Zoology; Evolutionary biology; Developmental biology

Neuroscience; Developmental neuroscience; Cell biology; Proteomics

Microbiology; Paleobiology; Paleogenetics; Anthropology

Biological sciences; Animal physiology; Molecular physiology

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Microbiology; Paleobiology; Paleogenetics; Anthropology

Paleogenetics; Archeology

Read the full paper: Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes

Read the full paper: Chemogenetic hyperpolarization in the entorhinal cortex during sleep facilitates delta oscillations and memory consolidation

Marine geochemistry; Ecology; Virology

Interventions; Medical imaging

Read the full paper: Targeted degradation of a constitutively active GPCR oncoprotein

Read the full paper: Form and function of actin impacts actin health and aging

Read the full paper: PP2A-dependent downregulation of GABAB receptors modulates somatostatin interneurons function and plasticity

Evolutionary biology; Biomechanics; Paleobiology

Read the full paper: Distinct cellular mechanisms underlie ON orientation selectivity in the mouse retina

Read the full paper: ICAM-5: A marker for neuronally derived extracellular vesicles

In a study published in iScience, researchers at Florida International University (FIU) tested how three of the world's most dangerous mosquito species responded to 119 human volunteers. Surprisingly, not a single participant attracted all three species. Instead, each species favored a different group of people, largely based on their individual body chemistry and natural skin odors. The discovery could change how scientists approach the prevention of mosquito-borne diseases. Because different mosquito species respond to different chemical signals from human skin, researchers may eventually be able to create next-generation, species-specific repellents that offer more targeted protection. "Isolating the components of human odor that attract or repel mosquitoes could lead to novel strategies to combat vector-borne diseases," said Matthew DeGennaro, a neurogeneticist who leads the research team and directs the Biomolecular Sciences Institute at FIU, Miami's state university. Different Mosquito Species Prefer Different People The researchers investigated three species responsible for spreading serious illnesses, including yellow fever, dengue, Zika, West Nile and other diseases. These were Aedes aegypti, Aedes albopictus (Asian tiger mosquito) and Culex quinquefasciatus (southern house mosquito). Led by Ph.D. student Kaylee Marrero, the investigation was the first to directly compare how several mosquito species reacted to the same human...

Read the full paper: LKMHCpan: Transformer-optimized HLA-I pseudo-sequences enhance neoantigen prediction for immunotherapy

Read the full paper: Exercise imprints a persistent tumor intrinsic suppressive state in colorectal cancer

Read the full paper: Long non-coding RNA prompts immune-related adverse events risk and immunotherapy response in pan-cancer

(Adnkronos) - Scoperto un gene polimorfico che induce gravi danni polmonari nei pazienti affetti da Covid-19. Il risultato dello studio, pubblicato su iScience, vede protagonista l’Azienda ospedaliero-universitaria Senese e l’Università di Siena, con la Genetica Medica, diretta dalla professoressa A