@biorxivpreprint.bsky.social TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression
www.biorxiv.org/content/10.6... @cfi-umn.bsky.social
www.biorxiv.org/content/10.6... @cfi-umn.bsky.social
November 3, 2026 at 1:39 AM
@biorxivpreprint.bsky.social TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression
www.biorxiv.org/content/10.6... @cfi-umn.bsky.social
www.biorxiv.org/content/10.6... @cfi-umn.bsky.social
Human airspace macrophage signatures are conserved during sterile lung injury and repair @atscommunity.bsky.social
academic.oup.com/ajrccm/artic...
academic.oup.com/ajrccm/artic...
Human airspace macrophage signatures are conserved during sterile lung injury and repair
AbstractRationale. Airspace macrophages (AM) are implicated in both persistent inflammation and tissue repair following acute lung injury. Distinct subsets
academic.oup.com
November 3, 2026 at 4:56 PM
Human airspace macrophage signatures are conserved during sterile lung injury and repair @atscommunity.bsky.social
academic.oup.com/ajrccm/artic...
academic.oup.com/ajrccm/artic...
TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression https://www.biorxiv.org/content/10.64898/2026.10.31.763330v1
November 2, 2026 at 11:15 PM
TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression https://www.biorxiv.org/content/10.64898/2026.10.31.763330v1
Oleic acid suppresses NLRP3 inflammasome activation to prevent dermal macrophage death and limit imiquimod-induced psoriasis https://www.biorxiv.org/content/10.64898/2026.10.27.760067v1
November 1, 2026 at 11:15 PM
Oleic acid suppresses NLRP3 inflammasome activation to prevent dermal macrophage death and limit imiquimod-induced psoriasis https://www.biorxiv.org/content/10.64898/2026.10.27.760067v1
“Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization”
This work positions the CTSB–non-canonical caspase-8 axis as a mechanistic checkpoint of human #Macrophage plasticity ⤵️
nature.com/articles/s41...
This work positions the CTSB–non-canonical caspase-8 axis as a mechanistic checkpoint of human #Macrophage plasticity ⤵️
nature.com/articles/s41...
Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization - Cell Death & Differentiation
Cell Death & Differentiation - Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization
nature.com
October 30, 2026 at 12:34 PM
“Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization”
This work positions the CTSB–non-canonical caspase-8 axis as a mechanistic checkpoint of human #Macrophage plasticity ⤵️
nature.com/articles/s41...
This work positions the CTSB–non-canonical caspase-8 axis as a mechanistic checkpoint of human #Macrophage plasticity ⤵️
nature.com/articles/s41...
The IFN-γ-inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization https://www.biorxiv.org/content/10.64898/2026.11.02.763539v1
November 3, 2026 at 1:19 PM
The IFN-γ-inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization https://www.biorxiv.org/content/10.64898/2026.11.02.763539v1
The IFN-γ-inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization https://www.biorxiv.org/content/10.64898/2026.11.02.763539v1
November 3, 2026 at 1:19 PM
The IFN-γ-inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization https://www.biorxiv.org/content/10.64898/2026.11.02.763539v1
Greater Oxford looking alarmingly like a macrophage about to engulf Radley and Abingdon.
October 29, 2026 at 2:21 PM
Greater Oxford looking alarmingly like a macrophage about to engulf Radley and Abingdon.
Oleic acid suppresses NLRP3 inflammasome activation to prevent dermal macrophage death and limit imiquimod-induced psoriasis https://www.biorxiv.org/content/10.64898/2026.10.27.760067v1
November 1, 2026 at 11:15 PM
Oleic acid suppresses NLRP3 inflammasome activation to prevent dermal macrophage death and limit imiquimod-induced psoriasis https://www.biorxiv.org/content/10.64898/2026.10.27.760067v1
Review: Macrophage biology and immunoregulation in health and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 28, 2026 at 2:17 AM
Review: Macrophage biology and immunoregulation in health and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury
Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury
Zhao et al. show histone lactylation drives FTO-mediated Arg1 mRNA stabilization. Lactylation controls macrophage metabolism via HIF1α/YY1 LLPS; IL-10 shapes its dual functions in hypoxic lung injury.
dlvr.it
October 29, 2026 at 11:23 PM
Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury
SIRT3 deficiency worsens olfactory dysfunction in chronic rhinosinusitis by driving proinflammatory, glycolysis-heavy macrophage activity and OSN loss in a murine model, identifying SIRT3 as a potential therapeutic target for #CRS with olfactory dysfunction
#Immunology #Rhinology
🔗 ino.to/e8lnwtc
#Immunology #Rhinology
🔗 ino.to/e8lnwtc
November 3, 2026 at 5:35 AM
SIRT3 deficiency worsens olfactory dysfunction in chronic rhinosinusitis by driving proinflammatory, glycolysis-heavy macrophage activity and OSN loss in a murine model, identifying SIRT3 as a potential therapeutic target for #CRS with olfactory dysfunction
#Immunology #Rhinology
🔗 ino.to/e8lnwtc
#Immunology #Rhinology
🔗 ino.to/e8lnwtc
The big picture: EMT states aren’t just intrinsic, they’re actively built and maintained by myeloid-derived niches.
Neutrophil OSM → hybrid EMT.
Macrophage/stroma TGFβ1 → late EMT.
Two signals, two niches, two fates.
🔗 doi.org/10.1038/s430...
15/15
Neutrophil OSM → hybrid EMT.
Macrophage/stroma TGFβ1 → late EMT.
Two signals, two niches, two fates.
🔗 doi.org/10.1038/s430...
15/15
November 2, 2026 at 10:53 AM
The big picture: EMT states aren’t just intrinsic, they’re actively built and maintained by myeloid-derived niches.
Neutrophil OSM → hybrid EMT.
Macrophage/stroma TGFβ1 → late EMT.
Two signals, two niches, two fates.
🔗 doi.org/10.1038/s430...
15/15
Neutrophil OSM → hybrid EMT.
Macrophage/stroma TGFβ1 → late EMT.
Two signals, two niches, two fates.
🔗 doi.org/10.1038/s430...
15/15
Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives. Q Zhou et al. Immun Ageing 2026 Jul 31 shorturl.at/QX51G ...growing interest in macrophage senescence in senile osteoporosis ... direct human evidence is limited
November 3, 2026 at 9:00 AM
Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives. Q Zhou et al. Immun Ageing 2026 Jul 31 shorturl.at/QX51G ...growing interest in macrophage senescence in senile osteoporosis ... direct human evidence is limited
TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression https://www.biorxiv.org/content/10.64898/2026.10.31.763330v1
November 2, 2026 at 11:15 PM
TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression https://www.biorxiv.org/content/10.64898/2026.10.31.763330v1
No no, I totally get that.
Jork responsibly, y'know?
I don't do it much, but it's still often enough to stay healthy.
I knew it was healthy by boosting macrophage (white blood cell) count in our bloodstream, but I didn't know that there harmful effects for NOT doing it.
Jork responsibly, y'know?
I don't do it much, but it's still often enough to stay healthy.
I knew it was healthy by boosting macrophage (white blood cell) count in our bloodstream, but I didn't know that there harmful effects for NOT doing it.
November 2, 2026 at 6:23 PM
No no, I totally get that.
Jork responsibly, y'know?
I don't do it much, but it's still often enough to stay healthy.
I knew it was healthy by boosting macrophage (white blood cell) count in our bloodstream, but I didn't know that there harmful effects for NOT doing it.
Jork responsibly, y'know?
I don't do it much, but it's still often enough to stay healthy.
I knew it was healthy by boosting macrophage (white blood cell) count in our bloodstream, but I didn't know that there harmful effects for NOT doing it.
#cats
Amazing news!
Japanese immunologist Dr.Toru Miyazaki who discovered the apoptosis inhibitor of macrophage protein, (AIM,) that could save cats from CKD, has his research findings under review for gov. approval in Japan with international manufacturing slated for 2027.
Amazing news!
Japanese immunologist Dr.Toru Miyazaki who discovered the apoptosis inhibitor of macrophage protein, (AIM,) that could save cats from CKD, has his research findings under review for gov. approval in Japan with international manufacturing slated for 2027.
AIM medicine for cat kidney treatment targets 2027 commercialization
A protein therapy that raised one-year survival rates for cats with advanced kidney disease is under regulatory review in Japan, with manufacturing and an international rollout targeted for 2027.
www.petfoodindustry.com
November 2, 2026 at 4:01 PM
#cats
Amazing news!
Japanese immunologist Dr.Toru Miyazaki who discovered the apoptosis inhibitor of macrophage protein, (AIM,) that could save cats from CKD, has his research findings under review for gov. approval in Japan with international manufacturing slated for 2027.
Amazing news!
Japanese immunologist Dr.Toru Miyazaki who discovered the apoptosis inhibitor of macrophage protein, (AIM,) that could save cats from CKD, has his research findings under review for gov. approval in Japan with international manufacturing slated for 2027.
Butyrate reverts Chlamydia pneumoniae -induced transcriptional suppression of macrophage polarization markers and promotes chlamydial clearance in macrophages https://www.biorxiv.org/content/10.64898/2026.10.30.763131v1
November 2, 2026 at 4:17 PM
Butyrate reverts Chlamydia pneumoniae -induced transcriptional suppression of macrophage polarization markers and promotes chlamydial clearance in macrophages https://www.biorxiv.org/content/10.64898/2026.10.30.763131v1
Butyrate reverts Chlamydia pneumoniae -induced transcriptional suppression of macrophage polarization markers and promotes chlamydial clearance in macrophages https://www.biorxiv.org/content/10.64898/2026.10.30.763131v1
November 2, 2026 at 4:17 PM
Butyrate reverts Chlamydia pneumoniae -induced transcriptional suppression of macrophage polarization markers and promotes chlamydial clearance in macrophages https://www.biorxiv.org/content/10.64898/2026.10.30.763131v1
Knockdown of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection
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t.co
November 2, 2026 at 11:42 PM
Knockdown of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection
🚨Preprint ALERT! This one is exciting- we have a new paper online, TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression. @CFI_UMN @UMN_IBP
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
November 3, 2026 at 7:41 PM
🚨Preprint ALERT! This one is exciting- we have a new paper online, TREM2 encodes plaque macrophage plasticity to mediate atherosclerosis regression. @CFI_UMN @UMN_IBP
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Chaperone-mediated autophagy curbs senescence
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Chaperone-mediated autophagy curbs senescence - Nature Aging
Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated immunosurveillanc...
www.nature.com
November 1, 2026 at 12:20 AM
Chaperone-mediated autophagy curbs senescence
www.nature.com/articles/s43...
www.nature.com/articles/s43...
CD74 governs synovial macrophage glycolytic-inflammatory synergy by an ENO2–HIF-1α/β-catenin axis to drive osteoarthritis progression
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 28, 2026 at 7:57 PM
CD74 governs synovial macrophage glycolytic-inflammatory synergy by an ENO2–HIF-1α/β-catenin axis to drive osteoarthritis progression
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...