Read the full paper: Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1

Read the full paper: The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity

This study reports that Saffold virus, associated with respiratory, gastrointestinal, and neurological illnesses, uses both sulfated glycosaminoglycans and integrin αVβ8 as cooperative attachment receptors essential for viral entry.

SUMMARY: Researchers will build on earlier research to determine the feasibility of using the cell surface  marker integrin α6β4 as a new therapeutic target. THE PROBLEM: Hemangiosarcoma is a deadly…

Integrins are a large family of α/β heterodimeric receptors whose activation is associated with the extension of the ectodomain and disruption of transient transmembrane domain (TMD) interactions. Whe...

The stem cell niche is a specialised microenvironment essential for maintaining haematopoietic stem cells (HSCs). Here we identify a distinct subset of mesenchymal stem cells (MSCs) expressing integrin α8 (Itga8⁺ MSCs) within the bone marrow (BM) endosteum. These cells exhibit distinct MSC properties and higher haematopoietic supportive activity than other MSC subsets. Depletion of Itga8⁺ MSCs decreased HSC numbers, reduced quiescence of endosteal HSCs and diminished BM repopulating capacity. Itga8⁺ MSCs support haematopoiesis through cell adhesion-related mechanisms. Single-cell RNA sequencing further identified Itga8⁺ MSCs as a distinct subpopulation within bone-lining cells. Moreover, we identified Mfap4 as a candidate factor expressed in Itga8⁺ MSCs, and Mfap4 supported the BM reconstitution capacity of HSCs. These results suggest that Itga8⁺ MSCs represent a distinct niche cell population for HSC maintenance. This work provides new insights into HSC regulation and strategies to op

Zhang et al. demonstrate that increased extracellular fluid viscosity promotes immunosuppressive M2-like macrophage polarization through integrin/FAK-STAT3 signaling and cytoskeletal remodeling. This viscosity-driven macrophage state accelerates breast cancer progression and reduces the response to anti-PD-1 immunotherapy, linking a physical property of the tumor microenvironment to immune evasion.

Lee et al. show that planar cell polarity organizes directional epithelial migration by polarizing basal protrusions and integrin adhesion during postnatal intestinal development. Coordinated migration maintains tissue architecture and spatially restricted gene expression, and metabolic function, revealing how epithelial movement preserves functional organization during continuous tissue renewal.

(Molecular Therapy 28, 1287–1298; May 2020)

Epithelial organoids are grown without Matrigel using a single-chain antibody.

Mutations in FERMT3 cause LAD-III by impairing integrin function in neutrophils. Using CRISPR/Cas9, we generated FERMT3 KO cultured neutrophils with normal

Objective: Much of the available real-world evidence on the gut-selective α4β7 integrin antibody vedolizumab comes from patients with repeated failure…

Integrins are bidirectional mechanochemical receptors that transmit signals upon ligand binding to the cytoskeleton (outside-in) and cytoskeletal forces back across the membrane (inside-out) to the…