Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans https://www.biorxiv.org/content/10.64898/2026.09.14.751545v1
September 17, 2026 at 6:15 PM
Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans https://www.biorxiv.org/content/10.64898/2026.09.14.751545v1
Super happy to share my first article at @diegromero.bsky.social´s lab, about Bacillus cyclic lipopeptides and how the diversification of structural variants production impacts biological activities!!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Diversification of Lipopeptide Analogues Drives Versatility in Biological Activities
Cyclic lipopeptides (CLPs) are potent secondary metabolites with diverse biological functions. Bacillus strains primarily produce CLPs of three key families, namely, iturins, fengycins, and surfactins...
pubs.acs.org
January 25, 2025 at 1:58 PM
Super happy to share my first article at @diegromero.bsky.social´s lab, about Bacillus cyclic lipopeptides and how the diversification of structural variants production impacts biological activities!!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
This is super interesting! Scientists found that skin normal flora will release lipopeptides to prevent an immune response. Eczema is triggered by the release of Interleukin-33 by the skin, and they showed that these lipopeptides blocked IL-33 release. This could be a
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice - Nature Communications
Here, the authors show that bacteria release immunosuppressive lipopeptides that suppress eczema and may serve as a potential therapy. This activity is independent of toll-like receptor signalling but...
www.nature.com
May 17, 2026 at 12:19 PM
This is super interesting! Scientists found that skin normal flora will release lipopeptides to prevent an immune response. Eczema is triggered by the release of Interleukin-33 by the skin, and they showed that these lipopeptides blocked IL-33 release. This could be a
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@diegromero.bsky.social gave an amazing seminar at #InstituteBiologyLeiden explaining how biofilm matrix components and lipopeptides promote plant growth and resilience - from seeds to seedlings
March 30, 2026 at 4:17 PM
@diegromero.bsky.social gave an amazing seminar at #InstituteBiologyLeiden explaining how biofilm matrix components and lipopeptides promote plant growth and resilience - from seeds to seedlings
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
December 29, 2025 at 1:54 PM
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Penicillium hordei acidification precipitates Bacillus subtilis lipopeptides to evade inhibition
bioRxiv by Manca Vertot on her #NNF_INTERACT project with Jens Frisvad
collaboration with @neftalyl.bsky.social, Morten Schostag, Scott Jarmusch at @cemist.bsky.social
www.biorxiv.org/content/10.1...
bioRxiv by Manca Vertot on her #NNF_INTERACT project with Jens Frisvad
collaboration with @neftalyl.bsky.social, Morten Schostag, Scott Jarmusch at @cemist.bsky.social
www.biorxiv.org/content/10.1...
Penicillium hordei acidification precipitates Bacillus subtilis lipopeptides to evade inhibition
Interkingdom interactions are crucial for community and ecosystem functioning, however secondary metabolites mediating interactions between plant beneficial bacteria and fungi remain understudied. Pen...
www.biorxiv.org
May 26, 2025 at 12:53 PM
Penicillium hordei acidification precipitates Bacillus subtilis lipopeptides to evade inhibition
bioRxiv by Manca Vertot on her #NNF_INTERACT project with Jens Frisvad
collaboration with @neftalyl.bsky.social, Morten Schostag, Scott Jarmusch at @cemist.bsky.social
www.biorxiv.org/content/10.1...
bioRxiv by Manca Vertot on her #NNF_INTERACT project with Jens Frisvad
collaboration with @neftalyl.bsky.social, Morten Schostag, Scott Jarmusch at @cemist.bsky.social
www.biorxiv.org/content/10.1...
Warfare among rice sheath pathogens: Rhizoctonia solani AG 1-IA neutralizes Pseudomonas fuscovaginae cyclic lipopeptides
#ApplEnvironMicrobiol by Jasmine De Rop from Monica Höfte at @fbwugent.bsky.social
journals.asm.org/doi/10.1128/...
#ApplEnvironMicrobiol by Jasmine De Rop from Monica Höfte at @fbwugent.bsky.social
journals.asm.org/doi/10.1128/...
Warfare among rice sheath pathogens: Rhizoctonia solani AG 1-IA neutralizes Pseudomonas fuscovaginae cyclic lipopeptides | Applied and Environmental Microbiology
Rice is a global staple crop that is susceptible to various pathogens, including Pseudomonas fuscovaginae, causing sheath brown rot, and Rhizoctonia solani AG 1-IA, which causes sheath blight. Notably...
journals.asm.org
January 19, 2026 at 7:07 AM
Warfare among rice sheath pathogens: Rhizoctonia solani AG 1-IA neutralizes Pseudomonas fuscovaginae cyclic lipopeptides
#ApplEnvironMicrobiol by Jasmine De Rop from Monica Höfte at @fbwugent.bsky.social
journals.asm.org/doi/10.1128/...
#ApplEnvironMicrobiol by Jasmine De Rop from Monica Höfte at @fbwugent.bsky.social
journals.asm.org/doi/10.1128/...
@davidmicro.bsky.social on
Life beyond lipopeptides: non-lipopeptide antimicrobial strategies of Bacillus velezensis against fungal pathogens
#BACELL2026
Life beyond lipopeptides: non-lipopeptide antimicrobial strategies of Bacillus velezensis against fungal pathogens
#BACELL2026
June 9, 2026 at 1:11 PM
@davidmicro.bsky.social on
Life beyond lipopeptides: non-lipopeptide antimicrobial strategies of Bacillus velezensis against fungal pathogens
#BACELL2026
Life beyond lipopeptides: non-lipopeptide antimicrobial strategies of Bacillus velezensis against fungal pathogens
#BACELL2026
Here is the published version of Manca's #NNF_INTERACT project in #ISMEcommunications from Scott Jarmusch and @neftalyl.bsky.social
academic.oup.com/ismecommun/a...
academic.oup.com/ismecommun/a...
September 28, 2025 at 2:41 PM
Here is the published version of Manca's #NNF_INTERACT project in #ISMEcommunications from Scott Jarmusch and @neftalyl.bsky.social
academic.oup.com/ismecommun/a...
academic.oup.com/ismecommun/a...
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
December 29, 2025 at 2:22 PM
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
Collaboration back at DTU now published in Microbiology Spectrum, including the Bacillus work by @neftalyl.bsky.social
Dual-function Aspergillus sulphureoviridis: antibacterial polyketides against Dickeya solani and elicitation of Bacillus subtilis lipopeptides
journals.asm.org/doi/10.1128/...
Dual-function Aspergillus sulphureoviridis: antibacterial polyketides against Dickeya solani and elicitation of Bacillus subtilis lipopeptides
journals.asm.org/doi/10.1128/...
July 23, 2026 at 8:25 AM
Collaboration back at DTU now published in Microbiology Spectrum, including the Bacillus work by @neftalyl.bsky.social
Dual-function Aspergillus sulphureoviridis: antibacterial polyketides against Dickeya solani and elicitation of Bacillus subtilis lipopeptides
journals.asm.org/doi/10.1128/...
Dual-function Aspergillus sulphureoviridis: antibacterial polyketides against Dickeya solani and elicitation of Bacillus subtilis lipopeptides
journals.asm.org/doi/10.1128/...
This week is World Antimicrobial Resistance Awareness Week 🦠
This graphic highlights the discovery dates of some key classes of antibiotics – note that no new class of antibiotics has reached the market since 1987
Download & read more here: www.compoundchem.com/2014/09/08/a...
#ChemSky #MedSky 🧪
This graphic highlights the discovery dates of some key classes of antibiotics – note that no new class of antibiotics has reached the market since 1987
Download & read more here: www.compoundchem.com/2014/09/08/a...
#ChemSky #MedSky 🧪
November 19, 2024 at 8:59 PM
This week is World Antimicrobial Resistance Awareness Week 🦠
This graphic highlights the discovery dates of some key classes of antibiotics – note that no new class of antibiotics has reached the market since 1987
Download & read more here: www.compoundchem.com/2014/09/08/a...
#ChemSky #MedSky 🧪
This graphic highlights the discovery dates of some key classes of antibiotics – note that no new class of antibiotics has reached the market since 1987
Download & read more here: www.compoundchem.com/2014/09/08/a...
#ChemSky #MedSky 🧪
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
December 29, 2025 at 2:21 PM
Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains
Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans https://www.biorxiv.org/content/10.64898/2026.09.14.751545v1
September 17, 2026 at 6:15 PM
Bacterial-derived cyclic lipopeptides suppress dauer arrest in C. elegans https://www.biorxiv.org/content/10.64898/2026.09.14.751545v1
Bacillus lipopeptides as key players in rhizosphere chemical ecology
#TrendsMicrobiol by Guillaume Balleux & Monica Höfte et al from Marc Ongena
www.cell.com/trends/micro...
#TrendsMicrobiol by Guillaume Balleux & Monica Höfte et al from Marc Ongena
www.cell.com/trends/micro...
August 30, 2024 at 8:27 AM
Bacillus lipopeptides as key players in rhizosphere chemical ecology
#TrendsMicrobiol by Guillaume Balleux & Monica Höfte et al from Marc Ongena
www.cell.com/trends/micro...
#TrendsMicrobiol by Guillaume Balleux & Monica Höfte et al from Marc Ongena
www.cell.com/trends/micro...
A Wagner–Meerwein-Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles onlinelibrary.wiley.com/doi/10.1002/...
A Wagner–Meerwein‐Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles
The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl-acyl carrier protein (ACP) precursor is rearranged through the action o...
onlinelibrary.wiley.com
July 8, 2026 at 9:47 AM
A Wagner–Meerwein-Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles onlinelibrary.wiley.com/doi/10.1002/...
This is pretty cool. A team of 21 researchers reports the discovery of a new class of antibiotics (the last family to see the market were lipopeptides in 1987). This was done by training neural models to estimate efficacy and toxicity. That led to scanning
🧪 1/
www.nature.com/articles/s41...
🧪 1/
www.nature.com/articles/s41...
December 21, 2023 at 9:04 AM
This is pretty cool. A team of 21 researchers reports the discovery of a new class of antibiotics (the last family to see the market were lipopeptides in 1987). This was done by training neural models to estimate efficacy and toxicity. That led to scanning
🧪 1/
www.nature.com/articles/s41...
🧪 1/
www.nature.com/articles/s41...
🎓 Congratulations to Aneta Čechová (Lenka Maletínská group) who successfully defended her PhD thesis entitled "Study of potential pharmaceuticals based on lipopeptides by LC-MS and ICP-MS" at #UCTPrague!
#phd #phdatIOCBPrague
#phd #phdatIOCBPrague
December 15, 2025 at 11:39 AM
🎓 Congratulations to Aneta Čechová (Lenka Maletínská group) who successfully defended her PhD thesis entitled "Study of potential pharmaceuticals based on lipopeptides by LC-MS and ICP-MS" at #UCTPrague!
#phd #phdatIOCBPrague
#phd #phdatIOCBPrague
At the 14th Conference of the European Foundation for Plant Pathology, Uppsala, Sweden.
We started with great talks by Monica Höfte on Pseudomonad pathogens that produce cyclic lipopeptides that can be used as biocontrol agents, and Sarah Gurr on the global movement of fungal pathogens. #EFPP2025
We started with great talks by Monica Höfte on Pseudomonad pathogens that produce cyclic lipopeptides that can be used as biocontrol agents, and Sarah Gurr on the global movement of fungal pathogens. #EFPP2025
June 4, 2025 at 8:05 AM
At the 14th Conference of the European Foundation for Plant Pathology, Uppsala, Sweden.
We started with great talks by Monica Höfte on Pseudomonad pathogens that produce cyclic lipopeptides that can be used as biocontrol agents, and Sarah Gurr on the global movement of fungal pathogens. #EFPP2025
We started with great talks by Monica Höfte on Pseudomonad pathogens that produce cyclic lipopeptides that can be used as biocontrol agents, and Sarah Gurr on the global movement of fungal pathogens. #EFPP2025
Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice @natcomms.nature.com @manchesterup.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 13, 2026 at 4:14 PM
Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice @natcomms.nature.com @manchesterup.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
When neighbors control metabolite fate: consequences for plant pathogen virulence and biocontrol outcomes
Applied Environmental Microbiology Commentary by @neftalyl.bsky.social and colleagues on De Rop et al AEM paper from Monica Höfte group at Gent University
journals.asm.org/doi/10.1128/...
Applied Environmental Microbiology Commentary by @neftalyl.bsky.social and colleagues on De Rop et al AEM paper from Monica Höfte group at Gent University
journals.asm.org/doi/10.1128/...
When neighbors control metabolite fate: consequences for plant pathogen virulence and biocontrol outcomes | Applied and Environmental Microbiology
Cyclic lipopeptides (CLiPs) are a structurally diverse class of small bioactive secondary
metabolites produced by many plant-associated bacteria, including beneficial rhizobacteria
such as Pseudomonas...
journals.asm.org
April 25, 2026 at 5:49 PM
When neighbors control metabolite fate: consequences for plant pathogen virulence and biocontrol outcomes
Applied Environmental Microbiology Commentary by @neftalyl.bsky.social and colleagues on De Rop et al AEM paper from Monica Höfte group at Gent University
journals.asm.org/doi/10.1128/...
Applied Environmental Microbiology Commentary by @neftalyl.bsky.social and colleagues on De Rop et al AEM paper from Monica Höfte group at Gent University
journals.asm.org/doi/10.1128/...
Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis
Microbial Cell Factories
microbialcellfactories.biomedcentral.com/articles/10....
Microbial Cell Factories
microbialcellfactories.biomedcentral.com/articles/10....
Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis - Microbial Cell Factories
Background The Bacillus genus is well known for producing structurally diverse lipopeptides, many of which exhibit remarkable surface-active and bioactive properties, such as surfactin and daptomycin....
microbialcellfactories.biomedcentral.com
May 15, 2025 at 10:30 AM
Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis
Microbial Cell Factories
microbialcellfactories.biomedcentral.com/articles/10....
Microbial Cell Factories
microbialcellfactories.biomedcentral.com/articles/10....
First lecture on innate immunity is underway! We're diving into Pattern Recognition Receptors (PRRs), with Dr. Helen Goodridge, and their ability to spot invaders by detecting microbial molecules like lipopeptides & glycolipids, ➕ danger signals such as heat shock proteins.
#AAIcourses #Immunology
#AAIcourses #Immunology
July 9, 2025 at 5:26 PM
First lecture on innate immunity is underway! We're diving into Pattern Recognition Receptors (PRRs), with Dr. Helen Goodridge, and their ability to spot invaders by detecting microbial molecules like lipopeptides & glycolipids, ➕ danger signals such as heat shock proteins.
#AAIcourses #Immunology
#AAIcourses #Immunology