Background: Discriminating mild cognitive impairment (MCI) from subjective cognitive decline (SCD), and healthy controls (HC) remains challenging. #Digital tools may overcome paper-and-pencil screening’s limitations. Objective: This study evaluated the diagnostic accuracy and usability of CogniPaz (Daniel Blanco), an ecologically oriented, #Mobile #Health (#mHealth), gamified cognitive assessment tool exploring memory and executive functions, in discriminating MCI (particularly amnestic phenotypes [aMCI]) from SCD, and HC. Methods: This prospective observational study recruited a convenience sample of consecutive patients with cognitive complaints and HC at La Paz University Hospital Cognitive Disorders Unit from April 2025 to January 2026. Demographic and clinical characteristics, and Montreal Cognitive Assessment (MoCA) scores were collected. An evaluator blinded to the MoCA scores oversaw the automated, self-administered CogniPaz assessment. Participants were classified into HC (no cognitive complaints, MoCA score≥26), SCD (cognitive complaints, MoCA score≥26), and MCI (cognitive complaints without functional impairment, MoCA score

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Original Article · Open Access

Background: Smoking remains the leading preventable cause of #Cancer mortality in the United States. Varenicline is the most effective monotherapy for smoking cessation, and combining it with nicotine replacement therapy (NRT) may further improve cessation rates. #Smartphone #mHealth-based medication adherence interventions could enhance pharmacotherapy adherence and cessation outcomes. Objective: This trial will evaluate the efficacy of varenicline plus nicotine lozenges and a #Smartphone #mHealth adherence intervention for promoting smoking cessation. Methods: This fully remote, 2 × 2 factorial #RCT #ClinicalTrial will enroll 496 adults from Oklahoma who smoke cigarettes daily. Participants will be randomized to 1 of 4 conditions: (1) varenicline (VAR) + nicotine lozenges (NRT) versus VAR alone and (2) a #Smartphone #mHealth-based smoking cessation #App with adherence components (COMBO-A [adherence]) or without adherence components (COMBO-B [basic]). The primary outcomes are biochemically verified 7-day point prevalence abstinence at 26 weeks post quit date and medication adherence during the treatment period. Secondary outcomes include withdrawal symptoms and medication side effects over the 12-week treatment period. Results: #Study recruitment began in July 2026. As of the date of this paper’s submission, 8 participants have been enrolled. Enrollment is expected to be completed by December 2028, with primary data collection and follow-up completed by June 2029. Primary #Study results are anticipated later in 2029. Conclusions: If effective, VAR+NRT would offer a new evidence-based cessation treatment option. If the #Smartphone #mHealth adherence intervention improves medication adherence and cessation, it could be adapted for other pharmacotherapies and widely implemented. Ultimately, this #Research aims to enhance cessation efforts and reduce #Cancer risk among adults who smoke. Trial Registration: ClinicalTrials.gov NCT07099638; https://clinicaltrials.gov/#Study/NCT07099638 International Registered Report Identifier (IRRID): DERR1-10.2196/108379

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