I don't know that I can put into words how frustrating it is that bad-faith actors take completely normal, appropriate responses to vaccines and attempt to pathologize them as something bad.
Vaccines are supposed to be immunogenic. S Antibodies are mechanistic correlates of protection in COVID-19.
Vaccines are supposed to be immunogenic. S Antibodies are mechanistic correlates of protection in COVID-19.
Mary this is literally how vaccines are supposed to work.
May 2, 2026 at 3:39 AM
I don't know that I can put into words how frustrating it is that bad-faith actors take completely normal, appropriate responses to vaccines and attempt to pathologize them as something bad.
Vaccines are supposed to be immunogenic. S Antibodies are mechanistic correlates of protection in COVID-19.
Vaccines are supposed to be immunogenic. S Antibodies are mechanistic correlates of protection in COVID-19.
elderly. These applications could provide rapid, non-immunogenic protection, complementing vaccination programs and enhancing public health defenses against future viral outbreaks. This discovery not only expands our arsenal against COVID-19 but also exemplifies the transformative potential
August 12, 2025 at 4:11 PM
elderly. These applications could provide rapid, non-immunogenic protection, complementing vaccination programs and enhancing public health defenses against future viral outbreaks. This discovery not only expands our arsenal against COVID-19 but also exemplifies the transformative potential
people who think they're "allergic to EMF" are probably actually allergic to some other pervasive immunogenic substance in homes and offices
July 14, 2025 at 6:07 PM
people who think they're "allergic to EMF" are probably actually allergic to some other pervasive immunogenic substance in homes and offices
Nature research paper: Membranolytic peptide programs immunogenic cell death for cancer therapy
go.nature.com/45d4wlQ
go.nature.com/45d4wlQ
Membranolytic peptide programs immunogenic cell death for cancer therapy - Nature
The synthetic-acid-responsive membranolytic peptide aMPC16-CA50 induces immunogenic membranolytic cell death in tumour cells, robustly potentiating immune checkpoint blockade therapy.
go.nature.com
August 6, 2026 at 7:16 PM
Nature research paper: Membranolytic peptide programs immunogenic cell death for cancer therapy
go.nature.com/45d4wlQ
go.nature.com/45d4wlQ
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology
Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...
www.nature.com
January 13, 2025 at 10:12 AM
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
1. The seminal work on the mRNA vaccine platform had already been done over the past 20 years.
2. The protein synthesis methods and genetics to develop stable immunogenic antigens was similarly done over the past 20 years, primarily in HIV.
3. The clinical trials were designed to…
2. The protein synthesis methods and genetics to develop stable immunogenic antigens was similarly done over the past 20 years, primarily in HIV.
3. The clinical trials were designed to…
May 21, 2026 at 2:34 AM
1. The seminal work on the mRNA vaccine platform had already been done over the past 20 years.
2. The protein synthesis methods and genetics to develop stable immunogenic antigens was similarly done over the past 20 years, primarily in HIV.
3. The clinical trials were designed to…
2. The protein synthesis methods and genetics to develop stable immunogenic antigens was similarly done over the past 20 years, primarily in HIV.
3. The clinical trials were designed to…
I'm incredibly proud to share our paper on the preclinical evaluation of the BNT164 mRNA tuberculosis vaccine candidates.
Now online in the final version at Nature Immunology.
www.nature.com/articles/s41...
Now online in the final version at Nature Immunology.
www.nature.com/articles/s41...
mRNA-based tuberculosis vaccines BNT164a1 and BNT164b1 are immunogenic, well tolerated and efficacious in rodent models - Nature Immunology
Here the authors characterize mRNA-based tuberculosis vaccine candidates BNT164a1 and BNT164b1 and show that they are immunogenic, well tolerated and efficacious in preclinical animal models.
www.nature.com
June 12, 2026 at 1:06 PM
I'm incredibly proud to share our paper on the preclinical evaluation of the BNT164 mRNA tuberculosis vaccine candidates.
Now online in the final version at Nature Immunology.
www.nature.com/articles/s41...
Now online in the final version at Nature Immunology.
www.nature.com/articles/s41...
Everything is horrible in science right now, but having a paper accepted for publication still feels good :)
March 6, 2025 at 7:15 AM
Everything is horrible in science right now, but having a paper accepted for publication still feels good :)
Salicylic acid-triggered apoplastic proteolysis releases cryptic phytocytokines with distinct immunogenic functions https://www.biorxiv.org/content/10.64898/2026.09.01.748544v1
September 3, 2026 at 10:02 AM
Salicylic acid-triggered apoplastic proteolysis releases cryptic phytocytokines with distinct immunogenic functions https://www.biorxiv.org/content/10.64898/2026.09.01.748544v1
I just had the pneumococcus vaccine [free for people 65+ in Australia].
It contains sugars from 21 types of pneumococcus, linked to CRM197 — a version of diphtheria toxin that is highly immunogenic, but rendered non-toxic by a single mutation, altering just 1 of 535 amino acids.
It contains sugars from 21 types of pneumococcus, linked to CRM197 — a version of diphtheria toxin that is highly immunogenic, but rendered non-toxic by a single mutation, altering just 1 of 535 amino acids.
September 22, 2026 at 5:26 AM
I just had the pneumococcus vaccine [free for people 65+ in Australia].
It contains sugars from 21 types of pneumococcus, linked to CRM197 — a version of diphtheria toxin that is highly immunogenic, but rendered non-toxic by a single mutation, altering just 1 of 535 amino acids.
It contains sugars from 21 types of pneumococcus, linked to CRM197 — a version of diphtheria toxin that is highly immunogenic, but rendered non-toxic by a single mutation, altering just 1 of 535 amino acids.
Ankara researchers found that mice vaccinated with a membrane-bound SARS-CoV-2 Spike protein engineered by deleting 21 amino acids produced stronger, safer immune responses than mRNA or inactivated virus vaccines.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Membrane-targeted immunogenic compositions using exosome mimetic approach for vaccine development against SARS-CoV-2 and other pathogens - Scientific Reports
Scientific Reports - Membrane-targeted immunogenic compositions using exosome mimetic approach for vaccine development against SARS-CoV-2 and other pathogens
www.nature.com
March 30, 2025 at 12:22 PM
Ankara researchers found that mice vaccinated with a membrane-bound SARS-CoV-2 Spike protein engineered by deleting 21 amino acids produced stronger, safer immune responses than mRNA or inactivated virus vaccines.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
A new function of glycosylated RNAs has been discovered by Graziano et al. in which
the glycosylation of RNA molecules shields acp³U RNA modification from triggering
innate immune responses.
www.cell.com
October 18, 2025 at 1:20 PM
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
Thrilled to share our recent review in Chemical Science exploring the potential of metal-based compounds to induce immunogenic cell death (ICD) in cancer cells!
Full text: pubs.rsc.org/en/content/a...
Full text: pubs.rsc.org/en/content/a...
Metal-based immunogenic cell death inducers for cancer immunotherapy
Immunogenic cell death (ICD) has attracted enormous attention in the last decade due to its unique characteristics of cancer cell death as well as activation of innate and adaptive immune responses ag...
pubs.rsc.org
March 5, 2025 at 3:06 PM
Thrilled to share our recent review in Chemical Science exploring the potential of metal-based compounds to induce immunogenic cell death (ICD) in cancer cells!
Full text: pubs.rsc.org/en/content/a...
Full text: pubs.rsc.org/en/content/a...
This is our paper! Read more here: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
May 16, 2025 at 11:18 PM
This is our paper! Read more here: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Instead, vaccine manufacturers submit data showing the new strains grow properly, are immunogenic (trigger an immune response), and are consistent with past safety profiles. This process is called an "annual strain update" rather than a full re-approval.
April 28, 2025 at 5:53 PM
Instead, vaccine manufacturers submit data showing the new strains grow properly, are immunogenic (trigger an immune response), and are consistent with past safety profiles. This process is called an "annual strain update" rather than a full re-approval.
Always love posts from @enirenberg.bsky.social--this is our hot off the press work with @gquirk96.bsky.social, but he does a better job explaining it than I would!
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
I've been yelling for a while about how imprinting is not the problem with our immune responses to Omicron, and the issue is much more about the intrinsic immunogenicity of Omicron's spike protein (which is poor). This freshly published study provides pretty definitive proof of that 🧵
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections - Nature Immunology
Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2 variants Delta and Omicron B...
www.nature.com
May 27, 2025 at 6:17 PM
Always love posts from @enirenberg.bsky.social--this is our hot off the press work with @gquirk96.bsky.social, but he does a better job explaining it than I would!
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
‘Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer’
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer - Nature Immunology
To mature, dendritic cells collect and synthesize cholesterol to construct lipid nanodomains on their membranes. Obstructing this process impairs their ability to prime T cells.
www.nature.com
February 3, 2025 at 9:04 PM
‘Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer’
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New Paper Alert: Silver nanoparticle induced immunogenic cell death can improve immunotherapy
oncodaily.com/oncolibrary/...
#Cancer #CancerResearch #Medicine #Health #Immunotherapy #CancerTreatment #Oncology #OncoDaily
oncodaily.com/oncolibrary/...
#Cancer #CancerResearch #Medicine #Health #Immunotherapy #CancerTreatment #Oncology #OncoDaily
New Paper Alert: Silver nanoparticle induced immunogenic cell death can improve immunotherapy - OncoDaily
Learn more about immunogenic cell death and silver nanoparticles latest research published in Journal of Nanobiotechnology, Natures, 2025
oncodaily.com
March 5, 2025 at 8:23 PM
New Paper Alert: Silver nanoparticle induced immunogenic cell death can improve immunotherapy
oncodaily.com/oncolibrary/...
#Cancer #CancerResearch #Medicine #Health #Immunotherapy #CancerTreatment #Oncology #OncoDaily
oncodaily.com/oncolibrary/...
#Cancer #CancerResearch #Medicine #Health #Immunotherapy #CancerTreatment #Oncology #OncoDaily
Solvothermal domino synthesis of an ER-targeted iron(II) complex for inducing immunogenic cell death
Solvothermal domino synthesis of an ER-targeted iron(II) complex for inducing immunogenic cell death
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
March 6, 2025 at 8:19 AM
Solvothermal domino synthesis of an ER-targeted iron(II) complex for inducing immunogenic cell death
The Babak Lab - Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors
@thebabaklab.bsky.social
oncodaily.com/science/2588...
#Cancer #CancerResearch #BabakLab #Mesothelioma #ImmuneResponse #Medicine #Health #Oncology #OncoDaily
@thebabaklab.bsky.social
oncodaily.com/science/2588...
#Cancer #CancerResearch #BabakLab #Mesothelioma #ImmuneResponse #Medicine #Health #Oncology #OncoDaily
Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors - The Babak Lab - OncoDaily
Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors - The Babak Lab / American Chemical Society,
oncodaily.com
March 22, 2025 at 8:02 PM
The Babak Lab - Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors
@thebabaklab.bsky.social
oncodaily.com/science/2588...
#Cancer #CancerResearch #BabakLab #Mesothelioma #ImmuneResponse #Medicine #Health #Oncology #OncoDaily
@thebabaklab.bsky.social
oncodaily.com/science/2588...
#Cancer #CancerResearch #BabakLab #Mesothelioma #ImmuneResponse #Medicine #Health #Oncology #OncoDaily
On top of the antivax insanity, the MAHA people are promoting compounded peptides that if aren’t extremely pure can trigger immunogenic reactions that can cause autoimmunity
August 10, 2026 at 10:11 PM
On top of the antivax insanity, the MAHA people are promoting compounded peptides that if aren’t extremely pure can trigger immunogenic reactions that can cause autoimmunity
3. Rotavirus
There have been 12 inert placebo-controlled trials!
Here's just one example: pubmed.ncbi.nlm.nih.gov/16088807/
There have been 12 inert placebo-controlled trials!
Here's just one example: pubmed.ncbi.nlm.nih.gov/16088807/
Evaluation of RIX4414, a live, attenuated rotavirus vaccine, in a randomized, double-blind, placebo-controlled phase 2 trial involving 2464 Singaporean infants - PubMed
The live, attenuated rotavirus vaccine (RIX4414) was well tolerated and highly immunogenic in Singaporean infants. The immunogenicity of routinely administered infant vaccines was not impaired by conc...
pubmed.ncbi.nlm.nih.gov
June 13, 2025 at 5:26 AM
3. Rotavirus
There have been 12 inert placebo-controlled trials!
Here's just one example: pubmed.ncbi.nlm.nih.gov/16088807/
There have been 12 inert placebo-controlled trials!
Here's just one example: pubmed.ncbi.nlm.nih.gov/16088807/
There is currently one trial recruiting for ivermectin (IVM) in cancer, combining IVM with the anti-PD-1 antibody balstilimab. The trial is based on a single study in which IVM induced immunogenic cell death and T-cell infiltration in a mouse model of triple-negative breast cancer. 2/
January 12, 2025 at 7:30 AM
There is currently one trial recruiting for ivermectin (IVM) in cancer, combining IVM with the anti-PD-1 antibody balstilimab. The trial is based on a single study in which IVM induced immunogenic cell death and T-cell infiltration in a mouse model of triple-negative breast cancer. 2/
Wohlwend et al. apply a deep learning model to reveal immunogenic T cell epitopes. Their method refines peptide binding predictions, surpasses prior tools, and uncovers new viral targets, advancing vaccine-focused immune research. www.nature.com/articles/s42...
Deep learning enhances the prediction of HLA class I-presented CD8+ T cell epitopes in foreign pathogens - Nature Machine Intelligence
Accurate prediction of immunogenic CD8+ T cell epitopes would greatly accelerate T cell vaccine development. A new deep learning model, MUNIS, can rapidly identify HLA-binding, immunogenic and immunod...
www.nature.com
January 30, 2025 at 5:28 PM
Wohlwend et al. apply a deep learning model to reveal immunogenic T cell epitopes. Their method refines peptide binding predictions, surpasses prior tools, and uncovers new viral targets, advancing vaccine-focused immune research. www.nature.com/articles/s42...