RRID:AB_2534104 from @thermofishersci.bsky.social was used by authors in their bioRxiv paper. RRIDs improve reproducibility in scientific research. #STMpublishing #methodsmatter #OpenResearch
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme
Read the full paper: In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme
doi.org
October 30, 2026 at 7:09 AM
RRID:AB_2534104 from @thermofishersci.bsky.social was used by authors in their bioRxiv paper. RRIDs improve reproducibility in scientific research. #STMpublishing #methodsmatter #OpenResearch
Since the technology labelled mesoderm, and in particular septum transversum mesenchyme, we wanted to investigate its possible derivative lineages, including liver mesothelium and heart epicardial lineages.
September 23, 2026 at 5:00 PM
Since the technology labelled mesoderm, and in particular septum transversum mesenchyme, we wanted to investigate its possible derivative lineages, including liver mesothelium and heart epicardial lineages.
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
September 23, 2026 at 2:30 PM
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
September 23, 2026 at 2:30 PM
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
This is why bypassing Cre drivers matters.
Enhancer/promoter-based drivers report marker expression, not ancestry. In organ mesenchyme, transient progenitors share markers, while distinct lineages can converge on similar transcriptional states.
Enhancer/promoter-based drivers report marker expression, not ancestry. In organ mesenchyme, transient progenitors share markers, while distinct lineages can converge on similar transcriptional states.
September 23, 2026 at 5:00 PM
This is why bypassing Cre drivers matters.
Enhancer/promoter-based drivers report marker expression, not ancestry. In organ mesenchyme, transient progenitors share markers, while distinct lineages can converge on similar transcriptional states.
Enhancer/promoter-based drivers report marker expression, not ancestry. In organ mesenchyme, transient progenitors share markers, while distinct lineages can converge on similar transcriptional states.
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
September 23, 2026 at 4:00 PM
In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
https://www.biorxiv.org/content/10.64898/2026.09.22.752134v1
Several long-standing controversies in cardiac and hepatic mesenchyme trace directly to this limitation.
In utero barcoding resolves ancestry without first choosing a marker, and opens a previously inaccessible germ layer to rapid genetic manipulation. 🤩
In utero barcoding resolves ancestry without first choosing a marker, and opens a previously inaccessible germ layer to rapid genetic manipulation. 🤩
September 23, 2026 at 5:00 PM
Several long-standing controversies in cardiac and hepatic mesenchyme trace directly to this limitation.
In utero barcoding resolves ancestry without first choosing a marker, and opens a previously inaccessible germ layer to rapid genetic manipulation. 🤩
In utero barcoding resolves ancestry without first choosing a marker, and opens a previously inaccessible germ layer to rapid genetic manipulation. 🤩
Most strikingly, transcriptionally similar valve-mesenchymal cells can have fundamentally different origins: epicardial/mesodermal or neural crest. (disclaimer, endocardium was not targeted with our approach)
So, cell state (convergent mesenchyme) does not reveal developmental history.
So, cell state (convergent mesenchyme) does not reveal developmental history.
September 23, 2026 at 5:00 PM
Most strikingly, transcriptionally similar valve-mesenchymal cells can have fundamentally different origins: epicardial/mesodermal or neural crest. (disclaimer, endocardium was not targeted with our approach)
So, cell state (convergent mesenchyme) does not reveal developmental history.
So, cell state (convergent mesenchyme) does not reveal developmental history.
13/23
(some papers in which the mesenchyme was shown to take part in morphogenesis)
www.cell.com/cell/fulltex...
pubmed.ncbi.nlm.nih.gov/38569553/
pubmed.ncbi.nlm.nih.gov/25437543/
(some papers in which the mesenchyme was shown to take part in morphogenesis)
www.cell.com/cell/fulltex...
pubmed.ncbi.nlm.nih.gov/38569553/
pubmed.ncbi.nlm.nih.gov/25437543/
Patterning and folding of intestinal villi by active mesenchymal dewetting
Subepithelial mesenchyme behaves like a dewetting fluid to pattern and fold the intestinal
epithelium, initiating the formation of villi.
www.cell.com
September 21, 2026 at 1:43 PM
13/23
(some papers in which the mesenchyme was shown to take part in morphogenesis)
www.cell.com/cell/fulltex...
pubmed.ncbi.nlm.nih.gov/38569553/
pubmed.ncbi.nlm.nih.gov/25437543/
(some papers in which the mesenchyme was shown to take part in morphogenesis)
www.cell.com/cell/fulltex...
pubmed.ncbi.nlm.nih.gov/38569553/
pubmed.ncbi.nlm.nih.gov/25437543/
We do not have mounting a trusty mesenchyme! I will designate it as RuckusCore~
September 12, 2026 at 10:30 AM
We do not have mounting a trusty mesenchyme! I will designate it as RuckusCore~
A NIH-funded postdoc position is available in our laboratory @cu-coms.bsky.social to study PDGFR dimer-specific dynamics in the mouse craniofacial mesenchyme. Please repost! Job description and how to apply: cu.taleo.net/careersectio...
Post-Doctoral Fellow
Click the link provided to see the complete job description.
cu.taleo.net
August 21, 2026 at 7:40 PM
A NIH-funded postdoc position is available in our laboratory @cu-coms.bsky.social to study PDGFR dimer-specific dynamics in the mouse craniofacial mesenchyme. Please repost! Job description and how to apply: cu.taleo.net/careersectio...
Inhibition of the AT-Hook DNA-Binding Domain Attenuates HMGA2-Mediated Epithelial Mesenchyme Transition in Esophageal Cancer Cells pubmed.ncbi.nlm.nih.gov/42589587/
August 15, 2026 at 1:39 AM
Inhibition of the AT-Hook DNA-Binding Domain Attenuates HMGA2-Mediated Epithelial Mesenchyme Transition in Esophageal Cancer Cells pubmed.ncbi.nlm.nih.gov/42589587/
What did the mesenchyme say when it fell on the rayon?
Poop stinky doo-doo fart smelly!
Poop stinky doo-doo fart smelly!
August 10, 2026 at 8:16 AM
What did the mesenchyme say when it fell on the rayon?
Poop stinky doo-doo fart smelly!
Poop stinky doo-doo fart smelly!
Instead, stem cells in planaria operate inside a mesenchyme that appears to act as a network of interconnected microenvironments, with signals overlapping and diffusing like a dynamic molecular ecology
October 19, 2025 at 7:56 PM
Instead, stem cells in planaria operate inside a mesenchyme that appears to act as a network of interconnected microenvironments, with signals overlapping and diffusing like a dynamic molecular ecology
Luca Schwarz from @cellbiol-mrclmb.bsky.social
presented his blastocyst-derived trophoblast organoid as an in vitro model of human placenta to investigate ExMe (extraembryonic mesenchyme)
presented his blastocyst-derived trophoblast organoid as an in vitro model of human placenta to investigate ExMe (extraembryonic mesenchyme)
May 19, 2025 at 7:59 PM
Luca Schwarz from @cellbiol-mrclmb.bsky.social
presented his blastocyst-derived trophoblast organoid as an in vitro model of human placenta to investigate ExMe (extraembryonic mesenchyme)
presented his blastocyst-derived trophoblast organoid as an in vitro model of human placenta to investigate ExMe (extraembryonic mesenchyme)
Lecture 3: Glandular Epithelium — Histology
Glands are collections of epithelial cells specialized for secretion—the synthesis and release of specific products that serve functions elsewhere in the body.
https://hibbertmed.com/lectures/year1/unit1.2_histology/lecture_03_glandular_epithelium
Glands are collections of epithelial cells specialized for secretion—the synthesis and release of specific products that serve functions elsewhere in the body.
https://hibbertmed.com/lectures/year1/unit1.2_histology/lecture_03_glandular_epithelium
February 20, 2026 at 5:27 PM
Lecture 3: Glandular Epithelium — Histology
Glands are collections of epithelial cells specialized for secretion—the synthesis and release of specific products that serve functions elsewhere in the body.
https://hibbertmed.com/lectures/year1/unit1.2_histology/lecture_03_glandular_epithelium
Glands are collections of epithelial cells specialized for secretion—the synthesis and release of specific products that serve functions elsewhere in the body.
https://hibbertmed.com/lectures/year1/unit1.2_histology/lecture_03_glandular_epithelium
News from our CoE by @katajistolab.bsky.social @sharifiqbal.bsky.social shed light on how the intestinal epithelium is repaired after injury, with implications for aging and chemotherapy-induced damage www.sciencedirect.com/science/arti... @helsinki.fi @helsinki-biotech.bsky.social Congratulations 🎉
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…
www.sciencedirect.com
March 7, 2025 at 12:38 PM
News from our CoE by @katajistolab.bsky.social @sharifiqbal.bsky.social shed light on how the intestinal epithelium is repaired after injury, with implications for aging and chemotherapy-induced damage www.sciencedirect.com/science/arti... @helsinki.fi @helsinki-biotech.bsky.social Congratulations 🎉
The nail mesenchyme creates a regeneration-specific ligand environment that orchestrates mammalian regeneration versus fibrotic wound healing #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.04.18.719303v1
https://www.biorxiv.org/content/10.64898/2026.04.18.719303v1
April 22, 2026 at 4:00 PM
The nail mesenchyme creates a regeneration-specific ligand environment that orchestrates mammalian regeneration versus fibrotic wound healing #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.04.18.719303v1
https://www.biorxiv.org/content/10.64898/2026.04.18.719303v1
Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.09.03.674033v1
https://www.biorxiv.org/content/10.1101/2025.09.03.674033v1
September 8, 2025 at 7:00 AM
Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.09.03.674033v1
https://www.biorxiv.org/content/10.1101/2025.09.03.674033v1
Tomorrow at noon @institutcochin.bsky.social seminar by Chris Mueller @cnrs.fr @unistra.fr on "Differentiation of B cell-associated mesenchymal cells in the lymph node" #Bcells #immunity #macrophages #mesenchyme
November 5, 2025 at 6:23 PM
Tomorrow at noon @institutcochin.bsky.social seminar by Chris Mueller @cnrs.fr @unistra.fr on "Differentiation of B cell-associated mesenchymal cells in the lymph node" #Bcells #immunity #macrophages #mesenchyme
Lens-regulated genes implicated in periocular mesenchyme, cornea and anterior optic cup development were identified.
January 15, 2025 at 1:37 PM
Lens-regulated genes implicated in periocular mesenchyme, cornea and anterior optic cup development were identified.
Delighted to share our updated work, led by former @molbcu.bsky.social student Thomas Forman, out now in @elife.bsky.social: elifesciences.org/articles/98531, PDGFRa signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking
PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking
Upon PDGFRα signaling in mouse embryonic palatal mesenchyme cells, Srsf3 exhibits differential transcript binding, resulting in retention of the receptor in early endosomes and increased downstream PI...
elifesciences.org
December 4, 2024 at 4:58 PM
Delighted to share our updated work, led by former @molbcu.bsky.social student Thomas Forman, out now in @elife.bsky.social: elifesciences.org/articles/98531, PDGFRa signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking
Nature research paper: Human assembloids recapitulate periportal liver tissue in vitro
go.nature.com/490uo5Y
go.nature.com/490uo5Y
Human assembloids recapitulate periportal liver tissue in vitro - Nature
Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.
go.nature.com
December 19, 2025 at 10:03 AM
Nature research paper: Human assembloids recapitulate periportal liver tissue in vitro
go.nature.com/490uo5Y
go.nature.com/490uo5Y
Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...
aacrjournals.org
February 7, 2025 at 2:14 PM
Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...