Fantastic setting for Keystone metastasis meeting. This is the view from the seminar room. #KSMetastasis25
January 19, 2025 at 4:06 PM
Fantastic setting for Keystone metastasis meeting. This is the view from the seminar room. #KSMetastasis25
Leah Cook presented on tumoricidal neutrophils in prostate cancer. Very interesting data supporting that sex hormones regulate neutrophil function.
KSMetastasis25
KSMetastasis25
January 19, 2025 at 5:41 PM
Leah Cook presented on tumoricidal neutrophils in prostate cancer. Very interesting data supporting that sex hormones regulate neutrophil function.
KSMetastasis25
KSMetastasis25
KSMetastasis25 has started - in a beautiful conference room - with a spectacular keynote by @batllelab.bsky.social on cancer cell plasticity and immune evasion at the metastatic site.
January 19, 2025 at 4:17 PM
KSMetastasis25 has started - in a beautiful conference room - with a spectacular keynote by @batllelab.bsky.social on cancer cell plasticity and immune evasion at the metastatic site.
Jonathan Rennhack presented on how CCL2 regulates metastasis in colorectal cancer by changing transcription factor dynamics in the cancer cells.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:42 PM
Jonathan Rennhack presented on how CCL2 regulates metastasis in colorectal cancer by changing transcription factor dynamics in the cancer cells.
#KSMetastasis25
#KSMetastasis25
Sergei Grivennikov presented on microbiota-induced interleukins and how they influence hepatocytes and immune cells to promote colon cancer metastasis (- and NETs made a very brief appearance).
KSMetastasis25
KSMetastasis25
January 21, 2025 at 12:08 AM
Sergei Grivennikov presented on microbiota-induced interleukins and how they influence hepatocytes and immune cells to promote colon cancer metastasis (- and NETs made a very brief appearance).
KSMetastasis25
KSMetastasis25
Pericytes can induce quiescence of aggressive cancer cells. Using a phospholipid stain, Meera Murgai show that transfer of phospholipids activates calcium signaling in cancer cells.
#KSMetastasis25
#KSMetastasis25
January 20, 2025 at 3:52 AM
Pericytes can induce quiescence of aggressive cancer cells. Using a phospholipid stain, Meera Murgai show that transfer of phospholipids activates calcium signaling in cancer cells.
#KSMetastasis25
#KSMetastasis25
Great talk by @morgan-fox.bsky.social representing the Cittelly Lab at the joint session of #KSMetastasis25 and #KSCancerNeuroscience25
Graduate student Morgan Fox gave a very nice talk on how the non-canonical activation of FGFR1 drives brain metastasis of ER+ breast cancer in aged mice (or “non-young” as Devon Lawson diplomatically put it for those of us over 40!)
KSMetastasis25
KSMetastasis25
January 21, 2025 at 1:39 AM
Great talk by @morgan-fox.bsky.social representing the Cittelly Lab at the joint session of #KSMetastasis25 and #KSCancerNeuroscience25
Thrilled to present at the joint session of #ksmetastasis25 and #kscancerneuroscience25! Huge thanks to everyone who came out to hear about our lab's work!
@venkatesh-lab.bsky.social presented data on neuronal activity affecting small cell lung cancer initiation/growth and establishment in the brain (preprint: www.biorxiv.org/content/10.1...)
January 21, 2025 at 1:42 PM
Thrilled to present at the joint session of #ksmetastasis25 and #kscancerneuroscience25! Huge thanks to everyone who came out to hear about our lab's work!
Daniela Quail presented exciting data (labeled do not post) linking diet, obesity, microbiota - and response to immune checkpoint inhibitors.
#KSMetastasis25
#KSMetastasis25
January 20, 2025 at 12:45 AM
Daniela Quail presented exciting data (labeled do not post) linking diet, obesity, microbiota - and response to immune checkpoint inhibitors.
#KSMetastasis25
#KSMetastasis25
Clare Isacke presented on ADC and car-T cell approaches to target myCAFs and perivascular CAFs.
#KSMetastasis25
#KSMetastasis25
January 20, 2025 at 1:54 AM
Clare Isacke presented on ADC and car-T cell approaches to target myCAFs and perivascular CAFs.
#KSMetastasis25
#KSMetastasis25
The pioneer in thinking about cancer a systemic disease - David Lyden - showed us how extracellular vesicles can drive not just metastasis but also altered lipid metabolism in the liver and clotting in cancer.
#KSMetastasis25
#KSMetastasis25
January 20, 2025 at 4:12 PM
The pioneer in thinking about cancer a systemic disease - David Lyden - showed us how extracellular vesicles can drive not just metastasis but also altered lipid metabolism in the liver and clotting in cancer.
#KSMetastasis25
#KSMetastasis25
The views are as as spectacular as the science. The sun is setting over Banff as we are about to start the last session of #KSMetastasis25.
January 21, 2025 at 11:54 PM
The views are as as spectacular as the science. The sun is setting over Banff as we are about to start the last session of #KSMetastasis25.
Postdoc Alexandra Newman from Kathryn Moore’s lab at NYU gave a thought provoking talk on how myocardial infection - by affecting myeloid cells - can drive metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 12:39 AM
Postdoc Alexandra Newman from Kathryn Moore’s lab at NYU gave a thought provoking talk on how myocardial infection - by affecting myeloid cells - can drive metastasis.
#KSMetastasis25
#KSMetastasis25
Ski break at #KSMetastasis25 this afternoon was 10 miles at the Canmore Nordic Centre. Trails were amazing and the snow was so cold it was squeaking under my poles! Pretty wild skiing the 1988 Olympic course.
January 20, 2025 at 12:34 AM
Ski break at #KSMetastasis25 this afternoon was 10 miles at the Canmore Nordic Centre. Trails were amazing and the snow was so cold it was squeaking under my poles! Pretty wild skiing the 1988 Olympic course.
Erica Sloan discussed how some cancer treatments - doxorubicin and radiation - stimulate sympathetic signaling to promote metastasis; explaining why women also treated with beta-blockers for high-blood pressure have much lower odds of metastatic relapse.
KSMetastasis25
KSMetastasis25
January 21, 2025 at 1:52 AM
Erica Sloan discussed how some cancer treatments - doxorubicin and radiation - stimulate sympathetic signaling to promote metastasis; explaining why women also treated with beta-blockers for high-blood pressure have much lower odds of metastatic relapse.
KSMetastasis25
KSMetastasis25
About to give the Keynote Lecture at the The #KSMetastasis25 @KeystoneSymp on Tumor Microenvironment: Metastasis and the Host. The location at Banff is impressive.
Thank you Manuel Valiente and Julio Aguirre-Ghiso for the invitation!
Thank you Manuel Valiente and Julio Aguirre-Ghiso for the invitation!
January 19, 2025 at 2:03 PM
About to give the Keynote Lecture at the The #KSMetastasis25 @KeystoneSymp on Tumor Microenvironment: Metastasis and the Host. The location at Banff is impressive.
Thank you Manuel Valiente and Julio Aguirre-Ghiso for the invitation!
Thank you Manuel Valiente and Julio Aguirre-Ghiso for the invitation!
Jean-Christophe Marine presented elegant work on niches (perivascular - hypoxic - invading front) in primary tumors that endow cancer cells with the ability to metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 10:37 PM
Jean-Christophe Marine presented elegant work on niches (perivascular - hypoxic - invading front) in primary tumors that endow cancer cells with the ability to metastasis.
#KSMetastasis25
#KSMetastasis25
First speaker in the joint session between #KSMetastasis25 and #KSNeuroCancer25: Devon Lawson presented on commonalities in multiorgan metastasis, including to the brain. Using niche labeling and scRNAseq they found a common signaling interaction between cancer cells and macrophages.
January 20, 2025 at 3:44 PM
First speaker in the joint session between #KSMetastasis25 and #KSNeuroCancer25: Devon Lawson presented on commonalities in multiorgan metastasis, including to the brain. Using niche labeling and scRNAseq they found a common signaling interaction between cancer cells and macrophages.
@danielheller.bsky.social presented exciting data using a nano-particle formulation to get a drug against medullablastoma across the blood-brain barrier - where it needs to go - and away from cells in the growth plates where it can have devastating effects.
#KSMetastasis25
#KSMetastasis25
January 22, 2025 at 1:47 AM
@danielheller.bsky.social presented exciting data using a nano-particle formulation to get a drug against medullablastoma across the blood-brain barrier - where it needs to go - and away from cells in the growth plates where it can have devastating effects.
#KSMetastasis25
#KSMetastasis25
Exciting presentation by co-organizer Manuel Valiente: through heroic efforts, his lab has established models to study the major clinical problems of local relapse of surgical excised brain metastasis and neurocognitive effects of brain masses.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 1:06 AM
Exciting presentation by co-organizer Manuel Valiente: through heroic efforts, his lab has established models to study the major clinical problems of local relapse of surgical excised brain metastasis and neurocognitive effects of brain masses.
#KSMetastasis25
#KSMetastasis25
Ronit Satchi-Fainar presented on using 4DCanPredict platform to identify p-selectin as a critical target in brain cancer - leading to clinical trial NCT05909618.
#KSMetastasis25
#KSMetastasis25
January 22, 2025 at 1:10 AM
Ronit Satchi-Fainar presented on using 4DCanPredict platform to identify p-selectin as a critical target in brain cancer - leading to clinical trial NCT05909618.
#KSMetastasis25
#KSMetastasis25
Second Spotlight speaker - Rebecca Dodd - spoke on Epigenetic Plasticity driving Metastasis of sarcoma through PRC2-Dependent Stromal Remodeling and, in particular, IL-17D Signaling.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:24 PM
Second Spotlight speaker - Rebecca Dodd - spoke on Epigenetic Plasticity driving Metastasis of sarcoma through PRC2-Dependent Stromal Remodeling and, in particular, IL-17D Signaling.
#KSMetastasis25
#KSMetastasis25
Rounding out the first Spot light session MD/PHD student Matthew Eason presents on old favorites of mine, matrix metalloproteinases, and a molecule I didn’t know: obscurin.
#KSMetastasis25
#KSMetastasis25
January 19, 2025 at 10:54 PM
Rounding out the first Spot light session MD/PHD student Matthew Eason presents on old favorites of mine, matrix metalloproteinases, and a molecule I didn’t know: obscurin.
#KSMetastasis25
#KSMetastasis25
Jelani Zarif starts the #KSMetastasis25 spotlight session with late-breaking abstract. He achieved the reprogramming of macrophages from tumor promoting to tumor inhibiting by targeting their metabolism.
January 19, 2025 at 9:56 PM
Jelani Zarif starts the #KSMetastasis25 spotlight session with late-breaking abstract. He achieved the reprogramming of macrophages from tumor promoting to tumor inhibiting by targeting their metabolism.
Postdoc Anna Adam Artigues presented very intruding data showing that peripheral sympathetic Nerve damage stimulate the metastatic outgrowth of cancer cells that have disseminated to the brain.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:32 PM
Postdoc Anna Adam Artigues presented very intruding data showing that peripheral sympathetic Nerve damage stimulate the metastatic outgrowth of cancer cells that have disseminated to the brain.
#KSMetastasis25
#KSMetastasis25