A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility @PNAS.org
A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility
Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026.
SignificanceCognitive flexibility, the ability to update behavior when circumstances change, depends on modifying stored information, but the underlying synaptic mechanisms are unclear. Using a mouse model with enhanced flexibility, we identify a protein ...
dlvr.it
October 30, 2026 at 9:31 AM
A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility @PNAS.org
A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility @PNAS.org
A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility
Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026.
SignificanceCognitive flexibility, the ability to update behavior when circumstances change, depends on modifying stored information, but the underlying synaptic mechanisms are unclear. Using a mouse model with enhanced flexibility, we identify a protein ...
dlvr.it
October 30, 2026 at 9:31 AM
A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility @PNAS.org
Shutting Down Runaway Protein Production In Genetic Autism
Source: pubmed.ncbi.nlm.nih.gov/23142366/
#autism #autismresearch #autismawareness #autismspectrum #fragilex #fragilexsyndrome #autismsymptoms #repetitivebehaviors #neuroscience #braincircuits #neurogenetics #neurodevelopment #mglur5
Source: pubmed.ncbi.nlm.nih.gov/23142366/
#autism #autismresearch #autismawareness #autismspectrum #fragilex #fragilexsyndrome #autismsymptoms #repetitivebehaviors #neuroscience #braincircuits #neurogenetics #neurodevelopment #mglur5
October 22, 2026 at 11:21 AM
Shutting Down Runaway Protein Production In Genetic Autism
Source: pubmed.ncbi.nlm.nih.gov/23142366/
#autism #autismresearch #autismawareness #autismspectrum #fragilex #fragilexsyndrome #autismsymptoms #repetitivebehaviors #neuroscience #braincircuits #neurogenetics #neurodevelopment #mglur5
Source: pubmed.ncbi.nlm.nih.gov/23142366/
#autism #autismresearch #autismawareness #autismspectrum #fragilex #fragilexsyndrome #autismsymptoms #repetitivebehaviors #neuroscience #braincircuits #neurogenetics #neurodevelopment #mglur5
Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior https://www.biorxiv.org/content/10.64898/2026.10.14.759089v1
October 16, 2026 at 10:18 AM
Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior https://www.biorxiv.org/content/10.64898/2026.10.14.759089v1
Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior https://www.biorxiv.org/content/10.64898/2026.10.14.759089v1
October 16, 2026 at 10:18 AM
Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior https://www.biorxiv.org/content/10.64898/2026.10.14.759089v1
Cole Malloy, Jia-Hua Hu, Ying Liu, Meghyn A Welch, Mumeko C Tsuda, Heather A Cameron, and Dax A Hoffman
A Kv4.2-mGluR5 complex drives enhanced depotentiation in a mouse model of improved cognitive flexibility
Memory updating promotes cognitive flexibility by enabling suppression of outdated information to optimize behavioral strategies in response to a changing environment. While some circuits involved have been identified, the synaptic mechanisms underlying this process remain uncertain. Here, using a recently developed Kv4.2 knock-in mouse model (Kv4.2TA), we identify a metaplasticity in the hippocampus that accompanies an improvement in cognitive flexibility. Mutation of a C-terminal...
pnas.org
October 12, 2026 at 10:00 PM
Cole Malloy, Jia-Hua Hu, Ying Liu, Meghyn A Welch, Mumeko C Tsuda, Heather A Cameron, and Dax A Hoffman
New paper in Imaging Neuroscience by Melanie A. Matyi, Lauren Massimo, et al:
Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration
doi.org/10.1162/IMAG...
Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration
doi.org/10.1162/IMAG...
September 14, 2026 at 9:26 PM
New paper in Imaging Neuroscience by Melanie A. Matyi, Lauren Massimo, et al:
Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration
doi.org/10.1162/IMAG...
Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration
doi.org/10.1162/IMAG...
In bvFTD, we found that the spatial relationship between neurodegeneration and a neurotransmitter receptor was associated with disease severity and cognition.
Read the paper from Penn FTDC's Melanie Matyi, PhD below!
direct.mit.edu/imag/article...
Read the paper from Penn FTDC's Melanie Matyi, PhD below!
direct.mit.edu/imag/article...
Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration
Abstract. Post-mortem human brain tissue and in vivo imaging studies of behavioral variant frontotemporal degeneration (bvFTD) suggest that metabotropic glutamate receptors (mGluR) may be vulnerable t...
direct.mit.edu
September 14, 2026 at 2:21 PM
In bvFTD, we found that the spatial relationship between neurodegeneration and a neurotransmitter receptor was associated with disease severity and cognition.
Read the paper from Penn FTDC's Melanie Matyi, PhD below!
direct.mit.edu/imag/article...
Read the paper from Penn FTDC's Melanie Matyi, PhD below!
direct.mit.edu/imag/article...
https://gregory-ms.com/articles/295299/
Activity-driven myelin sheath growth is mediated by mGluR5
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
Activity-driven myelin sheath growth is mediated by mGluR5
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
May 17, 2025 at 2:00 PM
https://gregory-ms.com/articles/295299/
Activity-driven myelin sheath growth is mediated by mGluR5
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
Activity-driven myelin sheath growth is mediated by mGluR5
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
Mavoglurant, el fármaco experimental que reduce el consumo de cocaína y alcohol https://elcomercio.pe/tecnologia/actualidad/mavoglurant-el-farmaco-experimental-que-reduce-el-consumo-de-cocaina-y-alcohol-noticia/
Mavoglurant, el fármaco experimental que reduce el consumo de cocaína y alcohol
El fármaco inhibe un receptor llamado mGluR5, el cual desempeña un papel central en la adicción a este narcótico y en el procesamiento de la recompensa
elcomercio.pe
April 3, 2025 at 9:54 PM
Mavoglurant, el fármaco experimental que reduce el consumo de cocaína y alcohol https://elcomercio.pe/tecnologia/actualidad/mavoglurant-el-farmaco-experimental-que-reduce-el-consumo-de-cocaina-y-alcohol-noticia/
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 11:45 AM
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our new paper in Science Advances on the proteome of neuronal primary cilia.
We found that neuronal cilia are enriched in postsynaptic signaling proteins, including mGluR5, GABAB receptors, GPR158, ion channels, and transporters.
www.science.org/doi/10.1126/...
We found that neuronal cilia are enriched in postsynaptic signaling proteins, including mGluR5, GABAB receptors, GPR158, ion channels, and transporters.
www.science.org/doi/10.1126/...
June 3, 2026 at 7:05 PM
Excited to share our new paper in Science Advances on the proteome of neuronal primary cilia.
We found that neuronal cilia are enriched in postsynaptic signaling proteins, including mGluR5, GABAB receptors, GPR158, ion channels, and transporters.
www.science.org/doi/10.1126/...
We found that neuronal cilia are enriched in postsynaptic signaling proteins, including mGluR5, GABAB receptors, GPR158, ion channels, and transporters.
www.science.org/doi/10.1126/...
many, many articles linking TRPV1 and TRPA1 with chronic pain and glutamate receptors
(PDF) Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity
PDF | Peripheral tissue inflammation or injury causes glutamate release from nociceptive axons, keratinocytes and Schwann cells, resulting in thermal... | Find, read and cite all the research you need...
www.researchgate.net
July 17, 2026 at 2:05 PM
many, many articles linking TRPV1 and TRPA1 with chronic pain and glutamate receptors
higher-order functional networks and brain's normative molecular architecture, with regions normally rich in GABA-A, 5-HT2A, mGluR5 and 5-HT1B receptors showing the greatest deficits. 2/4
June 29, 2026 at 4:09 AM
higher-order functional networks and brain's normative molecular architecture, with regions normally rich in GABA-A, 5-HT2A, mGluR5 and 5-HT1B receptors showing the greatest deficits. 2/4
Congratulations to the authors of this paper investigating mGluR5 inhibition as a potential clinical approach in cocaine use disorder. Great science and important findings the research community can build on to further understand glutamate signaling in abuse disorders www.science.org/doi/10.1126/...
April 2, 2025 at 8:43 PM
Congratulations to the authors of this paper investigating mGluR5 inhibition as a potential clinical approach in cocaine use disorder. Great science and important findings the research community can build on to further understand glutamate signaling in abuse disorders www.science.org/doi/10.1126/...
The authors included RRIDs in their in Science Advances paper! Thanks for making your methods matter! #STMpublishing #accelerateopenscience #ReproducibleResearch
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine
Read the full paper: TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine
doi.org
June 7, 2026 at 7:03 AM
The authors included RRIDs in their in Science Advances paper! Thanks for making your methods matter! #STMpublishing #accelerateopenscience #ReproducibleResearch
RRIDs were included in this paper. We value the author's support of reproducibility. #accelerateopenscience #OpenScience #STMpublishing
Activity deprivation modulates the Shank3/Homer1/mGluR5 signaling pathway to enable synaptic upscaling
doi.org
November 16, 2025 at 8:00 AM
RRIDs were included in this paper. We value the author's support of reproducibility. #accelerateopenscience #OpenScience #STMpublishing
@thermofishersci.bsky.social's resource, RRID:AB_2572212, was just reported to be used in the paper. We value the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience #OpenScience
Conditional mGluR5 Knockout in Glutamatergic Pathways Disrupts the Development of Excitatory Synaptic Transmission onto Mouse MNTB Neurons
doi.org
November 2, 2025 at 7:00 AM
@thermofishersci.bsky.social's resource, RRID:AB_2572212, was just reported to be used in the paper. We value the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience #OpenScience
RRIDs were included in this paper. We value the author's support of reproducibility. #STMpublishing #OpenScience #OpenScience
The mGluR5 agonist CHPG enhances human oligodendrocyte differentiation
doi.org
October 8, 2025 at 7:00 AM
RRIDs were included in this paper. We value the author's support of reproducibility. #STMpublishing #OpenScience #OpenScience
RRIDs were included in this bioRxiv paper. RRIDs improve reproducibility in scientific research. #RRID #RRID #methodsmatter
Astrocytic mGluR5 signaling tunes emotional and cognitive processing in the adult brain
doi.org
July 19, 2025 at 10:12 AM
RRIDs were included in this bioRxiv paper. RRIDs improve reproducibility in scientific research. #RRID #RRID #methodsmatter
RRIDs were included in this Experimental & Molecular Medicine paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #accelerateopenscience
Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain
doi.org
May 24, 2025 at 7:01 AM
RRIDs were included in this Experimental & Molecular Medicine paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #accelerateopenscience
A paper using RRID:SCR_003070 was just published in Communications Biology see "mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice". RRIDs like this improve reproducibility in scientific research. #RRID #accelerateopenscience
doi.org
March 27, 2025 at 10:13 PM
A paper using RRID:SCR_003070 was just published in Communications Biology see "mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice". RRIDs like this improve reproducibility in scientific research. #RRID #accelerateopenscience
Une lueur d'espoir pour Morano. RT @NatureMedicine: Drugs targeting mGluR5 receptor offer 'fragile' hope for autism:
bit.ly/LBJ1vd
bit.ly/LBJ1vd
November 24, 2024 at 9:08 AM
Une lueur d'espoir pour Morano. RT @NatureMedicine: Drugs targeting mGluR5 receptor offer 'fragile' hope for autism:
bit.ly/LBJ1vd
bit.ly/LBJ1vd