Hypothalamic secretion of gonadotropin-releasing hormone stimulating anterior pituitary release of follicle-stimulating hormone and luteinizing hormone if it were written by Vivziepop
May 19, 2026 at 11:25 PM
Hypothalamic secretion of gonadotropin-releasing hormone stimulating anterior pituitary release of follicle-stimulating hormone and luteinizing hormone if it were written by Vivziepop
Nature research paper: A hypothalamic circuit that modulates feeding and parenting behaviours
go.nature.com/4l0XKoB
go.nature.com/4l0XKoB
A hypothalamic circuit that modulates feeding and parenting behaviours - Nature
Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.
go.nature.com
August 5, 2025 at 8:58 AM
Nature research paper: A hypothalamic circuit that modulates feeding and parenting behaviours
go.nature.com/4l0XKoB
go.nature.com/4l0XKoB
Functional hypothalamic amenorrhea is an understudied condition. Please help me get two important studies filled by spreading the word! open.substack.com/pub/vajenda/...
When Periods Stop : Understanding Functional Hypothalamic Amenorrhea (FHA)
Why this under-recognized condition deserves more attention–and how you can help researchers close the data gap
open.substack.com
November 3, 2025 at 3:44 PM
Functional hypothalamic amenorrhea is an understudied condition. Please help me get two important studies filled by spreading the word! open.substack.com/pub/vajenda/...
SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!
❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠
In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.
Read the paper here: www.biorxiv.org/content/10.1... (1/6)
In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.
Read the paper here: www.biorxiv.org/content/10.1... (1/6)
November 22, 2024 at 8:16 PM
SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!
Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon.
rdcu.be/ebo63
rdcu.be/ebo63
A hypothalamic circuit underlying the dynamic control of social homeostasis
Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...
rdcu.be
February 26, 2025 at 5:21 PM
Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon.
rdcu.be/ebo63
rdcu.be/ebo63
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...
A hypothalamic circuit that modulates feeding and parenting behaviours - Nature
Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.
www.nature.com
July 30, 2025 at 4:35 PM
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...
After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sensory input, sex and function shape hypothalamic cell type development - Nature
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...
www.nature.com
March 5, 2025 at 4:50 PM
After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A hypothalamic circuit underlying the dynamic control of social homeostasis rdcu.be/ei6To - the neuroscience of loneliness... (in mice) 🐭😥
A hypothalamic circuit underlying the dynamic control of social homeostasis
Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...
rdcu.be
April 24, 2025 at 7:03 AM
A hypothalamic circuit underlying the dynamic control of social homeostasis rdcu.be/ei6To - the neuroscience of loneliness... (in mice) 🐭😥
Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity - Cell Research
Cell Research - Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity
www.nature.com
March 6, 2025 at 12:45 PM
Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature research paper: A hypothalamic circuit underlying the dynamic control of social homeostasis
https://go.nature.com/4kklEfC
https://go.nature.com/4kklEfC
A hypothalamic circuit underlying the dynamic control of social homeostasis - Nature
New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and the satiation of social need during social reunion.
go.nature.com
February 28, 2025 at 9:40 AM
Nature research paper: A hypothalamic circuit underlying the dynamic control of social homeostasis
https://go.nature.com/4kklEfC
https://go.nature.com/4kklEfC
Two dueling sets of hypothalamic neurons—one that responds to isolation and one to reunion—help maintain a mouse's social homeostasis, a new study reveals.
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/social-behav...
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/social-behav...
Soft touch quells loneliness in mice
Touch modulates one of two dueling types of hypothalamic neurons that, thermostat-like, balance an animal’s drive for social interaction.
www.thetransmitter.org
February 26, 2025 at 4:11 PM
Two dueling sets of hypothalamic neurons—one that responds to isolation and one to reunion—help maintain a mouse's social homeostasis, a new study reveals.
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/social-behav...
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/social-behav...
From Great Friend and acclaimed Cardiothoracic Surgeon
@harryspoelstra.bsky.social
Personal joke #Nerve_of_Joffe
www.frontiersin.org/journals/cel...
@harryspoelstra.bsky.social
Personal joke #Nerve_of_Joffe
www.frontiersin.org/journals/cel...
Frontiers | Connecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction
www.frontiersin.org
December 16, 2024 at 10:37 AM
From Great Friend and acclaimed Cardiothoracic Surgeon
@harryspoelstra.bsky.social
Personal joke #Nerve_of_Joffe
www.frontiersin.org/journals/cel...
@harryspoelstra.bsky.social
Personal joke #Nerve_of_Joffe
www.frontiersin.org/journals/cel...
Superb @nature.com study from @dulaclab.bsky.social’s lab, led by @dingliu.bsky.social, shedding light on the neural circuitry underlying social homeostasis, centred around two hypothalamic cell populations.
Deep similarities with other physiological needs 🧪🧠
www.nature.com/articles/s41...
Deep similarities with other physiological needs 🧪🧠
www.nature.com/articles/s41...
A hypothalamic circuit underlying the dynamic control of social homeostasis - Nature
New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and...
www.nature.com
February 26, 2025 at 6:09 PM
Superb @nature.com study from @dulaclab.bsky.social’s lab, led by @dingliu.bsky.social, shedding light on the neural circuitry underlying social homeostasis, centred around two hypothalamic cell populations.
Deep similarities with other physiological needs 🧪🧠
www.nature.com/articles/s41...
Deep similarities with other physiological needs 🧪🧠
www.nature.com/articles/s41...
I’m excited to share our publication from @dulaclab.bsky.social in @nature.com, where we illuminate the development of hypothalamic cell types involved in a broad range of functions, from social behaviors to thirst, thermoregulation, and sleep. Highlights below! 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sensory input, sex and function shape hypothalamic cell type development - Nature
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...
www.nature.com
March 5, 2025 at 10:04 PM
I’m excited to share our publication from @dulaclab.bsky.social in @nature.com, where we illuminate the development of hypothalamic cell types involved in a broad range of functions, from social behaviors to thirst, thermoregulation, and sleep. Highlights below! 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Decoding gene networks controlling hypothalamic and prethalamic neuron development
Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus
using single-cell multiomics, identifying regulators of regionalization and neurogenesis.
They further show...
www.cell.com
June 14, 2025 at 12:48 AM
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
I’m excited to share our new preprint! We built a single-nucleus multiomic (snRNA-seq+snATAC-seq) atlas of leptin receptor-expressing hypothalamic neurons (LepRᴴʸᵖᵒ) and identified conserved cis-regulatory elements overlapping human obesity-linked variants and eQTLs🧠🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity
Leptin receptor-expressing hypothalamic neurons (LepRHypo) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We pr...
www.biorxiv.org
October 8, 2025 at 5:02 PM
I’m excited to share our new preprint! We built a single-nucleus multiomic (snRNA-seq+snATAC-seq) atlas of leptin receptor-expressing hypothalamic neurons (LepRᴴʸᵖᵒ) and identified conserved cis-regulatory elements overlapping human obesity-linked variants and eQTLs🧠🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 23, 2025 at 10:23 AM
Whole-brain projections of over 7,000 hypothalamic neurons expressing distinct neuropeptides in male mice, identifying 2 main classes and 31 types using single-neuron projectome analysis 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Projectome-based characterization of hypothalamic peptidergic neurons in male mice - Nature Neuroscience
This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalam...
www.nature.com
March 31, 2025 at 1:08 PM
Whole-brain projections of over 7,000 hypothalamic neurons expressing distinct neuropeptides in male mice, identifying 2 main classes and 31 types using single-neuron projectome analysis 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧠 Compulsion has a wiring diagram
Flip one circuit between cortex and hypothalamus in a mouse and it stops caring about anything but nice food. In people, that same connection tracks body weight and binge eating.
www.cell.com/neuron/abstr...
🧪 #Neuroscience #SciComm
Flip one circuit between cortex and hypothalamus in a mouse and it stops caring about anything but nice food. In people, that same connection tracks body weight and binge eating.
www.cell.com/neuron/abstr...
🧪 #Neuroscience #SciComm
A cortical-hypothalamic neural circuit for compulsive eating in mice
Leow et al. identify a prefrontal-hypothalamic circuit that drives compulsive eating
despite negative consequences. In mice, binge eating reshapes prefrontal neural dynamics
into persistent food-seeki...
www.cell.com
August 1, 2026 at 1:11 PM
🧠 Compulsion has a wiring diagram
Flip one circuit between cortex and hypothalamus in a mouse and it stops caring about anything but nice food. In people, that same connection tracks body weight and binge eating.
www.cell.com/neuron/abstr...
🧪 #Neuroscience #SciComm
Flip one circuit between cortex and hypothalamus in a mouse and it stops caring about anything but nice food. In people, that same connection tracks body weight and binge eating.
www.cell.com/neuron/abstr...
🧪 #Neuroscience #SciComm
Ummm....
The Vagus Nerve innervates the vocal cords.
It also moves the foregut. That increases the risks of volume reflux and secondary cord damage
Start here
doi.org/10.3389/fcim...
The Vagus Nerve innervates the vocal cords.
It also moves the foregut. That increases the risks of volume reflux and secondary cord damage
Start here
doi.org/10.3389/fcim...
December 22, 2024 at 10:09 PM
Ummm....
The Vagus Nerve innervates the vocal cords.
It also moves the foregut. That increases the risks of volume reflux and secondary cord damage
Start here
doi.org/10.3389/fcim...
The Vagus Nerve innervates the vocal cords.
It also moves the foregut. That increases the risks of volume reflux and secondary cord damage
Start here
doi.org/10.3389/fcim...
Connecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction
FYI my friend David Joffe
https://buff.ly/3ZPzk9c
FYI my friend David Joffe
https://buff.ly/3ZPzk9c
December 31, 2024 at 4:08 AM
Connecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction
FYI my friend David Joffe
https://buff.ly/3ZPzk9c
FYI my friend David Joffe
https://buff.ly/3ZPzk9c
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
www.science.org
July 31, 2025 at 6:52 PM
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...