🇬🇧 National Disease Registrations Service
🟢 ⬇️ incidence pleural meso over time
🔺 no ⬇️ in sarcomatoid / biphasic
🟢 ⬆️ 2yr survival over time
👉 Older pts less likely to get SACT
👉 ⬇️ RT use over time
Publicly available 👏
nhsd-ndrs.shinyapps.io/get_data_out/
🟢 ⬇️ incidence pleural meso over time
🔺 no ⬇️ in sarcomatoid / biphasic
🟢 ⬆️ 2yr survival over time
👉 Older pts less likely to get SACT
👉 ⬇️ RT use over time
Publicly available 👏
nhsd-ndrs.shinyapps.io/get_data_out/
December 9, 2024 at 10:04 AM
@Anna_Minchom : what’s next in immunotherapy for mesothelioma?
👉 T-cell engagers
👉 CAR-T
👉 Vaccines
👉 Intra-pleural vaccines
All interesting, but increasingly complex with significant toxicities. No efficacy data yet.
‘Low hanging fruit’ of immunotherapy already taken
👉 T-cell engagers
👉 CAR-T
👉 Vaccines
👉 Intra-pleural vaccines
All interesting, but increasingly complex with significant toxicities. No efficacy data yet.
‘Low hanging fruit’ of immunotherapy already taken
December 9, 2024 at 2:12 PM
@crispinhiley
Radiotherapy for mesothelioma
👍 Meso is radiosensitive
❌ Prophylactic tract RT
🟢 Palliative thoracic RT: ⬇️ symptoms, might ⬆️ OS (SYSTEMS-2)
❓Palliative hemithoracic RT: ⬆️ OS, but toxicity++
⚡️ Protons: x2 🇬🇧 centres
👏 HIT-Meso trial ongoing at UCL + Manchester
Radiotherapy for mesothelioma
👍 Meso is radiosensitive
❌ Prophylactic tract RT
🟢 Palliative thoracic RT: ⬇️ symptoms, might ⬆️ OS (SYSTEMS-2)
❓Palliative hemithoracic RT: ⬆️ OS, but toxicity++
⚡️ Protons: x2 🇬🇧 centres
👏 HIT-Meso trial ongoing at UCL + Manchester
December 9, 2024 at 11:40 AM
Interesting conclusions from Matthew Tate of the Scottish Mesothelioma Network #mesoupdate24 #mesothelioma
December 9, 2024 at 9:48 AM
Interesting conclusions from Matthew Tate of the Scottish Mesothelioma Network #mesoupdate24 #mesothelioma
Thank you for the invite to present our @mesouk.bsky.social funded study on receipt of #PalliativeCare for patients with pleural #Mesothelioma -
& markers of quality care at end-of-life today at #MesoUpdate24
Our study will be published in @palliativemedj.bsky.social any day now!
@btog.bsky.social
& markers of quality care at end-of-life today at #MesoUpdate24
Our study will be published in @palliativemedj.bsky.social any day now!
@btog.bsky.social
December 9, 2024 at 7:39 PM
Thank you for the invite to present our @mesouk.bsky.social funded study on receipt of #PalliativeCare for patients with pleural #Mesothelioma -
& markers of quality care at end-of-life today at #MesoUpdate24
Our study will be published in @palliativemedj.bsky.social any day now!
@btog.bsky.social
& markers of quality care at end-of-life today at #MesoUpdate24
Our study will be published in @palliativemedj.bsky.social any day now!
@btog.bsky.social
Our next speaker will give a retrospective case notes review: multiple unmet palliative care needs in pleural mesothelioma
@donnawakefield.bsky.social #mesoupdate24 #LCSM #lungcancer #mesothelioma
@donnawakefield.bsky.social #mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 3:57 PM
Our next speaker will give a retrospective case notes review: multiple unmet palliative care needs in pleural mesothelioma
@donnawakefield.bsky.social #mesoupdate24 #LCSM #lungcancer #mesothelioma
@donnawakefield.bsky.social #mesoupdate24 #LCSM #lungcancer #mesothelioma
Final panel of the day, the pleural and palliative care session #mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 4:31 PM
Final panel of the day, the pleural and palliative care session #mesoupdate24 #LCSM #lungcancer #mesothelioma
Amanda Jones and Laura Morrison from the specialist asbestos diseases team at Thompsons attended the British Thoracic Oncology Group @btog.bsky.social for the
#mesoupdate24 day yesterday. #LCSM #lungcancer #mesothelioma #BTOG
#mesoupdate24 day yesterday. #LCSM #lungcancer #mesothelioma #BTOG
December 10, 2024 at 9:29 AM
Amanda Jones and Laura Morrison from the specialist asbestos diseases team at Thompsons attended the British Thoracic Oncology Group @btog.bsky.social for the
#mesoupdate24 day yesterday. #LCSM #lungcancer #mesothelioma #BTOG
#mesoupdate24 day yesterday. #LCSM #lungcancer #mesothelioma #BTOG
@mesouk.bsky.social CNS Louise Gilham tells the attendees what a Mesothelioma Clinical Nurse Specialist does #mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 2:11 PM
@mesouk.bsky.social CNS Louise Gilham tells the attendees what a Mesothelioma Clinical Nurse Specialist does #mesoupdate24 #LCSM #lungcancer #mesothelioma
What is the role of radiotherapy? Crispin Hiley of UCLH and UCL answers.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 11:22 AM
What is the role of radiotherapy? Crispin Hiley of UCLH and UCL answers.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
Next up is an update from Tom Cecil of the National Peritoneal Mesothelioma MDT hosted at Hampshire Hospitals.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 2:29 PM
Next up is an update from Tom Cecil of the National Peritoneal Mesothelioma MDT hosted at Hampshire Hospitals.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
Our final speaker today, Helen Jones presents the legal case for compensation for asbestos in talc
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 4:18 PM
Our final speaker today, Helen Jones presents the legal case for compensation for asbestos in talc
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
Novel Agents and New Drug Development by Anna Minchom of Royal Marsden Hospital and the Institute of Cancer Research
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 12:59 PM
Novel Agents and New Drug Development by Anna Minchom of Royal Marsden Hospital and the Institute of Cancer Research
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
@dean_fennell: 2L mesothelioma options
👉 (small) subset of non-epithelioid pts do very well with Vin
🟢 Gem+Ramucirumab = ⬆️ PFS
❓ Gem maintenance = ⬆️ PFS, but a bit forgotten
🟢 Platinum rechallenge RR 50%
❓Activity in immuno rechallenge, RR up to 50%
👉 (small) subset of non-epithelioid pts do very well with Vin
🟢 Gem+Ramucirumab = ⬆️ PFS
❓ Gem maintenance = ⬆️ PFS, but a bit forgotten
🟢 Platinum rechallenge RR 50%
❓Activity in immuno rechallenge, RR up to 50%
December 9, 2024 at 12:51 PM
PREDICT-Meso:
🧐 How does inflammation evolve into malignancy?
🧐 Can we diagnose mesothelioma at pre-malignant stage?
👉 80 institutions, 16 countries
👉 x5 work streams
Fantastic, ambitious, international, multi-faceted project
@btog.bsky.social
@mesouk.bsky.social
🧐 How does inflammation evolve into malignancy?
🧐 Can we diagnose mesothelioma at pre-malignant stage?
👉 80 institutions, 16 countries
👉 x5 work streams
Fantastic, ambitious, international, multi-faceted project
@btog.bsky.social
@mesouk.bsky.social
December 9, 2024 at 11:11 AM
Time for the ever-contentious area of surgery for mesothelioma 😬
Andrea Bille reminds us of MARS2 data:
Surgery =
⬇️ OS
⬆️ SAEs
⬇️ QoL (<6m)
⬆️ Cost (£30.4K v 15.8K)
Useful additional data from Italian surgical studies
Andrea Bille reminds us of MARS2 data:
Surgery =
⬇️ OS
⬆️ SAEs
⬇️ QoL (<6m)
⬆️ Cost (£30.4K v 15.8K)
Useful additional data from Italian surgical studies
December 9, 2024 at 12:11 PM
Time for the ever-contentious area of surgery for mesothelioma 😬
Andrea Bille reminds us of MARS2 data:
Surgery =
⬇️ OS
⬆️ SAEs
⬇️ QoL (<6m)
⬆️ Cost (£30.4K v 15.8K)
Useful additional data from Italian surgical studies
Andrea Bille reminds us of MARS2 data:
Surgery =
⬇️ OS
⬆️ SAEs
⬇️ QoL (<6m)
⬆️ Cost (£30.4K v 15.8K)
Useful additional data from Italian surgical studies
December 9, 2024 at 11:26 AM
After some VERY interesting presentations, some VERY interesting questions for the panel. "The Role of Surgery and Radiotherapy" may be the most controversial session of the day.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 12:09 PM
After some VERY interesting presentations, some VERY interesting questions for the panel. "The Role of Surgery and Radiotherapy" may be the most controversial session of the day.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
#mesoupdate24 #LCSM #lungcancer #mesothelioma
Surgery in mesothelioma: David Waller critiques MARS2
👉 Too many non-epithelioid, older pts
👉 Too much: diaphragm resection in 80%
👉 Too late: insufficient pre-op staging
= ⬆️ complications & deaths
Post-hoc analysis: 70% pts would not now be surgical candidates
👉 Too many non-epithelioid, older pts
👉 Too much: diaphragm resection in 80%
👉 Too late: insufficient pre-op staging
= ⬆️ complications & deaths
Post-hoc analysis: 70% pts would not now be surgical candidates
December 9, 2024 at 11:59 AM
Kevin Blyth of @uofglasgow.bsky.social will now discuss the best way to manage symptomatic malignant pleural effusions. #mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 3:43 PM
Kevin Blyth of @uofglasgow.bsky.social will now discuss the best way to manage symptomatic malignant pleural effusions. #mesoupdate24 #LCSM #lungcancer #mesothelioma
Full auditorium for todays #MesoUpdate24 - organised by @mesouk.bsky.social & @btog.bsky.social 👏
Brilliant to see such enthusiasm for #Mesothelioma from all backgrounds- respiratory/oncology/surgery/pathology/palliative care/legal, clinical and non-clinical researchers all working together 🙌
Brilliant to see such enthusiasm for #Mesothelioma from all backgrounds- respiratory/oncology/surgery/pathology/palliative care/legal, clinical and non-clinical researchers all working together 🙌
Kicking off today’s #mesoupdate24 with Mesothelioma UK, chaired by @drriyaz.bsky.social and Liz Darlison
December 9, 2024 at 7:06 PM
Full auditorium for todays #MesoUpdate24 - organised by @mesouk.bsky.social & @btog.bsky.social 👏
Brilliant to see such enthusiasm for #Mesothelioma from all backgrounds- respiratory/oncology/surgery/pathology/palliative care/legal, clinical and non-clinical researchers all working together 🙌
Brilliant to see such enthusiasm for #Mesothelioma from all backgrounds- respiratory/oncology/surgery/pathology/palliative care/legal, clinical and non-clinical researchers all working together 🙌
The Pleural and Palliative Care Session is Chaired by
Nick Maskell. Our first speaker in this final session for the day is Sarah Johnstone, telling us about the role of a pleural nurse.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
Nick Maskell. Our first speaker in this final session for the day is Sarah Johnstone, telling us about the role of a pleural nurse.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 3:28 PM
The Pleural and Palliative Care Session is Chaired by
Nick Maskell. Our first speaker in this final session for the day is Sarah Johnstone, telling us about the role of a pleural nurse.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
Nick Maskell. Our first speaker in this final session for the day is Sarah Johnstone, telling us about the role of a pleural nurse.
#mesoupdate24 #LCSM #lungcancer #mesothelioma
The next session is on “Biomarker Testing and Mesothelioma – Should we do it?” Chaired by Leah Taylor from @mesouk.bsky.social
The first speaker, Riyaz Shah of the Kent Oncology Centre talks about 1st line Systemic Anti-Cancer Therapy (SACT)
#mesoupdate24 #LCSM #lungcancer #mesothelioma
The first speaker, Riyaz Shah of the Kent Oncology Centre talks about 1st line Systemic Anti-Cancer Therapy (SACT)
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 12:21 PM
The next session is on “Biomarker Testing and Mesothelioma – Should we do it?” Chaired by Leah Taylor from @mesouk.bsky.social
The first speaker, Riyaz Shah of the Kent Oncology Centre talks about 1st line Systemic Anti-Cancer Therapy (SACT)
#mesoupdate24 #LCSM #lungcancer #mesothelioma
The first speaker, Riyaz Shah of the Kent Oncology Centre talks about 1st line Systemic Anti-Cancer Therapy (SACT)
#mesoupdate24 #LCSM #lungcancer #mesothelioma
December 9, 2024 at 12:54 PM
Kicking off today’s #mesoupdate24 with Mesothelioma UK, chaired by @drriyaz.bsky.social and Liz Darlison
December 9, 2024 at 9:13 AM
Kicking off today’s #mesoupdate24 with Mesothelioma UK, chaired by @drriyaz.bsky.social and Liz Darlison