A real-time deep learning system was developed to identify extrahepatic bile ducts during indocyanine green fluorescence-guided laparoscopic cholecystectom

To characterize the phenotypic spectrum of mid-phase hyperfluorescent plaques (MPHPs) on indocyanine green angiography (ICGA) in eyes with central serous chorioretinopathy (CSCR) and to evaluate their relationship with corresponding optical coherence tomography (OCT) features.

Anastomotic leaks are a significant complication in colorectal surgery. Indocyanine green fluorescence angiography (ICG-FA) has been suggested as a method to reduce the risk. This meta-analysis aims t...

Zheng et al. report the clinical value of indocyanine green (ICG)-guided laparoscopic lymphadenectomy for gastric cancer. The short-term results of this multicenter, open-label, superiority design randomized controlled trial (NCT04593615) indicate that ICG technology is safe and feasible and can significantly increase the number of LNs retrieved.

Background Indocyanine green is commonly used for laparoscopic hepatectomy but remains uncommon in pancreatic surgery. Given the increasing number of small neuroendocrine tumors found in the pancreas and the heavy reliance on laparoscopic ultrasound for intraoperative localization, we attempted to use indocyanine green for these tumors. Our results show good localization and have the potential to provide a valuable clinical aid. Case Presentation This case report details five patients with preoperative diagnosis of pancreatic neuroendocrine tumors of small endocrine tumors, intraoperative successful localization, and successful completion of laparoscopic partial resection of pancreatic tumors by indocyanine green fluorescence staining; none of the patients experienced serious complications after surgery and were discharged from the hospital, and routine pathology confirmed that four cases were pancreatic neuroendocrine tumors of G1 stage, and one case was pancreatic neuroendocrine cell hyperplasia. Conclusion Fluorescence imaging technology safely aids in the intraoperative localization of small pancreatic neuroendocrine tumors.

Anastomotic leaks are a significant complication in colorectal surgery. Indocyanine green fluorescence angiography (ICG-FA) has been suggested as a method to reduce the risk. This meta-analysis aims to evaluate the effect of ICG-FA on reducing anastomotic leaks in colorectal surgery. This study follows PRISMA guidelines and is registered on PROSPERO (CRD42022370748). We conducted a comprehensive search of multiple databases and registers for randomized controlled trials (RCTs) comparing ICG-FA with standard methods in colorectal surgery. Data extraction and quality assessment were performed by two independent reviewers, with a third resolving disputes. Odds ratios (OR) and mean differences (MD) were calculated using comprehensive meta-analysis software, version 3. Heterogeneity and publication bias were assessed, and a sensitivity analysis was performed. The analysis included five RCTs with a total of 1369 patients from four countries. The ICG-FA was associated with a 45% reduction in the risk of overall anastomotic leaks (OR: 0.550, p = 0.012). Subgroup analysis showed a 47% reduction in leaks for low anastomoses (OR: 0.53, p = 0.143) and a 69% reduction in grade A leaks (OR: 0.31, p = 0.008). No significant effects were observed for grade B and C leaks, blood loss, surgery duration, hospital stay, mortality, postoperative ileus, reoperation, or surgical site infections. ICG-FA significantly reduces the overall risk of anastomotic leaks, especially grade A leaks, and shows a trend towards fewer leaks in low anastomosis. No significant impact was found on secondary outcomes. Further RCTs are needed to confirm these findings.

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Indocyanine green angiography to evaluate immediate hypoparathyroidism after thyroid cancer surgery Introduction: Indocyanine green (ICG) fluorescence…

This prospective trial demonstrated that indocyanine green fluorescence performed similarly to technetium-99m lymphoscintigraphy and was potentially less c

Read the full paper: Serum indocyanine green quantification enables objective assessment of lymphatic function

Our work represents a step forward in the innovative design and synthesis of NIR-II fluorophores with novel scaffold Cy15s, which is feasible for multiple modifications while redshifting the wavelength of indocyanine polymethines beyond 1,200 nm to…

Optoacoustic tracking of small microparticles flowing throughout microvascular networks enables functional microangiography deep into optically opaque biological tissues, essentially breaking through ...