Mind blowing mechanotherapy of aged embryo 🤯👹
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 11:01 PM
Mind blowing mechanotherapy of aged embryo 🤯👹
New online! Dual mechanotherapy for the treatment of cardiac fibrosis #CardioSky
Dual mechanotherapy for the treatment of cardiac fibrosis
Nature Reviews Cardiology, Published online: 19 May 2025; doi:10.1038/s41569-025-01172-9Inhibition of mechanotransduction selectively in cardiac fibrolasts, especially when combined with inhibition of transforming growth factor-β signalling, triggers a reversal of fibroblast activation and suppresses fibrosis in diseased hearts.
bit.ly
May 19, 2025 at 5:59 PM
New online! Dual mechanotherapy for the treatment of cardiac fibrosis #CardioSky
gonna be That Person [tm]
massage does have science! just not what anyone expected, but it's good actually:
wyss.harvard.edu/news/massage...
massage does have science! just not what anyone expected, but it's good actually:
wyss.harvard.edu/news/massage...
Massage doesn’t just make muscles feel better, it makes them heal faster and stronger
Study confirms link between mechanotherapy and immunotherapy in muscle regeneration in mice
wyss.harvard.edu
September 13, 2024 at 3:34 AM
gonna be That Person [tm]
massage does have science! just not what anyone expected, but it's good actually:
wyss.harvard.edu/news/massage...
massage does have science! just not what anyone expected, but it's good actually:
wyss.harvard.edu/news/massage...
Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy | Journal of Applied Physiology
The purpose of this study was to investigate the ability of mechanotherapy to enhance recovery or prevent loss of muscle size with atrophy, in female rats. Female F344/BN rats were assigned to weight ...
journals.physiology.org
January 31, 2025 at 5:32 PM
Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
If #psychedelics are general amplifiers opening critical learning windows, then is the #psychotherapy, #mechanotherapy, movement therapy, art therapy, or other intervention "adjuctive"? Or, is the substance itself the adjunct to these other modalities? In other words, does #psychedelictherapy exist?
December 6, 2024 at 5:21 PM
If #psychedelics are general amplifiers opening critical learning windows, then is the #psychotherapy, #mechanotherapy, movement therapy, art therapy, or other intervention "adjuctive"? Or, is the substance itself the adjunct to these other modalities? In other words, does #psychedelictherapy exist?
Given the high levels of PIEZO1 in patients with early-stage breast cancer, we believe that our findings could be useful in identifying patients at risk of aggressive disease based on PIEZO1 levels and that this signalling axis may be a new mechanotherapy target.
March 9, 2026 at 11:02 PM
Given the high levels of PIEZO1 in patients with early-stage breast cancer, we believe that our findings could be useful in identifying patients at risk of aggressive disease based on PIEZO1 levels and that this signalling axis may be a new mechanotherapy target.
RRIDs were included in this in iScience paper. Thanks for making your methods matter! #OpenScience #accelerateopenscience #STMpublishing
An atom-edged magnetic nanomotor for cancer mechanotherapy
Read the full paper: An atom-edged magnetic nanomotor for cancer mechanotherapy
doi.org
March 4, 2026 at 8:01 AM
RRIDs were included in this in iScience paper. Thanks for making your methods matter! #OpenScience #accelerateopenscience #STMpublishing
Vitronectin binding affinity and cell viability effect of novel mechanotherapy drugs for neuroblastoma https://www.biorxiv.org/content/10.1101/2025.03.31.646300v1
April 3, 2025 at 3:49 PM
Vitronectin binding affinity and cell viability effect of novel mechanotherapy drugs for neuroblastoma https://www.biorxiv.org/content/10.1101/2025.03.31.646300v1
Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors https://www.biorxiv.org/content/10.1101/2024.11.28.625828v1
Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors https://www.biorxiv.org/content/10.1101/2024.11.28.625828v1
Mechanical solid stress plays a pivotal role in tumor progression and therapeutic response. Elevated
www.biorxiv.org
December 3, 2024 at 8:51 PM
Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors https://www.biorxiv.org/content/10.1101/2024.11.28.625828v1
Join us at the Physiology Forum today at 9:00 a.m. Dr. Ryan Pedrigi will be presenting “Toward a Mechanotherapy for Atherosclerosis.”
@gundrylab.bsky.social @unmc-chvr.bsky.social
@maalfaidi.bsky.social
@gundrylab.bsky.social @unmc-chvr.bsky.social
@maalfaidi.bsky.social
February 6, 2026 at 2:18 PM
Join us at the Physiology Forum today at 9:00 a.m. Dr. Ryan Pedrigi will be presenting “Toward a Mechanotherapy for Atherosclerosis.”
@gundrylab.bsky.social @unmc-chvr.bsky.social
@maalfaidi.bsky.social
@gundrylab.bsky.social @unmc-chvr.bsky.social
@maalfaidi.bsky.social
This review highlights the transformative potential of biomechanics and mechanobiology in driving scientific and clinical advancements and helps bridge the long-standing gap between biomechanical research and clinical practice.
doi.org/10.1016/j.xi...
#biomechanics #Mechanobiology #mechanotherapy
doi.org/10.1016/j.xi...
#biomechanics #Mechanobiology #mechanotherapy
March 5, 2026 at 4:41 AM
This review highlights the transformative potential of biomechanics and mechanobiology in driving scientific and clinical advancements and helps bridge the long-standing gap between biomechanical research and clinical practice.
doi.org/10.1016/j.xi...
#biomechanics #Mechanobiology #mechanotherapy
doi.org/10.1016/j.xi...
#biomechanics #Mechanobiology #mechanotherapy
Mechanotherapy and Rehabilitation would be a great start. It's bit chicken and egg since this is about what gets studied in clinical trials, and it's so hard for us to get clinical trials. It's only getting harder with the funding situation nationally.
June 7, 2025 at 2:21 PM
Mechanotherapy and Rehabilitation would be a great start. It's bit chicken and egg since this is about what gets studied in clinical trials, and it's so hard for us to get clinical trials. It's only getting harder with the funding situation nationally.
A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration
A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10 + phenotype that promotes angiogenesis and matrix remodeling while suppressing collagen deposition, thereby redirecting healing away from fibrosis and toward functional tissue regeneration.
ABSTRACT
Postoperative fibrotic complications persistently challenge urethral reconstruction due to dysregulated stromal repair and poor graft integration. Conventional rigid ultrasound transducers lack anatomical conformity on dynamic tissues, limiting therapeutic efficacy. Here, we introduce a conformal, wearable low-intensity pulsed ultrasound (LIPUS) bioelectronic system that overcomes these constraints via controlled adhesion printing and liquid metal interconnects. This low-cost (<$20), flexible device ensures stable acoustic coupling and programmable mechanostimulation while maintaining mechanical integrity and biocompatibility under repeated use. In a rabbit model of full-thickness urethral defect, LIPUS significantly improves luminal patency and urinary flow function, promotes angiogenesis and elastic fiber regeneration, while suppressing collagen deposition and pro-inflammatory macrophage infiltration. Integrated multi-omics and single-nucleus RNA sequencing reveal that LIPUS activates the Wnt pathway to drive fibroblast differentiation into a terminally differentiated FGF10 + subset (FB3), which engages in regenerative crosstalk with mural cells via FGF10-FGFR2b signaling and calcium dynamics. Wnt inhibition abrogates this process, confirming mechanistic specificity. This study bridges flexible bioelectronics with deep mechanobiology, providing new insights into how mechanical stimulation can redirect fibroblast fate and override pathological fibrosis, offering a scalable therapeutic framework for fibrotic disorders.
advanced.onlinelibrary.wiley.com
February 17, 2026 at 2:22 PM
A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration
Feed: "VoxelMatters – The heart of additive manufacturing"
By: Joseph Caron-Dawe on Sunday, March 22, 2026
By: Joseph Caron-Dawe on Sunday, March 22, 2026
Tenerife hospital using 3D printing to cut rehab equipment costs by up to 97.6%
La Candelaria University Hospital in Tenerife has started producing custom mechanotherapy tools using a 3D printer, with positive results.
www.voxelmatters.com
March 22, 2026 at 2:49 PM
Feed: "VoxelMatters – The heart of additive manufacturing"
By: Joseph Caron-Dawe on Sunday, March 22, 2026
By: Joseph Caron-Dawe on Sunday, March 22, 2026
I use this as a part of my set and setting design toolkit and place a 360 speaker under my massage table. As I explore synesthesia and expanded states as well as stimulating interoceptive capacity through mechanotherapy/myofascial bodywork, especially for ND/EDS folx, all this is wild and wonderful.
June 28, 2026 at 3:32 PM
I use this as a part of my set and setting design toolkit and place a 360 speaker under my massage table. As I explore synesthesia and expanded states as well as stimulating interoceptive capacity through mechanotherapy/myofascial bodywork, especially for ND/EDS folx, all this is wild and wonderful.
Recently, healthcare insurers are no longer covering me to use my NPI number & procedure codes for mechanotherapy. They are specifically excluding #massagetherapists, even when we are working within a clearly clinical context, prescribed, and in scope. I can still take the HSA/FSA, but for how long?
November 29, 2024 at 7:57 PM
Recently, healthcare insurers are no longer covering me to use my NPI number & procedure codes for mechanotherapy. They are specifically excluding #massagetherapists, even when we are working within a clearly clinical context, prescribed, and in scope. I can still take the HSA/FSA, but for how long?
Anyway today I go back to mechanotherapy and following that with a regular rehab session, and will be doing that 2 hours at the clinic twice a week, to figure out the strength thing and to go back to paying attention to my OTHER ailments especially the tennis elbow that's back with a vengeance 😬🤪🤦🏻♀️🤷🏻♀️
October 14, 2025 at 10:27 AM
Anyway today I go back to mechanotherapy and following that with a regular rehab session, and will be doing that 2 hours at the clinic twice a week, to figure out the strength thing and to go back to paying attention to my OTHER ailments especially the tennis elbow that's back with a vengeance 😬🤪🤦🏻♀️🤷🏻♀️
📢 Cytotherapy and Longevity Journal Recruitment: Early Career Editorial Board
Deadline: 30 October 2026
Learn more: www.icjn.net/news.php
🤝 Welcome to join us!
#Openacess #Academicpublishing #Editor #Journal #Celltherapy #Mechanobiology #Degenerativediseases #Regenerativetherapies #Mechanotherapy
Deadline: 30 October 2026
Learn more: www.icjn.net/news.php
🤝 Welcome to join us!
#Openacess #Academicpublishing #Editor #Journal #Celltherapy #Mechanobiology #Degenerativediseases #Regenerativetherapies #Mechanotherapy
July 24, 2026 at 10:19 AM
📢 Cytotherapy and Longevity Journal Recruitment: Early Career Editorial Board
Deadline: 30 October 2026
Learn more: www.icjn.net/news.php
🤝 Welcome to join us!
#Openacess #Academicpublishing #Editor #Journal #Celltherapy #Mechanobiology #Degenerativediseases #Regenerativetherapies #Mechanotherapy
Deadline: 30 October 2026
Learn more: www.icjn.net/news.php
🤝 Welcome to join us!
#Openacess #Academicpublishing #Editor #Journal #Celltherapy #Mechanobiology #Degenerativediseases #Regenerativetherapies #Mechanotherapy
CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2602.05451
https://arxiv.org/abs/2602.05451
February 11, 2026 at 8:00 AM
CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2602.05451
https://arxiv.org/abs/2602.05451
Somatic Mechanotherapy Activates a Spatiotemporally Synchronized CPTC Wnt Axis for Gut Regeneration #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2602.05451
https://arxiv.org/abs/2602.05451
February 6, 2026 at 8:00 AM
Somatic Mechanotherapy Activates a Spatiotemporally Synchronized CPTC Wnt Axis for Gut Regeneration #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2602.05451
https://arxiv.org/abs/2602.05451
Feed: "Our Weird Past"
By: punkrockbitch_j21wng on Saturday, January 31, 2026
By: punkrockbitch_j21wng on Saturday, January 31, 2026
hydrotherapy, electrotherapy, mechanotherapy, diathermy, radium, medical gymnastics, electrical exercises
www.punkrockbitch.com
February 2, 2026 at 2:50 AM
Feed: "Our Weird Past"
By: punkrockbitch_j21wng on Saturday, January 31, 2026
By: punkrockbitch_j21wng on Saturday, January 31, 2026
We face this in California. Insuance specifically exclues us from mechanotherapy codes.
My clients can only use HSA now to pay with their benefits. We were declared healthcare only Jan 1, 2026, and this came with almost no other benefits to make our businesses or jobs easier or less stigmatized.
My clients can only use HSA now to pay with their benefits. We were declared healthcare only Jan 1, 2026, and this came with almost no other benefits to make our businesses or jobs easier or less stigmatized.
RMTs/MTs — have you been delisted by an insurance company?
Clear communication helps patients understand how coverage may be impacted. Read this article for practical tips on informing patients, using factual language and supporting informed decisions: https://bit.ly/44hOmHf
Clear communication helps patients understand how coverage may be impacted. Read this article for practical tips on informing patients, using factual language and supporting informed decisions: https://bit.ly/44hOmHf
June 26, 2026 at 2:11 PM
We face this in California. Insuance specifically exclues us from mechanotherapy codes.
My clients can only use HSA now to pay with their benefits. We were declared healthcare only Jan 1, 2026, and this came with almost no other benefits to make our businesses or jobs easier or less stigmatized.
My clients can only use HSA now to pay with their benefits. We were declared healthcare only Jan 1, 2026, and this came with almost no other benefits to make our businesses or jobs easier or less stigmatized.
I very much enjoyed this video.
Shearing force (movement/mechanotherapy/myofascial massage) is also a big stimuli of HA secretion, and densification can have many other forms.
This is a ****great*** video to get clients up and moving between sessions.
#massagetherapists
Shearing force (movement/mechanotherapy/myofascial massage) is also a big stimuli of HA secretion, and densification can have many other forms.
This is a ****great*** video to get clients up and moving between sessions.
#massagetherapists
What Downward Dog Actually Does for Your Back & Fascia
YouTube video by Emma Forever Yoga
www.youtube.com
June 20, 2026 at 2:50 PM
I very much enjoyed this video.
Shearing force (movement/mechanotherapy/myofascial massage) is also a big stimuli of HA secretion, and densification can have many other forms.
This is a ****great*** video to get clients up and moving between sessions.
#massagetherapists
Shearing force (movement/mechanotherapy/myofascial massage) is also a big stimuli of HA secretion, and densification can have many other forms.
This is a ****great*** video to get clients up and moving between sessions.
#massagetherapists
