intelligence-powered handwriting analysis may serve as an early detection tool for dyslexia and dysgraphia among young children.